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Q8TC59

- PIWL2_HUMAN

UniProt

Q8TC59 - PIWL2_HUMAN

Protein

Piwi-like protein 2

Gene

PIWIL2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Plays an essential role in meiotic differentiation of spermatocytes, germ cell differentiation and in self-renewal of spermatogonial stem cells. Its presence in oocytes suggests that it may participate in similar functions during oogenesis in females. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Associates with primary piRNAs in the cytoplasm and is required for PIWIL4/MIWI2 nuclear localization and association with secondary piRNAs antisense. The piRNA process acts upstream of known mediators of DNA methylation. Participates in a piRNA amplification loop. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation. Indirectly modulate expression of genes such as PDGFRB, SLC2A1, ITGA6, GJA7, THY1, CD9 and STRA8. Inhibits tumor cell growth when repressed. When overexpressed, acts as an oncogene by inhibition of apoptosis and promotion of proliferation in tumors By similarity.By similarity

    GO - Molecular functioni

    1. mRNA binding Source: Ensembl
    2. piRNA binding Source: UniProtKB

    GO - Biological processi

    1. DNA methylation involved in gamete generation Source: UniProtKB
    2. gene silencing by RNA Source: UniProtKB
    3. germ-line stem cell maintenance Source: UniProtKB
    4. meiotic nuclear division Source: UniProtKB-KW
    5. multicellular organismal development Source: UniProtKB-KW
    6. oogenesis Source: UniProtKB
    7. piRNA metabolic process Source: UniProtKB
    8. positive regulation of meiosis I Source: Ensembl
    9. positive regulation of translation Source: UniProtKB
    10. RNA 5'-end processing Source: UniProtKB
    11. spermatogenesis Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Differentiation, Meiosis, Oogenesis, RNA-mediated gene silencing, Spermatogenesis, Translation regulation

    Keywords - Ligandi

    RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Piwi-like protein 2
    Alternative name(s):
    Cancer/testis antigen 80
    Short name:
    CT80
    Gene namesi
    Name:PIWIL2
    Synonyms:HILI
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:17644. PIWIL2.

    Subcellular locationi

    Cytoplasm By similarity
    Note: Present in chromatoid body. Probable component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis By similarity.By similarity

    GO - Cellular componenti

    1. chromatoid body Source: UniProtKB
    2. cytoplasm Source: UniProtKB
    3. P granule Source: UniProtKB
    4. pi-body Source: UniProtKB
    5. polysome Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38461.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 973973Piwi-like protein 2PRO_0000234569Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei47 – 471Symmetric dimethylarginineBy similarity
    Modified residuei76 – 761Omega-N-methylarginine; by PRMT5; alternateBy similarity
    Modified residuei76 – 761Symmetric dimethylarginine; by PRMT5; alternateBy similarity
    Modified residuei97 – 971Omega-N-methylarginine; by PRMT5; alternateBy similarity
    Modified residuei97 – 971Symmetric dimethylarginine; alternateBy similarity
    Modified residuei102 – 1021Omega-N-methylarginine; alternateBy similarity
    Modified residuei102 – 1021Symmetric dimethylarginine; by PRMT5; alternateBy similarity
    Modified residuei165 – 1651Symmetric dimethylarginine; by PRMT5By similarity
    Modified residuei551 – 5511Symmetric dimethylarginine; by PRMT5By similarity

    Post-translational modificationi

    Arginine methylation by PRMT5 is required for the interaction with Tudor domain-containing protein TDRD1 and subsequent localization to the meiotic nuage, also named P granule.By similarity

    Keywords - PTMi

    Methylation

    Proteomic databases

    PaxDbiQ8TC59.
    PRIDEiQ8TC59.

    PTM databases

    PhosphoSiteiQ8TC59.

    Expressioni

    Tissue specificityi

    Expressed in adult testis and in most tumors.1 Publication

    Gene expression databases

    BgeeiQ8TC59.
    CleanExiHS_PIWIL2.
    GenevestigatoriQ8TC59.

    Organism-specific databases

    HPAiHPA029345.

