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Protein

Protein kish-A

Gene

TMEM167A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the early part of the secretory pathway.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Protein kish-A
Alternative name(s):
Transmembrane protein 167
Transmembrane protein 167A
Gene namesi
Name:TMEM167A
Synonyms:TMEM167
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:28330. TMEM167A.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini27 – 5327ExtracellularSequence analysisAdd
BLAST
Transmembranei54 – 7118HelicalSequence analysisAdd
BLAST
Topological domaini72 – 721CytoplasmicSequence analysis

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162405909.

Polymorphism and mutation databases

BioMutaiTMEM167A.
DMDMi74730497.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence analysisAdd
BLAST
Chaini27 – 7246Protein kish-APRO_0000247768Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi35 – 351N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ8TBQ9.
MaxQBiQ8TBQ9.
PaxDbiQ8TBQ9.
PRIDEiQ8TBQ9.
TopDownProteomicsiQ8TBQ9.

PTM databases

iPTMnetiQ8TBQ9.
PhosphoSiteiQ8TBQ9.

Expressioni

Gene expression databases

BgeeiQ8TBQ9.
CleanExiHS_TMEM167A.
GenevisibleiQ8TBQ9. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000424707.

Structurei

3D structure databases

ProteinModelPortaliQ8TBQ9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the KISH family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3808. Eukaryota.
ENOG4112243. LUCA.
GeneTreeiENSGT00730000111214.
HOGENOMiHOG000231410.
HOVERGENiHBG080265.
InParanoidiQ8TBQ9.
OMAiFSILFMQ.
OrthoDBiEOG7VMP7X.
PhylomeDBiQ8TBQ9.
TreeFamiTF300138.

Family and domain databases

InterProiIPR009653. DUF1242.
[Graphical view]
PANTHERiPTHR13229. PTHR13229. 1 hit.
PfamiPF06842. DUF1242. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8TBQ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAIFNFQSL LTVILLLICT CAYIRSLAPS LLDRNKTGLL GIFWKCARIG
60 70
ERKSPYVAVC CIVMAFSILF IQ
Length:72
Mass (Da):8,060
Last modified:June 1, 2002 - v1
Checksum:i1A346F4BE4FD8C19
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC026285 mRNA. Translation: AAH26285.1.
BC028585 mRNA. Translation: AAH28585.1.
BC107575 mRNA. Translation: AAI07576.1.
CCDSiCCDS34198.1.
RefSeqiNP_777569.1. NM_174909.4.
UniGeneiHs.355606.

Genome annotation databases

EnsembliENST00000502346; ENSP00000424707; ENSG00000174695.
GeneIDi153339.
KEGGihsa:153339.
UCSCiuc003khx.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC026285 mRNA. Translation: AAH26285.1.
BC028585 mRNA. Translation: AAH28585.1.
BC107575 mRNA. Translation: AAI07576.1.
CCDSiCCDS34198.1.
RefSeqiNP_777569.1. NM_174909.4.
UniGeneiHs.355606.

3D structure databases

ProteinModelPortaliQ8TBQ9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000424707.

PTM databases

iPTMnetiQ8TBQ9.
PhosphoSiteiQ8TBQ9.

Polymorphism and mutation databases

BioMutaiTMEM167A.
DMDMi74730497.

Proteomic databases

EPDiQ8TBQ9.
MaxQBiQ8TBQ9.
PaxDbiQ8TBQ9.
PRIDEiQ8TBQ9.
TopDownProteomicsiQ8TBQ9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000502346; ENSP00000424707; ENSG00000174695.
GeneIDi153339.
KEGGihsa:153339.
UCSCiuc003khx.5. human.

Organism-specific databases

CTDi153339.
GeneCardsiTMEM167A.
HGNCiHGNC:28330. TMEM167A.
neXtProtiNX_Q8TBQ9.
PharmGKBiPA162405909.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3808. Eukaryota.
ENOG4112243. LUCA.
GeneTreeiENSGT00730000111214.
HOGENOMiHOG000231410.
HOVERGENiHBG080265.
InParanoidiQ8TBQ9.
OMAiFSILFMQ.
OrthoDBiEOG7VMP7X.
PhylomeDBiQ8TBQ9.
TreeFamiTF300138.

Miscellaneous databases

ChiTaRSiTMEM167A. human.
GenomeRNAii153339.
NextBioi87100.
PROiQ8TBQ9.

Gene expression databases

BgeeiQ8TBQ9.
CleanExiHS_TMEM167A.
GenevisibleiQ8TBQ9. HS.

Family and domain databases

InterProiIPR009653. DUF1242.
[Graphical view]
PANTHERiPTHR13229. PTHR13229. 1 hit.
PfamiPF06842. DUF1242. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain, Lung and Testis.
  2. "A genome-wide RNA interference screen identifies two novel components of the metazoan secretory pathway."
    Wendler F., Gillingham A.K., Sinka R., Rosa-Ferreira C., Gordon D.E., Franch-Marro X., Peden A.A., Vincent J.P., Munro S.
    EMBO J. 29:304-314(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiKISHA_HUMAN
AccessioniPrimary (citable) accession number: Q8TBQ9
Secondary accession number(s): Q0P692
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: June 1, 2002
Last modified: March 16, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.