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Protein

Membrane protein FAM174A

Gene

FAM174A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane protein FAM174A
Alternative name(s):
Hepatitis C virus NS5A-transactivated protein 6
Short name:
HCV NS5A-transactivated protein 6
Transmembrane protein 157
Gene namesi
Name:FAM174A
Synonyms:NS5ATP6, TMEM157
ORF Names:UNQ1912/PRO4371
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000174132.8.
HGNCiHGNC:24943. FAM174A.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 123ExtracellularSequence analysisAdd BLAST94
Transmembranei124 – 144HelicalSequence analysisAdd BLAST21
Topological domaini145 – 190CytoplasmicSequence analysisAdd BLAST46

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000174132.
PharmGKBiPA162387296.

Polymorphism and mutation databases

BioMutaiFAM174A.
DMDMi74730492.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000026365030 – 190Membrane protein FAM174AAdd BLAST161

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi83N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ8TBP5.
PaxDbiQ8TBP5.
PeptideAtlasiQ8TBP5.
PRIDEiQ8TBP5.

PTM databases

iPTMnetiQ8TBP5.
PhosphoSitePlusiQ8TBP5.

Expressioni

Gene expression databases

BgeeiENSG00000174132.
CleanExiHS_FAM174A.
GenevisibleiQ8TBP5. HS.

Organism-specific databases

HPAiHPA019539.

Interactioni

Protein-protein interaction databases

BioGridi131364. 55 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ8TBP5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi41 – 66Pro-richAdd BLAST26

Sequence similaritiesi

Belongs to the FAM174 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J24N. Eukaryota.
ENOG410Y1DI. LUCA.
GeneTreeiENSGT00730000111385.
HOGENOMiHOG000112446.
HOVERGENiHBG098565.
InParanoidiQ8TBP5.
OMAiAPHCCCC.
OrthoDBiEOG091G18XH.
PhylomeDBiQ8TBP5.
TreeFamiTF105425.

Family and domain databases

InterProiView protein in InterPro
IPR009565. DUF1180.
PfamiView protein in Pfam
PF06679. DUF1180. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8TBP5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKASQCCCCL SHLLASVLLL LLLPELSGPL AVLLQAAEAA PGLGPPDPRP
60 70 80 90 100
RTLPPLPPGP TPAQQPGRGL AEAAGPRGSE GGNGSNPVAG LETDDHGGKA
110 120 130 140 150
GEGSVGGGLA VSPNPGDKPM TQRALTVLMV VSGAVLVYFV VRTVRMRRRN
160 170 180 190
RKTRRYGVLD TNIENMELTP LEQDDEDDDN TLFDANHPRR
Length:190
Mass (Da):19,954
Last modified:June 1, 2002 - v1
Checksum:i8E2B9CB2B8FB72AD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF529367 mRNA. Translation: AAQ09601.1.
AY359108 mRNA. Translation: AAQ89466.1.
AK289539 mRNA. Translation: BAF82228.1.
AC021086 Genomic DNA. No translation available.
CH471086 Genomic DNA. Translation: EAW49106.1.
BC027332 mRNA. Translation: AAH27332.1.
CCDSiCCDS4090.1.
RefSeqiNP_940909.1. NM_198507.2.
UniGeneiHs.356108.

Genome annotation databases

EnsembliENST00000312637; ENSP00000307954; ENSG00000174132.
GeneIDi345757.
KEGGihsa:345757.
UCSCiuc003knj.2. human.

Similar proteinsi

Entry informationi

Entry nameiF174A_HUMAN
AccessioniPrimary (citable) accession number: Q8TBP5
Secondary accession number(s): A8K0H4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: June 1, 2002
Last modified: September 27, 2017
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families