Q8TBM8 (DJB14_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 78.
History...
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: DnaJ homolog subfamily B member 14 | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 379 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Function | May act as a co-chaperone By similarity. |
| Subcellular location | Membrane; Single-pass membrane protein Potential. |
| Sequence similarities | Contains 1 J domain. |
| Sequence caution | The sequence AAQ88639.1 differs from that shown. Reason: Erroneous termination at position 355. Translated as Arg. The sequence BAB14645.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAB14893.1 differs from that shown. Reason: Erroneous termination at position 190. Translated as Arg. The sequence CAD97796.1 differs from that shown. Reason: Intron retention. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Membrane |
| Coding sequence diversity | Alternative splicing |
| Domain | Transmembrane Transmembrane helix |
| Molecular function | Chaperone |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | protein folding Inferred from electronic annotation. Source: InterPro |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | heat shock protein binding Inferred from electronic annotation. Source: InterPro unfolded protein bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q8TBM8-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q8TBM8-2) The sequence of this isoform differs from the canonical sequence as follows: 1-85: Missing. 86-102: GEGGKGYTKDQVDGVLS → MDIGTLIWDGGPVPNTH |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 379 | 379 | DnaJ homolog subfamily B member 14 | PRO_0000281478 | |||||
Regions | |||||||||
| Transmembrane | 245 – 265 | 21 | Helical; Potential | ||||||
| Domain | 108 – 172 | 65 | J | ||||||
Natural variations | |||||||||
| Alternative sequence | 1 – 85 | 85 | Missing in isoform 2. | VSP_024006 | |||||
| Alternative sequence | 86 – 102 | 17 | GEGGK…DGVLS → MDIGTLIWDGGPVPNTH in isoform 2. | VSP_024007 | |||||
Experimental info | |||||||||
| Sequence conflict | 143 | 1 | P → L in BAB14893. Ref.6 | ||||||
| Sequence conflict | 187 | 1 | N → T in AAO31693. Ref.1 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | Sha J.H., Zhou Z.M., Xu M. Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Tissue: Testis. |
| [2] | "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. Gray A.M.Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). |
| [3] | "The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-101 (ISOFORM 1). Tissue: Fetal kidney and Spinal cord. |
| [4] | "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. Wilson R.K.Nature 434:724-731(2005) [PubMed: 15815621] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [5] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Testis. |
| [6] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 107-379. Tissue: Placenta. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AY186740 mRNA. Translation: AAO31693.1. AY358272 mRNA. Translation: AAQ88639.1. Sequence problems. AL833076 mRNA. Translation: CAD89928.1. BX537609 mRNA. Translation: CAD97796.1. Sequence problems. AC097460 Genomic DNA. Translation: AAY41012.1. BC022248 mRNA. Translation: AAH22248.1. AK024343 mRNA. Translation: BAB14893.1. Sequence problems. AK023700 mRNA. Translation: BAB14645.1. Different initiation. |
| IPI | IPI00178504. IPI00410274. |
| RefSeq | NP_001026893.1. NM_001031723.2. |
| UniGene | Hs.577426. |
3D structure databases | |
| HSSP | HSSP built from PDB template 2CTP based on UniProtKB Q9NXW2. |
| ProteinModelPortal | Q8TBM8. |
| SMR | Q8TBM8. Positions 107-203. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q8TBM8. 1 interaction. |
Polymorphism databases | |
| DMDM | 74751385. |
Proteomic databases | |
| PRIDE | Q8TBM8. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENST00000442697; ENSP00000404381; ENSG00000164031. |
| GeneID | 79982. |
| KEGG | hsa:79982. |
| UCSC | uc003hvj.1. human. uc003hvl.1. human. |
Organism-specific databases | |
| CTD | 79982. |
| GeneCards | GC04M100817. |
| H-InvDB | HIX0059463. HIX0200628. |
| HGNC | HGNC:25881. DNAJB14. |
| HPA | HPA036016. |
| neXtProt | NX_Q8TBM8. |
| PharmGKB | PA142671973. |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | prNOG15962. |
| GeneTree | ENSGT00550000074587. |
| HOGENOM | HBG737361. |
| HOVERGEN | HBG051373. |
| InParanoid | Q8TBM8. |
| OMA | GFSMFIQ. |
| OrthoDB | EOG42Z4QV. |
| PhylomeDB | Q8TBM8. |
Gene expression databases | |
| ArrayExpress | Q8TBM8. |
| Bgee | Q8TBM8. |
| CleanEx | HS_DNAJB14. |
| Genevestigator | Q8TBM8. |
Family and domain databases | |
| InterPro | IPR001623. DnaJ_N. IPR015399. DUF1977_DnaJ-like. IPR018253. Heat_shock_DnaJ_CS. IPR003095. Hsp_DnaJ. [Graphical view] |
| Gene3D | G3DSA:1.10.287.110. DnaJ_N. 1 hit. |
| KO | K09520. |
| Pfam | PF00226. DnaJ. 1 hit. PF09320. DUF1977. 1 hit. [Graphical view] |
| PRINTS | PR00625. JDOMAIN. |
| SMART | SM00271. DnaJ. 1 hit. [Graphical view] |
| SUPFAM | SSF46565. DnaJ_N. 1 hit. |
| PROSITE | PS00636. DNAJ_1. 1 hit. PS50076. DNAJ_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 70021. |
Entry information
| Entry name | DJB14_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q8TBM8 Secondary accession number(s): Q6UXN1 Q9GZU9 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 4 Human chromosome 4: entries, gene names and cross-references to MIM |
| SIMILARITY comments Index of protein domains and families |

Clusters with