Q8TC29 (ENKUR_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Enkurin

Gene names

Name:	ENKUR
Synonyms:	C10orf63

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	256 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Adapter that functions to localize a calcium-sensitive signal transduction machinery in sperm to a calcium-permeable ion channel By similarity.
Subunit structure	Binds calmodulin via its IQ domain. Interacts with TRPC1, TRPC2, TRPC5, but not TRPC3 By similarity.
Subcellular location	Cell projection › cilium › flagellum. Note: Sperm acrosomal crescent and flagellar principal piece.
Domain	Residues 160-255 contains the TRPC2 binding site By similarity. The IQ motif is involved in calmodulin binding By similarity.
Sequence similarities	Contains 1 IQ domain.

Ontologies

Keywords
Cellular component	Cell projection Cilium Flagellum
Domain	SH3-binding
Ligand	Calmodulin-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cilium Inferred from electronic annotation. Source: UniProtKB-KW flagellum Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	SH3 domain binding Inferred from electronic annotation. Source: UniProtKB-KW calmodulin binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 256	256	Enkurin		PRO_0000086975
Regions
	Domain	176 – 187	12	IQ
	Motif	83 – 89	7	SH3-binding Potential

Sequences

	Sequence		Length	Mass (Da)
	Q8TC29 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: 88F5BA7DD3FA6FE8	FASTA	256	29,454
	10 20 30 40 50 60 MDPTCSSECI YNLIPSDLKE PPQPPRYISI FKATVKDDMQ KAKTAMKTMG PAKVEVPSPK 70 80 90 100 110 120 DFLKKHSKEK TLPPKKNFDR NVPKKPAVPL KTDHPVMGIQ SGKNFINTNA ADIIMGVAKK 130 140 150 160 170 180 PKPIYVDKRT GDKHDLEPSG LVPKYINKKD YGVTPEYICK RNEEIKKAQE DYDRYIQENL 190 200 210 220 230 240 KKAAMKRLSD EEREAVLQGL KKNWEEVHKE FQSLSVFIDS IPKKIRKQRL EEEMKQLEHD 250 IGIIEKHKII YIANNA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Enkurin is a novel calmodulin and TRPC channel binding protein in sperm." Sutton K.A., Jungnickel M.K., Wang Y., Cullen K., Lambert S., Florman H.M. Dev. Biol. 274:426-435(2004) [PubMed: 15385169] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Testis.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Hippocampus and Testis.
[3]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed: 15164054] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY454125 mRNA. Translation: AAS45168.1. AK095021 mRNA. Translation: BAC04477.1. AK292495 mRNA. Translation: BAF85184.1. AL512598 Genomic DNA. Translation: CAH70788.1. CH471072 Genomic DNA. Translation: EAW86115.1. CH471072 Genomic DNA. Translation: EAW86116.1. BC026165 mRNA. Translation: AAH26165.1.
IPI	IPI00152257.
RefSeq	NP_659447.1. NM_145010.2.
UniGene	Hs.534486.
3D structure databases
ProteinModelPortal	Q8TC29.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8TC29.
Polymorphism databases
DMDM	71151870.
Proteomic databases
PRIDE	Q8TC29.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000331161; ENSP00000331044; ENSG00000151023.
GeneID	219670.
KEGG	hsa:219670.
UCSC	uc001isg.1. human.
Organism-specific databases
CTD	219670.
GeneCards	GC10M025311.
H-InvDB	HIX0008714.
HGNC	HGNC:28388. ENKUR.
HPA	HPA037593.
MIM	611025. gene.
neXtProt	NX_Q8TC29.
PharmGKB	PA134895154. PA165548526.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00390000009461.
HOGENOM	HBG715783.
HOVERGEN	HBG056756.
InParanoid	Q8TC29.
OMA	TDHPVMG.
OrthoDB	EOG444KM3.
PhylomeDB	Q8TC29.
Gene expression databases
ArrayExpress	Q8TC29.
Bgee	Q8TC29.
CleanEx	HS_C10orf63.
Genevestigator	Q8TC29.
GermOnline	ENSG00000151023. Homo sapiens.
Family and domain databases
PROSITE	PS50096. IQ. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	90711.
SOURCE	Search...

Entry information

Entry name

ENKUR_HUMAN

Accession

Primary (citable) accession number: Q8TC29
Secondary accession number(s): A8K8Y0, D3DRV2

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2005
Last sequence update:	June 1, 2002
Last modified:	January 25, 2012
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.