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Q8TC56

- FA71B_HUMAN

UniProt

Q8TC56 - FA71B_HUMAN

Protein

Protein FAM71B

Gene

FAM71B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 2 (01 May 2007)
      Previous versions | rss
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    Functioni

    May be involved in RNA biogenesis.1 Publication

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein FAM71B
    Gene namesi
    Name:FAM71B
    ORF Names:HSD-51, HSD51
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:28397. FAM71B.

    Subcellular locationi

    Nucleus 1 Publication
    Note: Cajal body and speckle localization.

    GO - Cellular componenti

    1. nucleus Source: UniProt

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142671832.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 605605Protein FAM71BPRO_0000285643Add
    BLAST

    Proteomic databases

    PaxDbiQ8TC56.
    PRIDEiQ8TC56.

    PTM databases

    PhosphoSiteiQ8TC56.

    Expressioni

    Gene expression databases

    BgeeiQ8TC56.
    CleanExiHS_FAM71B.
    GenevestigatoriQ8TC56.

    Organism-specific databases

    HPAiHPA039478.
    HPA040771.

    Interactioni

    Subunit structurei

    Interacts with FRG1.1 Publication

    Protein-protein interaction databases

    STRINGi9606.ENSP00000305596.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8TC56.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi441 – 45818Bipartite nuclear localization signalSequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi225 – 31793Ala-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the FAM71 family.Curated

    Phylogenomic databases

    eggNOGiNOG28184.
    HOGENOMiHOG000290696.
    HOVERGENiHBG058004.
    InParanoidiQ8TC56.
    OMAiVFNTSMG.
    OrthoDBiEOG71ZP2J.
    PhylomeDBiQ8TC56.
    TreeFamiTF336050.

    Family and domain databases

    InterProiIPR022168. DUF3699.
    [Graphical view]
    PfamiPF12480. DUF3699. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8TC56-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSNESCLPYY TAHSYSSMSA FKTSMGDLQR QLYNRGEYNI FKYAPMFESN    50
    FIQINKKGEV IDVHNRVRMV TVGIVCTSPI LPLPDVMVLA QPTKICEQHV 100
    RWGRFAKGRG RRPVKTLELT RLLPLKFVKI SIHDHEKQQL RLKLATGRTF 150
    YLQLCPSSDT REDLFCYWEK LVYLLRPPVE SYCSTPTLLS GDAPPEDNKS 200
    LVAAELHREG DQSETGLYKP CDVSAATSSA YAGGEGIQHA SHGTASAASP 250
    STSTPGAAEG GAARTAGGMA VAGTATGPRT DVAIAGAAMS PATGAMSIAT 300
    TKSAGPGQVT TALAGAAIKN PGENESSKSM AGAANISSEG ISLALVGAAS 350
    TSLEGTSTSM AGAASLSQDS SLSAAFAGSI TTSKCAAERT EGPAVGPLIS 400
    TLQSEGYMSE RDGSQKVSQP SAEVWNENKE RREKKDRHPS RKSSHHRKAG 450
    ESHRRRAGDK NQKASSHRSA SGHKNTRDDK KEKGYSNVRG KRHGSSRKSS 500
    THSSTKKESR TTQELGKNQS ASSTGALQKK ASKISSFLRS LRATPGSKTR 550
    VTSHDREVDI VAKMVEKQNI EAKVEKAQGG QELEMISGTM TSEKTEMIVF 600
    ETKSI 605
    Length:605
    Mass (Da):64,756
    Last modified:May 1, 2007 - v2
    Checksum:i84BF94215309E38A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti280 – 2801T → A in AAY41236. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti543 – 5431A → V.1 Publication
    Corresponds to variant rs17852327 [ dbSNP | Ensembl ].
    VAR_032036
    Natural varianti564 – 5641M → T.2 Publications
    Corresponds to variant rs31208 [ dbSNP | Ensembl ].
    VAR_032037
    Natural varianti599 – 5991V → I.
    Corresponds to variant rs2115480 [ dbSNP | Ensembl ].
    VAR_032038

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK057543 mRNA. Translation: BAB71526.1.
    AY973323 mRNA. Translation: AAY41236.1.
    BC022035 mRNA. Translation: AAH22035.1.
    BC025397 mRNA. Translation: AAH25397.1.
    BC025409 mRNA. Translation: AAH25409.1.
    BC025998 mRNA. Translation: AAH25998.1.
    CCDSiCCDS4335.1.
    RefSeqiNP_570969.2. NM_130899.2.
    UniGeneiHs.666099.

    Genome annotation databases

    EnsembliENST00000302938; ENSP00000305596; ENSG00000170613.
    GeneIDi153745.
    KEGGihsa:153745.
    UCSCiuc003lwn.3. human.

    Polymorphism databases

    DMDMi146286168.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK057543 mRNA. Translation: BAB71526.1 .
    AY973323 mRNA. Translation: AAY41236.1 .
    BC022035 mRNA. Translation: AAH22035.1 .
    BC025397 mRNA. Translation: AAH25397.1 .
    BC025409 mRNA. Translation: AAH25409.1 .
    BC025998 mRNA. Translation: AAH25998.1 .
    CCDSi CCDS4335.1.
    RefSeqi NP_570969.2. NM_130899.2.
    UniGenei Hs.666099.

    3D structure databases

    ProteinModelPortali Q8TC56.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000305596.

    PTM databases

    PhosphoSitei Q8TC56.

    Polymorphism databases

    DMDMi 146286168.

    Proteomic databases

    PaxDbi Q8TC56.
    PRIDEi Q8TC56.

    Protocols and materials databases

    DNASUi 153745.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000302938 ; ENSP00000305596 ; ENSG00000170613 .
    GeneIDi 153745.
    KEGGi hsa:153745.
    UCSCi uc003lwn.3. human.

    Organism-specific databases

    CTDi 153745.
    GeneCardsi GC05M156589.
    H-InvDB HIX0005354.
    HGNCi HGNC:28397. FAM71B.
    HPAi HPA039478.
    HPA040771.
    neXtProti NX_Q8TC56.
    PharmGKBi PA142671832.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG28184.
    HOGENOMi HOG000290696.
    HOVERGENi HBG058004.
    InParanoidi Q8TC56.
    OMAi VFNTSMG.
    OrthoDBi EOG71ZP2J.
    PhylomeDBi Q8TC56.
    TreeFami TF336050.

    Miscellaneous databases

    GenomeRNAii 153745.
    NextBioi 87175.
    PROi Q8TC56.

    Gene expression databases

    Bgeei Q8TC56.
    CleanExi HS_FAM71B.
    Genevestigatori Q8TC56.

    Family and domain databases

    InterProi IPR022168. DUF3699.
    [Graphical view ]
    Pfami PF12480. DUF3699. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-564.
      Tissue: Testis.
    2. "A new spermatogenesis-related gene."
      Wang Y., Miao S.Y., Zhang X.D., Qiao Y., Liang G., Wang L.F.
      Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS VAL-543 AND THR-564.
      Tissue: Testis.
    4. Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH FRG1.

    Entry informationi

    Entry nameiFA71B_HUMAN
    AccessioniPrimary (citable) accession number: Q8TC56
    Secondary accession number(s): Q1EDD9, Q8TC64, Q96LY8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 2007
    Last sequence update: May 1, 2007
    Last modified: October 1, 2014
    This is version 74 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3