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Protein

Coiled-coil domain-containing protein 110

Gene

CCDC110

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:ENSG00000168491-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 110
Alternative name(s):
Cancer/testis antigen 52
Short name:
CT52
Cancer/testis antigen KM-HN-1
Gene namesi
Name:CCDC110
Synonyms:KMHN1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:28504. CCDC110.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000168491.
PharmGKBiPA162381283.

Polymorphism and mutation databases

BioMutaiCCDC110.
DMDMi74730531.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002490761 – 833Coiled-coil domain-containing protein 110Add BLAST833

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei609PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8TBZ0.
PeptideAtlasiQ8TBZ0.
PRIDEiQ8TBZ0.

PTM databases

iPTMnetiQ8TBZ0.
PhosphoSitePlusiQ8TBZ0.

Expressioni

Tissue specificityi

Expressed specifically in testis. Also expressed in tumors of different origins.1 Publication

Gene expression databases

BgeeiENSG00000168491.
CleanExiHS_CCDC110.
ExpressionAtlasiQ8TBZ0. baseline and differential.
GenevisibleiQ8TBZ0. HS.

Organism-specific databases

HPAiHPA038475.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
DEPTORQ8TB453EBI-2837012,EBI-2359040

Protein-protein interaction databases

BioGridi129157. 4 interactors.
IntActiQ8TBZ0. 2 interactors.
STRINGi9606.ENSP00000306776.

Structurei

3D structure databases

ProteinModelPortaliQ8TBZ0.
SMRiQ8TBZ0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili431 – 778Sequence analysisAdd BLAST348

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IFF1. Eukaryota.
ENOG410YGCT. LUCA.
GeneTreeiENSGT00710000106843.
HOGENOMiHOG000057285.
HOVERGENiHBG081026.
InParanoidiQ8TBZ0.
PhylomeDBiQ8TBZ0.
TreeFamiTF335739.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TBZ0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSPEKQHREE DEVDSVLLSA SKILNSSEGV KESGCSDTEY GCIAESENQI
60 70 80 90 100
QPQSALKVLQ QQLESFQALR MQTLQNVSMV QSEISEILNK SIIEVENPQF
110 120 130 140 150
SSEKNLVFGT RIEKDLPTEN QEENLSMEKS HHFEDSKTLH SVEEKLSGDS
160 170 180 190 200
VNSLPQSVNV PSQIHSEDTL TLRTSTDNLS SNIIIHPSEN SDILKNYNNF
210 220 230 240 250
YRFLPTAPPN VMSQADTVIL DKSKITVPFL KHGFCENLDD ICHSIKQMKE
260 270 280 290 300
ELQKSHDGEV ALTNELQTLQ TDPDVHRNGK YDMSPIHQDK MNFIKEENLD
310 320 330 340 350
GNLNEDIKSK RISELEALVK KLLPFRETVS KFHVHFCRKC KKLSKSEMHR
360 370 380 390 400
GKKNEKNNKE IPITGKNITD LKFHSRVPRY TLSFLDQTKH EMKDKERQPF
410 420 430 440 450
LVKQGSIISE NEKTSKVNSV TEQCVAKIQY LQNYLKESVQ IQKKVMELES
460 470 480 490 500
ENLNLKSKMK PLIFTTQSLI QKVETYEKQL KNLVEEKSTI QSKLSKTEEY
510 520 530 540 550
SKECLKEFKK IISKYNVLQG QNKTLEEKNI QLSLEKQQMM EALDQLKSKE
560 570 580 590 600
HKTQSDMAIV NNENNRMSIE MEAMKTNILL IQDEKEMLEK KTHQLLKEKS
610 620 630 640 650
SLGNELKESQ LEIIQLKEKE RLAKTEQETL LQIIETVKDE KLNLETTLQE
660 670 680 690 700
STAARQIMER EIENIQTYQS TAEENFLQEI KNAKSEASIY KNSLSEIGKE
710 720 730 740 750
CEMLSKMVME TKTDNQILKE ELKKHSQENI KFENSISRLT EDKILLENYV
760 770 780 790 800
RSIENERDTL EFEMRHLQRE YLSLSDKICN QHNDPSKTTY ISRREKFHFD
810 820 830
NYTHEDTSSP QSRPLASDLK GYFKVKDRTL KHH
Length:833
Mass (Da):96,726
Last modified:June 1, 2002 - v1
Checksum:iAE76D1328CBED1BA
GO
Isoform 2 (identifier: Q8TBZ0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     80-116: Missing.

