Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Nuclear protein MDM1

Gene

MDM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear protein MDM1
Gene namesi
Name:MDM1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:29917. MDM1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134879752.

Polymorphism and mutation databases

BioMutaiMDM1.
DMDMi156632525.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 714714Nuclear protein MDM1PRO_0000299059Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei83 – 831Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8TC05.
PaxDbiQ8TC05.
PRIDEiQ8TC05.

PTM databases

PhosphoSiteiQ8TC05.

Expressioni

Gene expression databases

BgeeiQ8TC05.
CleanExiHS_MDM1.
ExpressionAtlasiQ8TC05. baseline and differential.
GenevisibleiQ8TC05. HS.

Organism-specific databases

HPAiHPA040411.
HPA041594.

Interactioni

Protein-protein interaction databases

BioGridi121220. 2 interactions.
IntActiQ8TC05. 2 interactions.
STRINGi9606.ENSP00000302537.

Structurei

3D structure databases

ProteinModelPortaliQ8TC05.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MDM1 family.Curated

Phylogenomic databases

eggNOGiNOG72701.
GeneTreeiENSGT00390000004106.
HOGENOMiHOG000113507.
HOVERGENiHBG108124.
InParanoidiQ8TC05.
KOiK17886.
OMAiHQRLGKV.
OrthoDBiEOG7P2XVF.
PhylomeDBiQ8TC05.
TreeFamiTF331015.

Family and domain databases

InterProiIPR029136. MDM1.
[Graphical view]
PfamiPF15501. MDM1. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TC05-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPVRFKGLSE YQRNFLWKKS YLSESCNSSV GRKYPWAGLR SDQLGITKEP
60 70 80 90 100
SFISKRRVPY HDPQISKSLE WNGAISESNV VASPEPEAPE TPKSQEAEQK
110 120 130 140 150
DVTQERVHSL EASRVPKRTR SHSADSRAEG ASDVENNEGV TNHTPVNENV
160 170 180 190 200
ELEHSTKVLS ENVDNGLDRL LRKKAGLTVV PSYNALRNSE YQRQFVWKTS
210 220 230 240 250
KETAPAFAAN QVFHNKSQFV PPFKGNSVIH ETEYKRNFKG LSPVKEPKLR
260 270 280 290 300
NDLRENRNLE TVSPERKSNK IDDRLKLEAE MELKDLHQPK RKLTPWKHQR
310 320 330 340 350
LGKVNSEYRA KFLSPAQYLY KAGAWTHVKG NMPNQVKELR EKAEFYRKRV
360 370 380 390 400
QGTHFSRDHL NQILSDSNCC WDVSSTTSSE GTVSSNIRAL DLAGDPTSHK
410 420 430 440 450
TLQKCPSTEP EEKGNIVEEQ PQKNTTEKLG VSAPTIPVRR RLAWDTENTS
460 470 480 490 500
EDVQKQPGEK EEEDDNEEEG DRKTGKQAFM GEQEKLDVRE KSKADKMKEG
510 520 530 540 550
SDSSVSSEKG GRLPTPKLRE LGGIQRTHHD LTTPAVGGAV LVSPSKMKPP
560 570 580 590 600
APEQRKRMTS QDCLETSKND FTKKESRAVS LLTSPAAGIK TVDPLPLRED
610 620 630 640 650
SEDNIHKFAE ATLPVSKIPK YPTNPPGQLP SPPHVPSYWH PSRRIQGSLR
660 670 680 690 700
DPEFQHNVGK ARMNNLQLPQ HEAFNDEDED RLSEISARSA ASSLRAFQTL
710
ARAKKRKENF WGKT
Length:714
Mass (Da):80,735
Last modified:August 21, 2007 - v2
Checksum:i301E3A89A5BFF13B
GO
Isoform 2 (identifier: Q8TC05-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     167-222: LDRLLRKKAG...FHNKSQFVPP → VGIFTAFLFK...NRLLTLVIVN
     223-714: Missing.

Show »
Length:222
Mass (Da):25,069
Checksum:i0CC6F35EADC1F98D
GO
Isoform 3 (identifier: Q8TC05-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     46-69: ITKEPSFISKRRVPYHDPQISKSL → NQGRCRTKIQHSDISSLLILVCST
     70-714: Missing.

Show »
Length:69
Mass (Da):7,926
Checksum:i51190BA06D5CD344
GO
Isoform 4 (identifier: Q8TC05-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     167-211: Missing.
     335-335: Q → QGSLNAMWYAE

Note: No experimental confirmation available.
Show »
Length:679
Mass (Da):76,709
Checksum:i0C31971CCCC30AFD
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti42 – 421D → Y in BAG59777 (PubMed:14702039).Curated
Sequence conflicti458 – 4581G → E in BAG59777 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti103 – 1031T → I.1 Publication
Corresponds to variant rs962976 [ dbSNP | Ensembl ].
VAR_034782
Natural varianti383 – 3831V → I.
Corresponds to variant rs17224810 [ dbSNP | Ensembl ].
VAR_034783
Natural varianti489 – 4891R → H.2 Publications
Corresponds to variant rs2306393 [ dbSNP | Ensembl ].
VAR_034784
Natural varianti552 – 5521P → L.1 Publication
Corresponds to variant rs2306392 [ dbSNP | Ensembl ].
VAR_034785

