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Protein

GRB2-related adapter protein-like

Gene

GRAPL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Enzyme and pathway databases

SignaLinkiQ8TC17

Names & Taxonomyi

Protein namesi
Recommended name:
GRB2-related adapter protein-like
Gene namesi
Name:GRAPL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000189152.10
HGNCiHGNC:37240 GRAPL
neXtProtiNX_Q8TC17

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000189152
PharmGKBiPA165431929

Polymorphism and mutation databases

DMDMi296439331

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003442361 – 118GRB2-related adapter protein-likeAdd BLAST118

Proteomic databases

MaxQBiQ8TC17
PaxDbiQ8TC17
PeptideAtlasiQ8TC17
PRIDEiQ8TC17
ProteomicsDBi74071
74072 [Q8TC17-2]

Expressioni

Gene expression databases

BgeeiENSG00000189152
ExpressionAtlasiQ8TC17 baseline and differential
GenevisibleiQ8TC17 HS

Organism-specific databases

HPAiHPA051796
HPA066654

Interactioni

Protein-protein interaction databases

BioGridi134647, 1 interactor
STRINGi9606.ENSP00000437409

Structurei

3D structure databases

ProteinModelPortaliQ8TC17
SMRiQ8TC17
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 58SH3PROSITE-ProRule annotationAdd BLAST58
Domaini60 – 118SH2PROSITE-ProRule annotationAdd BLAST59

Sequence similaritiesi

Belongs to the GRB2/sem-5/DRK family.Curated

Keywords - Domaini

SH2 domain, SH3 domain

Phylogenomic databases

eggNOGiKOG3601 Eukaryota
ENOG410XR1G LUCA
GeneTreeiENSGT00820000126999
HOGENOMiHOG000060310
HOVERGENiHBG060131
InParanoidiQ8TC17
OMAiCLGPKSH
OrthoDBiEOG091G0HWS
PhylomeDBiQ8TC17
TreeFamiTF354288

Family and domain databases

CDDicd11948 SH3_GRAP_N, 1 hit
InterProiView protein in InterPro
IPR035645 GRAP_N_SH3
IPR000980 SH2
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF00017 SH2, 1 hit
PF00018 SH3_1, 1 hit
PRINTSiPR00401 SH2DOMAIN
PR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00252 SH2, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50001 SH2, 1 hit
PS50002 SH3, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TC17-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MESVALYSFQ ATESDELAFN KGDTLKILNM EDDQNWYKAE LRGVEGFIPK
60 70 80 90 100
NYIRVKPHPW YSGRISRQLA EEILMKRNHL GAFLIRESES SPGEFSVSVN
110
NRAQRGPCLG PKSHSRLG
Note: No experimental confirmation available.
Length:118
Mass (Da):13,442
Last modified:May 18, 2010 - v3
Checksum:i15CCFC3347AA8ABE
GO
Isoform 2 (identifier: Q8TC17-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     100-102: NNR → K

Note: No experimental confirmation available.
Show »
Length:116
Mass (Da):13,186
Checksum:iA4381B5C11B51AEE
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_039172100 – 102NNR → K in isoform 2. 1 Publication3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007952 Genomic DNA No translation available.
BC026233 mRNA Translation: AAH26233.1
BC157869 mRNA Translation: AAI57870.1
CCDSiCCDS45627.1 [Q8TC17-1]
RefSeqiNP_001123250.1, NM_001129778.1 [Q8TC17-1]
XP_016880126.1, XM_017024637.1 [Q8TC17-1]
UniGeneiHs.647426
Hs.661470
Hs.677674

Genome annotation databases

EnsembliENST00000344415; ENSP00000437409; ENSG00000189152 [Q8TC17-1]
GeneIDi400581
KEGGihsa:400581
UCSCiuc010cqk.2 human [Q8TC17-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiGRAPL_HUMAN
AccessioniPrimary (citable) accession number: Q8TC17
Secondary accession number(s): B2RXI8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: May 18, 2010
Last modified: June 20, 2018
This is version 99 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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