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Q8TC17

- GRAPL_HUMAN

UniProt

Q8TC17 - GRAPL_HUMAN

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Protein

GRB2-related adapter protein-like

Gene

GRAPL

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Enzyme and pathway databases

SignaLinkiQ8TC17.

Names & Taxonomyi

Protein namesi
Recommended name:
GRB2-related adapter protein-like
Gene namesi
Name:GRAPL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:37240. GRAPL.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165431929.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 118118GRB2-related adapter protein-likePRO_0000344236Add
BLAST

Proteomic databases

PaxDbiQ8TC17.
PRIDEiQ8TC17.

Expressioni

Gene expression databases

BgeeiQ8TC17.
ExpressionAtlasiQ8TC17. baseline and differential.
GenevestigatoriQ8TC17.

Organism-specific databases

HPAiHPA051796.

Interactioni

Protein-protein interaction databases

BioGridi134647. 1 interaction.
STRINGi9606.ENSP00000345796.

Structurei

3D structure databases

ProteinModelPortaliQ8TC17.
SMRiQ8TC17. Positions 1-99.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 5858SH3PROSITE-ProRule annotationAdd
BLAST
Domaini60 – 11859SH2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the GRB2/sem-5/DRK family.Curated
Contains 1 SH2 domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH2 domain, SH3 domain

Phylogenomic databases

eggNOGiNOG298780.
GeneTreeiENSGT00550000074482.
HOGENOMiHOG000060310.
HOVERGENiHBG060131.
InParanoidiQ8TC17.
OMAiCLGPKSH.
OrthoDBiEOG75F4F6.
PhylomeDBiQ8TC17.
TreeFamiTF354288.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR000980. SH2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
SMARTiSM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8TC17) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MESVALYSFQ ATESDELAFN KGDTLKILNM EDDQNWYKAE LRGVEGFIPK
60 70 80 90 100
NYIRVKPHPW YSGRISRQLA EEILMKRNHL GAFLIRESES SPGEFSVSVN
110
NRAQRGPCLG PKSHSRLG

Note: No experimental confirmation available.

Length:118
Mass (Da):13,442
Last modified:May 18, 2010 - v3
Checksum:i15CCFC3347AA8ABE
GO
Isoform 2 (identifier: Q8TC17-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     100-102: NNR → K

Note: No experimental confirmation available.

Show »
Length:116
Mass (Da):13,186
Checksum:iA4381B5C11B51AEE
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei100 – 1023NNR → K in isoform 2. 1 PublicationVSP_039172

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC007952 Genomic DNA. No translation available.
BC026233 mRNA. Translation: AAH26233.1.
BC157869 mRNA. Translation: AAI57870.1.
CCDSiCCDS45627.1. [Q8TC17-1]
RefSeqiNP_001123250.1. NM_001129778.1. [Q8TC17-1]
UniGeneiHs.661470.
Hs.677674.

Genome annotation databases

EnsembliENST00000344415; ENSP00000437409; ENSG00000189152. [Q8TC17-1]
GeneIDi400581.
KEGGihsa:400581.
UCSCiuc010cqk.1. human. [Q8TC17-1]

Polymorphism databases

DMDMi296439331.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC007952 Genomic DNA. No translation available.
BC026233 mRNA. Translation: AAH26233.1 .
BC157869 mRNA. Translation: AAI57870.1 .
CCDSi CCDS45627.1. [Q8TC17-1 ]
RefSeqi NP_001123250.1. NM_001129778.1. [Q8TC17-1 ]
UniGenei Hs.661470.
Hs.677674.

3D structure databases

ProteinModelPortali Q8TC17.
SMRi Q8TC17. Positions 1-99.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 134647. 1 interaction.
STRINGi 9606.ENSP00000345796.

Polymorphism databases

DMDMi 296439331.

Proteomic databases

PaxDbi Q8TC17.
PRIDEi Q8TC17.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000344415 ; ENSP00000437409 ; ENSG00000189152 . [Q8TC17-1 ]
GeneIDi 400581.
KEGGi hsa:400581.
UCSCi uc010cqk.1. human. [Q8TC17-1 ]

Organism-specific databases

CTDi 400581.
GeneCardsi GC17P019030.
HGNCi HGNC:37240. GRAPL.
HPAi HPA051796.
neXtProti NX_Q8TC17.
PharmGKBi PA165431929.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG298780.
GeneTreei ENSGT00550000074482.
HOGENOMi HOG000060310.
HOVERGENi HBG060131.
InParanoidi Q8TC17.
OMAi CLGPKSH.
OrthoDBi EOG75F4F6.
PhylomeDBi Q8TC17.
TreeFami TF354288.

Enzyme and pathway databases

SignaLinki Q8TC17.

Miscellaneous databases

GenomeRNAii 400581.
NextBioi 106009.
PROi Q8TC17.

Gene expression databases

Bgeei Q8TC17.
ExpressionAtlasi Q8TC17. baseline and differential.
Genevestigatori Q8TC17.

Family and domain databases

Gene3Di 3.30.505.10. 1 hit.
InterProi IPR000980. SH2.
IPR001452. SH3_domain.
[Graphical view ]
Pfami PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view ]
PRINTSi PR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
SMARTi SM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view ]
SUPFAMi SSF50044. SSF50044. 1 hit.
PROSITEi PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 53-118 (ISOFORM 2).
    Tissue: Lung.

Entry informationi

Entry nameiGRAPL_HUMAN
AccessioniPrimary (citable) accession number: Q8TC17
Secondary accession number(s): B2RXI8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: May 18, 2010
Last modified: October 29, 2014
This is version 77 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3