Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

TBC1 domain family member 15

Gene

TBC1D15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a GTPase activating protein for RAB7A. Does not act on RAB4, RAB5 or RAB6 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGTPase activation

Enzyme and pathway databases

ReactomeiR-HSA-8854214. TBC/RABGAPs.

Names & Taxonomyi

Protein namesi
Recommended name:
TBC1 domain family member 15
Alternative name(s):
GTPase-activating protein RAB7
Short name:
GAP for RAB7
Short name:
Rab7-GAP
Gene namesi
Name:TBC1D15
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000121749.15.
HGNCiHGNC:25694. TBC1D15.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000121749.
PharmGKBiPA134946839.

Polymorphism and mutation databases

BioMutaiTBC1D15.
DMDMi143811467.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002080422 – 691TBC1 domain family member 15Add BLAST690

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei23PhosphoserineCombined sources1
Modified residuei70PhosphoserineCombined sources1
Modified residuei205PhosphoserineBy similarity1
Modified residuei274PhosphoserineCombined sources1
Modified residuei640PhosphoserineCombined sources1
Modified residuei675PhosphoserineCombined sources1
Modified residuei689PhosphothreonineCombined sources1
Isoform 2 (identifier: Q8TC07-2)
Modified residuei205PhosphoserineCombined sources1
Isoform 3 (identifier: Q8TC07-3)
Modified residuei213PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8TC07.
MaxQBiQ8TC07.
PaxDbiQ8TC07.
PeptideAtlasiQ8TC07.
PRIDEiQ8TC07.

PTM databases

iPTMnetiQ8TC07.
PhosphoSitePlusiQ8TC07.

Expressioni

Gene expression databases

BgeeiENSG00000121749.
CleanExiHS_TBC1D15.
ExpressionAtlasiQ8TC07. baseline and differential.
GenevisibleiQ8TC07. HS.

Organism-specific databases

HPAiHPA013388.
HPA015592.

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi122296. 68 interactors.
IntActiQ8TC07. 21 interactors.
STRINGi9606.ENSP00000448182.

Structurei

3D structure databases

ProteinModelPortaliQ8TC07.
SMRiQ8TC07.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini346 – 556Rab-GAP TBCPROSITE-ProRule annotationAdd BLAST211

Phylogenomic databases

eggNOGiKOG2197. Eukaryota.
COG5210. LUCA.
GeneTreeiENSGT00550000074386.
HOGENOMiHOG000012710.
HOVERGENiHBG057668.
InParanoidiQ8TC07.
KOiK20168.
OMAiVNCQNKS.
OrthoDBiEOG091G04IX.
PhylomeDBiQ8TC07.
TreeFamiTF314296.

