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Protein

TBC1 domain family member 16

Gene

TBC1D16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May act as a GTPase-activating protein for Rab family protein(s).

GO - Molecular functioni

  • GTPase activator activity Source: UniProtKB
  • Rab GTPase binding Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Names & Taxonomyi

Protein namesi
Recommended name:
TBC1 domain family member 16
Gene namesi
Name:TBC1D16
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:28356. TBC1D16.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: UniProtKB
  • early endosome Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134881634.

Polymorphism and mutation databases

DMDMi59798967.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 767767TBC1 domain family member 16PRO_0000208044Add
BLAST

Proteomic databases

EPDiQ8TBP0.
MaxQBiQ8TBP0.
PaxDbiQ8TBP0.
PeptideAtlasiQ8TBP0.
PRIDEiQ8TBP0.

PTM databases

iPTMnetiQ8TBP0.
PhosphoSiteiQ8TBP0.

Expressioni

Gene expression databases

BgeeiENSG00000167291.
CleanExiHS_TBC1D16.
ExpressionAtlasiQ8TBP0. baseline and differential.
GenevisibleiQ8TBP0. HS.

Organism-specific databases

HPAiHPA024482.
HPA065839.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi125913. 25 interactions.
IntActiQ8TBP0. 7 interactions.
STRINGi9606.ENSP00000309794.

Structurei

3D structure databases

ProteinModelPortaliQ8TBP0.
SMRiQ8TBP0. Positions 425-629.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini425 – 635211Rab-GAP TBCPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi212 – 26554Ser-richAdd
BLAST

Sequence similaritiesi

Contains 1 Rab-GAP TBC domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2224. Eukaryota.
COG5210. LUCA.
GeneTreeiENSGT00550000074386.
HOGENOMiHOG000231218.
HOVERGENiHBG062843.
InParanoidiQ8TBP0.
OMAiYSEIQQK.
OrthoDBiEOG091G06D6.
PhylomeDBiQ8TBP0.
TreeFamiTF314212.

Family and domain databases

InterProiIPR000195. Rab-GTPase-TBC_dom.
[Graphical view]
PfamiPF00566. RabGAP-TBC. 1 hit.
[Graphical view]
SMARTiSM00164. TBC. 1 hit.
[Graphical view]
SUPFAMiSSF47923. SSF47923. 2 hits.
PROSITEiPS50086. TBC_RABGAP. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TBP0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLGRLLRRA SSKASDLLTL TPGGSGSGSP SVLDGEIIYS KNNVCVHPPE
60 70 80 90 100
GLQGLGEHHP GYLCLYMEKD EMLGATLILA WVPNSRIQRQ DEEALRYITP
110 120 130 140 150
ESSPVRKAPR PRGRRTRSSG ASHQPSPTEL RPTLTPKDED ILVVAQSVPD
160 170 180 190 200
RMLASPAPED EEKLAQGLGV DGAQPASQPA CSPSGILSTV SPQDVTEEGR
210 220 230 240 250
EPRPEAGEED GSLELSAEGV SRDSSFDSDS DTFSSPFCLS PISAALAESR
260 270 280 290 300
GSVFLESDSS PPSSSDAGLR FPDSNGLLQT PRWDEPQRVC ALEQICGVFR
310 320 330 340 350
VDLGHMRSLR LFFSDEACTS GQLVVASRES QYKVFHFHHG GLDKLSDVFQ
360 370 380 390 400
QWKYCTEMQL KDQQVAPDKT CMQFSIRRPK LPSSETHPEE SMYKRLGVSA
410 420 430 440 450
WLNHLNELGQ VEEEYKLRKA IFFGGIDVSI RGEVWPFLLR YYSHESTSEE
460 470 480 490 500
REALRLQKRK EYSEIQQKRL SMTPEEHRAF WRNVQFTVDK DVVRTDRNNQ
510 520 530 540 550
FFRGEDNPNV ESMRRILLNY AVYNPAVGYS QGMSDLVAPI LAEVLDESDT
560 570 580 590 600
FWCFVGLMQN TIFVSSPRDE DMEKQLLYLR ELLRLTHVRF YQHLVSLGED
610 620 630 640 650
GLQMLFCHRW LLLCFKREFP EAEALRIWEA CWAHYQTDYF HLFICVAIVA
660 670 680 690 700
IYGDDVIEQQ LATDQMLLHF GNLAMHMNGE LVLRKARSLL YQFRLLPRIP
710 720 730 740 750
CSLHDLCKLC GSGMWDSGSM PAVECTGHHP GSESCPYGGT VEMPSPKSLR
760
EGKKGPKTPQ DGFGFRR
Length:767
Mass (Da):86,372
Last modified:June 1, 2002 - v1
Checksum:i689CD184A9E6A37C
GO
Isoform 2 (identifier: Q8TBP0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-2: MS → MK
     3-364: Missing.

