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Protein

WD repeat-containing protein 20

Gene

WDR20

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

SignaLinkiQ8TBZ3.

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 20
Alternative name(s):
Protein DMR
Gene namesi
Name:WDR20
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:19667. WDR20.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134936678.

Polymorphism and mutation databases

BioMutaiWDR20.
DMDMi143811476.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 569568WD repeat-containing protein 20PRO_0000051366Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication
Modified residuei432 – 4321Phosphoserine2 Publications
Modified residuei434 – 4341Phosphoserine2 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ8TBZ3.
PaxDbiQ8TBZ3.
PRIDEiQ8TBZ3.

PTM databases

PhosphoSiteiQ8TBZ3.

Expressioni

Gene expression databases

BgeeiQ8TBZ3.
CleanExiHS_WDR20.
ExpressionAtlasiQ8TBZ3. baseline and differential.
GenevisibleiQ8TBZ3. HS.

Organism-specific databases

HPAiHPA007720.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
DAPP1Q9UN193EBI-2511486,EBI-3918199

Protein-protein interaction databases

BioGridi124884. 28 interactions.
IntActiQ8TBZ3. 19 interactions.
STRINGi9606.ENSP00000406084.

Structurei

3D structure databases

ProteinModelPortaliQ8TBZ3.
SMRiQ8TBZ3. Positions 149-180, 223-385.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati94 – 13845WD 1Add
BLAST
Repeati139 – 21072WD 2Add
BLAST
Repeati211 – 25242WD 3Add
BLAST
Repeati253 – 33179WD 4Add
BLAST
Repeati332 – 42695WD 5Add
BLAST
Repeati427 – 52397WD 6Add
BLAST
Repeati524 – 55936WD 7Add
BLAST

Sequence similaritiesi

Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiCOG2319.
GeneTreeiENSGT00390000007686.
HOGENOMiHOG000007484.
HOVERGENiHBG011270.
InParanoidiQ8TBZ3.
OMAiTLLCPRM.
OrthoDBiEOG7G1V5P.
PhylomeDBiQ8TBZ3.
TreeFamiTF314961.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 4 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 3 hits.
PROSITEiPS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequences (8)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 8 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TBZ3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATEGGGKEM NEIKTQFTTR EGLYKLLPHS EYSRPNRVPF NSQGSNPVRV
60 70 80 90 100
SFVNLNDQSG NGDRLCFNVG RELYFYIYKG VRKAADLSKP IDKRIYKGTQ
110 120 130 140 150
PTCHDFNHLT ATAESVSLLV GFSAGQVQLI DPIKKETSKL FNEERLIDKS
160 170 180 190 200
RVTCVKWVPG SESLFLVAHS SGNMYLYNVE HTCGTTAPHY QLLKQGESFA
210 220 230 240 250
VHTCKSKSTR NPLLKWTVGE GALNEFAFSP DGKFLACVSQ DGFLRVFNFD
260 270 280 290 300
SVELHGTMKS YFGGLLCVCW SPDGKYIVTG GEDDLVTVWS FVDCRVIARG
310 320 330 340 350
HGHKSWVSVV AFDPYTTSVE EGDPMEFSGS DEDFQDLLHF GRDRANSTQS
360 370 380 390 400
RLSKRNSTDS RPVSVTYRFG SVGQDTQLCL WDLTEDILFP HQPLSRARTH
410 420 430 440 450
TNVMNATSPP AGSNGNSVTT PGNSVPPPLP RSNSLPHSAV SNAGSKSSVM
460 470 480 490 500
DGAIASGVSK FATLSLHDRK ERHHEKDHKR NHSMGHISSK SSDKLNLVTK
510 520 530 540 550
TKTDPAKTLG TPLCPRMEDV PLLEPLICKK IAHERLTVLI FLEDCIVTAC
560
QEGFICTWGR PGKVVSFNP
Length:569
Mass (Da):62,893
Last modified:April 3, 2007 - v2
Checksum:i5779A68D94C34CAF
GO
Isoform 2 (identifier: Q8TBZ3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     565-569: VSFNP → GSLSSPSQASSPGGTVV

Note: No experimental confirmation available.
Show »
Length:581
Mass (Da):63,848
Checksum:iBBCBE3C8CBEF8F75
GO
Isoform 3 (identifier: Q8TBZ3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     145-195: RLIDKSRVTC...TAPHYQLLKQ → NSCQHLWKVD...RMQGVLQDQN
     196-569: Missing.

Note: No experimental confirmation available.
Show »
Length:195
Mass (Da):22,205
Checksum:iF21E71C2C629E6CB
GO
Isoform 4 (identifier: Q8TBZ3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: Missing.
     84-144: Missing.

Note: No experimental confirmation available.
Show »
Length:499
Mass (Da):55,348
Checksum:iA8E7A7927C37544A
GO
Isoform 5 (identifier: Q8TBZ3-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     84-144: Missing.

