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Protein

Protein FAM110B

Gene

FAM110B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in tumor progression.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM110B
Gene namesi
Name:FAM110B
Synonyms:C8orf72
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000169122.11
HGNCiHGNC:28587 FAM110B
MIMi611394 gene
neXtProtiNX_Q8TC76

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

DisGeNETi90362
OpenTargetsiENSG00000169122
PharmGKBiPA162385659

Polymorphism and mutation databases

BioMutaiFAM110B
DMDMi74730569

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002856511 – 370Protein FAM110BAdd BLAST370

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei238PhosphoserineBy similarity1
Modified residuei301PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8TC76
PeptideAtlasiQ8TC76
PRIDEiQ8TC76

PTM databases

iPTMnetiQ8TC76
PhosphoSitePlusiQ8TC76

Expressioni

Tissue specificityi

Detected in thyroid, spleen and testis, and at lower levels in stomach, spinal cord, lymph node, trachea, adrenal gland, prostate, ovary and intestine.1 Publication

Gene expression databases

BgeeiENSG00000169122
CleanExiHS_FAM110B
ExpressionAtlasiQ8TC76 baseline and differential
GenevisibleiQ8TC76 HS

Organism-specific databases

HPAiHPA008318
HPA011781

Interactioni

Protein-protein interaction databases

BioGridi124703, 52 interactors
IntActiQ8TC76, 54 interactors
MINTiQ8TC76
STRINGi9606.ENSP00000355204

Structurei

3D structure databases

ProteinModelPortaliQ8TC76
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM110 family.Curated

Phylogenomic databases

eggNOGiENOG410IF7K Eukaryota
ENOG410ZHRK LUCA
GeneTreeiENSGT00530000063395
HOGENOMiHOG000112424
HOVERGENiHBG051171
InParanoidiQ8TC76
OMAiWPPHRPD
OrthoDBiEOG091G0LV4
PhylomeDBiQ8TC76
TreeFamiTF330964

Family and domain databases

InterProiView protein in InterPro
IPR025740 FAM110
IPR025741 FAM110_C
IPR025739 FAM110_N
PANTHERiPTHR14758 PTHR14758, 1 hit
PfamiView protein in Pfam
PF14160 FAM110_C, 1 hit
PF14161 FAM110_N, 1 hit

Sequencei

Sequence statusi: Complete.

Q8TC76-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPTETLQTGS MVKPVSPAGT FTSAVPLRIL NKGPDYFRRQ AEPNPKRLSA
60 70 80 90 100
VERLEADKAK YVKSQEVINA KQEPVKPAVL AKPPVCPAAK RALGSPTLKV
110 120 130 140 150
FGNHAKTESG VQRENLKLEI LKNIINSSEG SSSGSGHKHS SRNWPPHRSE
160 170 180 190 200
ATDLHRHSFA ESLKVYPTQG RRSPQEGGSH VGRRLLEQSA ESFLHVSHSS
210 220 230 240 250
SDIRKVTSVK PLKAIPCSSS APPLPPKPKI AAIASMKSPE ADPVEPACGV
260 270 280 290 300
SRRPSLQRSK SDLSDRYFRV DADVERFFNY CGLDPEELEN LGMENFARAN
310 320 330 340 350
SDIISLNFRS ASMISSDCEQ SQDSNSDLRN DDSANDRVPY GISAIERNAR
360 370
IIKWLYSIKQ ARESQKVSHV
Length:370
Mass (Da):40,728
Last modified:June 1, 2002 - v1
Checksum:i7D0F066083AE6C1B
GO

Sequence cautioni

The sequence AAB50224 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti41A → T in AAX28928 (Ref. 1) Curated1
Sequence conflicti296F → Y in AAX28928 (Ref. 1) Curated1
Sequence conflicti345I → N in AAX28928 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036319214A → S in a colorectal cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY937246 mRNA Translation: AAX28928.1
DQ431182 mRNA Translation: ABD92774.1
U79298 mRNA Translation: AAB50224.1 Different initiation.
BC024294 mRNA Translation: AAH24294.1
CCDSiCCDS6170.1
RefSeqiNP_671722.1, NM_147189.2
XP_005251381.1, XM_005251324.2
XP_005251382.1, XM_005251325.3
XP_005251383.1, XM_005251326.2
XP_016869437.1, XM_017013948.1
UniGeneiHs.154652

Genome annotation databases

EnsembliENST00000361488; ENSP00000355204; ENSG00000169122
GeneIDi90362
KEGGihsa:90362
UCSCiuc003xtj.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiF110B_HUMAN
AccessioniPrimary (citable) accession number: Q8TC76
Secondary accession number(s): Q5BM08, Q9Y4K2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: June 1, 2002
Last modified: March 28, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health