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Q8TBZ0

- CC110_HUMAN

UniProt

Q8TBZ0 - CC110_HUMAN

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Protein

Coiled-coil domain-containing protein 110

Gene
CCDC110, KMHN1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 110
Alternative name(s):
Cancer/testis antigen 52
Short name:
CT52
Cancer/testis antigen KM-HN-1
Gene namesi
Name:CCDC110
Synonyms:KMHN1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:28504. CCDC110.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162381283.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 833833Coiled-coil domain-containing protein 110PRO_0000249076Add
BLAST

Proteomic databases

PaxDbiQ8TBZ0.
PRIDEiQ8TBZ0.

PTM databases

PhosphoSiteiQ8TBZ0.

Expressioni

Tissue specificityi

Expressed specifically in testis. Also expressed in tumors of different origins.1 Publication

Gene expression databases

ArrayExpressiQ8TBZ0.
BgeeiQ8TBZ0.
CleanExiHS_CCDC110.
GenevestigatoriQ8TBZ0.

Organism-specific databases

HPAiHPA038475.

Interactioni

Protein-protein interaction databases

BioGridi129157. 2 interactions.
IntActiQ8TBZ0. 1 interaction.
STRINGi9606.ENSP00000306776.

Structurei

3D structure databases

ProteinModelPortaliQ8TBZ0.
SMRiQ8TBZ0. Positions 749-784.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili431 – 778348 Reviewed predictionAdd
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG128630.
HOGENOMiHOG000057285.
HOVERGENiHBG081026.
InParanoidiQ8TBZ0.
OrthoDBiEOG71K62D.
PhylomeDBiQ8TBZ0.
TreeFamiTF335739.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8TBZ0-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSPEKQHREE DEVDSVLLSA SKILNSSEGV KESGCSDTEY GCIAESENQI    50
QPQSALKVLQ QQLESFQALR MQTLQNVSMV QSEISEILNK SIIEVENPQF 100
SSEKNLVFGT RIEKDLPTEN QEENLSMEKS HHFEDSKTLH SVEEKLSGDS 150
VNSLPQSVNV PSQIHSEDTL TLRTSTDNLS SNIIIHPSEN SDILKNYNNF 200
YRFLPTAPPN VMSQADTVIL DKSKITVPFL KHGFCENLDD ICHSIKQMKE 250
ELQKSHDGEV ALTNELQTLQ TDPDVHRNGK YDMSPIHQDK MNFIKEENLD 300
GNLNEDIKSK RISELEALVK KLLPFRETVS KFHVHFCRKC KKLSKSEMHR 350
GKKNEKNNKE IPITGKNITD LKFHSRVPRY TLSFLDQTKH EMKDKERQPF 400
LVKQGSIISE NEKTSKVNSV TEQCVAKIQY LQNYLKESVQ IQKKVMELES 450
ENLNLKSKMK PLIFTTQSLI QKVETYEKQL KNLVEEKSTI QSKLSKTEEY 500
SKECLKEFKK IISKYNVLQG QNKTLEEKNI QLSLEKQQMM EALDQLKSKE 550
HKTQSDMAIV NNENNRMSIE MEAMKTNILL IQDEKEMLEK KTHQLLKEKS 600
SLGNELKESQ LEIIQLKEKE RLAKTEQETL LQIIETVKDE KLNLETTLQE 650
STAARQIMER EIENIQTYQS TAEENFLQEI KNAKSEASIY KNSLSEIGKE 700
CEMLSKMVME TKTDNQILKE ELKKHSQENI KFENSISRLT EDKILLENYV 750
RSIENERDTL EFEMRHLQRE YLSLSDKICN QHNDPSKTTY ISRREKFHFD 800
NYTHEDTSSP QSRPLASDLK GYFKVKDRTL KHH 833
Length:833
Mass (Da):96,726
Last modified:June 1, 2002 - v1
Checksum:iAE76D1328CBED1BA
GO
Isoform 2 (identifier: Q8TBZ0-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     80-116: Missing.

Note: No experimental confirmation available.

