Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein FAM57A

Gene

FAM57A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM57A
Alternative name(s):
Protein CT120
Gene namesi
Name:FAM57A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:29646. FAM57A.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1 – 2121HelicalSequence analysisAdd
BLAST
Transmembranei42 – 6221HelicalSequence analysisAdd
BLAST
Transmembranei77 – 9721HelicalSequence analysisAdd
BLAST
Transmembranei113 – 13523HelicalSequence analysisAdd
BLAST
Transmembranei142 – 16221HelicalSequence analysisAdd
BLAST
Transmembranei181 – 20121HelicalSequence analysisAdd
BLAST
Transmembranei220 – 24021HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671861.

Polymorphism and mutation databases

BioMutaiFAM57A.
DMDMi62512180.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 257257Protein FAM57APRO_0000185540Add
BLAST

Proteomic databases

MaxQBiQ8TBR7.
PaxDbiQ8TBR7.
PeptideAtlasiQ8TBR7.
PRIDEiQ8TBR7.

PTM databases

iPTMnetiQ8TBR7.
PhosphoSiteiQ8TBR7.

Expressioni

Tissue specificityi

Highly expressed in pancreas. Detected at intermediate levels in heart, placenta and kidney, and at low levels in brain, liver and skeletal muscle. Not detected in normal lung.1 Publication

Gene expression databases

BgeeiENSG00000167695.
CleanExiHS_FAM57A.
ExpressionAtlasiQ8TBR7. baseline and differential.
GenevisibleiQ8TBR7. HS.

Organism-specific databases

HPAiCAB072836.

Interactioni

Subunit structurei

Interacts with GGT7 isoform 3 and SLC3A2.1 Publication

Protein-protein interaction databases

BioGridi122941. 2 interactions.
IntActiQ8TBR7. 1 interaction.
STRINGi9606.ENSP00000312017.

Structurei

3D structure databases

ProteinModelPortaliQ8TBR7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini33 – 249217TLCPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 TLC (TRAM/LAG1/CLN8) domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4561. Eukaryota.
ENOG410XPW0. LUCA.
GeneTreeiENSGT00510000046654.
HOGENOMiHOG000237329.
HOVERGENiHBG051539.
InParanoidiQ8TBR7.
OMAiIRSCDDV.
OrthoDBiEOG091G0X5A.
PhylomeDBiQ8TBR7.
TreeFamiTF324847.

Family and domain databases

InterProiIPR006634. TLC-dom.
[Graphical view]
PfamiPF03798. TRAM_LAG1_CLN8. 1 hit.
[Graphical view]
SMARTiSM00724. TLC. 1 hit.
[Graphical view]
PROSITEiPS50922. TLC. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 2 (identifier: Q8TBR7-2) [UniParc]FASTAAdd to basket
Also known as: CT120A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLLTLAGGAL FFPGLFALCT WALRRSQPGW SRTDCVMIST RLVSSVHAVL
60 70 80 90 100
ATGSGIVIIR SCDDVITGRH WLAREYVWFL IPYMIYDSYA MYLCEWCRTR
110 120 130 140 150
DQNRAPSLTL RNFLSRNRLM ITHHAVILFV LVPVAQRLRG DLGDFFVGCI
160 170 180 190 200
FTAELSTPFV SLGRVLIQLK QQHTLLYKVN GILTLATFLS CRILLFPFMY
210 220 230 240 250
WSYGRQQGLS LLQVPFSIPF YCNVANAFLV APQIYWFCLL CRKAVRLFDT

PQAKKDG
Length:257
Mass (Da):29,383
Last modified:April 12, 2005 - v2
Checksum:iC799BF7143A6DA01
GO
Isoform 1 (identifier: Q8TBR7-1) [UniParc]FASTAAdd to basket
Also known as: CT120B

The sequence of this isoform differs from the canonical sequence as follows:
     137-168: Missing.