Note: No experimental confirmation available.
Show »
Length:796
Mass (Da):92,509
Checksum:i7B491F6E23D0DC27
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050729209P → Q.Corresponds to variant rs7699687dbSNPEnsembl.1
Natural variantiVAR_050730299L → M.Corresponds to variant rs7698680dbSNPEnsembl.1
Natural variantiVAR_050731382L → M.Corresponds to variant rs9999097dbSNPEnsembl.1
Natural variantiVAR_050732409S → F.Corresponds to variant rs11132306dbSNPEnsembl.1
Natural variantiVAR_061577500Y → D.Corresponds to variant rs59319722dbSNPEnsembl.1
Natural variantiVAR_050733614I → M.Corresponds to variant rs35596415dbSNPEnsembl.1
Natural variantiVAR_050734669Q → R.Corresponds to variant rs6827370dbSNPEnsembl.1
Natural variantiVAR_050735817S → L.Corresponds to variant rs9683564dbSNPEnsembl.1
Natural variantiVAR_050736819L → M.Corresponds to variant rs34800518dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02036580 – 116Missing in isoform 2. 1 PublicationAdd BLAST37

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB080722 mRNA. Translation: BAC81776.1.
BC028419 mRNA. Translation: AAH28419.1.
BC038515 mRNA. Translation: AAH38515.1.
AK097605 mRNA. Translation: BAC05116.1.
CCDSiCCDS3843.1. [Q8TBZ0-1]
CCDS47170.1. [Q8TBZ0-2]
RefSeqiNP_001138883.1. NM_001145411.1. [Q8TBZ0-2]
NP_689988.1. NM_152775.3. [Q8TBZ0-1]
UniGeneiHs.41101.

Genome annotation databases

EnsembliENST00000307588; ENSP00000306776; ENSG00000168491. [Q8TBZ0-1]
ENST00000393540; ENSP00000377172; ENSG00000168491. [Q8TBZ0-2]
GeneIDi256309.
KEGGihsa:256309.
UCSCiuc003ixu.5. human. [Q8TBZ0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB080722 mRNA. Translation: BAC81776.1.
BC028419 mRNA. Translation: AAH28419.1.
BC038515 mRNA. Translation: AAH38515.1.
AK097605 mRNA. Translation: BAC05116.1.
CCDSiCCDS3843.1. [Q8TBZ0-1]
CCDS47170.1. [Q8TBZ0-2]
RefSeqiNP_001138883.1. NM_001145411.1. [Q8TBZ0-2]
NP_689988.1. NM_152775.3. [Q8TBZ0-1]
UniGeneiHs.41101.

3D structure databases

ProteinModelPortaliQ8TBZ0.
SMRiQ8TBZ0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129157. 4 interactors.
IntActiQ8TBZ0. 2 interactors.
STRINGi9606.ENSP00000306776.

PTM databases

iPTMnetiQ8TBZ0.
PhosphoSitePlusiQ8TBZ0.

Polymorphism and mutation databases

BioMutaiCCDC110.
DMDMi74730531.

Proteomic databases

PaxDbiQ8TBZ0.
PeptideAtlasiQ8TBZ0.
PRIDEiQ8TBZ0.

Protocols and materials databases

DNASUi256309.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307588; ENSP00000306776; ENSG00000168491. [Q8TBZ0-1]
ENST00000393540; ENSP00000377172; ENSG00000168491. [Q8TBZ0-2]
GeneIDi256309.
KEGGihsa:256309.
UCSCiuc003ixu.5. human. [Q8TBZ0-1]

Organism-specific databases

CTDi256309.
GeneCardsiCCDC110.
HGNCiHGNC:28504. CCDC110.
HPAiHPA038475.
MIMi609488. gene.
neXtProtiNX_Q8TBZ0.
OpenTargetsiENSG00000168491.
PharmGKBiPA162381283.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFF1. Eukaryota.
ENOG410YGCT. LUCA.
GeneTreeiENSGT00710000106843.
HOGENOMiHOG000057285.
HOVERGENiHBG081026.
InParanoidiQ8TBZ0.
PhylomeDBiQ8TBZ0.
TreeFamiTF335739.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000168491-MONOMER.

Miscellaneous databases

GenomeRNAii256309.
PROiQ8TBZ0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000168491.
CleanExiHS_CCDC110.
ExpressionAtlasiQ8TBZ0. baseline and differential.
GenevisibleiQ8TBZ0. HS.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiCC110_HUMAN
AccessioniPrimary (citable) accession number: Q8TBZ0
Secondary accession number(s): Q86YI9, Q8N7W0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: June 1, 2002
Last modified: November 2, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.