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Protein

Meiosis 1 arrest protein

Gene

M1AP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Required for meiosis I progression during spermatogenesis.By similarity

GO - Biological processi

  • cell differentiation Source: UniProtKB-KW
  • chromatin assembly Source: UniProtKB
  • female gamete generation Source: UniProtKB
  • male meiosis chromosome separation Source: UniProtKB
  • RNA processing Source: UniProtKB
  • spermatogenesis Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Differentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Meiosis 1 arrest protein
Alternative name(s):
Meiosis 1-arresting protein
Meiosis 1-associated protein
Spermatogenesis-associated protein 37
Gene namesi
Name:M1AP
Synonyms:C2orf65, SPATA37
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:25183. M1AP.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • integral component of membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162379401.

Polymorphism and mutation databases

BioMutaiM1AP.
DMDMi74730556.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 530530Meiosis 1 arrest proteinPRO_0000349268Add
BLAST

Proteomic databases

PaxDbiQ8TC57.
PeptideAtlasiQ8TC57.
PRIDEiQ8TC57.

PTM databases

iPTMnetiQ8TC57.
PhosphoSiteiQ8TC57.

Expressioni

Gene expression databases

BgeeiQ8TC57.
CleanExiHS_C2orf65.
ExpressionAtlasiQ8TC57. baseline and differential.
GenevisibleiQ8TC57. HS.

Organism-specific databases

HPAiHPA045420.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TRIP13Q156453EBI-748182,EBI-358993

Protein-protein interaction databases

BioGridi126265. 3 interactions.
IntActiQ8TC57. 2 interactions.
MINTiMINT-1483049.
STRINGi9606.ENSP00000290536.

Structurei

3D structure databases

ProteinModelPortaliQ8TC57.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IGUR. Eukaryota.
ENOG4111HE9. LUCA.
GeneTreeiENSGT00390000005656.
HOGENOMiHOG000261652.
HOVERGENiHBG106165.
InParanoidiQ8TC57.
OMAiHECILPF.
OrthoDBiEOG7ZD1WW.
PhylomeDBiQ8TC57.
TreeFamiTF329502.

Family and domain databases

InterProiIPR033587. M1AP.
[Graphical view]
PANTHERiPTHR28642. PTHR28642. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TC57-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MHPGRTTGKG PSTHTQIDQQ PPRLLIVHIA LPSWADICTN LCEALQNFFS
60 70 80 90 100
LACSLMGPSR MSLFSLYMVQ DQHECILPFV QVKGNFARLQ TCISELRMLQ
110 120 130 140 150
REGCFRSQGA SLRLAVEDGL QQFKQYSRHV TTRAALTYTS LEITILTSQP
160 170 180 190 200
GKEVVKQLEE GLKDTDLARV RRFQVVEVTK GILEHVDSAS PVEDTSNDES
210 220 230 240 250
SILGTDIDLQ TIDNDIVSME IFFKAWLHNS GTDQEQIHLL LSSQCFSNIS
260 270 280 290 300
RPRDNPMCLK CDLQERLLCP SLLAGTADGS LRMDDPKGDF ITLYQMASQS
310 320 330 340 350
SASHYKLQVI KALKSSGLCE SLTYGLPFIL RPTSCWQLDW DELETNQQHF
360 370 380 390 400
HALCHSLLKR EWLLLAKGEP PGPGHSQRIP ASTFYVIMPS HSLTLLVKAV
410 420 430 440 450
ATRELMLPST FPLLPEDPHD DSLKNVESML DSLELEPTYN PLHVQSHLYS
460 470 480 490 500
HLSSIYAKPQ GRLHPHWESR APRKHPCKTG QLQTNRARAT VAPLPMTPVP
510 520 530
GRASKMPAAS KSSSDAFFLP SEWEKDPSRP
Length:530
Mass (Da):59,386
Last modified:June 1, 2002 - v1
Checksum:i14FF53B1F34E1884
GO
Isoform 2 (identifier: Q8TC57-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     359-365: KREWLLL → VSTHVPR
     366-530: Missing.

Note: No experimental confirmation available.
Show »
Length:365
Mass (Da):41,000
Checksum:iC9067DED1B67E011
GO
Isoform 3 (identifier: Q8TC57-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-282: Missing.
     359-427: Missing.

Note: No experimental confirmation available.
Show »
Length:179
Mass (Da):20,195
Checksum:i082F9AAA1CE12302
GO
Isoform 4 (identifier: Q8TC57-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     474-477: Missing.