Note: No experimental confirmation available.
Show »
Length:508
Mass (Da):56,208
Checksum:i88D69FEEBB379AE0
GO
Isoform 6 (identifier: Q8TBZ3-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     84-144: Missing.
     565-569: VSFNP → GSLSSPSQASSPGGTVV

Note: No experimental confirmation available.
Show »
Length:520
Mass (Da):57,163
Checksum:i3052279BDE983E1D
GO
Isoform 7 (identifier: Q8TBZ3-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     144-144: E → ENSCQHLWKVDWNEERQNEGSKTSEEALVTVQ

Show »
Length:600
Mass (Da):66,521
Checksum:iCD7F36221219CDEA
GO
Isoform 8 (identifier: Q8TBZ3-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     84-569: AADLSKPIDK...RPGKVVSFNP → TIP

Note: No experimental confirmation available.
Show »
Length:86
Mass (Da):9,820
Checksum:i9C7D52794DEBA5E3
GO

Sequence cautioni

The sequence AAL56014.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti195 – 1951Q → H in AAL56014 (Ref. 5) Curated
Sequence conflicti299 – 2991R → K in AAL56014 (Ref. 5) Curated
Sequence conflicti337 – 3371L → P in BAG60080 (PubMed:14702039).Curated
Sequence conflicti353 – 3531S → P in BAG60080 (PubMed:14702039).Curated
Sequence conflicti474 – 4741H → L in CAB63713 (PubMed:17974005).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti159 – 1591P → H.1 Publication
Corresponds to variant rs17852545 [ dbSNP | Ensembl ].
VAR_031580
Natural varianti444 – 4441G → C.
Corresponds to variant rs12888595 [ dbSNP | Ensembl ].
VAR_053425

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 99Missing in isoform 4. 1 PublicationVSP_045225
Alternative sequencei84 – 569486AADLS…VSFNP → TIP in isoform 8. CuratedVSP_047064Add
BLAST
Alternative sequencei84 – 14461Missing in isoform 4, isoform 5 and isoform 6. 1 PublicationVSP_045226Add
BLAST
Alternative sequencei144 – 1441E → ENSCQHLWKVDWNEERQNEG SKTSEEALVTVQ in isoform 7. 1 PublicationVSP_047065
Alternative sequencei145 – 19551RLIDK…QLLKQ → NSCQHLWKVDWNEERQNEGS KTSEEALVTVQPAEHFCRQE DRMQGVLQDQN in isoform 3. 1 PublicationVSP_043412Add
BLAST
Alternative sequencei196 – 569374Missing in isoform 3. 1 PublicationVSP_043413Add
BLAST
Alternative sequencei565 – 5695VSFNP → GSLSSPSQASSPGGTVV in isoform 2 and isoform 6. 1 PublicationVSP_024387

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248274 mRNA. Translation: CAD62602.1.
AK297727 mRNA. Translation: BAG60080.1.
AL133223 Genomic DNA. No translation available.
AL359402 Genomic DNA. No translation available.
BC028387 mRNA. Translation: AAH28387.1.
BC030654 mRNA. Translation: AAH30654.1.
AF327354 mRNA. Translation: AAL56014.1. Different initiation.
AL133558 mRNA. Translation: CAB63713.1.
CCDSiCCDS55942.1. [Q8TBZ3-8]
CCDS55943.1. [Q8TBZ3-7]
CCDS55944.1. [Q8TBZ3-3]
CCDS55945.1. [Q8TBZ3-6]
CCDS9968.1. [Q8TBZ3-2]
CCDS9969.1. [Q8TBZ3-1]
CCDS9970.1. [Q8TBZ3-5]
PIRiT43440.
RefSeqiNP_001229343.1. NM_001242414.1. [Q8TBZ3-8]
NP_001229344.1. NM_001242415.1. [Q8TBZ3-3]
NP_001229345.1. NM_001242416.1. [Q8TBZ3-6]
NP_001229346.1. NM_001242417.1. [Q8TBZ3-7]
NP_001229347.1. NM_001242418.1.
NP_653175.2. NM_144574.3. [Q8TBZ3-1]
NP_851808.1. NM_181291.2. [Q8TBZ3-2]
NP_851825.1. NM_181308.2. [Q8TBZ3-5]
UniGeneiHs.36859.