Note: No experimental confirmation available.
Show »
Length:405
Mass (Da):47,124
Checksum:iD7E04DFE735655B6
GO
Isoform 3 (identifier: Q8TBP0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-364: MSLGRLLRRA...CTEMQLKDQQ → MK
     637-767: TDYFHLFICV...TPQDGFGFRR → GADV

Note: No experimental confirmation available.
Show »
Length:278
Mass (Da):32,958
Checksum:i2875D3CB002C6E57
GO
Isoform 4 (identifier: Q8TBP0-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-363: MSLGRLLRRA...YCTEMQLKDQ → MK
     420-433: Missing.

Note: No experimental confirmation available.
Show »
Length:392
Mass (Da):45,790
Checksum:iCEFA68AF3AC28366
GO

Sequence cautioni

The sequence AAH01525 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti476 – 4761E → K.
Corresponds to variant rs34845477 [ dbSNP | Ensembl ].
VAR_052542

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 364364MSLGR…LKDQQ → MK in isoform 3. 1 PublicationVSP_055665Add
BLAST
Alternative sequencei1 – 363363MSLGR…QLKDQ → MK in isoform 4. CuratedVSP_055666Add
BLAST
Alternative sequencei1 – 22MS → MK in isoform 2. 1 PublicationVSP_053995
Alternative sequencei3 – 364362Missing in isoform 2. 1 PublicationVSP_053996Add
BLAST
Alternative sequencei420 – 43314Missing in isoform 4. CuratedVSP_055667Add
BLAST
Alternative sequencei637 – 767131TDYFH…FGFRR → GADV in isoform 3. 1 PublicationVSP_055668Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB449902 mRNA. Translation: BAH16645.1.
AC100791 Genomic DNA. No translation available.
AC116025 Genomic DNA. No translation available.
CH471099 Genomic DNA. Translation: EAW89575.1.
CH471099 Genomic DNA. Translation: EAW89576.1.
BC001525 mRNA. Translation: AAH01525.2. Different initiation.
BC028290 mRNA. Translation: AAH28290.1.
BC036947 mRNA. Translation: AAH36947.1.
CCDSiCCDS11766.1. [Q8TBP0-1]
CCDS62351.1. [Q8TBP0-2]
CCDS62352.1. [Q8TBP0-3]
CCDS62353.1. [Q8TBP0-4]
RefSeqiNP_001258773.1. NM_001271844.1. [Q8TBP0-4]
NP_001258774.1. NM_001271845.1. [Q8TBP0-2]
NP_001258775.1. NM_001271846.1. [Q8TBP0-3]
NP_061893.2. NM_019020.3. [Q8TBP0-1]
XP_005257106.1. XM_005257049.2. [Q8TBP0-1]
XP_006721757.1. XM_006721694.3. [Q8TBP0-1]
UniGeneiHs.369819.

