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Protein

Zinc finger protein 564

Gene

ZNF564

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri103 – 125C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri141 – 163C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri169 – 191C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri197 – 219C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri225 – 247C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri253 – 275C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri281 – 303C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri309 – 331C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri337 – 359C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri365 – 387C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri393 – 415C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri421 – 443C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri449 – 471C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri477 – 499C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri505 – 527C2H2-type 15PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 564
Gene namesi
Name:ZNF564
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:31106. ZNF564.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134876070.

Polymorphism and mutation databases

BioMutaiZNF564.
DMDMi55976746.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000476541 – 553Zinc finger protein 564Add BLAST553

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki438Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ8TBZ8.
MaxQBiQ8TBZ8.
PaxDbiQ8TBZ8.
PeptideAtlasiQ8TBZ8.
PRIDEiQ8TBZ8.

PTM databases

iPTMnetiQ8TBZ8.
PhosphoSitePlusiQ8TBZ8.

Expressioni

Gene expression databases

BgeeiENSG00000249709.
CleanExiHS_ZNF564.
ExpressionAtlasiQ8TBZ8. baseline and differential.
GenevisibleiQ8TBZ8. HS.

Organism-specific databases

HPAiHPA043998.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi127844. 25 interactors.
IntActiQ8TBZ8. 32 interactors.
STRINGi9606.ENSP00000340004.

Structurei

3D structure databases

ProteinModelPortaliQ8TBZ8.
SMRiQ8TBZ8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 83KRABPROSITE-ProRule annotationAdd BLAST80

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri103 – 125C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri141 – 163C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri169 – 191C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri197 – 219C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri225 – 247C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri253 – 275C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri281 – 303C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri309 – 331C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri337 – 359C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri365 – 387C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri393 – 415C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri421 – 443C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri449 – 471C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri477 – 499C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri505 – 527C2H2-type 15PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119089.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8TBZ8.
KOiK09228.
OMAiKRIRKHM.
OrthoDBiEOG091G02KC.
PhylomeDBiQ8TBZ8.
TreeFamiTF338854.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 15 hits.
InterProiView protein in InterPro
IPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
PfamiView protein in Pfam
PF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 3 hits.
PF13912. zf-C2H2_6. 4 hits.
SMARTiView protein in SMART
SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 15 hits.
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiView protein in PROSITE
PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 15 hits.
PS50157. ZINC_FINGER_C2H2_2. 15 hits.

Sequencei

Sequence statusi: Complete.

Q8TBZ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSVASEDVA VNFTLEEWAL LDPSQKKLYR DVMRETFRNL ACVGKKWEDQ
60 70 80 90 100
SIEDWYKNQG RILRNHMEEG LSESKEYDQC GEAFSQILNL NLNKKIPTIV
110 120 130 140 150
RPCECSLCGK VFMHHSSLSR HIRSHLGHKP YDYQEYGEKP YKCKQCGKAF
160 170 180 190 200
SSCQSFRRHE RTHTGEKPYA CPECGKAFIS LPSVRRHMIK HTGDGPYKCQ
210 220 230 240 250
ECGKAFDRPS LFQIHERTHT GEKPYECQEC AKAFISLPSF QRHMIRHTGD
260 270 280 290 300
GPYKCQECGK AFDRPSLFRI HERTHTGEKP HECKQCGKAF ISFTNFQSHM
310 320 330 340 350
IRHTGDGPYK CKVCGRAFIF PSYVRKHERT HTGEKPYECN KCGKTFSSSS
360 370 380 390 400
NVRTHERTHT GEKPYECKEC GKAFISLPSV RRHMIKHTGD GPYKCQVCGR
410 420 430 440 450
AFDCPSSFQI HERTHTGEKP YECQVCGKAF ISLKRIRKHM ILHTGDGPYK
460 470 480 490 500
CQVCGKAFDC PSSVRTHERT HTGEKPYECK ECGKAFNYAS SIRIHERTHT
510 520 530 540 550
GEKPYECKQC GKTFSYSSSF QRHERAHNGD KPYVKNVGKL SFITQPSNTC

ENE
Length:553
Mass (Da):63,735
Last modified:June 1, 2002 - v1
Checksum:iCE5DB6E5D47EE019
GO

Sequence cautioni

The sequence AAH28367 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK092760 mRNA. Translation: BAC03967.1.
BC028367 mRNA. Translation: AAH28367.2. Different initiation.
BC065023 mRNA. Translation: AAH65023.2.
BC136728 mRNA. Translation: AAI36729.1.
BC136729 mRNA. Translation: AAI36730.1.
CCDSiCCDS42505.1.
RefSeqiNP_659413.1. NM_144976.3.
UniGeneiHs.655615.

Genome annotation databases

EnsembliENST00000339282; ENSP00000340004; ENSG00000249709.
GeneIDi163050.
KEGGihsa:163050.
UCSCiuc002mty.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK092760 mRNA. Translation: BAC03967.1.
BC028367 mRNA. Translation: AAH28367.2. Different initiation.
BC065023 mRNA. Translation: AAH65023.2.
BC136728 mRNA. Translation: AAI36729.1.
BC136729 mRNA. Translation: AAI36730.1.
CCDSiCCDS42505.1.
RefSeqiNP_659413.1. NM_144976.3.
UniGeneiHs.655615.

3D structure databases

ProteinModelPortaliQ8TBZ8.
SMRiQ8TBZ8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127844. 25 interactors.
IntActiQ8TBZ8. 32 interactors.
STRINGi9606.ENSP00000340004.

PTM databases

iPTMnetiQ8TBZ8.
PhosphoSitePlusiQ8TBZ8.

Polymorphism and mutation databases

BioMutaiZNF564.
DMDMi55976746.

Proteomic databases

EPDiQ8TBZ8.
MaxQBiQ8TBZ8.
PaxDbiQ8TBZ8.
PeptideAtlasiQ8TBZ8.
PRIDEiQ8TBZ8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000339282; ENSP00000340004; ENSG00000249709.
GeneIDi163050.
KEGGihsa:163050.
UCSCiuc002mty.4. human.

Organism-specific databases

CTDi163050.
GeneCardsiZNF564.
HGNCiHGNC:31106. ZNF564.
HPAiHPA043998.
neXtProtiNX_Q8TBZ8.
PharmGKBiPA134876070.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119089.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8TBZ8.
KOiK09228.
OMAiKRIRKHM.
OrthoDBiEOG091G02KC.
PhylomeDBiQ8TBZ8.
TreeFamiTF338854.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii163050.
PROiQ8TBZ8.

Gene expression databases

BgeeiENSG00000249709.
CleanExiHS_ZNF564.
ExpressionAtlasiQ8TBZ8. baseline and differential.
GenevisibleiQ8TBZ8. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 15 hits.
InterProiView protein in InterPro
IPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
PfamiView protein in Pfam
PF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 3 hits.
PF13912. zf-C2H2_6. 4 hits.
SMARTiView protein in SMART
SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 15 hits.
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiView protein in PROSITE
PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 15 hits.
PS50157. ZINC_FINGER_C2H2_2. 15 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiZN564_HUMAN
AccessioniPrimary (citable) accession number: Q8TBZ8
Secondary accession number(s): B9EGT4, Q6P1K6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: June 1, 2002
Last modified: March 15, 2017
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.