Reviewed, UniProtKB/Swiss-Prot Q8TBR7 (FA57A_HUMAN)

Names and origin

Protein names

Recommended name:
    Protein FAM57A
Alternative name(s):
    Protein CT120

Gene names

Name:

FAM57A

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	257 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subunit structure	Interacts with GGT7 isoform 3 and SLC3A2. Ref.1
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Highly expressed in pancreas. Detected at intermediate levels in heart, placenta and kidney, and at low levels in brain, liver and skeletal muscle. Not detected in normal lung. Ref.1
Sequence similarities	Contains 1 TLC (TRAM/LAG1/CLN8) domain.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing
Domain	Transmembrane
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 2 (identifier: Q8TBR7-2)

Also known as: CT120A;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 1 (identifier: Q8TBR7-1)

Also known as: CT120B;

The sequence of this isoform differs from the canonical sequence as follows:
     137-168: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 257	257	Protein FAM57A		PRO_0000185540
Regions
	Transmembrane	1 – 21	21	Potential
	Transmembrane	42 – 62	21	Potential
	Transmembrane	77 – 97	21	Potential
	Transmembrane	113 – 135	23	Potential
	Transmembrane	142 – 162	21	Potential
	Transmembrane	181 – 201	21	Potential
	Transmembrane	220 – 240	21	Potential
	Domain	33 – 249	217	TLC
Natural variations
	Alternative sequence	137 – 168	32	Missing in isoform 1.		VSP_008149
Experimental info
	Sequence conflict	25	1	R → H in AAM90843. Ref.1
	Sequence conflict	129	1	F → L in AAM90843. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 2 (CT120A) [UniParc]. Last modified April 12, 2005. Version 2. Checksum: C799BF7143A6DA01	FASTA	257	29,383
	10 20 30 40 50 60 MLLTLAGGAL FFPGLFALCT WALRRSQPGW SRTDCVMIST RLVSSVHAVL ATGSGIVIIR 70 80 90 100 110 120 SCDDVITGRH WLAREYVWFL IPYMIYDSYA MYLCEWCRTR DQNRAPSLTL RNFLSRNRLM 130 140 150 160 170 180 ITHHAVILFV LVPVAQRLRG DLGDFFVGCI FTAELSTPFV SLGRVLIQLK QQHTLLYKVN 190 200 210 220 230 240 GILTLATFLS CRILLFPFMY WSYGRQQGLS LLQVPFSIPF YCNVANAFLV APQIYWFCLL 250 CRKAVRLFDT PQAKKDG
	Isoform 1 (CT120B). Checksum: 0ADF99DE9DC88B60	FASTA	225	25,873
	10 20 30 40 50 60 MLLTLAGGAL FFPGLFALCT WALRRSQPGW SRTDCVMIST RLVSSVHAVL ATGSGIVIIR 70 80 90 100 110 120 SCDDVITGRH WLAREYVWFL IPYMIYDSYA MYLCEWCRTR DQNRAPSLTL RNFLSRNRLM 130 140 150 160 170 180 ITHHAVILFV LVPVAQLKQQ HTLLYKVNGI LTLATFLSCR ILLFPFMYWS YGRQQGLSLL 190 200 210 220 QVPFSIPFYC NVANAFLVAP QIYWFCLLCR KAVRLFDTPQ AKKDG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and characterization of CT120, a novel membrane-associated gene involved in amino acid transport and glutathione metabolism." He X.H., Di Y., Li J., Xie Y., Tang Y., Zhang F., Wei L., Zhang Y., Qin W.X., Huo K., Li Y., Wan D.F., Gu J.R. Biochem. Biophys. Res. Commun. 297:528-536(2002) [PubMed: 12270127] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), INTERACTION WITH GGT7 AND SLC3A2, TISSUE SPECIFICITY.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Lung.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF477201 mRNA. Translation: AAM90843.1. AK025935 mRNA. Translation: BAB15286.1. BC009729 mRNA. Translation: AAH09729.1. BC026023 mRNA. Translation: AAH26023.1.
IPI	IPI00152247. IPI00747001.
RefSeq	NP_079068.1.
UniGene	Hs.154396
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSG00000167695. Homo sapiens. [Contig view]
GeneID	79850.
KEGG	hsa:79850.
Organism-specific databases
GeneCards	GC17P000583.
H-InvDB	HIX0012937. HIX0013388.
HGNC	HGNC:29646. FAM57A.
MIM	611627. gene.
PharmGKB	PA142671861.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q8TBR7.
OMA	Q8TBR7. YAMYLCE.
Gene expression databases
ArrayExpress	Q8TBR7.
Bgee	Q8TBR7.
CleanEx	HS_FAM57A.
GermOnline	ENSG00000167695. Homo sapiens.
Family and domain databases
InterPro	IPR006634. TLC. [Graphical view]
Pfam	PF03798. TRAM_LAG1_CLN8. 1 hit. [Graphical view]
SMART	SM00724. TLC. 1 hit. [Graphical view]
PROSITE	PS50922. TLC. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	69559.
SOURCE	Search...

Entry information

Entry name

FA57A_HUMAN

Accession

Primary (citable) accession number: Q8TBR7
Secondary accession number(s): Q7Z464, Q96D97, Q9H6H3

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 29, 2003
Last sequence update:	April 12, 2005
Last modified:	June 16, 2009
This is version 58 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)