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Q8TBX8

- PI42C_HUMAN

UniProt

Q8TBX8 - PI42C_HUMAN

Protein

Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma

Gene

PIP4K2C

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 3 (11 Jan 2011)
      Previous versions | rss
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    Functioni

    May play an important role in the production of Phosphatidylinositol bisphosphate (PIP2), in the endoplasmic reticulum.By similarity

    Catalytic activityi

    ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.

    GO - Molecular functioni

    1. 1-phosphatidylinositol-5-phosphate 4-kinase activity Source: UniProtKB-EC
    2. ATP binding Source: UniProtKB-KW
    3. identical protein binding Source: IntAct

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (EC:2.7.1.149)
    Alternative name(s):
    Phosphatidylinositol 5-phosphate 4-kinase type II gamma
    Short name:
    PI(5)P 4-kinase type II gamma
    Short name:
    PIP4KII-gamma
    Gene namesi
    Name:PIP4K2C
    Synonyms:PIP5K2C
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:23786. PIP4K2C.

    Subcellular locationi

    Cytoplasm. Membrane
    Note: Mostly found in the cytosol and surrounding plasma membrane. However, its presence in the endoplasmic reticulum seems to be a prerequisite for PIP2 synthesis By similarity.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. extracellular vesicular exosome Source: UniProt
    3. membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162399665.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 421420Phosphatidylinositol 5-phosphate 4-kinase type-2 gammaPRO_0000285750Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine1 Publication
    Modified residuei26 – 261Phosphoserine1 Publication
    Modified residuei349 – 3491Phosphoserine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ8TBX8.
    PaxDbiQ8TBX8.
    PeptideAtlasiQ8TBX8.
    PRIDEiQ8TBX8.

    PTM databases

    PhosphoSiteiQ8TBX8.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8TBX8.
    BgeeiQ8TBX8.
    CleanExiHS_PIP4K2C.
    GenevestigatoriQ8TBX8.

    Organism-specific databases

    HPAiHPA028658.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    itself2EBI-1383637,EBI-1383637

    Protein-protein interaction databases

    BioGridi122928. 6 interactions.
    IntActiQ8TBX8. 2 interactions.
    STRINGi9606.ENSP00000347032.

    Structurei

    Secondary structure

    1
    421
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi46 – 6217
    Helixi73 – 775
    Beta strandi79 – 857
    Beta strandi87 – 893
    Beta strandi92 – 943
    Beta strandi96 – 1049
    Helixi105 – 1139
    Turni114 – 1163
    Helixi119 – 1279
    Beta strandi147 – 1537
    Helixi156 – 17520
    Beta strandi180 – 1823
    Beta strandi185 – 1906
    Beta strandi193 – 1953
    Beta strandi199 – 2046
    Beta strandi209 – 2113
    Helixi260 – 27516
    Helixi405 – 41511

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2GK9X-ray2.80A/B/C/D32-421[»]
    ProteinModelPortaliQ8TBX8.
    SMRiQ8TBX8. Positions 39-420.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ8TBX8.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini43 – 420378PIPKPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 PIPK domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5253.
    HOGENOMiHOG000007832.
    HOVERGENiHBG000072.
    InParanoidiQ8TBX8.
    KOiK00920.
    OMAiCGLTGPP.
    OrthoDBiEOG708VZZ.
    PhylomeDBiQ8TBX8.
    TreeFamiTF354315.

