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Protein

Transmembrane protein 163

Gene

TMEM163

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May bind zinc and other divalent cations and recruit them to vesicular organelles.By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Zinc

Protein family/group databases

TCDBi2.A.4.8.3. the cation diffusion facilitator (cdf) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 163
Gene namesi
Name:TMEM163
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:25380. TMEM163.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 8888CytoplasmicSequence analysisAdd
BLAST
Transmembranei89 – 10921HelicalSequence analysisAdd
BLAST
Topological domaini110 – 1167ExtracellularSequence analysis
Transmembranei117 – 13721HelicalSequence analysisAdd
BLAST
Topological domaini138 – 15013CytoplasmicSequence analysisAdd
BLAST
Transmembranei151 – 17121HelicalSequence analysisAdd
BLAST
Topological domaini172 – 18716ExtracellularSequence analysisAdd
BLAST
Transmembranei188 – 20821HelicalSequence analysisAdd
BLAST
Topological domaini209 – 2179CytoplasmicSequence analysis
Transmembranei218 – 23821HelicalSequence analysisAdd
BLAST
Topological domaini239 – 25517ExtracellularSequence analysisAdd
BLAST
Transmembranei256 – 27621HelicalSequence analysisAdd
BLAST
Topological domaini277 – 28913CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Endosome, Membrane, Synapse

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA145148025.

Polymorphism and mutation databases

BioMutaiTMEM163.
DMDMi74730546.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 289289Transmembrane protein 163PRO_0000278539Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei11 – 111PhosphoserineBy similarity
Modified residuei55 – 551PhosphoserineBy similarity
Modified residuei57 – 571PhosphoserineBy similarity
Modified residuei61 – 611PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8TC26.
PRIDEiQ8TC26.

PTM databases

iPTMnetiQ8TC26.
PhosphoSiteiQ8TC26.

Expressioni

Gene expression databases

BgeeiQ8TC26.
CleanExiHS_TMEM163.
GenevisibleiQ8TC26. HS.

Organism-specific databases

HPAiHPA007224.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000281924.

Structurei

3D structure databases

ProteinModelPortaliQ8TC26.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM163 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE9N. Eukaryota.
ENOG410Z7QG. LUCA.
GeneTreeiENSGT00390000001170.
HOGENOMiHOG000294211.
HOVERGENiHBG094063.
InParanoidiQ8TC26.
OMAiFKHNSAV.
OrthoDBiEOG7M0NSD.
PhylomeDBiQ8TC26.
TreeFamiTF330782.

Family and domain databases

InterProiIPR026765. Tmem163.
[Graphical view]
PANTHERiPTHR31937. PTHR31937. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TC26-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEPAAGIQRR SSQGPTVPPP PRGHAPPAAA PGPAPLSSPV REPPQLEEER
60 70 80 90 100
QVRISESGQF SDGLEDRGLL ESSTRLKPHE AQNYRKKALW VSWFSIIVTL
110 120 130 140 150
ALAVAAFTVS VMRYSASAFG FAFDAILDVL SSAIVLWRYS NAAAVHSAHR
160 170 180 190 200
EYIACVILGV IFLLSSICIV VKAIHDLSTR LLPEVDDFLF SVSILSGILC
210 220 230 240 250
SILAVLKFML GKVLTSRALI TDGFNSLVGG VMGFSILLSA EVFKHDSAVW
260 270 280
YLDGSIGVLI GLTIFAYGVK LLIDMVPRVR QTRHYEMFE
Length:289
Mass (Da):31,469
Last modified:June 1, 2002 - v1
Checksum:i0255DAE6D7E8487A
GO
Isoform 2 (identifier: Q8TC26-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-60: Missing.
     61-68: SDGLEDRG → MLPVSRTC
     153-162: IACVILGVIF → MTISCSVSPF
     163-289: Missing.

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:102
Mass (Da):11,334
Checksum:i06F17B8F21B2B5A6
GO
Isoform 3 (identifier: Q8TC26-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-208: Missing.

Note: No experimental confirmation available. Dubious isoform that could be a cloning artifact.
Show »
Length:81
Mass (Da):8,966
Checksum:i0E596F8E75C84BA8
GO

Sequence cautioni

The sequence CAH10592.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 208208Missing in isoform 3. 1 PublicationVSP_023328Add
BLAST
Alternative sequencei1 – 6060Missing in isoform 2. 1 PublicationVSP_023329Add
BLAST
Alternative sequencei61 – 688SDGLEDRG → MLPVSRTC in isoform 2. 1 PublicationVSP_023330
Alternative sequencei153 – 16210IACVILGVIF → MTISCSVSPF in isoform 2. 1 PublicationVSP_023331
Alternative sequencei163 – 289127Missing in isoform 2. 1 PublicationVSP_023332Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL122044 mRNA. Translation: CAB59180.2.
AL833765 mRNA. Translation: CAH10592.1. Different initiation.
AC013718 Genomic DNA. Translation: AAX93249.1.
AC110620 Genomic DNA. Translation: AAY24144.1.
BC026170 mRNA. Translation: AAH26170.1.
CCDSiCCDS2172.1. [Q8TC26-1]
PIRiT34524.
RefSeqiNP_112185.1. NM_030923.4. [Q8TC26-1]
UniGeneiHs.369471.
Hs.595089.

Genome annotation databases

EnsembliENST00000281924; ENSP00000281924; ENSG00000152128. [Q8TC26-1]
GeneIDi81615.
KEGGihsa:81615.
UCSCiuc002ttx.4. human. [Q8TC26-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL122044 mRNA. Translation: CAB59180.2.
AL833765 mRNA. Translation: CAH10592.1. Different initiation.
AC013718 Genomic DNA. Translation: AAX93249.1.
AC110620 Genomic DNA. Translation: AAY24144.1.
BC026170 mRNA. Translation: AAH26170.1.
CCDSiCCDS2172.1. [Q8TC26-1]
PIRiT34524.
RefSeqiNP_112185.1. NM_030923.4. [Q8TC26-1]
UniGeneiHs.369471.
Hs.595089.

3D structure databases

ProteinModelPortaliQ8TC26.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000281924.

Protein family/group databases

TCDBi2.A.4.8.3. the cation diffusion facilitator (cdf) family.

PTM databases

iPTMnetiQ8TC26.
PhosphoSiteiQ8TC26.

Polymorphism and mutation databases

BioMutaiTMEM163.
DMDMi74730546.

Proteomic databases

PaxDbiQ8TC26.
PRIDEiQ8TC26.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000281924; ENSP00000281924; ENSG00000152128. [Q8TC26-1]
GeneIDi81615.
KEGGihsa:81615.
UCSCiuc002ttx.4. human. [Q8TC26-1]

Organism-specific databases

CTDi81615.
GeneCardsiTMEM163.
HGNCiHGNC:25380. TMEM163.
HPAiHPA007224.
neXtProtiNX_Q8TC26.
PharmGKBiPA145148025.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IE9N. Eukaryota.
ENOG410Z7QG. LUCA.
GeneTreeiENSGT00390000001170.
HOGENOMiHOG000294211.
HOVERGENiHBG094063.
InParanoidiQ8TC26.
OMAiFKHNSAV.
OrthoDBiEOG7M0NSD.
PhylomeDBiQ8TC26.
TreeFamiTF330782.

Miscellaneous databases

ChiTaRSiTMEM163. human.
GenomeRNAii81615.
PROiQ8TC26.

Gene expression databases

BgeeiQ8TC26.
CleanExiHS_TMEM163.
GenevisibleiQ8TC26. HS.

Family and domain databases

InterProiIPR026765. Tmem163.
[Graphical view]
PANTHERiPTHR31937. PTHR31937. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Tissue: Kidney and Stomach.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.

Entry informationi

Entry nameiTM163_HUMAN
AccessioniPrimary (citable) accession number: Q8TC26
Secondary accession number(s): Q53QM3
, Q53SV7, Q69YH3, Q9UFG3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: June 1, 2002
Last modified: June 8, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.