    Interactioni

    Subunit structurei

    Interacts with DDX4, MAEL, EIF3A, EIF4E, EIF4G, PRMT5 and WDR77. Associates with EIF4E- and EIF4G-containing m7G cap-binding complexes. Interacts (when methylated on arginine residues) with TDRD1 and TDRKH/TDRD2. Interacts with TDRD12 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi120431. 2 interactions.
    IntActiQ8TC59. 9 interactions.
    STRINGi9606.ENSP00000349208.

    Structurei

    Secondary structure

    1
    973
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi390 – 41324
    Beta strandi417 – 4204
    Turni421 – 4233
    Beta strandi426 – 4283
    Beta strandi431 – 4333
    Beta strandi440 – 4434
    Beta strandi449 – 4513
    Helixi452 – 4609
    Beta strandi471 – 4744
    Beta strandi477 – 4804
    Beta strandi482 – 4854
    Beta strandi491 – 4933
    Helixi495 – 4973

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3O7XX-ray2.92A/B/C/D387-525[»]
    3QIRX-ray2.45A/B/C/D386-533[»]
    ProteinModelPortaliQ8TC59.
    SMRiQ8TC59. Positions 218-962.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini384 – 496113PAZPROSITE-ProRule annotationAdd
    BLAST
    Domaini668 – 959292PiwiPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the argonaute family. Piwi subfamily.Curated
    Contains 1 PAZ domain.PROSITE-ProRule annotation
    Contains 1 Piwi domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG286051.
    HOVERGENiHBG049411.
    InParanoidiQ8TC59.
    KOiK02156.
    OMAiQELNWIK.
    OrthoDBiEOG712TVQ.
    PhylomeDBiQ8TC59.
    TreeFamiTF354206.

    Family and domain databases

    Gene3Di3.30.420.10. 1 hit.
    InterProiIPR003100. PAZ_dom.
    IPR003165. Piwi.
    IPR012337. RNaseH-like_dom.
    [Graphical view]
    PfamiPF02170. PAZ. 1 hit.
    PF02171. Piwi. 1 hit.
    [Graphical view]
    SMARTiSM00949. PAZ. 1 hit.
    SM00950. Piwi. 1 hit.
    [Graphical view]
    SUPFAMiSSF101690. SSF101690. 1 hit.
    SSF53098. SSF53098. 1 hit.
    PROSITEiPS50821. PAZ. 1 hit.
    PS50822. PIWI. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8TC59-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDPFRPSFRG QSPIHPSQCQ AVRMPGCWPQ ASKPLDPALG RGAPAGRGHV    50
    FGKPEEPSTQ RGPAQRESVG LVSMFRGLGI ETVSKTPLKR EMLPSGRGIL 100
    GRGLSANLVR KDREELSPTF WDPKVLAAGD SKMAETSVGW SRTLGRGSSD 150
    ASLLPLGRAA GGISREVDKP PCTFSTPSRG PPQLSSPPAL PQSPLHSPDR 200
    PLVLTVEHKE KELIVKQGSK GTPQSLGLNL VKIQCHNEAV YQYHVTFSPN 250
    VECKSMRFGM LKDHQAVTGN VTAFDGSILY LPVKLQQVLE LKSQRKTDSA 300
    EISIKIQMTK ILEPCSDLCI PFYNVVFRRV MKLLDMKLVG RNFYDPTSAM 350
    VLQQHRLQIW PGYAASIRRT DGGLFLLADV SHKVIRNDCV LDVMHAIYQQ 400
    NKEHFQDECT KLLVGNIVIT RYNNRTYRID DVDWNKTPKD SFTMSDGKEI 450
    TFLEYYSKNY GITVKEEDQP LLIHRPSERQ DNHGMLLKGE ILLLPELSFM 500
    TGIPEKMKKD FRAMKDLAQQ INLSPKQHHS ALECLLQRIA KNEAATNELM 550
    RWGLRLQKDV HKIEGRVLPM ERINLKNTSF ITSQELNWVK EVTRDPSILT 600
    IPMHFWALFY PKRAMDQARE LVNMLEKIAG PIGMRMSPPA WVELKDDRIE 650
    TYVRTIQSTL GAEGKIQMVV CIIMGPRDDL YGAIKKLCCV QSPVPSQVVN 700
    VRTIGQPTRL RSVAQKILLQ INCKLGGELW GVDIPLKQLM VIGMDVYHDP 750
    SRGMRSVVGF VASINLTLTK WYSRVVFQMP HQEIVDSLKL CLVGSLKKFY 800
    EVNHCLPEKI VVYRDGVSDG QLKTVANYEI PQLQKCFEAF ENYQPKMVVF 850
    VVQKKISTNL YLAAPQNFVT PTPGTVVDHT ITSCEWVDFY LLAHHVRQGC 900
    GIPTHYVCVL NTANLSPDHM QRLTFKLCHM YWNWPGTIRV PAPCKYAHKL 950
    AFLSGHILHH EPAIQLCENL FFL 973
    Length:973
    Mass (Da):109,849
    Last modified:June 1, 2002 - v1
    Checksum:iC44398136B144CA0
    GO
    Isoform 2 (identifier: Q8TC59-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         887-922: Missing.