Show »
Length:796
Mass (Da):92,509
Checksum:i7B491F6E23D0DC27
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti209 – 2091P → Q.
Corresponds to variant rs7699687 [ dbSNP | Ensembl ].
VAR_050729
Natural varianti299 – 2991L → M.
Corresponds to variant rs7698680 [ dbSNP | Ensembl ].
VAR_050730
Natural varianti382 – 3821L → M.
Corresponds to variant rs9999097 [ dbSNP | Ensembl ].
VAR_050731
Natural varianti409 – 4091S → F.
Corresponds to variant rs11132306 [ dbSNP | Ensembl ].
VAR_050732
Natural varianti500 – 5001Y → D.
Corresponds to variant rs59319722 [ dbSNP | Ensembl ].
VAR_061577
Natural varianti614 – 6141I → M.
Corresponds to variant rs35596415 [ dbSNP | Ensembl ].
VAR_050733
Natural varianti669 – 6691Q → R.
Corresponds to variant rs6827370 [ dbSNP | Ensembl ].
VAR_050734
Natural varianti817 – 8171S → L.
Corresponds to variant rs9683564 [ dbSNP | Ensembl ].
VAR_050735
Natural varianti819 – 8191L → M.
Corresponds to variant rs34800518 [ dbSNP | Ensembl ].
VAR_050736

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei80 – 11637Missing in isoform 2. VSP_020365Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB080722 mRNA. Translation: BAC81776.1.
BC028419 mRNA. Translation: AAH28419.1.
BC038515 mRNA. Translation: AAH38515.1.
AK097605 mRNA. Translation: BAC05116.1.
CCDSiCCDS3843.1. [Q8TBZ0-1]
CCDS47170.1. [Q8TBZ0-2]
RefSeqiNP_001138883.1. NM_001145411.1. [Q8TBZ0-2]
NP_689988.1. NM_152775.3. [Q8TBZ0-1]
UniGeneiHs.41101.

Genome annotation databases

EnsembliENST00000307588; ENSP00000306776; ENSG00000168491. [Q8TBZ0-1]
ENST00000393540; ENSP00000377172; ENSG00000168491. [Q8TBZ0-2]
GeneIDi256309.
KEGGihsa:256309.
UCSCiuc003ixu.4. human. [Q8TBZ0-1]
uc003ixv.4. human. [Q8TBZ0-2]

Polymorphism databases

DMDMi74730531.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB080722 mRNA. Translation: BAC81776.1 .
BC028419 mRNA. Translation: AAH28419.1 .
BC038515 mRNA. Translation: AAH38515.1 .
AK097605 mRNA. Translation: BAC05116.1 .
CCDSi CCDS3843.1. [Q8TBZ0-1 ]
CCDS47170.1. [Q8TBZ0-2 ]
RefSeqi NP_001138883.1. NM_001145411.1. [Q8TBZ0-2 ]
NP_689988.1. NM_152775.3. [Q8TBZ0-1 ]
UniGenei Hs.41101.

3D structure databases

ProteinModelPortali Q8TBZ0.
SMRi Q8TBZ0. Positions 749-784.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 129157. 2 interactions.
IntActi Q8TBZ0. 1 interaction.
STRINGi 9606.ENSP00000306776.

PTM databases

PhosphoSitei Q8TBZ0.

Polymorphism databases

DMDMi 74730531.

Proteomic databases

PaxDbi Q8TBZ0.
PRIDEi Q8TBZ0.

Protocols and materials databases

DNASUi 256309.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000307588 ; ENSP00000306776 ; ENSG00000168491 . [Q8TBZ0-1 ]
ENST00000393540 ; ENSP00000377172 ; ENSG00000168491 . [Q8TBZ0-2 ]
GeneIDi 256309.
KEGGi hsa:256309.
UCSCi uc003ixu.4. human. [Q8TBZ0-1 ]
uc003ixv.4. human. [Q8TBZ0-2 ]

Organism-specific databases

CTDi 256309.
GeneCardsi GC04M186366.
HGNCi HGNC:28504. CCDC110.
HPAi HPA038475.
MIMi 609488. gene.
neXtProti NX_Q8TBZ0.
PharmGKBi PA162381283.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG128630.
HOGENOMi HOG000057285.
HOVERGENi HBG081026.
InParanoidi Q8TBZ0.
OrthoDBi EOG71K62D.
PhylomeDBi Q8TBZ0.
TreeFami TF335739.

Miscellaneous databases

GenomeRNAii 256309.
NextBioi 92775.
PROi Q8TBZ0.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8TBZ0.
Bgeei Q8TBZ0.
CleanExi HS_CCDC110.
Genevestigatori Q8TBZ0.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a novel human cancer/testis antigen, KM-HN-1, recognized by cellular and humoral immune responses."
    Monji M., Nakatsura T., Senju S., Yoshitake Y., Sawatsubashi M., Shinohara M., Kageshita T., Ono T., Inokuchi A., Nishimura Y.
    Clin. Cancer Res. 10:6047-6057(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Testis.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-596.
    Tissue: Testis.

Entry informationi

Entry nameiCC110_HUMAN
AccessioniPrimary (citable) accession number: Q8TBZ0
Secondary accession number(s): Q86YI9, Q8N7W0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: June 1, 2002
Last modified: July 9, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

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