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Protein

WD repeat-containing protein 20

Gene

WDR20

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulator of deubiquitinating complexes. Activates deubiquitinating activity of complexes containing USP12 (PubMed:20147737, PubMed:27373336). Anchors at the base of the ubiquitin-contacting loop of USP12 and remotely modulates the catalytic center of the enzyme (PubMed:27373336).2 Publications

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-5689880 Ub-specific processing proteases
SignaLinkiQ8TBZ3

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 20
Alternative name(s):
Protein DMR
Gene namesi
Name:WDR20
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000140153.17
HGNCiHGNC:19667 WDR20
MIMi617741 gene
neXtProtiNX_Q8TBZ3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi262F → A: Impaired binding to USP12. 1 Publication1
Mutagenesisi306W → A: Impaired binding to USP12. 1 Publication1

Organism-specific databases

DisGeNETi91833
OpenTargetsiENSG00000140153
PharmGKBiPA134936678

Polymorphism and mutation databases

BioMutaiWDR20
DMDMi143811476

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000513662 – 569WD repeat-containing protein 20Add BLAST568

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei357PhosphoserineCombined sources1
Modified residuei360PhosphoserineCombined sources1
Modified residuei432PhosphoserineCombined sources1
Modified residuei434PhosphoserineCombined sources1
Modified residuei465PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ8TBZ3
PeptideAtlasiQ8TBZ3
PRIDEiQ8TBZ3

PTM databases

iPTMnetiQ8TBZ3
PhosphoSitePlusiQ8TBZ3

Expressioni

Gene expression databases

BgeeiENSG00000140153
CleanExiHS_WDR20
ExpressionAtlasiQ8TBZ3 baseline and differential
GenevisibleiQ8TBZ3 HS

Interactioni

Subunit structurei

Interacts with USP12 (PubMed:20147737, PubMed:27373336). Component of the USP12/WDR20/WDR48 deubiquitinating complex (PubMed:20147737, PubMed:27373336). Interacts with USP46 (PubMed:20147737).2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi124884, 39 interactors
CORUMiQ8TBZ3
IntActiQ8TBZ3, 26 interactors

Structurei

Secondary structure

1569
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi15 – 19Combined sources5
Beta strandi22 – 26Combined sources5
Helixi28 – 30Combined sources3
Beta strandi50 – 54Combined sources5
Beta strandi58 – 60Combined sources3
Beta strandi63 – 68Combined sources6
Beta strandi70 – 77Combined sources8
Beta strandi91 – 95Combined sources5
Beta strandi97 – 99Combined sources3
Beta strandi101 – 106Combined sources6
Turni108 – 110Combined sources3
Beta strandi118 – 122Combined sources5
Beta strandi127 – 130Combined sources4
Turni132 – 134Combined sources3
Beta strandi138 – 142Combined sources5
Beta strandi152 – 157Combined sources6
Beta strandi162 – 169Combined sources8
Beta strandi172 – 178Combined sources7
Beta strandi190 – 196Combined sources7
Beta strandi199 – 204Combined sources6
Beta strandi210 – 221Combined sources12
Beta strandi223 – 228Combined sources6
Beta strandi232 – 239Combined sources8
Beta strandi242 – 248Combined sources7
Turni249 – 252Combined sources4
Beta strandi253 – 259Combined sources7
Beta strandi261 – 263Combined sources3
Beta strandi265 – 270Combined sources6
Beta strandi274 – 281Combined sources8
Beta strandi286 – 290Combined sources5
Turni291 – 293Combined sources3
Beta strandi295 – 300Combined sources6
Beta strandi307 – 312Combined sources6
Helixi314 – 316Combined sources3
Beta strandi366 – 373Combined sources8
Beta strandi376 – 384Combined sources9
Helixi385 – 388Combined sources4
Beta strandi512 – 514Combined sources3
Turni517 – 519Combined sources3
Beta strandi526 – 530Combined sources5
Beta strandi536 – 541Combined sources6
Beta strandi543 – 550Combined sources8
Beta strandi555 – 559Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5K19X-ray2.60A/B/C1-569[»]
5K1CX-ray3.00C1-569[»]
ProteinModelPortaliQ8TBZ3
SMRiQ8TBZ3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati94 – 138WD 1Add BLAST45
Repeati139 – 210WD 2Add BLAST72
Repeati211 – 252WD 3Add BLAST42
Repeati253 – 331WD 4Add BLAST79
Repeati332 – 426WD 5Add BLAST95
Repeati427 – 523WD 6Add BLAST97
Repeati524 – 559WD 7Add BLAST36

