Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Solute carrier family 25 member 40

Gene

SLC25A40

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Protein family/group databases

TCDBi2.A.29.14.6. the mitochondrial carrier (mc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 25 member 40
Alternative name(s):
Mitochondrial carrier family protein
Gene namesi
Name:SLC25A40
Synonyms:MCFP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:29680. SLC25A40.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei19 – 3921Helical; Name=1Sequence analysisAdd
BLAST
Transmembranei103 – 12321Helical; Name=2Sequence analysisAdd
BLAST
Transmembranei142 – 16221Helical; Name=3Sequence analysisAdd
BLAST
Transmembranei199 – 22022Helical; Name=4Sequence analysisAdd
BLAST
Transmembranei239 – 25921Helical; Name=5Sequence analysisAdd
BLAST
Transmembranei298 – 31821Helical; Name=6Sequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162403655.

Polymorphism and mutation databases

BioMutaiSLC25A40.
DMDMi74751387.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 338338Solute carrier family 25 member 40PRO_0000291809Add
BLAST

Proteomic databases

EPDiQ8TBP6.
MaxQBiQ8TBP6.
PaxDbiQ8TBP6.
PRIDEiQ8TBP6.

Expressioni

Gene expression databases

BgeeiQ8TBP6.
CleanExiHS_SLC25A40.
ExpressionAtlasiQ8TBP6. baseline and differential.
GenevisibleiQ8TBP6. HS.

Organism-specific databases

HPAiHPA055197.

Interactioni

Protein-protein interaction databases

BioGridi121018. 1 interaction.
STRINGi9606.ENSP00000344831.

Structurei

3D structure databases

ProteinModelPortaliQ8TBP6.
SMRiQ8TBP6. Positions 18-322.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati13 – 131119Solcar 1Add
BLAST
Repeati139 – 22385Solcar 2Add
BLAST
Repeati233 – 32795Solcar 3Add
BLAST

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0761. Eukaryota.
ENOG410XQVP. LUCA.
GeneTreeiENSGT00790000123051.
HOGENOMiHOG000214473.
HOVERGENiHBG011439.
InParanoidiQ8TBP6.
KOiK15119.
OMAiLPKGKCF.
OrthoDBiEOG79KPFV.
PhylomeDBiQ8TBP6.
TreeFamiTF314720.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 2 hits.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TBP6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPETRGQEI IKVTPLQQML ASCTGAILTS VIVTPLDVVK IRLQAQNNPL
60 70 80 90 100
PKGKCFVYSN GLMDHLCVCE EGGNKLWYKK PGNFQGTLDA FFKIIRNEGI
110 120 130 140 150
KSLWSGLPPT LVMAVPATVI YFTCYDQLSA LLRSKLGENE TCIPIVAGIV
160 170 180 190 200
ARFGAVTVIS PLELIRTKMQ SKKFSYVELH RFVSKKVSED GWISLWRGWA
210 220 230 240 250
PTVLRDVPFS AMYWYNYEIL KKWLCEKSGL YEPTFMINFT SGALSGSFAA
260 270 280 290 300
VATLPFDVVK TQKQTQLWTY ESHKISMPLH MSTWIIMKNI VAKNGFSGLF
310 320 330
SGLIPRLIKI APACAIMIST YEFGKAFFQK QNVRRQQY
Length:338
Mass (Da):38,125
Last modified:June 1, 2002 - v1
Checksum:i19F3AC921F5A6961
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti71 – 711E → K in BAD96740 (Ref. 3) Curated
Sequence conflicti161 – 1611P → Q in AAF17225 (Ref. 1) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti123 – 1231T → I.
Corresponds to variant rs724665 [ dbSNP | Ensembl ].
VAR_032863
Natural varianti186 – 1861K → Q.
Corresponds to variant rs3213633 [ dbSNP | Ensembl ].
VAR_032864

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF125531 mRNA. Translation: AAF17225.1.
AK223020 mRNA. Translation: BAD96740.1.
AK290848 mRNA. Translation: BAF83537.1.
AC003083 Genomic DNA. Translation: AAS07443.1.
CH236949 Genomic DNA. Translation: EAL24171.1.
CH471091 Genomic DNA. Translation: EAW76933.1.
CH471091 Genomic DNA. Translation: EAW76935.1.
BC027322 mRNA. Translation: AAH27322.1.
CCDSiCCDS5610.1.
RefSeqiNP_061331.2. NM_018843.3.
XP_005250553.1. XM_005250496.3.
XP_011514703.1. XM_011516401.1.
XP_011514704.1. XM_011516402.1.
UniGeneiHs.208414.

