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Protein

Zinc finger protein 502

Gene

ZNF502

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri155 – 17723C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri183 – 20523C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri211 – 23323C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri239 – 26123C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri267 – 28923C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri295 – 31723C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri323 – 34523C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri351 – 37323C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri379 – 40123C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri407 – 42923C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri435 – 45723C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri463 – 48523C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri491 – 51323C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri519 – 54123C2H2-type 14PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • positive regulation by host of viral process Source: AgBase
  • positive regulation by host of viral release from host cell Source: AgBase
  • regulation of transcription, DNA-templated Source: GO_Central
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 502
Gene namesi
Name:ZNF502
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componentsi: Chromosome 3, Chromosome 6

Organism-specific databases

HGNCiHGNC:23718. ZNF502.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: AgBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134866656.

Polymorphism and mutation databases

BioMutaiZNF502.
DMDMi45477319.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 544544Zinc finger protein 502PRO_0000047623Add
BLAST

Proteomic databases

PaxDbiQ8TBZ5.
PRIDEiQ8TBZ5.

PTM databases

iPTMnetiQ8TBZ5.
PhosphoSiteiQ8TBZ5.

Expressioni

Gene expression databases

BgeeiQ8TBZ5.
CleanExiHS_ZNF502.
ExpressionAtlasiQ8TBZ5. baseline and differential.
GenevisibleiQ8TBZ5. HS.

Organism-specific databases

HPAiHPA024761.
HPA029557.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MP034193EBI-10273699,EBI-10042882From a different organism.
TRAF1Q130773EBI-10273699,EBI-359224

Protein-protein interaction databases

BioGridi124825. 2 interactions.
IntActiQ8TBZ5. 2 interactions.
STRINGi9606.ENSP00000296091.

Structurei

3D structure databases

ProteinModelPortaliQ8TBZ5.
SMRiQ8TBZ5. Positions 106-542.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 14 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri155 – 17723C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri183 – 20523C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri211 – 23323C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri239 – 26123C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri267 – 28923C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri295 – 31723C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri323 – 34523C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri351 – 37323C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri379 – 40123C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri407 – 42923C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri435 – 45723C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri463 – 48523C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri491 – 51323C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri519 – 54123C2H2-type 14PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129696.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8TBZ5.
OMAiEYQDSTF.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ8TBZ5.
TreeFamiTF341817.

Family and domain databases

Gene3Di3.30.160.60. 14 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 6 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 14 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 14 hits.
PS50157. ZINC_FINGER_C2H2_2. 14 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TBZ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLNMQGAEER DIRRETCPGW VNKNKPALEQ DVCKIDSSGI VVKRFQEDEY
60 70 80 90 100
QDSTFEEKYA CEGMKENSPR EIAESCLFQE GGFGRITFIH KEAPPEIISQ
110 120 130 140 150
GYNFEKSLLL TSSLVTRLRV STEESLHQWE TSNIQTNDIS DQSKCPTLCT
160 170 180 190 200
QKKSWKCNEC GKTFTQSSSL TQHQRTHTGE RPYTCEECGK AFSRSSFLVQ
210 220 230 240 250
HQRIHTGVKP YGCEQCGKTF RCRSFLTQHQ RIHTGEKPYK CNECGNSFRN
260 270 280 290 300
HSHLTEHQRI HTGEKPYKCN RCGKAFNQNT HLIHHQRIHT GEKPYICSEC
310 320 330 340 350
GSSFRKHSNL TQHQRIHTGE KPHKCDECGK TFQTKANLSQ HQRIHSGEKP
360 370 380 390 400
YKCKECGKAF CQSPSLIKHQ RIHTGEKPYK CKECGKAFTQ STPLTKHQRI
410 420 430 440 450
HTGERPYKCS ECGKAFIQSI CLIRHQRSHT GEKPYKCNEC GKGFNQNTCL
460 470 480 490 500
TQHMRIHTGE KPYKCKECGK AFAHSSSLTE HHRTHTGEKL YKCSECEKTF
510 520 530 540
RKYAHLSEHY RIHTGEKPYE CIECGKFFRH SSVLFRHQKL HSGD
Length:544
Mass (Da):62,920
Last modified:June 1, 2002 - v1
Checksum:i63437B670A6B22D0
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti28 – 281L → P.
Corresponds to variant rs6798400 [ dbSNP | Ensembl ].
VAR_033574
Natural varianti174 – 1741Q → R.
Corresponds to variant rs56084453 [ dbSNP | Ensembl ].
VAR_061953
Natural varianti243 – 2431E → A.
Corresponds to variant rs7640654 [ dbSNP | Ensembl ].
VAR_024220