    Family and domain databases

    Gene3Di3.30.800.10. 1 hit.
    3.30.810.10. 2 hits.
    InterProiIPR023610. PInositol-4-P-5-kinase.
    IPR027483. PInositol-4-P-5-kinase_C.
    IPR002498. PInositol-4-P-5-kinase_core.
    IPR027484. PInositol-4-P-5-kinase_N.
    IPR016034. PInositol-4P-5-kinase_core_sub.
    [Graphical view]
    PANTHERiPTHR23086. PTHR23086. 1 hit.
    PfamiPF01504. PIP5K. 1 hit.
    [Graphical view]
    SMARTiSM00330. PIPKc. 1 hit.
    [Graphical view]
    PROSITEiPS51455. PIPK. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8TBX8-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MASSSVPPAT VSAATAGPGP GFGFASKTKK KHFVQQKVKV FRAADPLVGV    50
    FLWGVAHSIN ELSQVPPPVM LLPDDFKASS KIKVNNHLFH RENLPSHFKF 100
    KEYCPQVFRN LRDRFGIDDQ DYLVSLTRNP PSESEGSDGR FLISYDRTLV 150
    IKEVSSEDIA DMHSNLSNYH QYIVKCHGNT LLPQFLGMYR VSVDNEDSYM 200
    LVMRNMFSHR LPVHRKYDLK GSLVSREASD KEKVKELPTL KDMDFLNKNQ 250
    KVYIGEEEKK IFLEKLKRDV EFLVQLKIMD YSLLLGIHDI IRGSEPEEEA 300
    PVREDESEVD GDCSLTGPPA LVGSYGTSPE GIGGYIHSHR PLGPGEFESF 350
    IDVYAIRSAE GAPQKEVYFM GLIDILTQYD AKKKAAHAAK TVKHGAGAEI 400
    STVHPEQYAK RFLDFITNIF A 421
    Length:421
    Mass (Da):47,300
    Last modified:January 11, 2011 - v3
    Checksum:i65D1CBCF0826D476
    GO
    Isoform 2 (identifier: Q8TBX8-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         124-171: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:373
    Mass (Da):41,922
    Checksum:i45948B5F37090624
    GO
    Isoform 3 (identifier: Q8TBX8-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         83-100: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:403
    Mass (Da):45,053
    Checksum:iA3980DE66031431E
    GO

    Sequence cautioni

    The sequence BAB15223.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti84 – 841V → A.
    Corresponds to variant rs17550713 [ dbSNP | Ensembl ].
    VAR_032049
    Natural varianti241 – 2411K → R.1 Publication
    Corresponds to variant rs17852569 [ dbSNP | Ensembl ].
    VAR_032050
    Natural varianti300 – 3001A → G.
    Corresponds to variant rs2277319 [ dbSNP | Ensembl ].
    VAR_032051

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei83 – 10018Missing in isoform 3. 1 PublicationVSP_043369Add
    BLAST
    Alternative sequencei124 – 17148Missing in isoform 2. 1 PublicationVSP_042929Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK025708 mRNA. Translation: BAB15223.1. Different initiation.
    AK297243 mRNA. Translation: BAG59723.1.
    AK302254 mRNA. Translation: BAG63606.1.
    AK315588 mRNA. Translation: BAG37960.1.
    AC022506 Genomic DNA. No translation available.
    CH471054 Genomic DNA. Translation: EAW97031.1.
    BC028596 mRNA. Translation: AAH28596.1.
    CCDSiCCDS53808.1. [Q8TBX8-2]
    CCDS55839.1. [Q8TBX8-3]
    CCDS8946.1. [Q8TBX8-1]
    RefSeqiNP_001139730.1. NM_001146258.1. [Q8TBX8-1]
    NP_001139731.1. NM_001146259.1. [Q8TBX8-3]
    NP_001139732.1. NM_001146260.1. [Q8TBX8-2]
    NP_079055.3. NM_024779.4. [Q8TBX8-1]
    UniGeneiHs.745011.

    Genome annotation databases

    EnsembliENST00000354947; ENSP00000347032; ENSG00000166908. [Q8TBX8-1]
    ENST00000422156; ENSP00000412035; ENSG00000166908. [Q8TBX8-2]
    ENST00000540759; ENSP00000439878; ENSG00000166908. [Q8TBX8-1]
    ENST00000550465; ENSP00000447390; ENSG00000166908. [Q8TBX8-3]
    GeneIDi79837.
    KEGGihsa:79837.
    UCSCiuc001sot.3. human. [Q8TBX8-1]
    uc010srs.2. human. [Q8TBX8-3]
    uc010srt.2. human. [Q8TBX8-2]