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

GeneTreeiENSGT00390000007686
HOGENOMiHOG000007484
HOVERGENiHBG011270
InParanoidiQ8TBZ3
PhylomeDBiQ8TBZ3
TreeFamiTF314961

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 2 hits
SMARTiView protein in SMART
SM00320 WD40, 4 hits
SUPFAMiSSF50978 SSF50978, 3 hits
PROSITEiView protein in PROSITE
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

Sequences (8)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 8 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TBZ3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATEGGGKEM NEIKTQFTTR EGLYKLLPHS EYSRPNRVPF NSQGSNPVRV
60 70 80 90 100
SFVNLNDQSG NGDRLCFNVG RELYFYIYKG VRKAADLSKP IDKRIYKGTQ
110 120 130 140 150
PTCHDFNHLT ATAESVSLLV GFSAGQVQLI DPIKKETSKL FNEERLIDKS
160 170 180 190 200
RVTCVKWVPG SESLFLVAHS SGNMYLYNVE HTCGTTAPHY QLLKQGESFA
210 220 230 240 250
VHTCKSKSTR NPLLKWTVGE GALNEFAFSP DGKFLACVSQ DGFLRVFNFD
260 270 280 290 300
SVELHGTMKS YFGGLLCVCW SPDGKYIVTG GEDDLVTVWS FVDCRVIARG
310 320 330 340 350
HGHKSWVSVV AFDPYTTSVE EGDPMEFSGS DEDFQDLLHF GRDRANSTQS
360 370 380 390 400
RLSKRNSTDS RPVSVTYRFG SVGQDTQLCL WDLTEDILFP HQPLSRARTH
410 420 430 440 450
TNVMNATSPP AGSNGNSVTT PGNSVPPPLP RSNSLPHSAV SNAGSKSSVM
460 470 480 490 500
DGAIASGVSK FATLSLHDRK ERHHEKDHKR NHSMGHISSK SSDKLNLVTK
510 520 530 540 550
TKTDPAKTLG TPLCPRMEDV PLLEPLICKK IAHERLTVLI FLEDCIVTAC
560
QEGFICTWGR PGKVVSFNP
Length:569
Mass (Da):62,893
Last modified:April 3, 2007 - v2
Checksum:i5779A68D94C34CAF
GO
Isoform 2 (identifier: Q8TBZ3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     565-569: VSFNP → GSLSSPSQASSPGGTVV

Note: No experimental confirmation available.
Show »
Length:581
Mass (Da):63,848
Checksum:iBBCBE3C8CBEF8F75
GO
Isoform 3 (identifier: Q8TBZ3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     145-195: RLIDKSRVTC...TAPHYQLLKQ → NSCQHLWKVD...RMQGVLQDQN
     196-569: Missing.

Note: No experimental confirmation available.
Show »
Length:195
Mass (Da):22,205
Checksum:iF21E71C2C629E6CB
GO
Isoform 4 (identifier: Q8TBZ3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: Missing.
     84-144: Missing.

Note: No experimental confirmation available.
Show »
Length:499
Mass (Da):55,348
Checksum:iA8E7A7927C37544A
GO
Isoform 5 (identifier: Q8TBZ3-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     84-144: Missing.

Note: No experimental confirmation available.
Show »
Length:508
Mass (Da):56,208
Checksum:i88D69FEEBB379AE0
GO
Isoform 6 (identifier: Q8TBZ3-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     84-144: Missing.
     565-569: VSFNP → GSLSSPSQASSPGGTVV

Note: No experimental confirmation available.
Show »
Length:520
Mass (Da):57,163
Checksum:i3052279BDE983E1D
GO
Isoform 7 (identifier: Q8TBZ3-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     144-144: E → ENSCQHLWKVDWNEERQNEGSKTSEEALVTVQ

Show »
Length:600
Mass (Da):66,521
Checksum:iCD7F36221219CDEA
GO
Isoform 8 (identifier: Q8TBZ3-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     84-569: AADLSKPIDK...RPGKVVSFNP → TIP

Note: No experimental confirmation available.
Show »
Length:86
Mass (Da):9,820
Checksum:i9C7D52794DEBA5E3
GO

