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Protein

Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma

Gene

PIP4K2C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play an important role in the production of Phosphatidylinositol bisphosphate (PIP2), in the endoplasmic reticulum.By similarity

Catalytic activityi

ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.

GO - Molecular functioni

GO - Biological processi

  • phosphatidylinositol biosynthetic process Source: Reactome
  • positive regulation of autophagosome assembly Source: ParkinsonsUK-UCL
  • regulation of autophagy Source: ParkinsonsUK-UCL
  • regulation of phosphatidylinositol 3-kinase signaling Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:HS09478-MONOMER.
BRENDAi2.7.1.149. 2681.
ReactomeiR-HSA-1660499. Synthesis of PIPs at the plasma membrane.
R-HSA-6811555. PI5P Regulates TP53 Acetylation.
R-HSA-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (EC:2.7.1.149)
Alternative name(s):
Phosphatidylinositol 5-phosphate 4-kinase type II gamma
Short name:
PI(5)P 4-kinase type II gamma
Short name:
PIP4KII-gamma
Gene namesi
Name:PIP4K2C
Synonyms:PIP5K2C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:23786. PIP4K2C.

Subcellular locationi

  • Cytoplasm
  • Membrane

  • Note: Mostly found in the cytosol and surrounding plasma membrane. However, its presence in the endoplasmic reticulum seems to be a prerequisite for PIP2 synthesis (By similarity).By similarity

GO - Cellular componenti

  • autophagosome Source: ParkinsonsUK-UCL
  • cytosol Source: Reactome
  • extracellular exosome Source: UniProtKB
  • membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi79837.
OpenTargetsiENSG00000166908.
PharmGKBiPA162399665.

Chemistry databases

ChEMBLiCHEMBL1770034.
GuidetoPHARMACOLOGYi2163.

Polymorphism and mutation databases

BioMutaiPIP4K2C.
DMDMi317373532.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002857502 – 421Phosphatidylinositol 5-phosphate 4-kinase type-2 gammaAdd BLAST420

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei26PhosphoserineCombined sources1
Modified residuei349PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8TBX8.
MaxQBiQ8TBX8.
PaxDbiQ8TBX8.
PeptideAtlasiQ8TBX8.
PRIDEiQ8TBX8.

PTM databases

iPTMnetiQ8TBX8.
PhosphoSitePlusiQ8TBX8.

Expressioni

Gene expression databases

BgeeiENSG00000166908.
CleanExiHS_PIP4K2C.
ExpressionAtlasiQ8TBX8. baseline and differential.
GenevisibleiQ8TBX8. HS.

Organism-specific databases

HPAiHPA028658.
HPA058551.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-1383637,EBI-1383637

Protein-protein interaction databases

BioGridi122928. 37 interactors.
IntActiQ8TBX8. 2 interactors.
STRINGi9606.ENSP00000347032.

Chemistry databases

BindingDBiQ8TBX8.

Structurei

Secondary structure

1421
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi46 – 62Combined sources17
Helixi73 – 77Combined sources5
Beta strandi79 – 85Combined sources7
Beta strandi87 – 89Combined sources3
Beta strandi92 – 94Combined sources3
Beta strandi96 – 104Combined sources9
Helixi105 – 113Combined sources9
Turni114 – 116Combined sources3
Helixi119 – 127Combined sources9
Beta strandi147 – 153Combined sources7
Helixi156 – 175Combined sources20
Beta strandi180 – 182Combined sources3
Beta strandi185 – 190Combined sources6
Beta strandi193 – 195Combined sources3
Beta strandi199 – 204Combined sources6
Beta strandi209 – 211Combined sources3
Helixi260 – 275Combined sources16
Helixi405 – 415Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2GK9X-ray2.80A/B/C/D32-421[»]
ProteinModelPortaliQ8TBX8.
SMRiQ8TBX8.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8TBX8.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini43 – 420PIPKPROSITE-ProRule annotationAdd BLAST378

Sequence similaritiesi

Contains 1 PIPK domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0229. Eukaryota.
COG5253. LUCA.
GeneTreeiENSGT00760000119184.
HOGENOMiHOG000007832.
HOVERGENiHBG000072.
InParanoidiQ8TBX8.
KOiK00920.
OMAiDFIANIF.
OrthoDBiEOG091G0857.
PhylomeDBiQ8TBX8.
TreeFamiTF354315.