    Show »
    Length:937
    Mass (Da):105,760
    Checksum:i5888D266DD32416C
    GO

    Sequence cautioni

    The sequence BAA91558.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAB55155.1 differs from that shown. Reason: Erroneous termination at position 421. Translated as Arg.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti18 – 181Q → R in BAG61134. (PubMed:14702039)Curated
    Sequence conflicti581 – 5811I → T in BAF98721. (PubMed:14702039)Curated
    Sequence conflicti685 – 6851K → N in BAA91558. (PubMed:14702039)Curated
    Sequence conflicti720 – 7201Q → R in BAF98724. (PubMed:14702039)Curated
    Sequence conflicti887 – 8871V → G in BAF83727. (PubMed:14702039)Curated
    Sequence conflicti961 – 9611E → G in BAB55155. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei887 – 92236Missing in isoform 2. 2 PublicationsVSP_036664Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB079367 mRNA. Translation: BAC81342.1.
    HQ651229 mRNA. Translation: ADV17663.1.
    AK001213 mRNA. Translation: BAA91558.1. Different initiation.
    AK027497 mRNA. Translation: BAB55155.1. Sequence problems.
    AK291038 mRNA. Translation: BAF83727.1.
    AK292440 mRNA. Translation: BAF85129.1.
    AK299068 mRNA. Translation: BAG61134.1.
    AK315830 mRNA. Translation: BAF98721.1.
    AK315833 mRNA. Translation: BAF98724.1.
    BC025995 mRNA. Translation: AAH25995.1.
    BC111751 mRNA. Translation: AAI11752.1.
    CCDSiCCDS6029.1. [Q8TC59-1]
    RefSeqiNP_001129193.1. NM_001135721.1. [Q8TC59-1]
    NP_060538.2. NM_018068.3. [Q8TC59-1]
    XP_005273607.1. XM_005273550.2. [Q8TC59-2]
    UniGeneiHs.614809.

    Genome annotation databases

    EnsembliENST00000356766; ENSP00000349208; ENSG00000197181. [Q8TC59-1]
    ENST00000454009; ENSP00000406956; ENSG00000197181. [Q8TC59-1]
    ENST00000521356; ENSP00000428267; ENSG00000197181. [Q8TC59-2]
    GeneIDi55124.
    KEGGihsa:55124.
    UCSCiuc003xbn.2. human. [Q8TC59-1]
    uc011kzf.1. human. [Q8TC59-2]

    Polymorphism databases

    DMDMi74730558.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB079367 mRNA. Translation: BAC81342.1 .
    HQ651229 mRNA. Translation: ADV17663.1 .
    AK001213 mRNA. Translation: BAA91558.1 . Different initiation.
    AK027497 mRNA. Translation: BAB55155.1 . Sequence problems.
    AK291038 mRNA. Translation: BAF83727.1 .
    AK292440 mRNA. Translation: BAF85129.1 .
    AK299068 mRNA. Translation: BAG61134.1 .
    AK315830 mRNA. Translation: BAF98721.1 .
    AK315833 mRNA. Translation: BAF98724.1 .
    BC025995 mRNA. Translation: AAH25995.1 .
    BC111751 mRNA. Translation: AAI11752.1 .
    CCDSi CCDS6029.1. [Q8TC59-1 ]
    RefSeqi NP_001129193.1. NM_001135721.1. [Q8TC59-1 ]
    NP_060538.2. NM_018068.3. [Q8TC59-1 ]
    XP_005273607.1. XM_005273550.2. [Q8TC59-2 ]
    UniGenei Hs.614809.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3O7X X-ray 2.92 A/B/C/D 387-525 [» ]
    3QIR X-ray 2.45 A/B/C/D 386-533 [» ]
    ProteinModelPortali Q8TC59.
    SMRi Q8TC59. Positions 218-962.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120431. 2 interactions.
    IntActi Q8TC59. 9 interactions.
    STRINGi 9606.ENSP00000349208.

