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Protein

Zinc finger protein 502

Gene

ZNF502

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri155 – 177C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri183 – 205C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri211 – 233C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri239 – 261C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri267 – 289C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri295 – 317C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri323 – 345C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri351 – 373C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri379 – 401C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri407 – 429C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri435 – 457C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri463 – 485C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri491 – 513C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri519 – 541C2H2-type 14PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

  • positive regulation by host of viral process Source: AgBase
  • positive regulation by host of viral release from host cell Source: AgBase
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 502
Gene namesi
Name:ZNF502
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:23718. ZNF502.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: AgBase

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000196653.
PharmGKBiPA134866656.

Polymorphism and mutation databases

BioMutaiZNF502.
DMDMi45477319.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000476231 – 544Zinc finger protein 502Add BLAST544

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki43Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiQ8TBZ5.
PaxDbiQ8TBZ5.
PeptideAtlasiQ8TBZ5.
PRIDEiQ8TBZ5.

PTM databases

iPTMnetiQ8TBZ5.
PhosphoSitePlusiQ8TBZ5.

Expressioni

Gene expression databases

BgeeiENSG00000196653.
CleanExiHS_ZNF502.
ExpressionAtlasiQ8TBZ5. baseline and differential.
GenevisibleiQ8TBZ5. HS.

Organism-specific databases

HPAiHPA024761.
HPA029557.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi124825. 2 interactors.
IntActiQ8TBZ5. 2 interactors.
STRINGi9606.ENSP00000296091.

Structurei

3D structure databases

ProteinModelPortaliQ8TBZ5.
SMRiQ8TBZ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri155 – 177C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri183 – 205C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri211 – 233C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri239 – 261C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri267 – 289C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri295 – 317C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri323 – 345C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri351 – 373C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri379 – 401C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri407 – 429C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri435 – 457C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri463 – 485C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri491 – 513C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri519 – 541C2H2-type 14PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00890000139326.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8TBZ5.
OMAiEYQDSTF.
OrthoDBiEOG091G02KC.
PhylomeDBiQ8TBZ5.
TreeFamiTF341817.

Family and domain databases

InterProiView protein in InterPro
IPR013087. Znf_C2H2_type.
SMARTiView protein in SMART
SM00355. ZnF_C2H2. 14 hits.
SUPFAMiSSF57667. SSF57667. 8 hits.
PROSITEiView protein in PROSITE
PS00028. ZINC_FINGER_C2H2_1. 14 hits.
PS50157. ZINC_FINGER_C2H2_2. 14 hits.

Sequencei

Sequence statusi: Complete.

Q8TBZ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLNMQGAEER DIRRETCPGW VNKNKPALEQ DVCKIDSSGI VVKRFQEDEY
60 70 80 90 100
QDSTFEEKYA CEGMKENSPR EIAESCLFQE GGFGRITFIH KEAPPEIISQ
110 120 130 140 150
GYNFEKSLLL TSSLVTRLRV STEESLHQWE TSNIQTNDIS DQSKCPTLCT
160 170 180 190 200
QKKSWKCNEC GKTFTQSSSL TQHQRTHTGE RPYTCEECGK AFSRSSFLVQ
210 220 230 240 250
HQRIHTGVKP YGCEQCGKTF RCRSFLTQHQ RIHTGEKPYK CNECGNSFRN
260 270 280 290 300
HSHLTEHQRI HTGEKPYKCN RCGKAFNQNT HLIHHQRIHT GEKPYICSEC
310 320 330 340 350
GSSFRKHSNL TQHQRIHTGE KPHKCDECGK TFQTKANLSQ HQRIHSGEKP
360 370 380 390 400
YKCKECGKAF CQSPSLIKHQ RIHTGEKPYK CKECGKAFTQ STPLTKHQRI
410 420 430 440 450
HTGERPYKCS ECGKAFIQSI CLIRHQRSHT GEKPYKCNEC GKGFNQNTCL
460 470 480 490 500
TQHMRIHTGE KPYKCKECGK AFAHSSSLTE HHRTHTGEKL YKCSECEKTF
510 520 530 540
RKYAHLSEHY RIHTGEKPYE CIECGKFFRH SSVLFRHQKL HSGD
Length:544
Mass (Da):62,920
Last modified:June 1, 2002 - v1
Checksum:i63437B670A6B22D0
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03357428L → P. Corresponds to variant dbSNP:rs6798400Ensembl.1
Natural variantiVAR_061953174Q → R. Corresponds to variant dbSNP:rs56084453Ensembl.1
Natural variantiVAR_024220243E → A. Corresponds to variant dbSNP:rs7640654Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC028377 mRNA. Translation: AAH28377.1.
CCDSiCCDS2719.1.
RefSeqiNP_001127912.1. NM_001134440.1.
NP_001127913.1. NM_001134441.1.
NP_001127914.1. NM_001134442.1.
NP_001269809.1. NM_001282880.1.
NP_149987.2. NM_033210.4.
XP_016862929.1. XM_017007440.1.
UniGeneiHs.224843.

Genome annotation databases

EnsembliENST00000296091; ENSP00000296091; ENSG00000196653.
ENST00000436624; ENSP00000406469; ENSG00000196653.
ENST00000449836; ENSP00000397390; ENSG00000196653.
ENST00000626630; ENSP00000487139; ENSG00000281448.
ENST00000628995; ENSP00000485847; ENSG00000281448.
ENST00000630464; ENSP00000486576; ENSG00000281448.
GeneIDi91392.
KEGGihsa:91392.
UCSCiuc003cns.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN502_HUMAN
AccessioniPrimary (citable) accession number: Q8TBZ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: June 1, 2002
Last modified: August 30, 2017
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families