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Protein

Enkurin

Gene

ENKUR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Adapter that functions to localize a calcium-sensitive signal transduction machinery in sperm to a calcium-permeable ion channel.By similarity

GO - Molecular functioni

Keywordsi

Molecular functionCalmodulin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Enkurin
Gene namesi
Name:ENKUR
Synonyms:C10orf63
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000151023.16.
HGNCiHGNC:28388. ENKUR.

Subcellular locationi

Keywords - Cellular componenti

Cell projection, Cilium, Flagellum

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000151023.
PharmGKBiPA165548526.

Polymorphism and mutation databases

BioMutaiENKUR.
DMDMi71151870.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000869751 – 256EnkurinAdd BLAST256

Proteomic databases

PaxDbiQ8TC29.
PeptideAtlasiQ8TC29.
PRIDEiQ8TC29.

PTM databases

iPTMnetiQ8TC29.
PhosphoSitePlusiQ8TC29.

Expressioni

Gene expression databases

BgeeiENSG00000151023.
CleanExiHS_C10orf63.
ExpressionAtlasiQ8TC29. baseline and differential.
GenevisibleiQ8TC29. HS.

Organism-specific databases

HPAiHPA037593.
HPA037594.
HPA061503.

Interactioni

Subunit structurei

Binds calmodulin via its IQ domain. Interacts with TRPC1, TRPC2, TRPC5, but not TRPC3 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
CFAP45Q9UL164EBI-9246952,EBI-13039584

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ8TC29. 2 interactors.
STRINGi9606.ENSP00000331044.

Structurei

3D structure databases

ProteinModelPortaliQ8TC29.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini160 – 252EnkurinPROSITE-ProRule annotationAdd BLAST93
Domaini176 – 187IQAdd BLAST12

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi83 – 89SH3-bindingSequence analysis7

Domaini

Residues 160-255 contains the TRPC2 binding site.By similarity
The IQ motif is involved in calmodulin binding.By similarity

Keywords - Domaini

SH3-binding

Phylogenomic databases

eggNOGiENOG410IET1. Eukaryota.
ENOG410ZNA7. LUCA.
GeneTreeiENSGT00390000009461.
HOGENOMiHOG000007231.
HOVERGENiHBG056756.
InParanoidiQ8TC29.
OMAiHPVMGIQ.
OrthoDBiEOG091G0MPU.
PhylomeDBiQ8TC29.
TreeFamiTF323892.

Family and domain databases

InterProiView protein in InterPro
IPR026150. Enkur.
IPR027012. Enkurin_dom.
PANTHERiPTHR21490:SF0. PTHR21490:SF0. 1 hit.
PfamiView protein in Pfam
PF13864. Enkurin. 1 hit.
PROSITEiView protein in PROSITE
PS51665. ENKURIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8TC29-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPTCSSECI YNLIPSDLKE PPQPPRYISI FKATVKDDMQ KAKTAMKTMG
60 70 80 90 100
PAKVEVPSPK DFLKKHSKEK TLPPKKNFDR NVPKKPAVPL KTDHPVMGIQ
110 120 130 140 150
SGKNFINTNA ADIIMGVAKK PKPIYVDKRT GDKHDLEPSG LVPKYINKKD
160 170 180 190 200
YGVTPEYICK RNEEIKKAQE DYDRYIQENL KKAAMKRLSD EEREAVLQGL
210 220 230 240 250
KKNWEEVHKE FQSLSVFIDS IPKKIRKQRL EEEMKQLEHD IGIIEKHKII

YIANNA
Length:256
Mass (Da):29,454
Last modified:June 1, 2002 - v1
Checksum:i88F5BA7DD3FA6FE8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY454125 mRNA. Translation: AAS45168.1.
AK095021 mRNA. Translation: BAC04477.1.
AK292495 mRNA. Translation: BAF85184.1.
AL512598 Genomic DNA. No translation available.
CH471072 Genomic DNA. Translation: EAW86115.1.
CH471072 Genomic DNA. Translation: EAW86116.1.
BC026165 mRNA. Translation: AAH26165.1.
CCDSiCCDS7146.1.
RefSeqiNP_001257312.1. NM_001270383.1.
NP_659447.1. NM_145010.3.
XP_011517650.1. XM_011519348.1.
UniGeneiHs.534486.

Genome annotation databases

EnsembliENST00000331161; ENSP00000331044; ENSG00000151023.
ENST00000496261; ENSP00000432930; ENSG00000151023.
GeneIDi219670.
KEGGihsa:219670.
UCSCiuc001isg.2. human.

Similar proteinsi

Entry informationi

Entry nameiENKUR_HUMAN
AccessioniPrimary (citable) accession number: Q8TC29
Secondary accession number(s): A8K8Y0, D3DRV2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: June 1, 2002
Last modified: November 22, 2017
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot