Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein FAM110B

Gene

FAM110B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in tumor progression.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM110B
Gene namesi
Name:FAM110B
Synonyms:C8orf72
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000169122.11.
HGNCiHGNC:28587. FAM110B.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

DisGeNETi90362.
OpenTargetsiENSG00000169122.
PharmGKBiPA162385659.

Polymorphism and mutation databases

BioMutaiFAM110B.
DMDMi74730569.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002856511 – 370Protein FAM110BAdd BLAST370

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei238PhosphoserineBy similarity1
Modified residuei301PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8TC76.
PaxDbiQ8TC76.
PeptideAtlasiQ8TC76.
PRIDEiQ8TC76.

PTM databases

iPTMnetiQ8TC76.
PhosphoSitePlusiQ8TC76.

Expressioni

Tissue specificityi

Detected in thyroid, spleen and testis, and at lower levels in stomach, spinal cord, lymph node, trachea, adrenal gland, prostate, ovary and intestine.1 Publication

Gene expression databases

BgeeiENSG00000169122.
CleanExiHS_FAM110B.
ExpressionAtlasiQ8TC76. baseline and differential.
GenevisibleiQ8TC76. HS.

Organism-specific databases

HPAiHPA008318.
HPA011781.

Interactioni

Protein-protein interaction databases

BioGridi124703. 5 interactors.
IntActiQ8TC76. 54 interactors.
MINTiMINT-8330050.
STRINGi9606.ENSP00000355204.

Structurei

3D structure databases

ProteinModelPortaliQ8TC76.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM110 family.Curated

Phylogenomic databases

eggNOGiENOG410IF7K. Eukaryota.
ENOG410ZHRK. LUCA.
GeneTreeiENSGT00530000063395.
HOGENOMiHOG000112424.
HOVERGENiHBG051171.
InParanoidiQ8TC76.
OMAiWPPHRPD.
OrthoDBiEOG091G0LV4.
PhylomeDBiQ8TC76.
TreeFamiTF330964.

Family and domain databases

InterProiView protein in InterPro
IPR025740. FAM110.
IPR025741. FAM110_C.
IPR025739. FAM110_N.
PANTHERiPTHR14758. PTHR14758. 1 hit.
PfamiView protein in Pfam
PF14160. FAM110_C. 1 hit.
PF14161. FAM110_N. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8TC76-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPTETLQTGS MVKPVSPAGT FTSAVPLRIL NKGPDYFRRQ AEPNPKRLSA
60 70 80 90 100
VERLEADKAK YVKSQEVINA KQEPVKPAVL AKPPVCPAAK RALGSPTLKV
110 120 130 140 150
FGNHAKTESG VQRENLKLEI LKNIINSSEG SSSGSGHKHS SRNWPPHRSE
160 170 180 190 200
ATDLHRHSFA ESLKVYPTQG RRSPQEGGSH VGRRLLEQSA ESFLHVSHSS
210 220 230 240 250
SDIRKVTSVK PLKAIPCSSS APPLPPKPKI AAIASMKSPE ADPVEPACGV
260 270 280 290 300
SRRPSLQRSK SDLSDRYFRV DADVERFFNY CGLDPEELEN LGMENFARAN
310 320 330 340 350
SDIISLNFRS ASMISSDCEQ SQDSNSDLRN DDSANDRVPY GISAIERNAR
360 370
IIKWLYSIKQ ARESQKVSHV
Length:370
Mass (Da):40,728
Last modified:June 1, 2002 - v1
Checksum:i7D0F066083AE6C1B
GO

Sequence cautioni

The sequence AAB50224 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti41A → T in AAX28928 (Ref. 1) Curated1
Sequence conflicti296F → Y in AAX28928 (Ref. 1) Curated1
Sequence conflicti345I → N in AAX28928 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036319214A → S in a colorectal cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY937246 mRNA. Translation: AAX28928.1.
DQ431182 mRNA. Translation: ABD92774.1.
U79298 mRNA. Translation: AAB50224.1. Different initiation.
BC024294 mRNA. Translation: AAH24294.1.
CCDSiCCDS6170.1.
RefSeqiNP_671722.1. NM_147189.2.
XP_005251381.1. XM_005251324.2.
XP_005251382.1. XM_005251325.3.
XP_005251383.1. XM_005251326.2.
XP_016869437.1. XM_017013948.1.
UniGeneiHs.154652.

Genome annotation databases

EnsembliENST00000361488; ENSP00000355204; ENSG00000169122.
GeneIDi90362.
KEGGihsa:90362.
UCSCiuc003xtj.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiF110B_HUMAN
AccessioniPrimary (citable) accession number: Q8TC76
Secondary accession number(s): Q5BM08, Q9Y4K2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: June 1, 2002
Last modified: September 27, 2017
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families