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Protein

Zinc finger protein 564

Gene

ZNF564

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri103 – 12523C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri141 – 16323C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri169 – 19123C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri197 – 21923C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri225 – 24723C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri253 – 27523C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri281 – 30323C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri309 – 33123C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri337 – 35923C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri365 – 38723C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri393 – 41523C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri421 – 44323C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri449 – 47123C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri477 – 49923C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri505 – 52723C2H2-type 15PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 564
Gene namesi
Name:ZNF564
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:31106. ZNF564.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134876070.

Polymorphism and mutation databases

BioMutaiZNF564.
DMDMi55976746.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 553553Zinc finger protein 564PRO_0000047654Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki438 – 438Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ8TBZ8.
MaxQBiQ8TBZ8.
PaxDbiQ8TBZ8.
PeptideAtlasiQ8TBZ8.
PRIDEiQ8TBZ8.

PTM databases

iPTMnetiQ8TBZ8.
PhosphoSiteiQ8TBZ8.

Expressioni

Gene expression databases

BgeeiENSG00000249709.
CleanExiHS_ZNF564.
ExpressionAtlasiQ8TBZ8. baseline and differential.
GenevisibleiQ8TBZ8. HS.

Organism-specific databases

HPAiHPA043998.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ALAS1P131963EBI-10273713,EBI-3905054
CALCOCO2Q131373EBI-10273713,EBI-739580
CCDC136Q96JN2-23EBI-10273713,EBI-10171416
CCDC85BQ158343EBI-10273713,EBI-739674
CCNDBP1O952733EBI-10273713,EBI-748961
GOPCQ9HD263EBI-10273713,EBI-349832
KRT40Q6A1623EBI-10273713,EBI-10171697
KRTAP10-7P604093EBI-10273713,EBI-10172290
KRTAP10-9P604113EBI-10273713,EBI-10172052
LDOC1O957513EBI-10273713,EBI-740738
MAGEA1P433553EBI-10273713,EBI-740978
MDFIQ997503EBI-10273713,EBI-724076
MEOX2A4D1273EBI-10273713,EBI-10172134
MID2Q9UJV3-23EBI-10273713,EBI-10172526
PNMA1Q8ND903EBI-10273713,EBI-302345
RELQ048643EBI-10273713,EBI-307352
RPGRIP1Q96KN73EBI-10273713,EBI-1050213
SPERTQ8NA613EBI-10273713,EBI-741724
TADA2AO754783EBI-10273713,EBI-742268
TRAF1Q130773EBI-10273713,EBI-359224
TRIM23P364063EBI-10273713,EBI-740098
TRIM41Q8WV443EBI-10273713,EBI-725997

Protein-protein interaction databases

BioGridi127844. 25 interactions.
IntActiQ8TBZ8. 22 interactions.
STRINGi9606.ENSP00000340004.

Structurei

3D structure databases

ProteinModelPortaliQ8TBZ8.
SMRiQ8TBZ8. Positions 4-54, 79-533.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 8380KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 15 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri103 – 12523C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri141 – 16323C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri169 – 19123C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri197 – 21923C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri225 – 24723C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri253 – 27523C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri281 – 30323C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri309 – 33123C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri337 – 35923C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri365 – 38723C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri393 – 41523C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri421 – 44323C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri449 – 47123C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri477 – 49923C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri505 – 52723C2H2-type 15PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119089.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8TBZ8.
KOiK09228.
OMAiKRIRKHM.
OrthoDBiEOG091G02KC.
PhylomeDBiQ8TBZ8.
TreeFamiTF338854.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 15 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 3 hits.
PF13912. zf-C2H2_6. 4 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 15 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 15 hits.
PS50157. ZINC_FINGER_C2H2_2. 15 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TBZ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSVASEDVA VNFTLEEWAL LDPSQKKLYR DVMRETFRNL ACVGKKWEDQ
60 70 80 90 100
SIEDWYKNQG RILRNHMEEG LSESKEYDQC GEAFSQILNL NLNKKIPTIV
110 120 130 140 150
RPCECSLCGK VFMHHSSLSR HIRSHLGHKP YDYQEYGEKP YKCKQCGKAF
160 170 180 190 200
SSCQSFRRHE RTHTGEKPYA CPECGKAFIS LPSVRRHMIK HTGDGPYKCQ
210 220 230 240 250
ECGKAFDRPS LFQIHERTHT GEKPYECQEC AKAFISLPSF QRHMIRHTGD
260 270 280 290 300
GPYKCQECGK AFDRPSLFRI HERTHTGEKP HECKQCGKAF ISFTNFQSHM
310 320 330 340 350
IRHTGDGPYK CKVCGRAFIF PSYVRKHERT HTGEKPYECN KCGKTFSSSS
360 370 380 390 400
NVRTHERTHT GEKPYECKEC GKAFISLPSV RRHMIKHTGD GPYKCQVCGR
410 420 430 440 450
AFDCPSSFQI HERTHTGEKP YECQVCGKAF ISLKRIRKHM ILHTGDGPYK
460 470 480 490 500
CQVCGKAFDC PSSVRTHERT HTGEKPYECK ECGKAFNYAS SIRIHERTHT
510 520 530 540 550
GEKPYECKQC GKTFSYSSSF QRHERAHNGD KPYVKNVGKL SFITQPSNTC

