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Protein

Protein FAM110B

Gene

FAM110B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in tumor progression.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM110B
Gene namesi
Name:FAM110B
Synonyms:C8orf72
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:28587. FAM110B.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162385659.

Polymorphism and mutation databases

BioMutaiFAM110B.
DMDMi74730569.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 370370Protein FAM110BPRO_0000285651Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei238 – 2381PhosphoserineBy similarity
Modified residuei301 – 3011PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8TC76.
PRIDEiQ8TC76.

PTM databases

iPTMnetiQ8TC76.
PhosphoSiteiQ8TC76.

Expressioni

Tissue specificityi

Detected in thyroid, spleen and testis, and at lower levels in stomach, spinal cord, lymph node, trachea, adrenal gland, prostate, ovary and intestine.1 Publication

Gene expression databases

BgeeiQ8TC76.
CleanExiHS_FAM110B.
ExpressionAtlasiQ8TC76. baseline and differential.
GenevisibleiQ8TC76. HS.

Organism-specific databases

HPAiHPA008318.
HPA011781.

Interactioni

Protein-protein interaction databases

BioGridi124703. 4 interactions.
IntActiQ8TC76. 4 interactions.
MINTiMINT-8330050.
STRINGi9606.ENSP00000355204.

Structurei

3D structure databases

ProteinModelPortaliQ8TC76.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM110 family.Curated

Phylogenomic databases

eggNOGiENOG410IF7K. Eukaryota.
ENOG410ZHRK. LUCA.
GeneTreeiENSGT00530000063395.
HOGENOMiHOG000112424.
HOVERGENiHBG051171.
InParanoidiQ8TC76.
OMAiWPPHRPD.
OrthoDBiEOG7NGQCF.
PhylomeDBiQ8TC76.
TreeFamiTF330964.

Family and domain databases

InterProiIPR025741. FAM110_C.
IPR025739. FAM110_N.
[Graphical view]
PfamiPF14160. FAM110_C. 1 hit.
PF14161. FAM110_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TC76-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPTETLQTGS MVKPVSPAGT FTSAVPLRIL NKGPDYFRRQ AEPNPKRLSA
60 70 80 90 100
VERLEADKAK YVKSQEVINA KQEPVKPAVL AKPPVCPAAK RALGSPTLKV
110 120 130 140 150
FGNHAKTESG VQRENLKLEI LKNIINSSEG SSSGSGHKHS SRNWPPHRSE
160 170 180 190 200
ATDLHRHSFA ESLKVYPTQG RRSPQEGGSH VGRRLLEQSA ESFLHVSHSS
210 220 230 240 250
SDIRKVTSVK PLKAIPCSSS APPLPPKPKI AAIASMKSPE ADPVEPACGV
260 270 280 290 300
SRRPSLQRSK SDLSDRYFRV DADVERFFNY CGLDPEELEN LGMENFARAN
310 320 330 340 350
SDIISLNFRS ASMISSDCEQ SQDSNSDLRN DDSANDRVPY GISAIERNAR
360 370
IIKWLYSIKQ ARESQKVSHV
Length:370
Mass (Da):40,728
Last modified:June 1, 2002 - v1
Checksum:i7D0F066083AE6C1B
GO

Sequence cautioni

The sequence AAB50224.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti41 – 411A → T in AAX28928 (Ref. 1) Curated
Sequence conflicti296 – 2961F → Y in AAX28928 (Ref. 1) Curated
Sequence conflicti345 – 3451I → N in AAX28928 (Ref. 1) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti214 – 2141A → S in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_036319

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY937246 mRNA. Translation: AAX28928.1.
DQ431182 mRNA. Translation: ABD92774.1.
U79298 mRNA. Translation: AAB50224.1. Different initiation.
BC024294 mRNA. Translation: AAH24294.1.
CCDSiCCDS6170.1.
RefSeqiNP_671722.1. NM_147189.2.
XP_005251381.1. XM_005251324.1.
XP_005251382.1. XM_005251325.2.
XP_005251383.1. XM_005251326.1.
UniGeneiHs.154652.

