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Protein

Zinc finger CCHC domain-containing protein 10

Gene

ZCCHC10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri43 – 60CCHC-typeAdd BLAST18

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger CCHC domain-containing protein 10
Gene namesi
Name:ZCCHC10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:25954. ZCCHC10.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000155329.
PharmGKBiPA134876515.

Polymorphism and mutation databases

BioMutaiZCCHC10.
DMDMi84028163.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001509671 – 192Zinc finger CCHC domain-containing protein 10Add BLAST192

Proteomic databases

EPDiQ8TBK6.
MaxQBiQ8TBK6.
PeptideAtlasiQ8TBK6.
PRIDEiQ8TBK6.

PTM databases

iPTMnetiQ8TBK6.
PhosphoSitePlusiQ8TBK6.

Expressioni

Gene expression databases

BgeeiENSG00000155329.
CleanExiHS_ZCCHC10.
ExpressionAtlasiQ8TBK6. baseline and differential.
GenevisibleiQ8TBK6. HS.

Organism-specific databases

HPAiHPA038944.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
BEND7Q8N7W2-23EBI-597063,EBI-10181188
CEP63Q96MT83EBI-597063,EBI-741977
CEP70Q8NHQ13EBI-597063,EBI-739624
COILP384323EBI-597063,EBI-945751
DAB1O755533EBI-597063,EBI-7875264
DACH1Q9UI36-23EBI-597063,EBI-10186082
DZIP3Q86Y133EBI-597063,EBI-948630
EPB41P11171-23EBI-597063,EBI-10197451
FAM9BQ8IZU03EBI-597063,EBI-10175124
KCTD6Q8NC693EBI-597063,EBI-2511344
KPNA3Q8IYQ93EBI-597063,EBI-742146
LNX1Q8TBB13EBI-597063,EBI-739832
NUDT14O958483EBI-597063,EBI-536866
PRR13Q9NZ813EBI-597063,EBI-740924
PSME3P612896EBI-597063,EBI-355546
PTPN3P260453EBI-597063,EBI-1047946
RBM39Q144984EBI-597063,EBI-395290
RBM39Q14498-33EBI-597063,EBI-6654703
SDCBPO005603EBI-597063,EBI-727004
SDCBP2Q9H1903EBI-597063,EBI-742426
SF3B4Q154273EBI-597063,EBI-348469
SFMBT1Q9UHJ35EBI-597063,EBI-747398
SIAH1Q8IUQ43EBI-597063,EBI-747107
STAC3Q96MF26EBI-597063,EBI-745680
STX11O755584EBI-597063,EBI-714135
TCEB3BQ8IYF13EBI-597063,EBI-741705
TFCP2Q128003EBI-597063,EBI-717422
THAP1Q9NVV96EBI-597063,EBI-741515
ZBTB14O438293EBI-597063,EBI-10176632
ZBTB8AQ96BR93EBI-597063,EBI-742740

Protein-protein interaction databases

BioGridi120174. 51 interactors.
IntActiQ8TBK6. 54 interactors.
MINTiMINT-1369718.

Structurei

3D structure databases

ProteinModelPortaliQ8TBK6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi105 – 181Ser-richAdd BLAST77
Compositional biasi187 – 192Poly-Lys6

Sequence similaritiesi

Contains 1 CCHC-type zinc finger.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri43 – 60CCHC-typeAdd BLAST18

Keywords - Domaini

Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00730000111200.
HOVERGENiHBG079370.
InParanoidiQ8TBK6.
OMAiREANKQH.
OrthoDBiEOG091G1CLN.
PhylomeDBiQ8TBK6.

Family and domain databases

InterProiIPR001878. Znf_CCHC.
[Graphical view]
SUPFAMiSSF57756. SSF57756. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TBK6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATPMHRLIA RRQAFDTELQ PVKTFWILIQ PSIVISEANK QHVRCQKCLE
60 70 80 90 100
FGHWTYECTG KRKYLHRPSR TAELKKALKE KENRLLLQQS IGETNVERKA
110 120 130 140 150
KKKRSKSVTS SSSSSSDSSA SDSSSESEET STSSSSEDSD TDESSSSSSS
160 170 180 190
SASSTTSSSS SDSDSDSSSS SSSSTSTDSS SDDEPPKKKK KK
Length:192
Mass (Da):20,967
Last modified:June 1, 2002 - v1
Checksum:iE600FD109936B53E
GO
Isoform 2 (identifier: Q8TBK6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     15-36: Missing.

