Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

MYCBP-associated protein

Gene

MYCBPAP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in spermatogenesis. May be involved in synaptic processes (By similarity).By similarity1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
MYCBP-associated protein
Alternative name(s):
AMAM-1
AMY-1-binding protein 1
Short name:
AMAP-1
Gene namesi
Name:MYCBPAPImported
Synonyms:AMAP1Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:19677. MYCBPAP.

Subcellular locationi

  • Cytoplasm 1 Publication
  • Membrane By similarity

  • Note: Colocalizes with MYCBP in the cytoplasm.By similarity1 Publication

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi84073.
PharmGKBiPA134886355.

Polymorphism and mutation databases

BioMutaiMYCBPAP.
DMDMi158563934.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003028771 – 947MYCBP-associated proteinAdd BLAST947

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei576PhosphothreonineBy similarity1
Modified residuei582PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8TBZ2.
PeptideAtlasiQ8TBZ2.
PRIDEiQ8TBZ2.
TopDownProteomicsiQ8TBZ2.

PTM databases

iPTMnetiQ8TBZ2.
PhosphoSitePlusiQ8TBZ2.

Expressioni

Tissue specificityi

Expressed specifically in testis.1 Publication

Gene expression databases

BgeeiENSG00000136449.
CleanExiHS_MYCBPAP.
ExpressionAtlasiQ8TBZ2. baseline and differential.
GenevisibleiQ8TBZ2. HS.

Organism-specific databases

HPAiHPA023257.
HPA024405.

Interactioni

Subunit structurei

Interacts with MYCBP.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
MYCBPQ994174EBI-1391585,EBI-716185

Protein-protein interaction databases

BioGridi123868. 5 interactors.
IntActiQ8TBZ2. 3 interactors.
MINTiMINT-4716081.
STRINGi9606.ENSP00000323184.

Structurei

3D structure databases

ProteinModelPortaliQ8TBZ2.
SMRiQ8TBZ2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IECW. Eukaryota.
ENOG410XZES. LUCA.
HOGENOMiHOG000113703.
HOVERGENiHBG058031.
InParanoidiQ8TBZ2.
OrthoDBiEOG091G0DGO.
PhylomeDBiQ8TBZ2.
TreeFamiTF329788.

Family and domain databases

InterProiIPR032707. MYCBPAP.
[Graphical view]
PfamiPF14646. MYCBPAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TBZ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVPGGTMKSL KKDSRLRITP TRLLEASENV KEKKRAKGPE QPTPTIQEEP
60 70 80 90 100
EPVSNVLQGD DILALAIKKE DLKEQHIPRL TEKEDKRVIT QKFIIRKLKP
110 120 130 140 150
MDPRRKVCHL VARPANPDEA TKPLDYSGPG DSFDGSDQIL PHHILGSLQD
160 170 180 190 200
FKRIALARGN TQLAERIPTS PCLMTLISAE GESKQKAPKE EKRPPWAPPP
210 220 230 240 250
QHNFLKNWQR NTALRKKQQE ALSEHLKKPV SELLMHTGET YRRIQEEREL
260 270 280 290 300
IDCTLPTRRD RKSWENSGFW SRLEYLGDEM TGLVMTKTKT QRGLMEPITH
310 320 330 340 350
IRKPHSIRVE TGLPAQRDAS YRYTWDRSLF LIYRRKELQR IMEELDFSQQ
360 370 380 390 400
DIDGLEVVGK GWPFSAVTVE DYTVFERSQG SSSEDTAYLG TLASSSDVSM
410 420 430 440 450
PILGPSLLFC GKPACWIRGS NPQDKRQVGI AAHLTFETLE GEKTSSELTV
460 470 480 490 500
VNNGTVAIWY DWRRQHQPDT FQDLKKNRMQ RFYFDNREGV ILPGEIKTFT
510 520 530 540 550
FFFKSLTAGV FREFWEFRTH PTLLGGAILQ VNLHAVSLTQ DVFEDERKVL
560 570 580 590 600
ESKLTAHEAV TVVREVLQEL LMGVLTPERT PSPVDAYLTE EDLFRHRNPP
610 620 630 640 650
LHYEHQVVQS LHQLWRQYMT LPAKAEEARP GDKEHVSPIA TEKASVNAEL
660 670 680 690 700
LPRFRSPISE TQVPRPENEA LRESGSQKAR VGTKSPQRKS IMEEILVEES
710 720 730 740 750
PDVDSTKSPW EPDGLPLLEW NLCLEDFRKA VMVLPDENHR EDALMRLNKA
760 770 780 790 800
ALELCQKPRP LQSNLLHQMC LQLWRDVIDS LVGHSMWLRS VLGLPEKETI
810 820 830 840 850
YLNVPEEQDQ KSPPIMEVKV PVGKAGKEER KGAAQEKKQL GIKDKEDKKG
860 870 880 890 900
AKLLGKEDRP NSKKHKAKDD KKVIKSASQD RFSLEDPTPD IILSSQEPID
910 920 930 940
PLVMGKYTQS LHSEVRGLLD TLVTDLMVLA DELSPIKNVE EALRLCR
Length:947
Mass (Da):108,153
Last modified:September 11, 2007 - v2
Checksum:iD3AB62D00F5621A1
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035003387A → T.2 PublicationsCorresponds to variant rs1380657dbSNPEnsembl.1
Natural variantiVAR_035004688R → W.1 PublicationCorresponds to variant rs9890721dbSNPEnsembl.1
Natural variantiVAR_035005910S → R.2 PublicationsCorresponds to variant rs1133818dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB083068 mRNA. Translation: BAB88692.1.
AC021491 Genomic DNA. No translation available.
BC028393 mRNA. Translation: AAH28393.1.
AL136765 mRNA. Translation: CAB66699.2.
RefSeqiNP_115509.4. NM_032133.4.
UniGeneiHs.398196.

