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Q8TBZ0 (CC110_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Coiled-coil domain-containing protein 110
Alternative name(s):
Cancer/testis antigen 52
Short name=CT52
Cancer/testis antigen KM-HN-1
Gene names
Name:CCDC110
Synonyms:KMHN1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length833 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Nucleus Ref.1.

Tissue specificity

Expressed specifically in testis. Also expressed in tumors of different origins. Ref.1

Ontologies

Keywords
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainCoiled coil
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8TBZ0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8TBZ0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     80-116: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 833833Coiled-coil domain-containing protein 110
PRO_0000249076

Regions

Coiled coil431 – 778348 Potential

Natural variations

Alternative sequence80 – 11637Missing in isoform 2.
VSP_020365
Natural variant2091P → Q.
Corresponds to variant rs7699687 [ dbSNP | Ensembl ].
VAR_050729
Natural variant2991L → M.
Corresponds to variant rs7698680 [ dbSNP | Ensembl ].
VAR_050730
Natural variant3821L → M.
Corresponds to variant rs9999097 [ dbSNP | Ensembl ].
VAR_050731
Natural variant4091S → F.
Corresponds to variant rs11132306 [ dbSNP | Ensembl ].
VAR_050732
Natural variant5001Y → D.
Corresponds to variant rs59319722 [ dbSNP | Ensembl ].
VAR_061577
Natural variant6141I → M.
Corresponds to variant rs35596415 [ dbSNP | Ensembl ].
VAR_050733
Natural variant6691Q → R.
Corresponds to variant rs6827370 [ dbSNP | Ensembl ].
VAR_050734
Natural variant8171S → L.
Corresponds to variant rs9683564 [ dbSNP | Ensembl ].
VAR_050735
Natural variant8191L → M.
Corresponds to variant rs34800518 [ dbSNP | Ensembl ].
VAR_050736

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: AE76D1328CBED1BA

FASTA83396,726
        10         20         30         40         50         60 
MSPEKQHREE DEVDSVLLSA SKILNSSEGV KESGCSDTEY GCIAESENQI QPQSALKVLQ 

        70         80         90        100        110        120 
QQLESFQALR MQTLQNVSMV QSEISEILNK SIIEVENPQF SSEKNLVFGT RIEKDLPTEN 

       130        140        150        160        170        180 
QEENLSMEKS HHFEDSKTLH SVEEKLSGDS VNSLPQSVNV PSQIHSEDTL TLRTSTDNLS 

       190        200        210        220        230        240 
SNIIIHPSEN SDILKNYNNF YRFLPTAPPN VMSQADTVIL DKSKITVPFL KHGFCENLDD 

       250        260        270        280        290        300 
ICHSIKQMKE ELQKSHDGEV ALTNELQTLQ TDPDVHRNGK YDMSPIHQDK MNFIKEENLD 

       310        320        330        340        350        360 
GNLNEDIKSK RISELEALVK KLLPFRETVS KFHVHFCRKC KKLSKSEMHR GKKNEKNNKE 

       370        380        390        400        410        420 
IPITGKNITD LKFHSRVPRY TLSFLDQTKH EMKDKERQPF LVKQGSIISE NEKTSKVNSV 

       430        440        450        460        470        480 
TEQCVAKIQY LQNYLKESVQ IQKKVMELES ENLNLKSKMK PLIFTTQSLI QKVETYEKQL 

       490        500        510        520        530        540 
KNLVEEKSTI QSKLSKTEEY SKECLKEFKK IISKYNVLQG QNKTLEEKNI QLSLEKQQMM 

       550        560        570        580        590        600 
EALDQLKSKE HKTQSDMAIV NNENNRMSIE MEAMKTNILL IQDEKEMLEK KTHQLLKEKS 

       610        620        630        640        650        660 
SLGNELKESQ LEIIQLKEKE RLAKTEQETL LQIIETVKDE KLNLETTLQE STAARQIMER 

       670        680        690        700        710        720 
EIENIQTYQS TAEENFLQEI KNAKSEASIY KNSLSEIGKE CEMLSKMVME TKTDNQILKE 

       730        740        750        760        770        780 
ELKKHSQENI KFENSISRLT EDKILLENYV RSIENERDTL EFEMRHLQRE YLSLSDKICN 

       790        800        810        820        830 
QHNDPSKTTY ISRREKFHFD NYTHEDTSSP QSRPLASDLK GYFKVKDRTL KHH 

« Hide

Isoform 2 [UniParc].

Checksum: 7B491F6E23D0DC27
Show »

FASTA79692,509

References

« Hide 'large scale' references
[1]"Identification of a novel human cancer/testis antigen, KM-HN-1, recognized by cellular and humoral immune responses."
Monji M., Nakatsura T., Senju S., Yoshitake Y., Sawatsubashi M., Shinohara M., Kageshita T., Ono T., Inokuchi A., Nishimura Y.
Clin. Cancer Res. 10:6047-6057(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
Tissue: Testis.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Testis.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-596.
Tissue: Testis.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB080722 mRNA. Translation: BAC81776.1.
BC028419 mRNA. Translation: AAH28419.1.
BC038515 mRNA. Translation: AAH38515.1.
AK097605 mRNA. Translation: BAC05116.1.
RefSeqNP_001138883.1. NM_001145411.1.
NP_689988.1. NM_152775.3.
UniGeneHs.41101.

3D structure databases

ProteinModelPortalQ8TBZ0.
SMRQ8TBZ0. Positions 749-784.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid129157. 2 interactions.
IntActQ8TBZ0. 1 interaction.
STRING9606.ENSP00000306776.

PTM databases

PhosphoSiteQ8TBZ0.

Polymorphism databases

DMDM74730531.

Proteomic databases

PaxDbQ8TBZ0.
PRIDEQ8TBZ0.

Protocols and materials databases

DNASU256309.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000307588; ENSP00000306776; ENSG00000168491. [Q8TBZ0-1]
ENST00000393540; ENSP00000377172; ENSG00000168491. [Q8TBZ0-2]
GeneID256309.
KEGGhsa:256309.
UCSCuc003ixu.4. human. [Q8TBZ0-1]
uc003ixv.4. human. [Q8TBZ0-2]

Organism-specific databases

CTD256309.
GeneCardsGC04M186366.
HGNCHGNC:28504. CCDC110.
HPAHPA038475.
MIM609488. gene.
neXtProtNX_Q8TBZ0.
PharmGKBPA162381283.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG128630.
HOGENOMHOG000057285.
HOVERGENHBG081026.
InParanoidQ8TBZ0.
OrthoDBEOG71K62D.
PhylomeDBQ8TBZ0.
TreeFamTF335739.

Gene expression databases

ArrayExpressQ8TBZ0.
BgeeQ8TBZ0.
CleanExHS_CCDC110.
GenevestigatorQ8TBZ0.

Family and domain databases

ProtoNetSearch...

Other

GenomeRNAi256309.
NextBio92775.
PROQ8TBZ0.
SOURCESearch...

Entry information

Entry nameCC110_HUMAN
AccessionPrimary (citable) accession number: Q8TBZ0
Secondary accession number(s): Q86YI9, Q8N7W0
Entry history
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: June 1, 2002
Last modified: April 16, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM