ID   GRAPL_HUMAN             Reviewed;         118 AA.
AC   Q8TC17; B2RXI8;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   18-MAY-2010, sequence version 3.
DT   24-JAN-2024, entry version 128.
DE   RecName: Full=GRB2-related adapter protein-like;
GN   Name=GRAPL;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA   Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA   Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA   LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA   Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA   Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA   Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT   human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND NUCLEOTIDE SEQUENCE
RP   [LARGE SCALE MRNA] OF 53-118 (ISOFORM 2).
RC   TISSUE=Lung;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- INTERACTION:
CC       Q8TC17; O43741: PRKAB2; NbExp=3; IntAct=EBI-18300553, EBI-1053424;
CC       Q8TC17; Q0D2K3: RIPPLY1; NbExp=3; IntAct=EBI-18300553, EBI-10226430;
CC       Q8TC17; Q8WWU5-7: TCP11; NbExp=3; IntAct=EBI-18300553, EBI-17721485;
CC       Q8TC17; P36508: ZNF76; NbExp=3; IntAct=EBI-18300553, EBI-7254550;
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q8TC17-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q8TC17-2; Sequence=VSP_039172;
CC   -!- SIMILARITY: Belongs to the GRB2/sem-5/DRK family. {ECO:0000305}.
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DR   EMBL; AC007952; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC026233; AAH26233.1; -; mRNA.
DR   EMBL; BC157869; AAI57870.1; -; mRNA.
DR   CCDS; CCDS45627.1; -. [Q8TC17-1]
DR   RefSeq; NP_001123250.1; NM_001129778.1. [Q8TC17-1]
DR   RefSeq; XP_016880126.1; XM_017024637.1.
DR   AlphaFoldDB; Q8TC17; -.
DR   SMR; Q8TC17; -.
DR   BioGRID; 134647; 5.
DR   IntAct; Q8TC17; 4.
DR   STRING; 9606.ENSP00000437409; -.
DR   iPTMnet; Q8TC17; -.
DR   PhosphoSitePlus; Q8TC17; -.
DR   BioMuta; GRAPL; -.
DR   DMDM; 296439331; -.
DR   jPOST; Q8TC17; -.
DR   MassIVE; Q8TC17; -.
DR   MaxQB; Q8TC17; -.
DR   PaxDb; 9606-ENSP00000437409; -.
DR   PeptideAtlas; Q8TC17; -.
DR   ProteomicsDB; 74071; -. [Q8TC17-1]
DR   ProteomicsDB; 74072; -. [Q8TC17-2]
DR   Antibodypedia; 63469; 5 antibodies from 5 providers.
DR   DNASU; 400581; -.
DR   Ensembl; ENST00000344415.9; ENSP00000437409.2; ENSG00000189152.11. [Q8TC17-1]
DR   GeneID; 400581; -.
DR   KEGG; hsa:400581; -.
DR   MANE-Select; ENST00000344415.9; ENSP00000437409.2; NM_001129778.3; NP_001123250.1.
DR   UCSC; uc010cqk.2; human. [Q8TC17-1]
DR   AGR; HGNC:37240; -.
DR   CTD; 400581; -.
DR   GeneCards; GRAPL; -.
DR   HGNC; HGNC:37240; GRAPL.
DR   HPA; ENSG00000189152; Tissue enhanced (lymphoid).
DR   neXtProt; NX_Q8TC17; -.
DR   OpenTargets; ENSG00000189152; -.
DR   PharmGKB; PA165431929; -.
DR   VEuPathDB; HostDB:ENSG00000189152; -.
DR   eggNOG; KOG3601; Eukaryota.
DR   GeneTree; ENSGT00940000156254; -.
DR   InParanoid; Q8TC17; -.
DR   OMA; WANAERD; -.
DR   OrthoDB; 25371at2759; -.
DR   PhylomeDB; Q8TC17; -.
DR   TreeFam; TF354288; -.
DR   PathwayCommons; Q8TC17; -.
DR   SignaLink; Q8TC17; -.
DR   BioGRID-ORCS; 400581; 13 hits in 690 CRISPR screens.
DR   ChiTaRS; GRAPL; human.
DR   GenomeRNAi; 400581; -.
DR   Pharos; Q8TC17; Tdark.
DR   PRO; PR:Q8TC17; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   RNAct; Q8TC17; Protein.
DR   Bgee; ENSG00000189152; Expressed in spleen and 94 other cell types or tissues.
DR   ExpressionAtlas; Q8TC17; baseline and differential.
DR   GO; GO:0005829; C:cytosol; IEA:UniProt.
DR   GO; GO:0030971; F:receptor tyrosine kinase binding; IBA:GO_Central.
DR   GO; GO:0035591; F:signaling adaptor activity; IBA:GO_Central.
DR   GO; GO:0016477; P:cell migration; IBA:GO_Central.
DR   GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR   CDD; cd11948; SH3_GRAP_N; 1.
DR   Gene3D; 3.30.505.10; SH2 domain; 1.
DR   Gene3D; 2.30.30.40; SH3 Domains; 1.
DR   InterPro; IPR035645; GRAP_N_SH3.
DR   InterPro; IPR043539; Grb2-like.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   PANTHER; PTHR46037:SF2; GRB2-RELATED ADAPTER PROTEIN; 1.
DR   PANTHER; PTHR46037; PROTEIN ENHANCER OF SEVENLESS 2B; 1.
DR   Pfam; PF00017; SH2; 1.
DR   Pfam; PF00018; SH3_1; 1.
DR   PRINTS; PR00401; SH2DOMAIN.
DR   PRINTS; PR00452; SH3DOMAIN.
DR   SMART; SM00252; SH2; 1.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF50044; SH3-domain; 1.
DR   PROSITE; PS50001; SH2; 1.
DR   PROSITE; PS50002; SH3; 1.
DR   Genevisible; Q8TC17; HS.
PE   1: Evidence at protein level;
KW   Alternative splicing; Reference proteome; SH2 domain; SH3 domain.
FT   CHAIN           1..118
FT                   /note="GRB2-related adapter protein-like"
FT                   /id="PRO_0000344236"
FT   DOMAIN          1..58
FT                   /note="SH3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT   DOMAIN          60..118
FT                   /note="SH2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00191"
FT   REGION          89..118
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         100..102
FT                   /note="NNR -> K (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_039172"
SQ   SEQUENCE   118 AA;  13442 MW;  15CCFC3347AA8ABE CRC64;
     MESVALYSFQ ATESDELAFN KGDTLKILNM EDDQNWYKAE LRGVEGFIPK NYIRVKPHPW
     YSGRISRQLA EEILMKRNHL GAFLIRESES SPGEFSVSVN NRAQRGPCLG PKSHSRLG
//