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Q8TC27

- ADA32_HUMAN

UniProt

Q8TC27 - ADA32_HUMAN

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Protein
Disintegrin and metalloproteinase domain-containing protein 32
Gene
ADAM32, UNQ5982/PRO21340
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

May play a role in sperm development and fertilization This is a non-catalytic metalloprotease-like protein By similarity.

GO - Molecular functioni

  1. metalloendopeptidase activity Source: InterPro
  2. zinc ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Protein family/group databases

    MEROPSiM12.960.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Disintegrin and metalloproteinase domain-containing protein 32
    Short name:
    ADAM 32
    Gene namesi
    Name:ADAM32
    ORF Names:UNQ5982/PRO21340
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:15479. ADAM32.

    Subcellular locationi

    Topology

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini175 – 682508Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei683 – 70321Helical; Reviewed prediction
    Add
    BLAST
    Topological domaini704 – 78784Cytoplasmic Reviewed prediction
    Add
    BLAST

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    Complete GO annotation...

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134932610.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 16161 Publication
    Add
    BLAST
    Propeptidei17 – 174158 Reviewed prediction
    PRO_0000029138Add
    BLAST
    Chaini175 – 787613Disintegrin and metalloproteinase domain-containing protein 32
    PRO_0000029139Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei17 – 171Phosphoserine2 Publications
    Glycosylationi39 – 391N-linked (GlcNAc...) Reviewed prediction
    Glycosylationi125 – 1251N-linked (GlcNAc...) Reviewed prediction
    Disulfide bondi295 ↔ 378 By similarity
    Disulfide bondi337 ↔ 362 By similarity
    Disulfide bondi339 ↔ 344 By similarity
    Disulfide bondi450 ↔ 471 By similarity
    Glycosylationi465 – 4651N-linked (GlcNAc...) Reviewed prediction
    Glycosylationi598 – 5981N-linked (GlcNAc...) Reviewed prediction
    Disulfide bondi626 ↔ 636 By similarity
    Disulfide bondi630 ↔ 642 By similarity
    Disulfide bondi644 ↔ 653 By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiQ8TC27.
    PRIDEiQ8TC27.

    PTM databases

    PhosphoSiteiQ8TC27.

    Expressioni

    Tissue specificityi

    Testis specific.1 Publication

    Gene expression databases

    ArrayExpressiQ8TC27.
    BgeeiQ8TC27.
    CleanExiHS_ADAM32.
    GenevestigatoriQ8TC27.

    Organism-specific databases

    HPAiHPA044156.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000369238.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8TC27.
    SMRiQ8TC27. Positions 187-653.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini186 – 383198Peptidase M12B
    Add
    BLAST
    Domaini391 – 47989Disintegrin
    Add
    BLAST
    Domaini622 – 65433EGF-like
    Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi480 – 50223Cys-rich
    Add
    BLAST

    Sequence similaritiesi

    Contains 1 disintegrin domain.
    Contains 1 EGF-like domain.

    Keywords - Domaini

    EGF-like domain, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG245239.
    HOGENOMiHOG000230883.
    HOVERGENiHBG103628.
    InParanoidiQ8TC27.
    KOiK16070.
    OMAiFPLYLEM.
    PhylomeDBiQ8TC27.
    TreeFamiTF314733.