    PTM databases

    PhosphoSitei Q8TC59.

    Polymorphism databases

    DMDMi 74730558.

    Proteomic databases

    PaxDbi Q8TC59.
    PRIDEi Q8TC59.

    Protocols and materials databases

    DNASUi 55124.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000356766 ; ENSP00000349208 ; ENSG00000197181 . [Q8TC59-1 ]
    ENST00000454009 ; ENSP00000406956 ; ENSG00000197181 . [Q8TC59-1 ]
    ENST00000521356 ; ENSP00000428267 ; ENSG00000197181 . [Q8TC59-2 ]
    GeneIDi 55124.
    KEGGi hsa:55124.
    UCSCi uc003xbn.2. human. [Q8TC59-1 ]
    uc011kzf.1. human. [Q8TC59-2 ]

    Organism-specific databases

    CTDi 55124.
    GeneCardsi GC08P022132.
    HGNCi HGNC:17644. PIWIL2.
    HPAi HPA029345.
    MIMi 610312. gene.
    neXtProti NX_Q8TC59.
    PharmGKBi PA38461.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG286051.
    HOVERGENi HBG049411.
    InParanoidi Q8TC59.
    KOi K02156.
    OMAi QELNWIK.
    OrthoDBi EOG712TVQ.
    PhylomeDBi Q8TC59.
    TreeFami TF354206.

    Miscellaneous databases

    GenomeRNAii 55124.
    NextBioi 58776.
    PROi Q8TC59.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8TC59.
    CleanExi HS_PIWIL2.
    Genevestigatori Q8TC59.

    Family and domain databases

    Gene3Di 3.30.420.10. 1 hit.
    InterProi IPR003100. PAZ_dom.
    IPR003165. Piwi.
    IPR012337. RNaseH-like_dom.
    [Graphical view ]
    Pfami PF02170. PAZ. 1 hit.
    PF02171. Piwi. 1 hit.
    [Graphical view ]
    SMARTi SM00949. PAZ. 1 hit.
    SM00950. Piwi. 1 hit.
    [Graphical view ]
    SUPFAMi SSF101690. SSF101690. 1 hit.
    SSF53098. SSF53098. 1 hit.
    PROSITEi PS50821. PAZ. 1 hit.
    PS50822. PIWI. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of eight members of the Argonaute family in the human genome."
      Sasaki T., Shiohama A., Minoshima S., Shimizu N.
      Genomics 82:323-330(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Identification of piwil2-like (PL2L106) protein in HeLa cells."
      Zhang K., Lu Y., Li C.
      Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Testis.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Testis.
    5. "Stem-cell protein Piwil2 is widely expressed in tumors and inhibits apoptosis through activation of Stat3/Bcl-XL pathway."
      Lee J.H., Schutte D., Wulf G., Fuzesi L., Radzun H.-J., Schweyer S., Engel W., Nayernia K.
      Hum. Mol. Genet. 15:201-211(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY.
    6. "Structural basis for piRNA 2'-O-methylated 3'-end recognition by Piwi PAZ (Piwi/Argonaute/Zwille) domains."
      Tian Y., Simanshu D.K., Ma J.B., Patel D.J.
      Proc. Natl. Acad. Sci. U.S.A. 108:903-910(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.92 ANGSTROMS) OF 387-525, RNA-BINDING.

    Entry informationi

    Entry nameiPIWL2_HUMAN
    AccessioniPrimary (citable) accession number: Q8TC59
    Secondary accession number(s): A8K4S3
    , A8K8S5, B0AZN9, B0AZP2, B4DR22, E7ECA4, Q96SW6, Q9NW28
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 16, 2006
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3