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC028377 mRNA. Translation: AAH28377.1.
CCDSiCCDS2719.1.
RefSeqiNP_001127912.1. NM_001134440.1.
NP_001127913.1. NM_001134441.1.
NP_001127914.1. NM_001134442.1.
NP_001269809.1. NM_001282880.1.
NP_149987.2. NM_033210.4.
XP_011532515.1. XM_011534213.1.
XP_011547050.1. XM_011548748.1.
UniGeneiHs.224843.

Genome annotation databases

EnsembliENST00000296091; ENSP00000296091; ENSG00000196653.
ENST00000436624; ENSP00000406469; ENSG00000196653.
ENST00000449836; ENSP00000397390; ENSG00000196653.
ENST00000626630; ENSP00000487139; ENSG00000281448.
ENST00000628995; ENSP00000485847; ENSG00000281448.
ENST00000630464; ENSP00000486576; ENSG00000281448.
GeneIDi91392.
KEGGihsa:91392.
UCSCiuc003cns.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC028377 mRNA. Translation: AAH28377.1.
CCDSiCCDS2719.1.
RefSeqiNP_001127912.1. NM_001134440.1.
NP_001127913.1. NM_001134441.1.
NP_001127914.1. NM_001134442.1.
NP_001269809.1. NM_001282880.1.
NP_149987.2. NM_033210.4.
XP_011532515.1. XM_011534213.1.
XP_011547050.1. XM_011548748.1.
UniGeneiHs.224843.

3D structure databases

ProteinModelPortaliQ8TBZ5.
SMRiQ8TBZ5. Positions 106-542.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124825. 2 interactions.
IntActiQ8TBZ5. 2 interactions.
STRINGi9606.ENSP00000296091.

PTM databases

iPTMnetiQ8TBZ5.
PhosphoSiteiQ8TBZ5.

Polymorphism and mutation databases

BioMutaiZNF502.
DMDMi45477319.

Proteomic databases

PaxDbiQ8TBZ5.
PRIDEiQ8TBZ5.

Protocols and materials databases

DNASUi91392.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296091; ENSP00000296091; ENSG00000196653.
ENST00000436624; ENSP00000406469; ENSG00000196653.
ENST00000449836; ENSP00000397390; ENSG00000196653.
ENST00000626630; ENSP00000487139; ENSG00000281448.
ENST00000628995; ENSP00000485847; ENSG00000281448.
ENST00000630464; ENSP00000486576; ENSG00000281448.
GeneIDi91392.
KEGGihsa:91392.
UCSCiuc003cns.4. human.

Organism-specific databases

CTDi91392.
GeneCardsiZNF502.
HGNCiHGNC:23718. ZNF502.
HPAiHPA024761.
HPA029557.
neXtProtiNX_Q8TBZ5.
PharmGKBiPA134866656.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129696.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8TBZ5.
OMAiEYQDSTF.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ8TBZ5.
TreeFamiTF341817.

Miscellaneous databases

GenomeRNAii91392.
PROiQ8TBZ5.

Gene expression databases

BgeeiQ8TBZ5.
CleanExiHS_ZNF502.
ExpressionAtlasiQ8TBZ5. baseline and differential.
GenevisibleiQ8TBZ5. HS.

Family and domain databases

Gene3Di3.30.160.60. 14 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 6 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 14 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 14 hits.
PS50157. ZINC_FINGER_C2H2_2. 14 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiZN502_HUMAN
AccessioniPrimary (citable) accession number: Q8TBZ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: June 1, 2002
Last modified: June 8, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.