    Family and domain databases

    Gene3Di3.40.390.10. 1 hit.
    4.10.70.10. 1 hit.
    InterProiIPR006586. ADAM_Cys-rich.
    IPR001762. Blood-coag_inhib_Disintegrin.
    IPR018358. Disintegrin_CS.
    IPR000742. EG-like_dom.
    IPR013032. EGF-like_CS.
    IPR024079. MetalloPept_cat_dom.
    IPR001590. Peptidase_M12B.
    IPR002870. Peptidase_M12B_N.
    [Graphical view]
    PfamiPF08516. ADAM_CR. 1 hit.
    PF00200. Disintegrin. 1 hit.
    PF01562. Pep_M12B_propep. 1 hit.
    PF01421. Reprolysin. 1 hit.
    [Graphical view]
    SMARTiSM00608. ACR. 1 hit.
    SM00050. DISIN. 1 hit.
    SM00181. EGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF57552. SSF57552. 1 hit.
    PROSITEiPS50215. ADAM_MEPRO. 1 hit.
    PS00427. DISINTEGRIN_1. 1 hit.
    PS50214. DISINTEGRIN_2. 1 hit.
    PS01186. EGF_2. 1 hit.
    PS50026. EGF_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8TC27-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFRLWLLLAG LCGLLASRPG FQNSLLQIVI PEKIQTNTND SSEIEYEQIS    50
    YIIPIDEKLY TVHLKQRYFL ADNFMIYLYN QGSMNTYSSD IQTQCYYQGN 100
    IEGYPDSMVT LSTCSGLRGI LQFENVSYGI EPLESAVEFQ HVLYKLKNED 150
    NDIAIFIDRS LKEQPMDDNI FISEKSEPAV PDLFPLYLEM HIVVDKTLYD 200
    YWGSDSMIVT NKVIEIVGLA NSMFTQFKVT IVLSSLELWS DENKISTVGE 250
    ADELLQKFLE WKQSYLNLRP HDIAYLLIYM DYPRYLGAVF PGTMCITRYS 300
    AGVALYPKEI TLEAFAVIVT QMLALSLGIS YDDPKKCQCS ESTCIMNPEV 350
    VQSNGVKTFS SCSLRSFQNF ISNVGVKCLQ NKPQMQKKSP KPVCGNGRLE 400
    GNEICDCGTE AQCGPASCCD FRTCVLKDGA KCYKGLCCKD CQILQSGVEC 450
    RPKAHPECDI AENCNGTSPE CGPDITLING LSCKNNKFIC YDGDCHDLDA 500
    RCESVFGKGS RNAPFACYEE IQSQSDRFGN CGRDRNNKYV FCGWRNLICG 550
    RLVCTYPTRK PFHQENGDVI YAFVRDSVCI TVDYKLPRTV PDPLAVKNGS 600
    QCDIGRVCVN RECVESRIIK ASAHVCSQQC SGHGVCDSRN KCHCSPGYKP 650
    PNCQIRSKGF SIFPEEDMGS IMERASGKTE NTWLLGFLIA LPILIVTTAI 700
    VLARKQLKKW FAKEEEFPSS ESKSEGSTQT YASQSSSEGS TQTYASQTRS 750
    ESSSQADTSK SKSEDSAEAY TSRSKSQDST QTQSSSN 787
    Length:787
    Mass (Da):87,948
    Last modified:May 18, 2010 - v2
    Checksum:i841EDA9EFF483A2C
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti98 – 981Q → R.1 Publication
    Corresponds to variant rs17856744 [ dbSNP | Ensembl ].
    VAR_055241
    Natural varianti160 – 1601S → G.1 Publication
    Corresponds to variant rs17852343 [ dbSNP | Ensembl ].
    VAR_055242
    Natural varianti327 – 3271L → V.
    Corresponds to variant rs9643859 [ dbSNP | Ensembl ].
    VAR_055243
    Natural varianti467 – 4671T → S.2 Publications
    Corresponds to variant rs7845771 [ dbSNP | Ensembl ].
    VAR_051591
    Natural varianti658 – 6581K → N.
    Corresponds to variant rs13277386 [ dbSNP | Ensembl ].
    VAR_055244
    Natural varianti778 – 7781D → E.
    Corresponds to variant rs28705715 [ dbSNP | Ensembl ].
    VAR_061739

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY358739 mRNA. Translation: AAQ89099.1.
    AC105091 Genomic DNA. No translation available.
    AC105185 Genomic DNA. No translation available.
    BC026085 mRNA. Translation: AAH26085.1.
    BC026169 mRNA. Translation: AAH26169.1.
    BC028702 mRNA. Translation: AAH28702.1.
    BC030014 mRNA. Translation: AAH30014.1.
    BC030698 mRNA. Translation: AAH30698.1.
    BC034975 mRNA. Translation: AAH34975.1.
    CCDSiCCDS47846.1.
    RefSeqiNP_659441.3. NM_145004.5.
    UniGeneiHs.521545.

    Genome annotation databases

    EnsembliENST00000379907; ENSP00000369238; ENSG00000197140.
    GeneIDi203102.
    KEGGihsa:203102.
    UCSCiuc003xmt.4. human.

    Polymorphism databases

    DMDMi296434389.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY358739 mRNA. Translation: AAQ89099.1 .
    AC105091 Genomic DNA. No translation available.
    AC105185 Genomic DNA. No translation available.
    BC026085 mRNA. Translation: AAH26085.1 .
    BC026169 mRNA. Translation: AAH26169.1 .
    BC028702 mRNA. Translation: AAH28702.1 .
    BC030014 mRNA. Translation: AAH30014.1 .
    BC030698 mRNA. Translation: AAH30698.1 .
    BC034975 mRNA. Translation: AAH34975.1 .
    CCDSi CCDS47846.1.
    RefSeqi NP_659441.3. NM_145004.5.
    UniGenei Hs.521545.

    3D structure databases

    ProteinModelPortali Q8TC27.
    SMRi Q8TC27. Positions 187-653.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000369238.

    Protein family/group databases

    MEROPSi M12.960.

    PTM databases

    PhosphoSitei Q8TC27.

    Polymorphism databases

    DMDMi 296434389.

    Proteomic databases

    PaxDbi Q8TC27.
    PRIDEi Q8TC27.

    Protocols and materials databases

    DNASUi 203102.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000379907 ; ENSP00000369238 ; ENSG00000197140 .
    GeneIDi 203102.
    KEGGi hsa:203102.
    UCSCi uc003xmt.4. human.

    Organism-specific databases

    CTDi 203102.
    GeneCardsi GC08P038965.
    HGNCi HGNC:15479. ADAM32.
    HPAi HPA044156.
    neXtProti NX_Q8TC27.
    PharmGKBi PA134932610.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG245239.
    HOGENOMi HOG000230883.
    HOVERGENi HBG103628.
    InParanoidi Q8TC27.
    KOi K16070.
    OMAi FPLYLEM.
    PhylomeDBi Q8TC27.
    TreeFami TF314733.

    Miscellaneous databases

    GenomeRNAii 203102.
    NextBioi 90349.
    PROi Q8TC27.

    Gene expression databases

    ArrayExpressi Q8TC27.
    Bgeei Q8TC27.
    CleanExi HS_ADAM32.
    Genevestigatori Q8TC27.

    Family and domain databases

    Gene3Di 3.40.390.10. 1 hit.
    4.10.70.10. 1 hit.
    InterProi IPR006586. ADAM_Cys-rich.
    IPR001762. Blood-coag_inhib_Disintegrin.
    IPR018358. Disintegrin_CS.
    IPR000742. EG-like_dom.
    IPR013032. EGF-like_CS.
    IPR024079. MetalloPept_cat_dom.
    IPR001590. Peptidase_M12B.
    IPR002870. Peptidase_M12B_N.
    [Graphical view ]
    Pfami PF08516. ADAM_CR. 1 hit.
    PF00200. Disintegrin. 1 hit.
    PF01562. Pep_M12B_propep. 1 hit.
    PF01421. Reprolysin. 1 hit.
    [Graphical view ]
    SMARTi SM00608. ACR. 1 hit.
    SM00050. DISIN. 1 hit.
    SM00181. EGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57552. SSF57552. 1 hit.
    PROSITEi PS50215. ADAM_MEPRO. 1 hit.
    PS00427. DISINTEGRIN_1. 1 hit.
    PS50214. DISINTEGRIN_2. 1 hit.
    PS01186. EGF_2. 1 hit.
    PS50026. EGF_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-467.
    2. "DNA sequence and analysis of human chromosome 8."
      Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
      , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
      Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ARG-98; GLY-160 AND SER-467.
      Tissue: Testis.
    4. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z., Henzel W.J.
      Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 17-31.
    5. "Identification and characterization of ADAM32 with testis-predominant gene expression."
      Choi I., Woo J.-M., Hong S., Jung Y.-K., Kim D.H., Cho C.
      Gene 304:151-162(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    6. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-17, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-17, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiADA32_HUMAN
    AccessioniPrimary (citable) accession number: Q8TC27
    Secondary accession number(s): Q8TC42
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 7, 2004
    Last sequence update: May 18, 2010
    Last modified: July 9, 2014
    This is version 105 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. Peptidase families
      Classification of peptidase families and list of entries
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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