Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Coiled-coil domain-containing protein 110

Gene

CCDC110

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 110
Alternative name(s):
Cancer/testis antigen 52
Short name:
CT52
Cancer/testis antigen KM-HN-1
Gene namesi
Name:CCDC110
Synonyms:KMHN1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000168491.9
HGNCiHGNC:28504 CCDC110
MIMi609488 gene
neXtProtiNX_Q8TBZ0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000168491
PharmGKBiPA162381283

Polymorphism and mutation databases

BioMutaiCCDC110
DMDMi74730531

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002490761 – 833Coiled-coil domain-containing protein 110Add BLAST833

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei609PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8TBZ0
PeptideAtlasiQ8TBZ0
PRIDEiQ8TBZ0
ProteomicsDBi74054
74055 [Q8TBZ0-2]

PTM databases

iPTMnetiQ8TBZ0
PhosphoSitePlusiQ8TBZ0

Expressioni

Tissue specificityi

Expressed specifically in testis. Also expressed in tumors of different origins.1 Publication

Gene expression databases

BgeeiENSG00000168491
CleanExiHS_CCDC110
ExpressionAtlasiQ8TBZ0 baseline and differential
GenevisibleiQ8TBZ0 HS

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
DEPTORQ8TB453EBI-2837012,EBI-2359040

Protein-protein interaction databases

BioGridi129157, 4 interactors
IntActiQ8TBZ0, 2 interactors
STRINGi9606.ENSP00000306776

Structurei

3D structure databases

ProteinModelPortaliQ8TBZ0
SMRiQ8TBZ0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili431 – 778Sequence analysisAdd BLAST348

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IFF1 Eukaryota
ENOG410YGCT LUCA
GeneTreeiENSGT00710000106843
HOGENOMiHOG000057285
HOVERGENiHBG081026
InParanoidiQ8TBZ0
PhylomeDBiQ8TBZ0
TreeFamiTF335739

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TBZ0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSPEKQHREE DEVDSVLLSA SKILNSSEGV KESGCSDTEY GCIAESENQI
60 70 80 90 100
QPQSALKVLQ QQLESFQALR MQTLQNVSMV QSEISEILNK SIIEVENPQF
110 120 130 140 150
SSEKNLVFGT RIEKDLPTEN QEENLSMEKS HHFEDSKTLH SVEEKLSGDS
160 170 180 190 200
VNSLPQSVNV PSQIHSEDTL TLRTSTDNLS SNIIIHPSEN SDILKNYNNF
210 220 230 240 250
YRFLPTAPPN VMSQADTVIL DKSKITVPFL KHGFCENLDD ICHSIKQMKE
260 270 280 290 300
ELQKSHDGEV ALTNELQTLQ TDPDVHRNGK YDMSPIHQDK MNFIKEENLD
310 320 330 340 350
GNLNEDIKSK RISELEALVK KLLPFRETVS KFHVHFCRKC KKLSKSEMHR
360 370 380 390 400
GKKNEKNNKE IPITGKNITD LKFHSRVPRY TLSFLDQTKH EMKDKERQPF
410 420 430 440 450
LVKQGSIISE NEKTSKVNSV TEQCVAKIQY LQNYLKESVQ IQKKVMELES
460 470 480 490 500
ENLNLKSKMK PLIFTTQSLI QKVETYEKQL KNLVEEKSTI QSKLSKTEEY
510 520 530 540 550
SKECLKEFKK IISKYNVLQG QNKTLEEKNI QLSLEKQQMM EALDQLKSKE
560 570 580 590 600
HKTQSDMAIV NNENNRMSIE MEAMKTNILL IQDEKEMLEK KTHQLLKEKS
610 620 630 640 650
SLGNELKESQ LEIIQLKEKE RLAKTEQETL LQIIETVKDE KLNLETTLQE
660 670 680 690 700
STAARQIMER EIENIQTYQS TAEENFLQEI KNAKSEASIY KNSLSEIGKE
710 720 730 740 750
CEMLSKMVME TKTDNQILKE ELKKHSQENI KFENSISRLT EDKILLENYV
760 770 780 790 800
RSIENERDTL EFEMRHLQRE YLSLSDKICN QHNDPSKTTY ISRREKFHFD
810 820 830
NYTHEDTSSP QSRPLASDLK GYFKVKDRTL KHH
Length:833
Mass (Da):96,726
Last modified:June 1, 2002 - v1
Checksum:iAE76D1328CBED1BA
GO
Isoform 2 (identifier: Q8TBZ0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     80-116: Missing.

Note: No experimental confirmation available.
Show »
Length:796
Mass (Da):92,509
Checksum:i7B491F6E23D0DC27
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050729209P → Q. Corresponds to variant dbSNP:rs7699687Ensembl.1
Natural variantiVAR_050730299L → M. Corresponds to variant dbSNP:rs7698680Ensembl.1
Natural variantiVAR_050731382L → M. Corresponds to variant dbSNP:rs9999097Ensembl.1
Natural variantiVAR_050732409S → F. Corresponds to variant dbSNP:rs11132306Ensembl.1
Natural variantiVAR_061577500Y → D. Corresponds to variant dbSNP:rs59319722Ensembl.1
Natural variantiVAR_050733614I → M. Corresponds to variant dbSNP:rs35596415Ensembl.1
Natural variantiVAR_050734669Q → R. Corresponds to variant dbSNP:rs6827370Ensembl.1
Natural variantiVAR_050735817S → L. Corresponds to variant dbSNP:rs9683564Ensembl.1
Natural variantiVAR_050736819L → M. Corresponds to variant dbSNP:rs34800518Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02036580 – 116Missing in isoform 2. 1 PublicationAdd BLAST37

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB080722 mRNA Translation: BAC81776.1
BC028419 mRNA Translation: AAH28419.1
BC038515 mRNA Translation: AAH38515.1
AK097605 mRNA Translation: BAC05116.1
CCDSiCCDS3843.1 [Q8TBZ0-1]
CCDS47170.1 [Q8TBZ0-2]
RefSeqiNP_001138883.1, NM_001145411.1 [Q8TBZ0-2]
NP_689988.1, NM_152775.3 [Q8TBZ0-1]
UniGeneiHs.41101

Genome annotation databases

EnsembliENST00000307588; ENSP00000306776; ENSG00000168491 [Q8TBZ0-1]
ENST00000393540; ENSP00000377172; ENSG00000168491 [Q8TBZ0-2]
GeneIDi256309
KEGGihsa:256309
UCSCiuc003ixu.5 human [Q8TBZ0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCC110_HUMAN
AccessioniPrimary (citable) accession number: Q8TBZ0
Secondary accession number(s): Q86YI9, Q8N7W0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: June 1, 2002
Last modified: June 20, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health