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei46 – 6924ITKEP…ISKSL → NQGRCRTKIQHSDISSLLIL VCST in isoform 3. 1 PublicationVSP_027544Add
BLAST
Alternative sequencei70 – 714645Missing in isoform 3. 1 PublicationVSP_027545Add
BLAST
Alternative sequencei167 – 22256LDRLL…QFVPP → VGIFTAFLFKSIEFFIGFIV ISVILHFVFQNFPLLFSCLM SIRIVDNRLLTLVIVN in isoform 2. 1 PublicationVSP_027546Add
BLAST
Alternative sequencei167 – 21145Missing in isoform 4. 1 PublicationVSP_046400Add
BLAST
Alternative sequencei223 – 714492Missing in isoform 2. 1 PublicationVSP_027547Add
BLAST
Alternative sequencei335 – 3351Q → QGSLNAMWYAE in isoform 4. 1 PublicationVSP_046401

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF267851 mRNA. Translation: AAF78952.1.
AK297311 mRNA. Translation: BAG59777.1.
AC022511 Genomic DNA. No translation available.
BC022042 mRNA. Translation: AAH22042.1.
BC028355 mRNA. Translation: AAH28355.1.
AF007130 mRNA. Translation: AAC19149.1.
CCDSiCCDS44938.1. [Q8TC05-2]
CCDS55841.1. [Q8TC05-4]
CCDS55842.1. [Q8TC05-3]
CCDS8983.1. [Q8TC05-1]
RefSeqiNP_001191957.1. NM_001205028.1. [Q8TC05-4]
NP_001191958.1. NM_001205029.1. [Q8TC05-3]
NP_059136.2. NM_017440.4. [Q8TC05-1]
NP_064513.1. NM_020128.2. [Q8TC05-2]
UniGeneiHs.655702.

Genome annotation databases

EnsembliENST00000303145; ENSP00000302537; ENSG00000111554.
ENST00000393543; ENSP00000377175; ENSG00000111554. [Q8TC05-3]
ENST00000411698; ENSP00000391006; ENSG00000111554. [Q8TC05-4]
ENST00000430606; ENSP00000408694; ENSG00000111554. [Q8TC05-2]
GeneIDi56890.
KEGGihsa:56890.
UCSCiuc001stz.2. human. [Q8TC05-1]
uc001sua.4. human. [Q8TC05-2]
uc010std.2. human. [Q8TC05-3]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF267851 mRNA. Translation: AAF78952.1.
AK297311 mRNA. Translation: BAG59777.1.
AC022511 Genomic DNA. No translation available.
BC022042 mRNA. Translation: AAH22042.1.
BC028355 mRNA. Translation: AAH28355.1.
AF007130 mRNA. Translation: AAC19149.1.
CCDSiCCDS44938.1. [Q8TC05-2]
CCDS55841.1. [Q8TC05-4]
CCDS55842.1. [Q8TC05-3]
CCDS8983.1. [Q8TC05-1]
RefSeqiNP_001191957.1. NM_001205028.1. [Q8TC05-4]
NP_001191958.1. NM_001205029.1. [Q8TC05-3]
NP_059136.2. NM_017440.4. [Q8TC05-1]
NP_064513.1. NM_020128.2. [Q8TC05-2]
UniGeneiHs.655702.

3D structure databases

ProteinModelPortaliQ8TC05.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121220. 2 interactions.
IntActiQ8TC05. 2 interactions.
STRINGi9606.ENSP00000302537.

PTM databases

PhosphoSiteiQ8TC05.

Polymorphism and mutation databases

BioMutaiMDM1.
DMDMi156632525.

Proteomic databases

MaxQBiQ8TC05.
PaxDbiQ8TC05.
PRIDEiQ8TC05.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000303145; ENSP00000302537; ENSG00000111554.
ENST00000393543; ENSP00000377175; ENSG00000111554. [Q8TC05-3]
ENST00000411698; ENSP00000391006; ENSG00000111554. [Q8TC05-4]
ENST00000430606; ENSP00000408694; ENSG00000111554. [Q8TC05-2]
GeneIDi56890.
KEGGihsa:56890.
UCSCiuc001stz.2. human. [Q8TC05-1]
uc001sua.4. human. [Q8TC05-2]
uc010std.2. human. [Q8TC05-3]

Organism-specific databases

CTDi56890.
GeneCardsiGC12M068688.
HGNCiHGNC:29917. MDM1.
HPAiHPA040411.
HPA041594.
MIMi613813. gene.
neXtProtiNX_Q8TC05.
PharmGKBiPA134879752.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG72701.
GeneTreeiENSGT00390000004106.
HOGENOMiHOG000113507.
HOVERGENiHBG108124.
InParanoidiQ8TC05.
KOiK17886.
OMAiHQRLGKV.
OrthoDBiEOG7P2XVF.
PhylomeDBiQ8TC05.
TreeFamiTF331015.

Miscellaneous databases

GenomeRNAii56890.
NextBioi62299.
PROiQ8TC05.
SOURCEiSearch...

Gene expression databases

BgeeiQ8TC05.
CleanExiHS_MDM1.
ExpressionAtlasiQ8TC05. baseline and differential.
GenevisibleiQ8TC05. HS.

Family and domain databases

InterProiIPR029136. MDM1.
[Graphical view]
PfamiPF15501. MDM1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, mapping and characterization of a novel human MDM1 protein."
    Yang Q.S., Ying K., Wu H., Xia F., Xie Y., Mao Y.M.
    Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Tissue: Brain.
  3. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), VARIANTS ILE-103; HIS-489 AND LEU-552.
    Tissue: Prostate and Testis.
  5. Yu W., Sarginson J., Gibbs R.A.
    Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 462-714 (ISOFORM 1), VARIANT HIS-489.
    Tissue: Brain.
  6. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-83, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiMDM1_HUMAN
AccessioniPrimary (citable) accession number: Q8TC05
Secondary accession number(s): B4DM65
, E7EPQ3, O43406, Q8WTV9, Q9NR04
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: August 21, 2007
Last modified: July 22, 2015
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.