Genome annotation databases

EnsembliENST00000361488; ENSP00000355204; ENSG00000169122.
GeneIDi90362.
KEGGihsa:90362.
UCSCiuc003xtj.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY937246 mRNA. Translation: AAX28928.1.
DQ431182 mRNA. Translation: ABD92774.1.
U79298 mRNA. Translation: AAB50224.1. Different initiation.
BC024294 mRNA. Translation: AAH24294.1.
CCDSiCCDS6170.1.
RefSeqiNP_671722.1. NM_147189.2.
XP_005251381.1. XM_005251324.1.
XP_005251382.1. XM_005251325.2.
XP_005251383.1. XM_005251326.1.
UniGeneiHs.154652.

3D structure databases

ProteinModelPortaliQ8TC76.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124703. 4 interactions.
IntActiQ8TC76. 4 interactions.
MINTiMINT-8330050.
STRINGi9606.ENSP00000355204.

PTM databases

iPTMnetiQ8TC76.
PhosphoSiteiQ8TC76.

Polymorphism and mutation databases

BioMutaiFAM110B.
DMDMi74730569.

Proteomic databases

PaxDbiQ8TC76.
PRIDEiQ8TC76.

Protocols and materials databases

DNASUi90362.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361488; ENSP00000355204; ENSG00000169122.
GeneIDi90362.
KEGGihsa:90362.
UCSCiuc003xtj.2. human.

Organism-specific databases

CTDi90362.
GeneCardsiFAM110B.
H-InvDBHIX0007524.
HGNCiHGNC:28587. FAM110B.
HPAiHPA008318.
HPA011781.
MIMi611394. gene.
neXtProtiNX_Q8TC76.
PharmGKBiPA162385659.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IF7K. Eukaryota.
ENOG410ZHRK. LUCA.
GeneTreeiENSGT00530000063395.
HOGENOMiHOG000112424.
HOVERGENiHBG051171.
InParanoidiQ8TC76.
OMAiWPPHRPD.
OrthoDBiEOG7NGQCF.
PhylomeDBiQ8TC76.
TreeFamiTF330964.

Miscellaneous databases

GenomeRNAii90362.
PROiQ8TC76.
SOURCEiSearch...

Gene expression databases

BgeeiQ8TC76.
CleanExiHS_FAM110B.
ExpressionAtlasiQ8TC76. baseline and differential.
GenevisibleiQ8TC76. HS.

Family and domain databases

InterProiIPR025741. FAM110_C.
IPR025739. FAM110_N.
[Graphical view]
PfamiPF14160. FAM110_C. 1 hit.
PF14161. FAM110_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and bioinformatic analysis of a novel tumor-associated gene MGC39325."
    Li X.-N., Li Y.-L., Liu G.-B., Ding Y.-Q.
    Shi Jie Hua Ren Xiao Hua Za Zhi 13:1059-1064(2005)
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Colon carcinoma.
  2. "Characterization of the FAM110 gene family."
    Hauge H., Patzke S., Aasheim H.-C.
    Genomics 90:14-27(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  3. "Large-scale concatenation cDNA sequencing."
    Yu W., Andersson B., Worley K.C., Muzny D.M., Ding Y., Liu W., Ricafrente J.Y., Wentland M.A., Lennon G., Gibbs R.A.
    Genome Res. 7:353-358(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Spleen.
  5. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-301, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-301, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  8. Cited for: VARIANT [LARGE SCALE ANALYSIS] SER-214.

Entry informationi

Entry nameiF110B_HUMAN
AccessioniPrimary (citable) accession number: Q8TC76
Secondary accession number(s): Q5BM08, Q9Y4K2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: June 1, 2002
Last modified: June 8, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.