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Protein

GRB2-related adapter protein-like

Gene

GRAPL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Enzyme and pathway databases

SignaLinkiQ8TC17.

Names & Taxonomyi

Protein namesi
Recommended name:
GRB2-related adapter protein-like
Gene namesi
Name:GRAPL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:37240. GRAPL.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165431929.

Polymorphism and mutation databases

DMDMi296439331.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 118118GRB2-related adapter protein-likePRO_0000344236Add
BLAST

Proteomic databases

PaxDbiQ8TC17.
PRIDEiQ8TC17.

Expressioni

Gene expression databases

BgeeiQ8TC17.
ExpressionAtlasiQ8TC17. baseline and differential.
GenevestigatoriQ8TC17.

Organism-specific databases

HPAiHPA051796.

Interactioni

Protein-protein interaction databases

BioGridi134647. 1 interaction.
STRINGi9606.ENSP00000345796.

Structurei

3D structure databases

ProteinModelPortaliQ8TC17.
SMRiQ8TC17. Positions 1-99.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 5858SH3PROSITE-ProRule annotationAdd
BLAST
Domaini60 – 11859SH2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the GRB2/sem-5/DRK family.Curated
Contains 1 SH2 domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH2 domain, SH3 domain

Phylogenomic databases

eggNOGiNOG298780.
GeneTreeiENSGT00550000074482.
HOGENOMiHOG000060310.
HOVERGENiHBG060131.
InParanoidiQ8TC17.
OMAiCLGPKSH.
OrthoDBiEOG75F4F6.
PhylomeDBiQ8TC17.
TreeFamiTF354288.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR000980. SH2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
SMARTiSM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TC17-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MESVALYSFQ ATESDELAFN KGDTLKILNM EDDQNWYKAE LRGVEGFIPK
60 70 80 90 100
NYIRVKPHPW YSGRISRQLA EEILMKRNHL GAFLIRESES SPGEFSVSVN
110
NRAQRGPCLG PKSHSRLG

Note: No experimental confirmation available.

Length:118
Mass (Da):13,442
Last modified:May 18, 2010 - v3
Checksum:i15CCFC3347AA8ABE
GO
Isoform 2 (identifier: Q8TC17-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     100-102: NNR → K

Note: No experimental confirmation available.

Show »
Length:116
Mass (Da):13,186
Checksum:iA4381B5C11B51AEE
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei100 – 1023NNR → K in isoform 2. 1 PublicationVSP_039172

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007952 Genomic DNA. No translation available.
BC026233 mRNA. Translation: AAH26233.1.
BC157869 mRNA. Translation: AAI57870.1.
CCDSiCCDS45627.1. [Q8TC17-1]
RefSeqiNP_001123250.1. NM_001129778.1. [Q8TC17-1]
UniGeneiHs.661470.
Hs.677674.

Genome annotation databases

EnsembliENST00000344415; ENSP00000437409; ENSG00000189152. [Q8TC17-1]
GeneIDi400581.
KEGGihsa:400581.
UCSCiuc010cqk.1. human. [Q8TC17-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007952 Genomic DNA. No translation available.
BC026233 mRNA. Translation: AAH26233.1.
BC157869 mRNA. Translation: AAI57870.1.
CCDSiCCDS45627.1. [Q8TC17-1]
RefSeqiNP_001123250.1. NM_001129778.1. [Q8TC17-1]
UniGeneiHs.661470.
Hs.677674.

3D structure databases

ProteinModelPortaliQ8TC17.
SMRiQ8TC17. Positions 1-99.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi134647. 1 interaction.
STRINGi9606.ENSP00000345796.

Polymorphism and mutation databases

DMDMi296439331.

Proteomic databases

PaxDbiQ8TC17.
PRIDEiQ8TC17.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000344415; ENSP00000437409; ENSG00000189152. [Q8TC17-1]
GeneIDi400581.
KEGGihsa:400581.
UCSCiuc010cqk.1. human. [Q8TC17-1]

Organism-specific databases

CTDi400581.
GeneCardsiGC17P019030.
HGNCiHGNC:37240. GRAPL.
HPAiHPA051796.
neXtProtiNX_Q8TC17.
PharmGKBiPA165431929.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG298780.
GeneTreeiENSGT00550000074482.
HOGENOMiHOG000060310.
HOVERGENiHBG060131.
InParanoidiQ8TC17.
OMAiCLGPKSH.
OrthoDBiEOG75F4F6.
PhylomeDBiQ8TC17.
TreeFamiTF354288.

Enzyme and pathway databases

SignaLinkiQ8TC17.

Miscellaneous databases

ChiTaRSiGRAPL. human.
GenomeRNAii400581.
NextBioi106009.
PROiQ8TC17.

Gene expression databases

BgeeiQ8TC17.
ExpressionAtlasiQ8TC17. baseline and differential.
GenevestigatoriQ8TC17.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR000980. SH2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
SMARTiSM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 53-118 (ISOFORM 2).
    Tissue: Lung.

Entry informationi

Entry nameiGRAPL_HUMAN
AccessioniPrimary (citable) accession number: Q8TC17
Secondary accession number(s): B2RXI8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: May 18, 2010
Last modified: January 7, 2015
This is version 79 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.