Genome annotation databases

EnsembliENST00000323776; ENSP00000323184; ENSG00000136449.
ENST00000436259; ENSP00000397209; ENSG00000136449.
GeneIDi84073.
KEGGihsa:84073.
UCSCiuc010wmr.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB083068 mRNA. Translation: BAB88692.1.
AC021491 Genomic DNA. No translation available.
BC028393 mRNA. Translation: AAH28393.1.
AL136765 mRNA. Translation: CAB66699.2.
RefSeqiNP_115509.4. NM_032133.4.
UniGeneiHs.398196.

3D structure databases

ProteinModelPortaliQ8TBZ2.
SMRiQ8TBZ2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123868. 5 interactors.
IntActiQ8TBZ2. 3 interactors.
MINTiMINT-4716081.
STRINGi9606.ENSP00000323184.

PTM databases

iPTMnetiQ8TBZ2.
PhosphoSitePlusiQ8TBZ2.

Polymorphism and mutation databases

BioMutaiMYCBPAP.
DMDMi158563934.

Proteomic databases

PaxDbiQ8TBZ2.
PeptideAtlasiQ8TBZ2.
PRIDEiQ8TBZ2.
TopDownProteomicsiQ8TBZ2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000323776; ENSP00000323184; ENSG00000136449.
ENST00000436259; ENSP00000397209; ENSG00000136449.
GeneIDi84073.
KEGGihsa:84073.
UCSCiuc010wmr.3. human.

Organism-specific databases

CTDi84073.
DisGeNETi84073.
GeneCardsiMYCBPAP.
HGNCiHGNC:19677. MYCBPAP.
HPAiHPA023257.
HPA024405.
MIMi609835. gene.
neXtProtiNX_Q8TBZ2.
PharmGKBiPA134886355.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IECW. Eukaryota.
ENOG410XZES. LUCA.
HOGENOMiHOG000113703.
HOVERGENiHBG058031.
InParanoidiQ8TBZ2.
OrthoDBiEOG091G0DGO.
PhylomeDBiQ8TBZ2.
TreeFamiTF329788.

Miscellaneous databases

GenomeRNAii84073.
PROiQ8TBZ2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000136449.
CleanExiHS_MYCBPAP.
ExpressionAtlasiQ8TBZ2. baseline and differential.
GenevisibleiQ8TBZ2. HS.

Family and domain databases

InterProiIPR032707. MYCBPAP.
[Graphical view]
PfamiPF14646. MYCBPAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMYBPP_HUMAN
AccessioniPrimary (citable) accession number: Q8TBZ2
Secondary accession number(s): A6NHJ3, Q8TDV8, Q9H0K0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 11, 2007
Last modified: November 2, 2016
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.