Show »
Length:225
Mass (Da):25,873
Checksum:i0ADF99DE9DC88B60
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti25 – 251R → H in AAM90843 (PubMed:12270127).Curated
Sequence conflicti129 – 1291F → L in AAM90843 (PubMed:12270127).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei137 – 16832Missing in isoform 1. 1 PublicationVSP_008149Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF477201 mRNA. Translation: AAM90843.1.
AK025935 mRNA. Translation: BAB15286.1.
AK292065 mRNA. Translation: BAF84754.1.
CH471108 Genomic DNA. Translation: EAW90655.1.
BC009729 mRNA. Translation: AAH09729.1.
BC026023 mRNA. Translation: AAH26023.1.
CCDSiCCDS10996.1. [Q8TBR7-2]
RefSeqiNP_001304935.1. NM_001318006.1. [Q8TBR7-1]
NP_001304936.1. NM_001318007.1.
NP_001304937.1. NM_001318008.1.
NP_079068.1. NM_024792.2. [Q8TBR7-2]
UniGeneiHs.154396.

Genome annotation databases

EnsembliENST00000301324; ENSP00000301324; ENSG00000167695. [Q8TBR7-1]
ENST00000308278; ENSP00000312017; ENSG00000167695. [Q8TBR7-2]
GeneIDi79850.
KEGGihsa:79850.
UCSCiuc002frp.4. human. [Q8TBR7-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF477201 mRNA. Translation: AAM90843.1.
AK025935 mRNA. Translation: BAB15286.1.
AK292065 mRNA. Translation: BAF84754.1.
CH471108 Genomic DNA. Translation: EAW90655.1.
BC009729 mRNA. Translation: AAH09729.1.
BC026023 mRNA. Translation: AAH26023.1.
CCDSiCCDS10996.1. [Q8TBR7-2]
RefSeqiNP_001304935.1. NM_001318006.1. [Q8TBR7-1]
NP_001304936.1. NM_001318007.1.
NP_001304937.1. NM_001318008.1.
NP_079068.1. NM_024792.2. [Q8TBR7-2]
UniGeneiHs.154396.

3D structure databases

ProteinModelPortaliQ8TBR7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122941. 2 interactions.
IntActiQ8TBR7. 1 interaction.
STRINGi9606.ENSP00000312017.

PTM databases

iPTMnetiQ8TBR7.
PhosphoSiteiQ8TBR7.

Polymorphism and mutation databases

BioMutaiFAM57A.
DMDMi62512180.

Proteomic databases

MaxQBiQ8TBR7.
PaxDbiQ8TBR7.
PeptideAtlasiQ8TBR7.
PRIDEiQ8TBR7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000301324; ENSP00000301324; ENSG00000167695. [Q8TBR7-1]
ENST00000308278; ENSP00000312017; ENSG00000167695. [Q8TBR7-2]
GeneIDi79850.
KEGGihsa:79850.
UCSCiuc002frp.4. human. [Q8TBR7-2]

Organism-specific databases

CTDi79850.
GeneCardsiFAM57A.
HGNCiHGNC:29646. FAM57A.
HPAiCAB072836.
MIMi611627. gene.
neXtProtiNX_Q8TBR7.
PharmGKBiPA142671861.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4561. Eukaryota.
ENOG410XPW0. LUCA.
GeneTreeiENSGT00510000046654.
HOGENOMiHOG000237329.
HOVERGENiHBG051539.
InParanoidiQ8TBR7.
OMAiIRSCDDV.
OrthoDBiEOG091G0X5A.
PhylomeDBiQ8TBR7.
TreeFamiTF324847.

Miscellaneous databases

ChiTaRSiFAM57A. human.
GenomeRNAii79850.
PROiQ8TBR7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000167695.
CleanExiHS_FAM57A.
ExpressionAtlasiQ8TBR7. baseline and differential.
GenevisibleiQ8TBR7. HS.

Family and domain databases

InterProiIPR006634. TLC-dom.
[Graphical view]
PfamiPF03798. TRAM_LAG1_CLN8. 1 hit.
[Graphical view]
SMARTiSM00724. TLC. 1 hit.
[Graphical view]
PROSITEiPS50922. TLC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFA57A_HUMAN
AccessioniPrimary (citable) accession number: Q8TBR7
Secondary accession number(s): A8K7Q0
, Q7Z464, Q96D97, Q9H6H3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: April 12, 2005
Last modified: September 7, 2016
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.