Genome annotation databases

EnsembliENST00000299135; ENSP00000299135; ENSG00000140153. [Q8TBZ3-8]
ENST00000322340; ENSP00000314209; ENSG00000140153. [Q8TBZ3-3]
ENST00000335263; ENSP00000335434; ENSG00000140153. [Q8TBZ3-2]
ENST00000342702; ENSP00000341037; ENSG00000140153. [Q8TBZ3-1]
ENST00000454394; ENSP00000406084; ENSG00000140153. [Q8TBZ3-7]
ENST00000555879; ENSP00000452470; ENSG00000140153. [Q8TBZ3-8]
ENST00000556511; ENSP00000451633; ENSG00000140153. [Q8TBZ3-5]
ENST00000556807; ENSP00000450636; ENSG00000140153. [Q8TBZ3-6]
GeneIDi91833.
KEGGihsa:91833.
UCSCiuc001ykz.3. human. [Q8TBZ3-1]
uc001ylc.3. human. [Q8TBZ3-3]
uc001yld.3. human. [Q8TBZ3-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248274 mRNA. Translation: CAD62602.1.
AK297727 mRNA. Translation: BAG60080.1.
AL133223 Genomic DNA. No translation available.
AL359402 Genomic DNA. No translation available.
BC028387 mRNA. Translation: AAH28387.1.
BC030654 mRNA. Translation: AAH30654.1.
AF327354 mRNA. Translation: AAL56014.1. Different initiation.
AL133558 mRNA. Translation: CAB63713.1.
CCDSiCCDS55942.1. [Q8TBZ3-8]
CCDS55943.1. [Q8TBZ3-7]
CCDS55944.1. [Q8TBZ3-3]
CCDS55945.1. [Q8TBZ3-6]
CCDS9968.1. [Q8TBZ3-2]
CCDS9969.1. [Q8TBZ3-1]
CCDS9970.1. [Q8TBZ3-5]
PIRiT43440.
RefSeqiNP_001229343.1. NM_001242414.1. [Q8TBZ3-8]
NP_001229344.1. NM_001242415.1. [Q8TBZ3-3]
NP_001229345.1. NM_001242416.1. [Q8TBZ3-6]
NP_001229346.1. NM_001242417.1. [Q8TBZ3-7]
NP_001229347.1. NM_001242418.1.
NP_653175.2. NM_144574.3. [Q8TBZ3-1]
NP_851808.1. NM_181291.2. [Q8TBZ3-2]
NP_851825.1. NM_181308.2. [Q8TBZ3-5]
UniGeneiHs.36859.

3D structure databases

ProteinModelPortaliQ8TBZ3.
SMRiQ8TBZ3. Positions 149-180, 223-385.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124884. 28 interactions.
IntActiQ8TBZ3. 19 interactions.
STRINGi9606.ENSP00000406084.

PTM databases

PhosphoSiteiQ8TBZ3.

Polymorphism and mutation databases

BioMutaiWDR20.
DMDMi143811476.

Proteomic databases

MaxQBiQ8TBZ3.
PaxDbiQ8TBZ3.
PRIDEiQ8TBZ3.

Protocols and materials databases

DNASUi91833.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000299135; ENSP00000299135; ENSG00000140153. [Q8TBZ3-8]
ENST00000322340; ENSP00000314209; ENSG00000140153. [Q8TBZ3-3]
ENST00000335263; ENSP00000335434; ENSG00000140153. [Q8TBZ3-2]
ENST00000342702; ENSP00000341037; ENSG00000140153. [Q8TBZ3-1]
ENST00000454394; ENSP00000406084; ENSG00000140153. [Q8TBZ3-7]
ENST00000555879; ENSP00000452470; ENSG00000140153. [Q8TBZ3-8]
ENST00000556511; ENSP00000451633; ENSG00000140153. [Q8TBZ3-5]
ENST00000556807; ENSP00000450636; ENSG00000140153. [Q8TBZ3-6]
GeneIDi91833.
KEGGihsa:91833.
UCSCiuc001ykz.3. human. [Q8TBZ3-1]
uc001ylc.3. human. [Q8TBZ3-3]
uc001yld.3. human. [Q8TBZ3-2]

Organism-specific databases

CTDi91833.
GeneCardsiGC14P102606.
HGNCiHGNC:19667. WDR20.
HPAiHPA007720.
neXtProtiNX_Q8TBZ3.
PharmGKBiPA134936678.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG2319.
GeneTreeiENSGT00390000007686.
HOGENOMiHOG000007484.
HOVERGENiHBG011270.
InParanoidiQ8TBZ3.
OMAiTLLCPRM.
OrthoDBiEOG7G1V5P.
PhylomeDBiQ8TBZ3.
TreeFamiTF314961.

Enzyme and pathway databases

SignaLinkiQ8TBZ3.

Miscellaneous databases

ChiTaRSiWDR20. human.
GenomeRNAii91833.
NextBioi77478.
PROiQ8TBZ3.

Gene expression databases

BgeeiQ8TBZ3.
CleanExiHS_WDR20.
ExpressionAtlasiQ8TBZ3. baseline and differential.
GenevisibleiQ8TBZ3. HS.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 4 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 3 hits.
PROSITEiPS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Full-length cDNA libraries and normalization."
    Li W.B., Gruber C., Jessee J., Polayes D.
    Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Tissue: Neuroblastoma.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 7).
  3. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), VARIANT HIS-159.
    Tissue: Testis.
  5. Li N., Chen T., Wan T., Zhang W., Cao X.
    Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2-569 (ISOFORM 2).
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 232-569 (ISOFORM 1).
    Tissue: Testis.
  7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-432 AND SER-434, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-434, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-432, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiWDR20_HUMAN
AccessioniPrimary (citable) accession number: Q8TBZ3
Secondary accession number(s): B4DN18
, E7EUY8, F8W9S4, G3V2F8, G3V5R0, H0YJJ1, Q86TU2, Q8NCN7, Q8WXX2, Q9UF86
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: April 3, 2007
Last modified: June 24, 2015
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.