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Protein

SUN domain-containing protein 5

Gene

SUN5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in meiotic stage of spermatogenesis.By similarity

GO - Biological processi

Keywordsi

Biological processDifferentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
SUN domain-containing protein 5
Alternative name(s):
Sad1 and UNC84 domain-containing protein 5
Sperm-associated antigen 4-like protein
Testis and spermatogenesis-related gene 4 protein
Gene namesi
Name:SUN5
Synonyms:SPAG4L, TSARG4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:16252. SUN5.

Subcellular locationi

  • Nucleus inner membrane By similarity; Single-pass membrane protein By similarity

  • Note: Restricted to the apical nuclear region of round spermatids that face the acrosomic vesicle. However, this localization is questioned.By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 105NuclearSequence analysisAdd BLAST105
Transmembranei106 – 122HelicalSequence analysisAdd BLAST17
Topological domaini123 – 379Perinuclear spaceSequence analysisAdd BLAST257

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000167098.
PharmGKBiPA38095.

Polymorphism and mutation databases

BioMutaiSUN5.
DMDMi27805720.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002189191 – 379SUN domain-containing protein 5Add BLAST379

Post-translational modificationi

Highly glycosylated during spermatogenesis.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8TC36.
PeptideAtlasiQ8TC36.
PRIDEiQ8TC36.

PTM databases

iPTMnetiQ8TC36.
PhosphoSitePlusiQ8TC36.

Expressioni

Tissue specificityi

Widely expressed (PubMed:12621555). Conflictingly shown to be specifically expressed in testis (PubMed:21711156).2 Publications

Gene expression databases

BgeeiENSG00000167098.
CleanExiHS_SPAG4L.
ExpressionAtlasiQ8TC36. baseline and differential.
GenevisibleiQ8TC36. HS.

Organism-specific databases

HPAiHPA048529.

Interactioni

Subunit structurei

Probable homotrimer.By similarity

Protein-protein interaction databases

BioGridi126678. 2 interactors.
STRINGi9606.ENSP00000348496.

Structurei

3D structure databases

ProteinModelPortaliQ8TC36.
SMRiQ8TC36.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini205 – 364SUNPROSITE-ProRule annotationAdd BLAST160

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili141 – 182Sequence analysisAdd BLAST42

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2687. Eukaryota.
ENOG410YM6S. LUCA.
GeneTreeiENSGT00390000011587.
HOGENOMiHOG000007503.
HOVERGENiHBG055206.
InParanoidiQ8TC36.
OMAiGNPRFTC.
OrthoDBiEOG090B08VD.
PhylomeDBiQ8TC36.
TreeFamiTF323915.

Family and domain databases

InterProiView protein in InterPro
IPR030273. SUN5.
IPR012919. SUN_dom.
PANTHERiPTHR12911:SF37. PTHR12911:SF37. 1 hit.
PfamiView protein in Pfam
PF07738. Sad1_UNC. 1 hit.
PROSITEiView protein in PROSITE
PS51469. SUN. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8TC36-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRSSRSPGD PGALLEDVAH NPRPRRIAQR GRNTSRMAED TSPNMNDNIL
60 70 80 90 100
LPVRNNDQAL GLTQCMLGCV SWFTCFACSL RTQAQQVLFN TCRCKLLCQK
110 120 130 140 150
LMEKTGILLL CAFGFWMFSI HLPSKMKVWQ DDSINGPLQS LRLYQEKVRH
160 170 180 190 200
HSGEIQDLRG SMNQLIAKLQ EMEAMSDEQK MAQKIMKMIH GDYIEKPDFA
210 220 230 240 250
LKSIGASIDF EHTSVTYNHE KAHSYWNWIQ LWNYAQPPDV ILEPNVTPGN
260 270 280 290 300
CWAFEGDRGQ VTIQLAQKVY LSNLTLQHIP KTISLSGSLD TAPKDFVIYG
310 320 330 340 350
MEGSPKEEVF LGAFQFQPEN IIQMFPLQNQ PARAFSAVKV KISSNWGNPG
360 370
FTCLYRVRVH GSVAPPREQP HQNPYPKRD
Length:379
Mass (Da):43,081
Last modified:June 1, 2002 - v1
Checksum:i0FAE87B1CC1DBCDF
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01514716E → K. Corresponds to variant dbSNP:rs3746387Ensembl.1
Natural variantiVAR_02667739E → D. Corresponds to variant dbSNP:rs1133358Ensembl.1
Natural variantiVAR_052285120I → V. Corresponds to variant dbSNP:rs35216976Ensembl.1
Natural variantiVAR_026678174A → T. Corresponds to variant dbSNP:rs17123951Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF401350 mRNA. Translation: AAM90665.1.
AL139826, AL121756 Genomic DNA. Translation: CAI16148.1.
AL121756, AL139826 Genomic DNA. Translation: CAI22528.1.
CH471077 Genomic DNA. Translation: EAW76343.1.
BC026118 mRNA. Translation: AAH26118.1.
BC029528 mRNA. Translation: AAH29528.1.
CCDSiCCDS13209.1.
RefSeqiNP_542406.2. NM_080675.3.
UniGeneiHs.375186.

