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Q8TC56 (FA71B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein FAM71B
Gene names
Name:FAM71B
ORF Names:HSD-51, HSD51
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length605 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be involved in RNA biogenesis. Ref.4

Subunit structure

Interacts with FRG1. Ref.4

Subcellular location

Nucleus. Note: Cajal body and speckle localization. Ref.4

Sequence similarities

Belongs to the FAM71 family.

Ontologies

Keywords
   Cellular componentNucleus
   Coding sequence diversityPolymorphism
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentnucleus

Inferred from direct assay PubMed 21630459. Source: UniProt

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 605605Protein FAM71B
PRO_0000285643

Regions

Motif441 – 45818Bipartite nuclear localization signal Potential
Compositional bias225 – 31793Ala-rich

Natural variations

Natural variant5431A → V. Ref.3
Corresponds to variant rs17852327 [ dbSNP | Ensembl ].
VAR_032036
Natural variant5641M → T. Ref.1 Ref.3
Corresponds to variant rs31208 [ dbSNP | Ensembl ].
VAR_032037
Natural variant5991V → I.
Corresponds to variant rs2115480 [ dbSNP | Ensembl ].
VAR_032038

Experimental info

Sequence conflict2801T → A in AAY41236. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q8TC56 [UniParc].

Last modified May 1, 2007. Version 2.
Checksum: 84BF94215309E38A

FASTA60564,756
        10         20         30         40         50         60 
MSNESCLPYY TAHSYSSMSA FKTSMGDLQR QLYNRGEYNI FKYAPMFESN FIQINKKGEV 

        70         80         90        100        110        120 
IDVHNRVRMV TVGIVCTSPI LPLPDVMVLA QPTKICEQHV RWGRFAKGRG RRPVKTLELT 

       130        140        150        160        170        180 
RLLPLKFVKI SIHDHEKQQL RLKLATGRTF YLQLCPSSDT REDLFCYWEK LVYLLRPPVE 

       190        200        210        220        230        240 
SYCSTPTLLS GDAPPEDNKS LVAAELHREG DQSETGLYKP CDVSAATSSA YAGGEGIQHA 

       250        260        270        280        290        300 
SHGTASAASP STSTPGAAEG GAARTAGGMA VAGTATGPRT DVAIAGAAMS PATGAMSIAT 

       310        320        330        340        350        360 
TKSAGPGQVT TALAGAAIKN PGENESSKSM AGAANISSEG ISLALVGAAS TSLEGTSTSM 

       370        380        390        400        410        420 
AGAASLSQDS SLSAAFAGSI TTSKCAAERT EGPAVGPLIS TLQSEGYMSE RDGSQKVSQP 

       430        440        450        460        470        480 
SAEVWNENKE RREKKDRHPS RKSSHHRKAG ESHRRRAGDK NQKASSHRSA SGHKNTRDDK 

       490        500        510        520        530        540 
KEKGYSNVRG KRHGSSRKSS THSSTKKESR TTQELGKNQS ASSTGALQKK ASKISSFLRS 

       550        560        570        580        590        600 
LRATPGSKTR VTSHDREVDI VAKMVEKQNI EAKVEKAQGG QELEMISGTM TSEKTEMIVF 


ETKSI 

« Hide

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-564.
Tissue: Testis.
[2]"A new spermatogenesis-related gene."
Wang Y., Miao S.Y., Zhang X.D., Qiao Y., Liang G., Wang L.F.
Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS VAL-543 AND THR-564.
Tissue: Testis.
[4]"FRG1P-mediated aggregation of proteins involved in pre-mRNA processing."
van Koningsbruggen S., Straasheijm K.R., Sterrenburg E., de Graaf N., Dauwerse H.G., Frants R.R., van der Maarel S.M.
Chromosoma 116:53-64(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH FRG1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK057543 mRNA. Translation: BAB71526.1.
AY973323 mRNA. Translation: AAY41236.1.
BC022035 mRNA. Translation: AAH22035.1.
BC025397 mRNA. Translation: AAH25397.1.
BC025409 mRNA. Translation: AAH25409.1.
BC025998 mRNA. Translation: AAH25998.1.
CCDSCCDS4335.1.
RefSeqNP_570969.2. NM_130899.2.
UniGeneHs.666099.

3D structure databases

ProteinModelPortalQ8TC56.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000305596.

PTM databases

PhosphoSiteQ8TC56.

Polymorphism databases

DMDM146286168.

Proteomic databases

PaxDbQ8TC56.
PRIDEQ8TC56.

Protocols and materials databases

DNASU153745.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000302938; ENSP00000305596; ENSG00000170613.
GeneID153745.
KEGGhsa:153745.
UCSCuc003lwn.3. human.

Organism-specific databases

CTD153745.
GeneCardsGC05M156589.
H-InvDBHIX0005354.
HGNCHGNC:28397. FAM71B.
HPAHPA039478.
HPA040771.
neXtProtNX_Q8TC56.
PharmGKBPA142671832.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG28184.
HOGENOMHOG000290696.
HOVERGENHBG058004.
InParanoidQ8TC56.
OMAVFNTSMG.
OrthoDBEOG71ZP2J.
PhylomeDBQ8TC56.
TreeFamTF336050.

Gene expression databases

BgeeQ8TC56.
CleanExHS_FAM71B.
GenevestigatorQ8TC56.

Family and domain databases

InterProIPR022168. DUF3699.
[Graphical view]
PfamPF12480. DUF3699. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi153745.
NextBio87175.
PROQ8TC56.

Entry information

Entry nameFA71B_HUMAN
AccessionPrimary (citable) accession number: Q8TC56
Secondary accession number(s): Q1EDD9, Q8TC64, Q96LY8
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: May 1, 2007
Last modified: July 9, 2014
This is version 73 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM