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Q8TC56

- FA71B_HUMAN

UniProt

Q8TC56 - FA71B_HUMAN

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Protein
Protein FAM71B
Gene
FAM71B, HSD-51, HSD51
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

May be involved in RNA biogenesis.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM71B
Gene namesi
Name:FAM71B
ORF Names:HSD-51, HSD51
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:28397. FAM71B.

Subcellular locationi

Nucleus
Note: Cajal body and speckle localization.1 Publication

GO - Cellular componenti

  1. nucleus Source: UniProt
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671832.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 605605Protein FAM71B
PRO_0000285643Add
BLAST

Proteomic databases

PaxDbiQ8TC56.
PRIDEiQ8TC56.

PTM databases

PhosphoSiteiQ8TC56.

Expressioni

Gene expression databases

BgeeiQ8TC56.
CleanExiHS_FAM71B.
GenevestigatoriQ8TC56.

Organism-specific databases

HPAiHPA039478.
HPA040771.

Interactioni

Subunit structurei

Interacts with FRG1.1 Publication

Protein-protein interaction databases

STRINGi9606.ENSP00000305596.

Structurei

3D structure databases

ProteinModelPortaliQ8TC56.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi441 – 45818Bipartite nuclear localization signal Reviewed prediction
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi225 – 31793Ala-rich
Add
BLAST

Sequence similaritiesi

Belongs to the FAM71 family.

Phylogenomic databases

eggNOGiNOG28184.
HOGENOMiHOG000290696.
HOVERGENiHBG058004.
InParanoidiQ8TC56.
OMAiVFNTSMG.
OrthoDBiEOG71ZP2J.
PhylomeDBiQ8TC56.
TreeFamiTF336050.

Family and domain databases

InterProiIPR022168. DUF3699.
[Graphical view]
PfamiPF12480. DUF3699. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TC56-1 [UniParc]FASTAAdd to Basket

« Hide

MSNESCLPYY TAHSYSSMSA FKTSMGDLQR QLYNRGEYNI FKYAPMFESN    50
FIQINKKGEV IDVHNRVRMV TVGIVCTSPI LPLPDVMVLA QPTKICEQHV 100
RWGRFAKGRG RRPVKTLELT RLLPLKFVKI SIHDHEKQQL RLKLATGRTF 150
YLQLCPSSDT REDLFCYWEK LVYLLRPPVE SYCSTPTLLS GDAPPEDNKS 200
LVAAELHREG DQSETGLYKP CDVSAATSSA YAGGEGIQHA SHGTASAASP 250
STSTPGAAEG GAARTAGGMA VAGTATGPRT DVAIAGAAMS PATGAMSIAT 300
TKSAGPGQVT TALAGAAIKN PGENESSKSM AGAANISSEG ISLALVGAAS 350
TSLEGTSTSM AGAASLSQDS SLSAAFAGSI TTSKCAAERT EGPAVGPLIS 400
TLQSEGYMSE RDGSQKVSQP SAEVWNENKE RREKKDRHPS RKSSHHRKAG 450
ESHRRRAGDK NQKASSHRSA SGHKNTRDDK KEKGYSNVRG KRHGSSRKSS 500
THSSTKKESR TTQELGKNQS ASSTGALQKK ASKISSFLRS LRATPGSKTR 550
VTSHDREVDI VAKMVEKQNI EAKVEKAQGG QELEMISGTM TSEKTEMIVF 600
ETKSI 605
Length:605
Mass (Da):64,756
Last modified:May 1, 2007 - v2
Checksum:i84BF94215309E38A
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti543 – 5431A → V.1 Publication
Corresponds to variant rs17852327 [ dbSNP | Ensembl ].
VAR_032036
Natural varianti564 – 5641M → T.2 Publications
Corresponds to variant rs31208 [ dbSNP | Ensembl ].
VAR_032037
Natural varianti599 – 5991V → I.
Corresponds to variant rs2115480 [ dbSNP | Ensembl ].
VAR_032038

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti280 – 2801T → A in AAY41236. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK057543 mRNA. Translation: BAB71526.1.
AY973323 mRNA. Translation: AAY41236.1.
BC022035 mRNA. Translation: AAH22035.1.
BC025397 mRNA. Translation: AAH25397.1.
BC025409 mRNA. Translation: AAH25409.1.
BC025998 mRNA. Translation: AAH25998.1.
CCDSiCCDS4335.1.
RefSeqiNP_570969.2. NM_130899.2.
UniGeneiHs.666099.

Genome annotation databases

EnsembliENST00000302938; ENSP00000305596; ENSG00000170613.
GeneIDi153745.
KEGGihsa:153745.
UCSCiuc003lwn.3. human.

Polymorphism databases

DMDMi146286168.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK057543 mRNA. Translation: BAB71526.1 .
AY973323 mRNA. Translation: AAY41236.1 .
BC022035 mRNA. Translation: AAH22035.1 .
BC025397 mRNA. Translation: AAH25397.1 .
BC025409 mRNA. Translation: AAH25409.1 .
BC025998 mRNA. Translation: AAH25998.1 .
CCDSi CCDS4335.1.
RefSeqi NP_570969.2. NM_130899.2.
UniGenei Hs.666099.

3D structure databases

ProteinModelPortali Q8TC56.
ModBasei Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000305596.

PTM databases

PhosphoSitei Q8TC56.

Polymorphism databases

DMDMi 146286168.

Proteomic databases

PaxDbi Q8TC56.
PRIDEi Q8TC56.

Protocols and materials databases

DNASUi 153745.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000302938 ; ENSP00000305596 ; ENSG00000170613 .
GeneIDi 153745.
KEGGi hsa:153745.
UCSCi uc003lwn.3. human.

Organism-specific databases

CTDi 153745.
GeneCardsi GC05M156589.
H-InvDB HIX0005354.
HGNCi HGNC:28397. FAM71B.
HPAi HPA039478.
HPA040771.
neXtProti NX_Q8TC56.
PharmGKBi PA142671832.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG28184.
HOGENOMi HOG000290696.
HOVERGENi HBG058004.
InParanoidi Q8TC56.
OMAi VFNTSMG.
OrthoDBi EOG71ZP2J.
PhylomeDBi Q8TC56.
TreeFami TF336050.

Miscellaneous databases

GenomeRNAii 153745.
NextBioi 87175.
PROi Q8TC56.

Gene expression databases

Bgeei Q8TC56.
CleanExi HS_FAM71B.
Genevestigatori Q8TC56.

Family and domain databases

InterProi IPR022168. DUF3699.
[Graphical view ]
Pfami PF12480. DUF3699. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-564.
    Tissue: Testis.
  2. "A new spermatogenesis-related gene."
    Wang Y., Miao S.Y., Zhang X.D., Qiao Y., Liang G., Wang L.F.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS VAL-543 AND THR-564.
    Tissue: Testis.
  4. Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH FRG1.

Entry informationi

Entry nameiFA71B_HUMAN
AccessioniPrimary (citable) accession number: Q8TC56
Secondary accession number(s): Q1EDD9, Q8TC64, Q96LY8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: May 1, 2007
Last modified: July 9, 2014
This is version 73 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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