Genome annotation databases

EnsembliENST00000356173; ENSP00000348496; ENSG00000167098.
GeneIDi140732.
KEGGihsa:140732.
UCSCiuc002wyi.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF401350 mRNA. Translation: AAM90665.1.
AL139826, AL121756 Genomic DNA. Translation: CAI16148.1.
AL121756, AL139826 Genomic DNA. Translation: CAI22528.1.
CH471077 Genomic DNA. Translation: EAW76343.1.
BC026118 mRNA. Translation: AAH26118.1.
BC029528 mRNA. Translation: AAH29528.1.
CCDSiCCDS13209.1.
RefSeqiNP_542406.2. NM_080675.3.
UniGeneiHs.375186.

3D structure databases

ProteinModelPortaliQ8TC36.
SMRiQ8TC36.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126678. 2 interactors.
STRINGi9606.ENSP00000348496.

PTM databases

iPTMnetiQ8TC36.
PhosphoSitePlusiQ8TC36.

Polymorphism and mutation databases

BioMutaiSUN5.
DMDMi27805720.

Proteomic databases

PaxDbiQ8TC36.
PeptideAtlasiQ8TC36.
PRIDEiQ8TC36.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000356173; ENSP00000348496; ENSG00000167098.
GeneIDi140732.
KEGGihsa:140732.
UCSCiuc002wyi.4. human.

Organism-specific databases

CTDi140732.
GeneCardsiSUN5.
HGNCiHGNC:16252. SUN5.
HPAiHPA048529.
MIMi613942. gene.
neXtProtiNX_Q8TC36.
OpenTargetsiENSG00000167098.
PharmGKBiPA38095.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2687. Eukaryota.
ENOG410YM6S. LUCA.
GeneTreeiENSGT00390000011587.
HOGENOMiHOG000007503.
HOVERGENiHBG055206.
InParanoidiQ8TC36.
OMAiGNPRFTC.
OrthoDBiEOG090B08VD.
PhylomeDBiQ8TC36.
TreeFamiTF323915.

Miscellaneous databases

GeneWikiiSPAG4L.
GenomeRNAii140732.
PROiQ8TC36.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000167098.
CleanExiHS_SPAG4L.
ExpressionAtlasiQ8TC36. baseline and differential.
GenevisibleiQ8TC36. HS.

Family and domain databases

InterProiView protein in InterPro
IPR030273. SUN5.
IPR012919. SUN_dom.
PANTHERiPTHR12911:SF37. PTHR12911:SF37. 1 hit.
PfamiView protein in Pfam
PF07738. Sad1_UNC. 1 hit.
PROSITEiView protein in PROSITE
PS51469. SUN. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSUN5_HUMAN
AccessioniPrimary (citable) accession number: Q8TC36
Secondary accession number(s): A6NJ82, Q5T9R0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 17, 2003
Last sequence update: June 1, 2002
Last modified: February 15, 2017
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.