Genome annotation databases

EnsembliENST00000341119; ENSP00000344831; ENSG00000075303.
GeneIDi55972.
KEGGihsa:55972.
UCSCiuc003uje.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF125531 mRNA. Translation: AAF17225.1.
AK223020 mRNA. Translation: BAD96740.1.
AK290848 mRNA. Translation: BAF83537.1.
AC003083 Genomic DNA. Translation: AAS07443.1.
CH236949 Genomic DNA. Translation: EAL24171.1.
CH471091 Genomic DNA. Translation: EAW76933.1.
CH471091 Genomic DNA. Translation: EAW76935.1.
BC027322 mRNA. Translation: AAH27322.1.
CCDSiCCDS5610.1.
RefSeqiNP_061331.2. NM_018843.3.
XP_005250553.1. XM_005250496.3.
XP_011514703.1. XM_011516401.1.
XP_011514704.1. XM_011516402.1.
UniGeneiHs.208414.

3D structure databases

ProteinModelPortaliQ8TBP6.
SMRiQ8TBP6. Positions 18-322.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121018. 1 interaction.
STRINGi9606.ENSP00000344831.

Protein family/group databases

TCDBi2.A.29.14.6. the mitochondrial carrier (mc) family.

Polymorphism and mutation databases

BioMutaiSLC25A40.
DMDMi74751387.

Proteomic databases

EPDiQ8TBP6.
MaxQBiQ8TBP6.
PaxDbiQ8TBP6.
PRIDEiQ8TBP6.

Protocols and materials databases

DNASUi55972.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000341119; ENSP00000344831; ENSG00000075303.
GeneIDi55972.
KEGGihsa:55972.
UCSCiuc003uje.4. human.

Organism-specific databases

CTDi55972.
GeneCardsiSLC25A40.
HGNCiHGNC:29680. SLC25A40.
HPAiHPA055197.
MIMi610821. gene.
neXtProtiNX_Q8TBP6.
PharmGKBiPA162403655.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0761. Eukaryota.
ENOG410XQVP. LUCA.
GeneTreeiENSGT00790000123051.
HOGENOMiHOG000214473.
HOVERGENiHBG011439.
InParanoidiQ8TBP6.
KOiK15119.
OMAiLPKGKCF.
OrthoDBiEOG79KPFV.
PhylomeDBiQ8TBP6.
TreeFamiTF314720.

Miscellaneous databases

ChiTaRSiSLC25A40. human.
GenomeRNAii55972.
NextBioi61411.
PROiQ8TBP6.
SOURCEiSearch...

Gene expression databases

BgeeiQ8TBP6.
CleanExiHS_SLC25A40.
ExpressionAtlasiQ8TBP6. baseline and differential.
GenevisibleiQ8TBP6. HS.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 2 hits.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A novel gene expressed in the human adrenal gland."
    Fu S., Shi J., Ren S., Gu J., Jin W., Huang Q., Dong H., Yu Y., Fu G., Wang Y., Chen Z., Han Z.
    Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Adrenal gland.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Small intestine.
  4. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Adrenal cortex.
  8. "Fourteen novel human members of mitochondrial solute carrier family 25 (SLC25) widely expressed in the central nervous system."
    Haitina T., Lindblom J., Renstroem T., Fredriksson R.
    Genomics 88:779-790(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiS2540_HUMAN
AccessioniPrimary (citable) accession number: Q8TBP6
Secondary accession number(s): A8K483
, D6W5P6, Q53GB1, Q9UHR1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: June 1, 2002
Last modified: March 16, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.