ENE
Length:553
Mass (Da):63,735
Last modified:June 1, 2002 - v1
Checksum:iCE5DB6E5D47EE019
GO

Sequence cautioni

The sequence AAH28367 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK092760 mRNA. Translation: BAC03967.1.
BC028367 mRNA. Translation: AAH28367.2. Different initiation.
BC065023 mRNA. Translation: AAH65023.2.
BC136728 mRNA. Translation: AAI36729.1.
BC136729 mRNA. Translation: AAI36730.1.
CCDSiCCDS42505.1.
RefSeqiNP_659413.1. NM_144976.3.
UniGeneiHs.655615.

Genome annotation databases

EnsembliENST00000339282; ENSP00000340004; ENSG00000249709.
GeneIDi163050.
KEGGihsa:163050.
UCSCiuc002mty.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK092760 mRNA. Translation: BAC03967.1.
BC028367 mRNA. Translation: AAH28367.2. Different initiation.
BC065023 mRNA. Translation: AAH65023.2.
BC136728 mRNA. Translation: AAI36729.1.
BC136729 mRNA. Translation: AAI36730.1.
CCDSiCCDS42505.1.
RefSeqiNP_659413.1. NM_144976.3.
UniGeneiHs.655615.

3D structure databases

ProteinModelPortaliQ8TBZ8.
SMRiQ8TBZ8. Positions 4-54, 79-533.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127844. 25 interactions.
IntActiQ8TBZ8. 22 interactions.
STRINGi9606.ENSP00000340004.

PTM databases

iPTMnetiQ8TBZ8.
PhosphoSiteiQ8TBZ8.

Polymorphism and mutation databases

BioMutaiZNF564.
DMDMi55976746.

Proteomic databases

EPDiQ8TBZ8.
MaxQBiQ8TBZ8.
PaxDbiQ8TBZ8.
PeptideAtlasiQ8TBZ8.
PRIDEiQ8TBZ8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000339282; ENSP00000340004; ENSG00000249709.
GeneIDi163050.
KEGGihsa:163050.
UCSCiuc002mty.4. human.

Organism-specific databases

CTDi163050.
GeneCardsiZNF564.
HGNCiHGNC:31106. ZNF564.
HPAiHPA043998.
neXtProtiNX_Q8TBZ8.
PharmGKBiPA134876070.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119089.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8TBZ8.
KOiK09228.
OMAiKRIRKHM.
OrthoDBiEOG091G02KC.
PhylomeDBiQ8TBZ8.
TreeFamiTF338854.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii163050.
PROiQ8TBZ8.

Gene expression databases

BgeeiENSG00000249709.
CleanExiHS_ZNF564.
ExpressionAtlasiQ8TBZ8. baseline and differential.
GenevisibleiQ8TBZ8. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 15 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 3 hits.
PF13912. zf-C2H2_6. 4 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 15 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 15 hits.
PS50157. ZINC_FINGER_C2H2_2. 15 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN564_HUMAN
AccessioniPrimary (citable) accession number: Q8TBZ8
Secondary accession number(s): B9EGT4, Q6P1K6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: June 1, 2002
Last modified: September 7, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.