Family and domain databases

Gene3Di3.30.800.10. 1 hit.
3.30.810.10. 2 hits.
InterProiIPR023610. PInositol-4-P-5-kinase.
IPR027483. PInositol-4-P-5-kinase_C.
IPR002498. PInositol-4-P-5-kinase_core.
IPR027484. PInositol-4-P-5-kinase_N.
[Graphical view]
PANTHERiPTHR23086. PTHR23086. 1 hit.
PfamiPF01504. PIP5K. 1 hit.
[Graphical view]
SMARTiSM00330. PIPKc. 1 hit.
[Graphical view]
PROSITEiPS51455. PIPK. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TBX8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASSSVPPAT VSAATAGPGP GFGFASKTKK KHFVQQKVKV FRAADPLVGV
60 70 80 90 100
FLWGVAHSIN ELSQVPPPVM LLPDDFKASS KIKVNNHLFH RENLPSHFKF
110 120 130 140 150
KEYCPQVFRN LRDRFGIDDQ DYLVSLTRNP PSESEGSDGR FLISYDRTLV
160 170 180 190 200
IKEVSSEDIA DMHSNLSNYH QYIVKCHGNT LLPQFLGMYR VSVDNEDSYM
210 220 230 240 250
LVMRNMFSHR LPVHRKYDLK GSLVSREASD KEKVKELPTL KDMDFLNKNQ
260 270 280 290 300
KVYIGEEEKK IFLEKLKRDV EFLVQLKIMD YSLLLGIHDI IRGSEPEEEA
310 320 330 340 350
PVREDESEVD GDCSLTGPPA LVGSYGTSPE GIGGYIHSHR PLGPGEFESF
360 370 380 390 400
IDVYAIRSAE GAPQKEVYFM GLIDILTQYD AKKKAAHAAK TVKHGAGAEI
410 420
STVHPEQYAK RFLDFITNIF A
Length:421
Mass (Da):47,300
Last modified:January 11, 2011 - v3
Checksum:i65D1CBCF0826D476
GO
Isoform 2 (identifier: Q8TBX8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     124-171: Missing.

Note: No experimental confirmation available.
Show »
Length:373
Mass (Da):41,922
Checksum:i45948B5F37090624
GO
Isoform 3 (identifier: Q8TBX8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     83-100: Missing.

Note: No experimental confirmation available.
Show »
Length:403
Mass (Da):45,053
Checksum:iA3980DE66031431E
GO

Sequence cautioni

The sequence BAB15223 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03204984V → A.Corresponds to variant rs17550713dbSNPEnsembl.1
Natural variantiVAR_032050241K → R.1 PublicationCorresponds to variant rs17852569dbSNPEnsembl.1
Natural variantiVAR_032051300A → G.Corresponds to variant rs2277319dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04336983 – 100Missing in isoform 3. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_042929124 – 171Missing in isoform 2. 1 PublicationAdd BLAST48

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK025708 mRNA. Translation: BAB15223.1. Different initiation.
AK297243 mRNA. Translation: BAG59723.1.
AK302254 mRNA. Translation: BAG63606.1.
AK315588 mRNA. Translation: BAG37960.1.
AC022506 Genomic DNA. No translation available.
CH471054 Genomic DNA. Translation: EAW97031.1.
BC028596 mRNA. Translation: AAH28596.1.
CCDSiCCDS53808.1. [Q8TBX8-2]
CCDS55839.1. [Q8TBX8-3]
CCDS8946.1. [Q8TBX8-1]
RefSeqiNP_001139730.1. NM_001146258.1. [Q8TBX8-1]
NP_001139731.1. NM_001146259.1. [Q8TBX8-3]
NP_001139732.1. NM_001146260.1. [Q8TBX8-2]
NP_079055.3. NM_024779.4. [Q8TBX8-1]
UniGeneiHs.745011.

Genome annotation databases

EnsembliENST00000354947; ENSP00000347032; ENSG00000166908. [Q8TBX8-1]
ENST00000422156; ENSP00000412035; ENSG00000166908. [Q8TBX8-2]
ENST00000540759; ENSP00000439878; ENSG00000166908. [Q8TBX8-1]
ENST00000550465; ENSP00000447390; ENSG00000166908. [Q8TBX8-3]
GeneIDi79837.
KEGGihsa:79837.
UCSCiuc001sot.4. human. [Q8TBX8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK025708 mRNA. Translation: BAB15223.1. Different initiation.
AK297243 mRNA. Translation: BAG59723.1.
AK302254 mRNA. Translation: BAG63606.1.
AK315588 mRNA. Translation: BAG37960.1.
AC022506 Genomic DNA. No translation available.
CH471054 Genomic DNA. Translation: EAW97031.1.
BC028596 mRNA. Translation: AAH28596.1.
CCDSiCCDS53808.1. [Q8TBX8-2]
CCDS55839.1. [Q8TBX8-3]
CCDS8946.1. [Q8TBX8-1]
RefSeqiNP_001139730.1. NM_001146258.1. [Q8TBX8-1]
NP_001139731.1. NM_001146259.1. [Q8TBX8-3]
NP_001139732.1. NM_001146260.1. [Q8TBX8-2]
NP_079055.3. NM_024779.4. [Q8TBX8-1]
UniGeneiHs.745011.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2GK9X-ray2.80A/B/C/D32-421[»]
ProteinModelPortaliQ8TBX8.
SMRiQ8TBX8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122928. 37 interactors.
IntActiQ8TBX8. 2 interactors.
STRINGi9606.ENSP00000347032.

Chemistry databases

BindingDBiQ8TBX8.
ChEMBLiCHEMBL1770034.
GuidetoPHARMACOLOGYi2163.

PTM databases

iPTMnetiQ8TBX8.
PhosphoSitePlusiQ8TBX8.

Polymorphism and mutation databases

BioMutaiPIP4K2C.
DMDMi317373532.

Proteomic databases

EPDiQ8TBX8.
MaxQBiQ8TBX8.
PaxDbiQ8TBX8.
PeptideAtlasiQ8TBX8.
PRIDEiQ8TBX8.

Protocols and materials databases

DNASUi79837.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000354947; ENSP00000347032; ENSG00000166908. [Q8TBX8-1]
ENST00000422156; ENSP00000412035; ENSG00000166908. [Q8TBX8-2]
ENST00000540759; ENSP00000439878; ENSG00000166908. [Q8TBX8-1]
ENST00000550465; ENSP00000447390; ENSG00000166908. [Q8TBX8-3]
GeneIDi79837.
KEGGihsa:79837.
UCSCiuc001sot.4. human. [Q8TBX8-1]

Organism-specific databases

CTDi79837.
DisGeNETi79837.
GeneCardsiPIP4K2C.
H-InvDBHIX0201836.
HGNCiHGNC:23786. PIP4K2C.
HPAiHPA028658.
HPA058551.
neXtProtiNX_Q8TBX8.
OpenTargetsiENSG00000166908.
PharmGKBiPA162399665.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0229. Eukaryota.
COG5253. LUCA.
GeneTreeiENSGT00760000119184.
HOGENOMiHOG000007832.
HOVERGENiHBG000072.
InParanoidiQ8TBX8.
KOiK00920.
OMAiDFIANIF.
OrthoDBiEOG091G0857.
PhylomeDBiQ8TBX8.
TreeFamiTF354315.

Enzyme and pathway databases

BioCyciZFISH:HS09478-MONOMER.
BRENDAi2.7.1.149. 2681.
ReactomeiR-HSA-1660499. Synthesis of PIPs at the plasma membrane.
R-HSA-6811555. PI5P Regulates TP53 Acetylation.
R-HSA-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.

Miscellaneous databases

ChiTaRSiPIP4K2C. human.
EvolutionaryTraceiQ8TBX8.
GenomeRNAii79837.
PROiQ8TBX8.

Gene expression databases

BgeeiENSG00000166908.
CleanExiHS_PIP4K2C.
ExpressionAtlasiQ8TBX8. baseline and differential.
GenevisibleiQ8TBX8. HS.

Family and domain databases

Gene3Di3.30.800.10. 1 hit.
3.30.810.10. 2 hits.
InterProiIPR023610. PInositol-4-P-5-kinase.
IPR027483. PInositol-4-P-5-kinase_C.
IPR002498. PInositol-4-P-5-kinase_core.
IPR027484. PInositol-4-P-5-kinase_N.
[Graphical view]
PANTHERiPTHR23086. PTHR23086. 1 hit.
PfamiPF01504. PIP5K. 1 hit.
[Graphical view]
SMARTiSM00330. PIPKc. 1 hit.
[Graphical view]
PROSITEiPS51455. PIPK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPI42C_HUMAN
AccessioniPrimary (citable) accession number: Q8TBX8
Secondary accession number(s): B2RDL3
, B4DM11, B4DY44, Q9H6N2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: January 11, 2011
Last modified: November 30, 2016
This is version 125 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.