Genome annotation databases

EnsembliENST00000310924; ENSP00000309794; ENSG00000167291. [Q8TBP0-1]
ENST00000340848; ENSP00000341517; ENSG00000167291. [Q8TBP0-2]
ENST00000572862; ENSP00000458766; ENSG00000167291. [Q8TBP0-3]
ENST00000576768; ENSP00000461522; ENSG00000167291. [Q8TBP0-4]
GeneIDi125058.
KEGGihsa:125058.
UCSCiuc002jxg.3. human. [Q8TBP0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB449902 mRNA. Translation: BAH16645.1.
AC100791 Genomic DNA. No translation available.
AC116025 Genomic DNA. No translation available.
CH471099 Genomic DNA. Translation: EAW89575.1.
CH471099 Genomic DNA. Translation: EAW89576.1.
BC001525 mRNA. Translation: AAH01525.2. Different initiation.
BC028290 mRNA. Translation: AAH28290.1.
BC036947 mRNA. Translation: AAH36947.1.
CCDSiCCDS11766.1. [Q8TBP0-1]
CCDS62351.1. [Q8TBP0-2]
CCDS62352.1. [Q8TBP0-3]
CCDS62353.1. [Q8TBP0-4]
RefSeqiNP_001258773.1. NM_001271844.1. [Q8TBP0-4]
NP_001258774.1. NM_001271845.1. [Q8TBP0-2]
NP_001258775.1. NM_001271846.1. [Q8TBP0-3]
NP_061893.2. NM_019020.3. [Q8TBP0-1]
XP_005257106.1. XM_005257049.2. [Q8TBP0-1]
XP_006721757.1. XM_006721694.3. [Q8TBP0-1]
UniGeneiHs.369819.

3D structure databases

ProteinModelPortaliQ8TBP0.
SMRiQ8TBP0. Positions 425-629.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125913. 25 interactions.
IntActiQ8TBP0. 7 interactions.
STRINGi9606.ENSP00000309794.

PTM databases

iPTMnetiQ8TBP0.
PhosphoSiteiQ8TBP0.

Polymorphism and mutation databases

DMDMi59798967.

Proteomic databases

EPDiQ8TBP0.
MaxQBiQ8TBP0.
PaxDbiQ8TBP0.
PeptideAtlasiQ8TBP0.
PRIDEiQ8TBP0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000310924; ENSP00000309794; ENSG00000167291. [Q8TBP0-1]
ENST00000340848; ENSP00000341517; ENSG00000167291. [Q8TBP0-2]
ENST00000572862; ENSP00000458766; ENSG00000167291. [Q8TBP0-3]
ENST00000576768; ENSP00000461522; ENSG00000167291. [Q8TBP0-4]
GeneIDi125058.
KEGGihsa:125058.
UCSCiuc002jxg.3. human. [Q8TBP0-1]

Organism-specific databases

CTDi125058.
GeneCardsiTBC1D16.
HGNCiHGNC:28356. TBC1D16.
HPAiHPA024482.
HPA065839.
MIMi616637. gene.
neXtProtiNX_Q8TBP0.
PharmGKBiPA134881634.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2224. Eukaryota.
COG5210. LUCA.
GeneTreeiENSGT00550000074386.
HOGENOMiHOG000231218.
HOVERGENiHBG062843.
InParanoidiQ8TBP0.
OMAiYSEIQQK.
OrthoDBiEOG091G06D6.
PhylomeDBiQ8TBP0.
TreeFamiTF314212.

Miscellaneous databases

ChiTaRSiTBC1D16. human.
GenomeRNAii125058.
PROiQ8TBP0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000167291.
CleanExiHS_TBC1D16.
ExpressionAtlasiQ8TBP0. baseline and differential.
GenevisibleiQ8TBP0. HS.

Family and domain databases

InterProiIPR000195. Rab-GTPase-TBC_dom.
[Graphical view]
PfamiPF00566. RabGAP-TBC. 1 hit.
[Graphical view]
SMARTiSM00164. TBC. 1 hit.
[Graphical view]
SUPFAMiSSF47923. SSF47923. 2 hits.
PROSITEiPS50086. TBC_RABGAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTBC16_HUMAN
AccessioniPrimary (citable) accession number: Q8TBP0
Secondary accession number(s): B9A6L7
, I3L1E0, I3L4U2, Q8N3Z4, Q96DH7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: June 1, 2002
Last modified: September 7, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.