Show »
Length:170
Mass (Da):18,410
Checksum:iF1864E485E59C931
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01371815 – 36Missing in isoform 2. 2 PublicationsAdd BLAST22

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000101 mRNA. Translation: BAA90946.1.
BC005211 mRNA. Translation: AAH05211.1.
BC022443 mRNA. Translation: AAH22443.1.
CCDSiCCDS4165.1. [Q8TBK6-2]
CCDS75301.1. [Q8TBK6-1]
RefSeqiNP_001287745.1. NM_001300816.2. [Q8TBK6-1]
NP_001287746.1. NM_001300817.2.
NP_001287747.1. NM_001300818.2.
NP_001287748.1. NM_001300819.2.
NP_001287751.1. NM_001300822.2.
NP_001295056.1. NM_001308127.1.
NP_001295057.1. NM_001308128.1.
NP_001295058.1. NM_001308129.1.
NP_001295059.1. NM_001308130.1.
NP_060135.1. NM_017665.3. [Q8TBK6-2]
UniGeneiHs.29700.

Genome annotation databases

EnsembliENST00000324170; ENSP00000324274; ENSG00000155329. [Q8TBK6-2]
ENST00000509437; ENSP00000423276; ENSG00000155329. [Q8TBK6-1]
GeneIDi54819.
KEGGihsa:54819.
UCSCiuc003kyg.4. human. [Q8TBK6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000101 mRNA. Translation: BAA90946.1.
BC005211 mRNA. Translation: AAH05211.1.
BC022443 mRNA. Translation: AAH22443.1.
CCDSiCCDS4165.1. [Q8TBK6-2]
CCDS75301.1. [Q8TBK6-1]
RefSeqiNP_001287745.1. NM_001300816.2. [Q8TBK6-1]
NP_001287746.1. NM_001300817.2.
NP_001287747.1. NM_001300818.2.
NP_001287748.1. NM_001300819.2.
NP_001287751.1. NM_001300822.2.
NP_001295056.1. NM_001308127.1.
NP_001295057.1. NM_001308128.1.
NP_001295058.1. NM_001308129.1.
NP_001295059.1. NM_001308130.1.
NP_060135.1. NM_017665.3. [Q8TBK6-2]
UniGeneiHs.29700.

3D structure databases

ProteinModelPortaliQ8TBK6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120174. 51 interactors.
IntActiQ8TBK6. 54 interactors.
MINTiMINT-1369718.

PTM databases

iPTMnetiQ8TBK6.
PhosphoSitePlusiQ8TBK6.

Polymorphism and mutation databases

BioMutaiZCCHC10.
DMDMi84028163.

Proteomic databases

EPDiQ8TBK6.
MaxQBiQ8TBK6.
PeptideAtlasiQ8TBK6.
PRIDEiQ8TBK6.

Protocols and materials databases

DNASUi54819.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000324170; ENSP00000324274; ENSG00000155329. [Q8TBK6-2]
ENST00000509437; ENSP00000423276; ENSG00000155329. [Q8TBK6-1]
GeneIDi54819.
KEGGihsa:54819.
UCSCiuc003kyg.4. human. [Q8TBK6-1]

Organism-specific databases

CTDi54819.
GeneCardsiZCCHC10.
HGNCiHGNC:25954. ZCCHC10.
HPAiHPA038944.
neXtProtiNX_Q8TBK6.
OpenTargetsiENSG00000155329.
PharmGKBiPA134876515.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00730000111200.
HOVERGENiHBG079370.
InParanoidiQ8TBK6.
OMAiREANKQH.
OrthoDBiEOG091G1CLN.
PhylomeDBiQ8TBK6.

Miscellaneous databases

ChiTaRSiZCCHC10. human.
GenomeRNAii54819.
PROiQ8TBK6.

Gene expression databases

BgeeiENSG00000155329.
CleanExiHS_ZCCHC10.
ExpressionAtlasiQ8TBK6. baseline and differential.
GenevisibleiQ8TBK6. HS.

Family and domain databases

InterProiIPR001878. Znf_CCHC.
[Graphical view]
SUPFAMiSSF57756. SSF57756. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiZCH10_HUMAN
AccessioniPrimary (citable) accession number: Q8TBK6
Secondary accession number(s): Q9NXR4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: June 1, 2002
Last modified: November 30, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.