Q8TC17 (GRAPL_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
GRB2-related adapter protein-like

Gene names

Name:

GRAPL

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	118 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Sequence similarities

Belongs to the GRB2/sem-5/DRK family. Contains 1 SH2 domain. Contains 1 SH3 domain.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Domain	SH2 domain SH3 domain
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8TC17-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: No experimental confirmation available.

Isoform 2 (identifier: Q8TC17-2)

The sequence of this isoform differs from the canonical sequence as follows:
     100-102: NNR → K

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 118	118	GRB2-related adapter protein-like		PRO_0000344236
Regions
	Domain	1 – 58	58	SH3
	Domain	60 – 118	59	SH2
Natural variations
	Alternative sequence	100 – 102	3	NNR → K in isoform 2.		VSP_039172

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 18, 2010. Version 3. Checksum: 15CCFC3347AA8ABE	FASTA	118	13,442
	10 20 30 40 50 60 MESVALYSFQ ATESDELAFN KGDTLKILNM EDDQNWYKAE LRGVEGFIPK NYIRVKPHPW 70 80 90 100 110 YSGRISRQLA EEILMKRNHL GAFLIRESES SPGEFSVSVN NRAQRGPCLG PKSHSRLG
	Isoform 2 [UniParc]. Checksum: A4381B5C11B51AEE	FASTA	116	13,186
	10 20 30 40 50 60 MESVALYSFQ ATESDELAFN KGDTLKILNM EDDQNWYKAE LRGVEGFIPK NYIRVKPHPW 70 80 90 100 110 YSGRISRQLA EEILMKRNHL GAFLIRESES SPGEFSVSVK AQRGPCLGPK SHSRLG

References

[1]

"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C. Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

[2]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 53-118 (ISOFORM 2). Tissue: Lung.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC007952 Genomic DNA. No translation available. BC026233 mRNA. Translation: AAH26233.1. BC157869 mRNA. Translation: AAI57870.1.
IPI	IPI00886800. IPI00964608.
RefSeq	NP_001123250.1. NM_001129778.1.
UniGene	Hs.661470. Hs.677674.
3D structure databases
ProteinModelPortal	Q8TC17.
SMR	Q8TC17. Positions 1-99.
ModBase	Search...
Polymorphism databases
DMDM	296439331.
Proteomic databases
PaxDb	Q8TC17.
PRIDE	Q8TC17.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000344415; ENSP00000437409; ENSG00000189152.
GeneID	400581.
KEGG	hsa:400581.
UCSC	uc010cqk.1. human.
Organism-specific databases
CTD	400581.
GeneCards	GC17P019030.
HGNC	HGNC:37240. GRAPL.
HPA	HPA051796.
neXtProt	NX_Q8TC17.
PharmGKB	PA165431929.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG298780.
HOGENOM	HOG000060310.
HOVERGEN	HBG060131.
OMA	KWYAGRI.
Enzyme and pathway databases
SignaLink	Q8TC17.
Gene expression databases
Bgee	Q8TC17.
Genevestigator	Q8TC17.
Family and domain databases
Gene3D	3.30.505.10. 1 hit.
InterPro	IPR000980. SH2. IPR001452. SH3_domain. [Graphical view]
Pfam	PF00017. SH2. 1 hit. PF00018. SH3_1. 1 hit. [Graphical view]
PRINTS	PR00401. SH2DOMAIN. PR00452. SH3DOMAIN.
SMART	SM00252. SH2. 1 hit. SM00326. SH3. 1 hit. [Graphical view]
PROSITE	PS50001. SH2. 1 hit. PS50002. SH3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	400581.
NextBio	106009.

Entry information

Entry name

GRAPL_HUMAN

Accession

Primary (citable) accession number: Q8TC17
Secondary accession number(s): B2RXI8

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 22, 2008
Last sequence update:	May 18, 2010
Last modified:	May 29, 2013
This is version 66 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.