Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8TC17

- GRAPL_HUMAN

UniProt

Q8TC17 - GRAPL_HUMAN

Protein

GRB2-related adapter protein-like

Gene

GRAPL

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
  1. Functioni

    Enzyme and pathway databases

    SignaLinkiQ8TC17.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GRB2-related adapter protein-like
    Gene namesi
    Name:GRAPL
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:37240. GRAPL.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA165431929.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 118118GRB2-related adapter protein-likePRO_0000344236Add
    BLAST

    Proteomic databases

    PaxDbiQ8TC17.
    PRIDEiQ8TC17.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8TC17.
    BgeeiQ8TC17.
    GenevestigatoriQ8TC17.

    Organism-specific databases

    HPAiHPA051796.

    Interactioni

    Protein-protein interaction databases

    BioGridi134647. 1 interaction.
    STRINGi9606.ENSP00000345796.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8TC17.
    SMRiQ8TC17. Positions 1-99.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 5858SH3PROSITE-ProRule annotationAdd
    BLAST
    Domaini60 – 11859SH2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the GRB2/sem-5/DRK family.Curated
    Contains 1 SH2 domain.PROSITE-ProRule annotation
    Contains 1 SH3 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    SH2 domain, SH3 domain

    Phylogenomic databases

    eggNOGiNOG298780.
    HOGENOMiHOG000060310.
    HOVERGENiHBG060131.
    OMAiCLGPKSH.
    OrthoDBiEOG75F4F6.
    PhylomeDBiQ8TC17.
    TreeFamiTF354288.

    Family and domain databases

    Gene3Di3.30.505.10. 1 hit.
    InterProiIPR000980. SH2.
    IPR001452. SH3_domain.
    [Graphical view]
    PfamiPF00017. SH2. 1 hit.
    PF00018. SH3_1. 1 hit.
    [Graphical view]
    PRINTSiPR00401. SH2DOMAIN.
    PR00452. SH3DOMAIN.
    SMARTiSM00252. SH2. 1 hit.
    SM00326. SH3. 1 hit.
    [Graphical view]
    SUPFAMiSSF50044. SSF50044. 1 hit.
    PROSITEiPS50001. SH2. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8TC17-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MESVALYSFQ ATESDELAFN KGDTLKILNM EDDQNWYKAE LRGVEGFIPK    50
    NYIRVKPHPW YSGRISRQLA EEILMKRNHL GAFLIRESES SPGEFSVSVN 100
    NRAQRGPCLG PKSHSRLG 118

    Note: No experimental confirmation available.

    Length:118
    Mass (Da):13,442
    Last modified:May 18, 2010 - v3
    Checksum:i15CCFC3347AA8ABE
    GO
    Isoform 2 (identifier: Q8TC17-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         100-102: NNR → K

    Note: No experimental confirmation available.

    Show »
    Length:116
    Mass (Da):13,186
    Checksum:iA4381B5C11B51AEE
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei100 – 1023NNR → K in isoform 2. 1 PublicationVSP_039172

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC007952 Genomic DNA. No translation available.
    BC026233 mRNA. Translation: AAH26233.1.
    BC157869 mRNA. Translation: AAI57870.1.
    CCDSiCCDS45627.1. [Q8TC17-1]
    RefSeqiNP_001123250.1. NM_001129778.1. [Q8TC17-1]
    UniGeneiHs.661470.
    Hs.677674.

    Genome annotation databases

    EnsembliENST00000344415; ENSP00000437409; ENSG00000189152. [Q8TC17-1]
    GeneIDi400581.
    KEGGihsa:400581.
    UCSCiuc010cqk.1. human. [Q8TC17-1]

    Polymorphism databases

    DMDMi296439331.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC007952 Genomic DNA. No translation available.
    BC026233 mRNA. Translation: AAH26233.1 .
    BC157869 mRNA. Translation: AAI57870.1 .
    CCDSi CCDS45627.1. [Q8TC17-1 ]
    RefSeqi NP_001123250.1. NM_001129778.1. [Q8TC17-1 ]
    UniGenei Hs.661470.
    Hs.677674.

    3D structure databases

    ProteinModelPortali Q8TC17.
    SMRi Q8TC17. Positions 1-99.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 134647. 1 interaction.
    STRINGi 9606.ENSP00000345796.

    Polymorphism databases

    DMDMi 296439331.

    Proteomic databases

    PaxDbi Q8TC17.
    PRIDEi Q8TC17.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000344415 ; ENSP00000437409 ; ENSG00000189152 . [Q8TC17-1 ]
    GeneIDi 400581.
    KEGGi hsa:400581.
    UCSCi uc010cqk.1. human. [Q8TC17-1 ]

    Organism-specific databases

    CTDi 400581.
    GeneCardsi GC17P019030.
    HGNCi HGNC:37240. GRAPL.
    HPAi HPA051796.
    neXtProti NX_Q8TC17.
    PharmGKBi PA165431929.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG298780.
    HOGENOMi HOG000060310.
    HOVERGENi HBG060131.
    OMAi CLGPKSH.
    OrthoDBi EOG75F4F6.
    PhylomeDBi Q8TC17.
    TreeFami TF354288.

    Enzyme and pathway databases

    SignaLinki Q8TC17.

    Miscellaneous databases

    GenomeRNAii 400581.
    NextBioi 106009.
    PROi Q8TC17.

    Gene expression databases

    ArrayExpressi Q8TC17.
    Bgeei Q8TC17.
    Genevestigatori Q8TC17.

    Family and domain databases

    Gene3Di 3.30.505.10. 1 hit.
    InterProi IPR000980. SH2.
    IPR001452. SH3_domain.
    [Graphical view ]
    Pfami PF00017. SH2. 1 hit.
    PF00018. SH3_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00401. SH2DOMAIN.
    PR00452. SH3DOMAIN.
    SMARTi SM00252. SH2. 1 hit.
    SM00326. SH3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50044. SSF50044. 1 hit.
    PROSITEi PS50001. SH2. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 53-118 (ISOFORM 2).
      Tissue: Lung.

    Entry informationi

    Entry nameiGRAPL_HUMAN
    AccessioniPrimary (citable) accession number: Q8TC17
    Secondary accession number(s): B2RXI8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 22, 2008
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 76 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3