    Polymorphism databases

    DMDMi317373532.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK025708 mRNA. Translation: BAB15223.1 . Different initiation.
    AK297243 mRNA. Translation: BAG59723.1 .
    AK302254 mRNA. Translation: BAG63606.1 .
    AK315588 mRNA. Translation: BAG37960.1 .
    AC022506 Genomic DNA. No translation available.
    CH471054 Genomic DNA. Translation: EAW97031.1 .
    BC028596 mRNA. Translation: AAH28596.1 .
    CCDSi CCDS53808.1. [Q8TBX8-2 ]
    CCDS55839.1. [Q8TBX8-3 ]
    CCDS8946.1. [Q8TBX8-1 ]
    RefSeqi NP_001139730.1. NM_001146258.1. [Q8TBX8-1 ]
    NP_001139731.1. NM_001146259.1. [Q8TBX8-3 ]
    NP_001139732.1. NM_001146260.1. [Q8TBX8-2 ]
    NP_079055.3. NM_024779.4. [Q8TBX8-1 ]
    UniGenei Hs.745011.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2GK9 X-ray 2.80 A/B/C/D 32-421 [» ]
    ProteinModelPortali Q8TBX8.
    SMRi Q8TBX8. Positions 39-420.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122928. 6 interactions.
    IntActi Q8TBX8. 2 interactions.
    STRINGi 9606.ENSP00000347032.

    Chemistry

    BindingDBi Q8TBX8.
    ChEMBLi CHEMBL1770034.
    GuidetoPHARMACOLOGYi 2163.

    PTM databases

    PhosphoSitei Q8TBX8.

    Polymorphism databases

    DMDMi 317373532.

    Proteomic databases

    MaxQBi Q8TBX8.
    PaxDbi Q8TBX8.
    PeptideAtlasi Q8TBX8.
    PRIDEi Q8TBX8.

    Protocols and materials databases

    DNASUi 79837.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000354947 ; ENSP00000347032 ; ENSG00000166908 . [Q8TBX8-1 ]
    ENST00000422156 ; ENSP00000412035 ; ENSG00000166908 . [Q8TBX8-2 ]
    ENST00000540759 ; ENSP00000439878 ; ENSG00000166908 . [Q8TBX8-1 ]
    ENST00000550465 ; ENSP00000447390 ; ENSG00000166908 . [Q8TBX8-3 ]
    GeneIDi 79837.
    KEGGi hsa:79837.
    UCSCi uc001sot.3. human. [Q8TBX8-1 ]
    uc010srs.2. human. [Q8TBX8-3 ]
    uc010srt.2. human. [Q8TBX8-2 ]

    Organism-specific databases

    CTDi 79837.
    GeneCardsi GC12P057985.
    H-InvDB HIX0201836.
    HGNCi HGNC:23786. PIP4K2C.
    HPAi HPA028658.
    neXtProti NX_Q8TBX8.
    PharmGKBi PA162399665.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5253.
    HOGENOMi HOG000007832.
    HOVERGENi HBG000072.
    InParanoidi Q8TBX8.
    KOi K00920.
    OMAi CGLTGPP.
    OrthoDBi EOG708VZZ.
    PhylomeDBi Q8TBX8.
    TreeFami TF354315.

    Miscellaneous databases

    ChiTaRSi PIP4K2C. human.
    EvolutionaryTracei Q8TBX8.
    GenomeRNAii 79837.
    NextBioi 69498.
    PROi Q8TBX8.

    Gene expression databases

    ArrayExpressi Q8TBX8.
    Bgeei Q8TBX8.
    CleanExi HS_PIP4K2C.
    Genevestigatori Q8TBX8.

    Family and domain databases

    Gene3Di 3.30.800.10. 1 hit.
    3.30.810.10. 2 hits.
    InterProi IPR023610. PInositol-4-P-5-kinase.
    IPR027483. PInositol-4-P-5-kinase_C.
    IPR002498. PInositol-4-P-5-kinase_core.
    IPR027484. PInositol-4-P-5-kinase_N.
    IPR016034. PInositol-4P-5-kinase_core_sub.
    [Graphical view ]
    PANTHERi PTHR23086. PTHR23086. 1 hit.
    Pfami PF01504. PIP5K. 1 hit.
    [Graphical view ]
    SMARTi SM00330. PIPKc. 1 hit.
    [Graphical view ]
    PROSITEi PS51455. PIPK. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
      Tissue: Placenta and Testis.
    2. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-241.
      Tissue: Testis.
    5. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-26 AND SER-349, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    6. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. "Structure of human phosphatidylinositol-4-phosphate 5-kinase, type II, gamma."
      Structural genomics consortium (SGC)
      Submitted (APR-2007) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 32-421.

    Entry informationi

    Entry nameiPI42C_HUMAN
    AccessioniPrimary (citable) accession number: Q8TBX8
    Secondary accession number(s): B2RDL3
    , B4DM11, B4DY44, Q9H6N2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 2007
    Last sequence update: January 11, 2011
    Last modified: October 1, 2014
    This is version 101 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3