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Protein

Enkurin

Gene

ENKUR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Adapter that functions to localize a calcium-sensitive signal transduction machinery in sperm to a calcium-permeable ion channel.By similarity

Keywords - Ligandi

Calmodulin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Enkurin
Gene namesi
Name:ENKUR
Synonyms:C10orf63
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:28388. ENKUR.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Flagellum

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165548526.

Polymorphism and mutation databases

BioMutaiENKUR.
DMDMi71151870.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 256256EnkurinPRO_0000086975Add
BLAST

Proteomic databases

PaxDbiQ8TC29.
PeptideAtlasiQ8TC29.
PRIDEiQ8TC29.

PTM databases

iPTMnetiQ8TC29.
PhosphoSiteiQ8TC29.

Expressioni

Gene expression databases

BgeeiQ8TC29.
CleanExiHS_C10orf63.
ExpressionAtlasiQ8TC29. baseline and differential.
GenevisibleiQ8TC29. HS.

Organism-specific databases

HPAiHPA037593.
HPA037594.
HPA061503.

Interactioni

Subunit structurei

Binds calmodulin via its IQ domain. Interacts with TRPC1, TRPC2, TRPC5, but not TRPC3 (By similarity).By similarity

Protein-protein interaction databases

IntActiQ8TC29. 1 interaction.
STRINGi9606.ENSP00000331044.

Structurei

3D structure databases

ProteinModelPortaliQ8TC29.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini160 – 25293EnkurinPROSITE-ProRule annotationAdd
BLAST
Domaini176 – 18712IQAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi83 – 897SH3-bindingSequence analysis

Domaini

Residues 160-255 contains the TRPC2 binding site.By similarity
The IQ motif is involved in calmodulin binding.By similarity

Sequence similaritiesi

Contains 1 enkurin domain.PROSITE-ProRule annotation
Contains 1 IQ domain.Curated

Keywords - Domaini

SH3-binding

Phylogenomic databases

eggNOGiENOG410IET1. Eukaryota.
ENOG410ZNA7. LUCA.
GeneTreeiENSGT00390000009461.
HOGENOMiHOG000007231.
HOVERGENiHBG056756.
InParanoidiQ8TC29.
OMAiTVKDDMQ.
OrthoDBiEOG75J0Q4.
PhylomeDBiQ8TC29.
TreeFamiTF323892.

Family and domain databases

InterProiIPR026150. Enkur.
IPR027012. Enkurin_dom.
[Graphical view]
PANTHERiPTHR21490:SF0. PTHR21490:SF0. 1 hit.
PfamiPF13864. Enkurin. 1 hit.
[Graphical view]
PROSITEiPS51665. ENKURIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TC29-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPTCSSECI YNLIPSDLKE PPQPPRYISI FKATVKDDMQ KAKTAMKTMG
60 70 80 90 100
PAKVEVPSPK DFLKKHSKEK TLPPKKNFDR NVPKKPAVPL KTDHPVMGIQ
110 120 130 140 150
SGKNFINTNA ADIIMGVAKK PKPIYVDKRT GDKHDLEPSG LVPKYINKKD
160 170 180 190 200
YGVTPEYICK RNEEIKKAQE DYDRYIQENL KKAAMKRLSD EEREAVLQGL
210 220 230 240 250
KKNWEEVHKE FQSLSVFIDS IPKKIRKQRL EEEMKQLEHD IGIIEKHKII

YIANNA
Length:256
Mass (Da):29,454
Last modified:June 1, 2002 - v1
Checksum:i88F5BA7DD3FA6FE8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY454125 mRNA. Translation: AAS45168.1.
AK095021 mRNA. Translation: BAC04477.1.
AK292495 mRNA. Translation: BAF85184.1.
AL512598 Genomic DNA. Translation: CAH70788.1.
CH471072 Genomic DNA. Translation: EAW86115.1.
CH471072 Genomic DNA. Translation: EAW86116.1.
BC026165 mRNA. Translation: AAH26165.1.
CCDSiCCDS7146.1.
RefSeqiNP_001257312.1. NM_001270383.1.
NP_659447.1. NM_145010.3.
XP_011517650.1. XM_011519348.1.
UniGeneiHs.534486.

Genome annotation databases

EnsembliENST00000331161; ENSP00000331044; ENSG00000151023.
ENST00000496261; ENSP00000432930; ENSG00000151023.
GeneIDi219670.
KEGGihsa:219670.
UCSCiuc001isg.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY454125 mRNA. Translation: AAS45168.1.
AK095021 mRNA. Translation: BAC04477.1.
AK292495 mRNA. Translation: BAF85184.1.
AL512598 Genomic DNA. Translation: CAH70788.1.
CH471072 Genomic DNA. Translation: EAW86115.1.
CH471072 Genomic DNA. Translation: EAW86116.1.
BC026165 mRNA. Translation: AAH26165.1.
CCDSiCCDS7146.1.
RefSeqiNP_001257312.1. NM_001270383.1.
NP_659447.1. NM_145010.3.
XP_011517650.1. XM_011519348.1.
UniGeneiHs.534486.

3D structure databases

ProteinModelPortaliQ8TC29.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8TC29. 1 interaction.
STRINGi9606.ENSP00000331044.

PTM databases

iPTMnetiQ8TC29.
PhosphoSiteiQ8TC29.

Polymorphism and mutation databases

BioMutaiENKUR.
DMDMi71151870.

Proteomic databases

PaxDbiQ8TC29.
PeptideAtlasiQ8TC29.
PRIDEiQ8TC29.

Protocols and materials databases

DNASUi219670.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000331161; ENSP00000331044; ENSG00000151023.
ENST00000496261; ENSP00000432930; ENSG00000151023.
GeneIDi219670.
KEGGihsa:219670.
UCSCiuc001isg.2. human.

Organism-specific databases

CTDi219670.
GeneCardsiENKUR.
HGNCiHGNC:28388. ENKUR.
HPAiHPA037593.
HPA037594.
HPA061503.
MIMi611025. gene.
neXtProtiNX_Q8TC29.
PharmGKBiPA165548526.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IET1. Eukaryota.
ENOG410ZNA7. LUCA.
GeneTreeiENSGT00390000009461.
HOGENOMiHOG000007231.
HOVERGENiHBG056756.
InParanoidiQ8TC29.
OMAiTVKDDMQ.
OrthoDBiEOG75J0Q4.
PhylomeDBiQ8TC29.
TreeFamiTF323892.

Miscellaneous databases

ChiTaRSiENKUR. human.
GeneWikiiEnkurin.
GenomeRNAii219670.
PROiQ8TC29.
SOURCEiSearch...

Gene expression databases

BgeeiQ8TC29.
CleanExiHS_C10orf63.
ExpressionAtlasiQ8TC29. baseline and differential.
GenevisibleiQ8TC29. HS.

Family and domain databases

InterProiIPR026150. Enkur.
IPR027012. Enkurin_dom.
[Graphical view]
PANTHERiPTHR21490:SF0. PTHR21490:SF0. 1 hit.
PfamiPF13864. Enkurin. 1 hit.
[Graphical view]
PROSITEiPS51665. ENKURIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Enkurin is a novel calmodulin and TRPC channel binding protein in sperm."
    Sutton K.A., Jungnickel M.K., Wang Y., Cullen K., Lambert S., Florman H.M.
    Dev. Biol. 274:426-435(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Hippocampus and Testis.
  3. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiENKUR_HUMAN
AccessioniPrimary (citable) accession number: Q8TC29
Secondary accession number(s): A8K8Y0, D3DRV2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: June 1, 2002
Last modified: July 6, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.