Sequence cautioni

The sequence AAL56014 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti195Q → H in AAL56014 (Ref. 5) Curated1
Sequence conflicti299R → K in AAL56014 (Ref. 5) Curated1
Sequence conflicti337L → P in BAG60080 (PubMed:14702039).Curated1
Sequence conflicti353S → P in BAG60080 (PubMed:14702039).Curated1
Sequence conflicti474H → L in CAB63713 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_031580159P → H1 PublicationCorresponds to variant dbSNP:rs17852545Ensembl.1
Natural variantiVAR_053425444G → C. Corresponds to variant dbSNP:rs12888595Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0452251 – 9Missing in isoform 4. 1 Publication9
Alternative sequenceiVSP_04706484 – 569AADLS…VSFNP → TIP in isoform 8. CuratedAdd BLAST486
Alternative sequenceiVSP_04522684 – 144Missing in isoform 4, isoform 5 and isoform 6. 1 PublicationAdd BLAST61
Alternative sequenceiVSP_047065144E → ENSCQHLWKVDWNEERQNEG SKTSEEALVTVQ in isoform 7. 1 Publication1
Alternative sequenceiVSP_043412145 – 195RLIDK…QLLKQ → NSCQHLWKVDWNEERQNEGS KTSEEALVTVQPAEHFCRQE DRMQGVLQDQN in isoform 3. 1 PublicationAdd BLAST51
Alternative sequenceiVSP_043413196 – 569Missing in isoform 3. 1 PublicationAdd BLAST374
Alternative sequenceiVSP_024387565 – 569VSFNP → GSLSSPSQASSPGGTVV in isoform 2 and isoform 6. 1 Publication5

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248274 mRNA Translation: CAD62602.1
AK297727 mRNA Translation: BAG60080.1
AL133223 Genomic DNA No translation available.
AL359402 Genomic DNA No translation available.
BC028387 mRNA Translation: AAH28387.1
BC030654 mRNA Translation: AAH30654.1
AF327354 mRNA Translation: AAL56014.1 Different initiation.
AL133558 mRNA Translation: CAB63713.1
CCDSiCCDS55942.1 [Q8TBZ3-8]
CCDS55943.1 [Q8TBZ3-7]
CCDS55944.1 [Q8TBZ3-3]
CCDS55945.1 [Q8TBZ3-6]
CCDS9968.1 [Q8TBZ3-2]
CCDS9969.1 [Q8TBZ3-1]
CCDS9970.1 [Q8TBZ3-5]
PIRiT43440
RefSeqiNP_001229343.1, NM_001242414.1 [Q8TBZ3-8]
NP_001229344.1, NM_001242415.1 [Q8TBZ3-3]
NP_001229345.1, NM_001242416.1 [Q8TBZ3-6]
NP_001229346.1, NM_001242417.1 [Q8TBZ3-7]
NP_001229347.1, NM_001242418.1
NP_653175.2, NM_144574.3 [Q8TBZ3-1]
NP_851808.1, NM_181291.2 [Q8TBZ3-2]
NP_851825.1, NM_181308.2 [Q8TBZ3-5]
UniGeneiHs.36859

Genome annotation databases

EnsembliENST00000299135; ENSP00000299135; ENSG00000140153 [Q8TBZ3-8]
ENST00000322340; ENSP00000314209; ENSG00000140153 [Q8TBZ3-3]
ENST00000335263; ENSP00000335434; ENSG00000140153 [Q8TBZ3-2]
ENST00000342702; ENSP00000341037; ENSG00000140153 [Q8TBZ3-1]
ENST00000454394; ENSP00000406084; ENSG00000140153 [Q8TBZ3-7]
ENST00000555879; ENSP00000452470; ENSG00000140153 [Q8TBZ3-8]
ENST00000556511; ENSP00000451633; ENSG00000140153 [Q8TBZ3-5]
ENST00000556807; ENSP00000450636; ENSG00000140153 [Q8TBZ3-6]
GeneIDi91833
KEGGihsa:91833
UCSCiuc001ykz.4 human [Q8TBZ3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiWDR20_HUMAN
AccessioniPrimary (citable) accession number: Q8TBZ3
Secondary accession number(s): B4DN18
, E7EUY8, F8W9S4, G3V2F8, G3V5R0, H0YJJ1, Q86TU2, Q8NCN7, Q8WXX2, Q9UF86
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: April 3, 2007
Last modified: May 23, 2018
This is version 143 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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