Note: No experimental confirmation available.
Show »
Length:526
Mass (Da):58,920
Checksum:iB5CC281CAE4A7BB6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti359 – 3591K → E in BAH13233 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti5 – 51R → Q.
Corresponds to variant rs3025980 [ dbSNP | Ensembl ].
VAR_046335
Natural varianti195 – 1951T → P.
Corresponds to variant rs7602159 [ dbSNP | Ensembl ].
VAR_046336

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 282282Missing in isoform 3. 1 PublicationVSP_035291Add
BLAST
Alternative sequencei359 – 42769Missing in isoform 3. 1 PublicationVSP_035292Add
BLAST
Alternative sequencei359 – 3657KREWLLL → VSTHVPR in isoform 2. 1 PublicationVSP_035293
Alternative sequencei366 – 530165Missing in isoform 2. 1 PublicationVSP_035294Add
BLAST
Alternative sequencei474 – 4774Missing in isoform 4. 1 PublicationVSP_055677

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK130161 mRNA. Translation: BAC85295.1.
AK300188 mRNA. Translation: BAH13233.1.
AC005033 Genomic DNA. Translation: AAX93225.1.
AC007387 Genomic DNA. No translation available.
CH471053 Genomic DNA. Translation: EAW99611.1.
BC014602 mRNA. Translation: AAH14602.1.
BC025997 mRNA. Translation: AAH25997.1.
CCDSiCCDS33229.1. [Q8TC57-1]
CCDS62941.1. [Q8TC57-4]
RefSeqiNP_001268224.1. NM_001281295.1. [Q8TC57-2]
NP_001268225.1. NM_001281296.1. [Q8TC57-4]
NP_001308668.1. NM_001321739.1. [Q8TC57-1]
NP_620159.2. NM_138804.4. [Q8TC57-1]
XP_011530852.1. XM_011532550.1. [Q8TC57-1]
XP_011530853.1. XM_011532551.1. [Q8TC57-1]
UniGeneiHs.348645.

Genome annotation databases

EnsembliENST00000290536; ENSP00000290536; ENSG00000159374. [Q8TC57-1]
ENST00000409585; ENSP00000386793; ENSG00000159374. [Q8TC57-4]
ENST00000536235; ENSP00000445662; ENSG00000159374. [Q8TC57-4]
GeneIDi130951.
KEGGihsa:130951.
UCSCiuc002smy.3. human. [Q8TC57-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK130161 mRNA. Translation: BAC85295.1.
AK300188 mRNA. Translation: BAH13233.1.
AC005033 Genomic DNA. Translation: AAX93225.1.
AC007387 Genomic DNA. No translation available.
CH471053 Genomic DNA. Translation: EAW99611.1.
BC014602 mRNA. Translation: AAH14602.1.
BC025997 mRNA. Translation: AAH25997.1.
CCDSiCCDS33229.1. [Q8TC57-1]
CCDS62941.1. [Q8TC57-4]
RefSeqiNP_001268224.1. NM_001281295.1. [Q8TC57-2]
NP_001268225.1. NM_001281296.1. [Q8TC57-4]
NP_001308668.1. NM_001321739.1. [Q8TC57-1]
NP_620159.2. NM_138804.4. [Q8TC57-1]
XP_011530852.1. XM_011532550.1. [Q8TC57-1]
XP_011530853.1. XM_011532551.1. [Q8TC57-1]
UniGeneiHs.348645.

3D structure databases

ProteinModelPortaliQ8TC57.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126265. 3 interactions.
IntActiQ8TC57. 2 interactions.
MINTiMINT-1483049.
STRINGi9606.ENSP00000290536.

PTM databases

iPTMnetiQ8TC57.
PhosphoSiteiQ8TC57.

Polymorphism and mutation databases

BioMutaiM1AP.
DMDMi74730556.

Proteomic databases

PaxDbiQ8TC57.
PeptideAtlasiQ8TC57.
PRIDEiQ8TC57.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000290536; ENSP00000290536; ENSG00000159374. [Q8TC57-1]
ENST00000409585; ENSP00000386793; ENSG00000159374. [Q8TC57-4]
ENST00000536235; ENSP00000445662; ENSG00000159374. [Q8TC57-4]
GeneIDi130951.
KEGGihsa:130951.
UCSCiuc002smy.3. human. [Q8TC57-1]

Organism-specific databases

CTDi130951.
GeneCardsiM1AP.
HGNCiHGNC:25183. M1AP.
HPAiHPA045420.
neXtProtiNX_Q8TC57.
PharmGKBiPA162379401.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGUR. Eukaryota.
ENOG4111HE9. LUCA.
GeneTreeiENSGT00390000005656.
HOGENOMiHOG000261652.
HOVERGENiHBG106165.
InParanoidiQ8TC57.
OMAiHECILPF.
OrthoDBiEOG7ZD1WW.
PhylomeDBiQ8TC57.
TreeFamiTF329502.

Miscellaneous databases

GenomeRNAii130951.
PROiQ8TC57.

Gene expression databases

BgeeiQ8TC57.
CleanExiHS_C2orf65.
ExpressionAtlasiQ8TC57. baseline and differential.
GenevisibleiQ8TC57. HS.

Family and domain databases

InterProiIPR033587. M1AP.
[Graphical view]
PANTHERiPTHR28642. PTHR28642. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4).
    Tissue: Macrophage.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Testis.

Entry informationi

Entry nameiM1AP_HUMAN
AccessioniPrimary (citable) accession number: Q8TC57
Secondary accession number(s): B7Z6E7
, E9PGG8, Q6ZP30, Q96L07
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: June 1, 2002
Last modified: July 6, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.