Family and domain databases

InterProiView protein in InterPro
IPR021935. DUF3548.
IPR000195. Rab-GTPase-TBC_dom.
PfamiView protein in Pfam
PF12068. DUF3548. 1 hit.
PF00566. RabGAP-TBC. 1 hit.
SMARTiView protein in SMART
SM00164. TBC. 1 hit.
SUPFAMiSSF47923. SSF47923. 2 hits.
PROSITEiView protein in PROSITE
PS50086. TBC_RABGAP. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TC07-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAGVVSGK IIYEQEGVYI HSSCGKTNDQ DGLISGILRV LEKDAEVIVD
60 70 80 90 100
WRPLDDALDS SSILYARKDS SSVVEWTQAP KERGHRGSEH LNSYEAEWDM
110 120 130 140 150
VNTVSFKRKP HTNGDAPSHR NGKSKWSFLF SLTDLKSIKQ NKEGMGWSYL
160 170 180 190 200
VFCLKDDVVL PALHFHQGDS KLLIESLEKY VVLCESPQDK RTLLVNCQNK
210 220 230 240 250
SLSQSFENLL DEPAYGLIQA GLLDRRKLLW AIHHWKKIKK DPYTATMIGF
260 270 280 290 300
SKVTNYIFDS LRGSDPSTHQ RPPSEMADFL SDAIPGLKIN QQEEPGFEVI
310 320 330 340 350
TRIDLGERPV VQRREPVSLE EWTKNIDSEG RILNVDNMKQ MIFRGGLSHA
360 370 380 390 400
LRKQAWKFLL GYFPWDSTKE ERTQLQKQKT DEYFRMKLQW KSISQEQEKR
410 420 430 440 450
NSRLRDYRSL IEKDVNRTDR TNKFYEGQDN PGLILLHDIL MTYCMYDFDL
460 470 480 490 500
GYVQGMSDLL SPLLYVMENE VDAFWCFASY MDQMHQNFEE QMQGMKTQLI
510 520 530 540 550
QLSTLLRLLD SGFCSYLESQ DSGYLYFCFR WLLIRFKREF SFLDILRLWE
560 570 580 590 600
VMWTELPCTN FHLLLCCAIL ESEKQQIMEK HYGFNEILKH INELSMKIDV
610 620 630 640 650
EDILCKAEAI SLQMVKCKEL PQAVCEILGL QGSEVTTPDS DVGEDENVVM
660 670 680 690
TPCPTSAFQS NALPTLSASG ARNDSPTQIP VSSDVCRLTP A
Length:691
Mass (Da):79,491
Last modified:April 3, 2007 - v2
Checksum:iD880DBE4D5758EC7
GO
Isoform 2 (identifier: Q8TC07-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     220-236: Missing.

Show »
Length:674
Mass (Da):77,395
Checksum:iA40A9F8838A2EB9E
GO
Isoform 3 (identifier: Q8TC07-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: MAAAGVVSGK → MCPGLYPYSSLLEYGRSM
     220-236: Missing.

Note: No experimental confirmation available.Combined sources
Show »
Length:682
Mass (Da):78,572
Checksum:i02F379CC94953EA9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti52R → G in BAB13971 (PubMed:19077034).Curated1
Sequence conflicti298E → G in BAG60001 (PubMed:14702039).Curated1
Sequence conflicti498Q → R in BAG60001 (PubMed:14702039).Curated1
Sequence conflicti541S → G in AAH28352 (PubMed:16541075).Curated1
Sequence conflicti633S → G in BAB13971 (PubMed:19077034).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0464021 – 10MAAAGVVSGK → MCPGLYPYSSLLEYGRSM in isoform 3. 1 Publication10
Alternative sequenceiVSP_023094220 – 236Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST17

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB449901 mRNA. Translation: BAH16644.1.
AK022147 mRNA. Translation: BAB13971.1.
AK297626 mRNA. Translation: BAG60001.1.
AC089984 Genomic DNA. No translation available.
AC090109 Genomic DNA. No translation available.
BC028352 mRNA. Translation: AAH28352.1.
CCDSiCCDS31858.1. [Q8TC07-1]
CCDS53814.1. [Q8TC07-2]
CCDS55849.1. [Q8TC07-3]
RefSeqiNP_001139685.2. NM_001146213.1. [Q8TC07-2]
NP_001139686.1. NM_001146214.1. [Q8TC07-3]
NP_073608.4. NM_022771.4. [Q8TC07-1]
UniGeneiHs.284630.

Genome annotation databases

EnsembliENST00000319106; ENSP00000318262; ENSG00000121749. [Q8TC07-3]
ENST00000485960; ENSP00000420678; ENSG00000121749. [Q8TC07-2]
ENST00000550746; ENSP00000448182; ENSG00000121749. [Q8TC07-1]
GeneIDi64786.
KEGGihsa:64786.
UCSCiuc001swu.4. human. [Q8TC07-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTBC15_HUMAN
AccessioniPrimary (citable) accession number: Q8TC07
Secondary accession number(s): B4DMT9
, B9A6L6, J3KNI9, Q9HA83
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: April 3, 2007
Last modified: September 27, 2017
This is version 127 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot