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Q8TC17 (GRAPL_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GRB2-related adapter protein-like
Gene names
Name:GRAPL
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length118 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Sequence similarities

Belongs to the GRB2/sem-5/DRK family.

Contains 1 SH2 domain.

Contains 1 SH3 domain.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   DomainSH2 domain
SH3 domain
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8TC17-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: No experimental confirmation available.
Isoform 2 (identifier: Q8TC17-2)

The sequence of this isoform differs from the canonical sequence as follows:
     100-102: NNR → K
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 118118GRB2-related adapter protein-like
PRO_0000344236

Regions

Domain1 – 5858SH3
Domain60 – 11859SH2

Natural variations

Alternative sequence100 – 1023NNR → K in isoform 2.
VSP_039172

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 18, 2010. Version 3.
Checksum: 15CCFC3347AA8ABE

FASTA11813,442
        10         20         30         40         50         60 
MESVALYSFQ ATESDELAFN KGDTLKILNM EDDQNWYKAE LRGVEGFIPK NYIRVKPHPW 

        70         80         90        100        110 
YSGRISRQLA EEILMKRNHL GAFLIRESES SPGEFSVSVN NRAQRGPCLG PKSHSRLG 

« Hide

Isoform 2 [UniParc].

Checksum: A4381B5C11B51AEE
Show »

FASTA11613,186

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC007952 Genomic DNA. No translation available.
BC026233 mRNA. Translation: AAH26233.1.
BC157869 mRNA. Translation: AAI57870.1.
CCDSCCDS45627.1. [Q8TC17-1]
RefSeqNP_001123250.1. NM_001129778.1. [Q8TC17-1]
UniGeneHs.661470.
Hs.677674.

3D structure databases

ProteinModelPortalQ8TC17.
SMRQ8TC17. Positions 1-99.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000345796.

Polymorphism databases

DMDM296439331.

Proteomic databases

PaxDbQ8TC17.
PRIDEQ8TC17.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000344415; ENSP00000437409; ENSG00000189152. [Q8TC17-1]
GeneID400581.
KEGGhsa:400581.
UCSCuc010cqk.1. human. [Q8TC17-1]

Organism-specific databases

CTD400581.
GeneCardsGC17P019030.
HGNCHGNC:37240. GRAPL.
HPAHPA051796.
neXtProtNX_Q8TC17.
PharmGKBPA165431929.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG298780.
HOGENOMHOG000060310.
HOVERGENHBG060131.
OMACLGPKSH.
OrthoDBEOG75F4F6.
PhylomeDBQ8TC17.
TreeFamTF354288.

Enzyme and pathway databases

SignaLinkQ8TC17.

Gene expression databases

ArrayExpressQ8TC17.
BgeeQ8TC17.
GenevestigatorQ8TC17.

Family and domain databases

Gene3D3.30.505.10. 1 hit.
InterProIPR000980. SH2.
IPR001452. SH3_domain.
[Graphical view]
PfamPF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
SMARTSM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMSSF50044. SSF50044. 1 hit.
PROSITEPS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi400581.
NextBio106009.
PROQ8TC17.

Entry information

Entry nameGRAPL_HUMAN
AccessionPrimary (citable) accession number: Q8TC17
Secondary accession number(s): B2RXI8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: May 18, 2010
Last modified: July 9, 2014
This is version 75 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM