Q8TBK6 (ZCH10_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger CCHC domain-containing protein 10

Gene names

Name:

ZCCHC10

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	192 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 CCHC-type zinc finger.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Domain	Zinc-finger
Ligand	Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	nucleic acid binding Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8TBK6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8TBK6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     15-36: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 192	192	Zinc finger CCHC domain-containing protein 10		PRO_0000150967
Regions
	Zinc finger	43 – 60	18	CCHC-type
	Compositional bias	105 – 181	77	Ser-rich
	Compositional bias	187 – 192	6	Poly-Lys
Natural variations
	Alternative sequence	15 – 36	22	Missing in isoform 2.		VSP_013718

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: E600FD109936B53E	FASTA	192	20,967
	10 20 30 40 50 60 MATPMHRLIA RRQAFDTELQ PVKTFWILIQ PSIVISEANK QHVRCQKCLE FGHWTYECTG 70 80 90 100 110 120 KRKYLHRPSR TAELKKALKE KENRLLLQQS IGETNVERKA KKKRSKSVTS SSSSSSDSSA 130 140 150 160 170 180 SDSSSESEET STSSSSEDSD TDESSSSSSS SASSTTSSSS SDSDSDSSSS SSSSTSTDSS 190 SDDEPPKKKK KK
	Isoform 2 [UniParc]. Checksum: F1864E485E59C931	FASTA	170	18,410
	10 20 30 40 50 60 MATPMHRLIA RRQAEANKQH VRCQKCLEFG HWTYECTGKR KYLHRPSRTA ELKKALKEKE 70 80 90 100 110 120 NRLLLQQSIG ETNVERKAKK KRSKSVTSSS SSSSDSSASD SSSESEETST SSSSEDSDTD 130 140 150 160 170 ESSSSSSSSA SSTTSSSSSD SDSDSSSSSS SSTSTDSSSD DEPPKKKKKK

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Colon.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK000101 mRNA. Translation: BAA90946.1. BC005211 mRNA. Translation: AAH05211.1. BC022443 mRNA. Translation: AAH22443.1.
IPI	IPI00014891. IPI00395436.
RefSeq	NP_060135.1. NM_017665.1.
UniGene	Hs.29700.
3D structure databases
ProteinModelPortal	Q8TBK6.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8TBK6. 9 interactions.
MINT	MINT-1369718.
Polymorphism databases
DMDM	84028163.
Proteomic databases
PRIDE	Q8TBK6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000355372; ENSP00000347533; ENSG00000155329.
GeneID	54819.
KEGG	hsa:54819.
UCSC	uc003kyg.1. human. uc003kyh.1. human.
Organism-specific databases
CTD	54819.
GeneCards	GC05M132332.
HGNC	HGNC:25954. ZCCHC10.
HPA	HPA038944.
neXtProt	NX_Q8TBK6.
PharmGKB	PA134876515.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG20767.
GeneTree	ENSGT00580000081568.
HOVERGEN	HBG079370.
InParanoid	Q8TBK6.
OMA	HRIIARR.
OrthoDB	EOG4Q58R0.
PhylomeDB	Q8TBK6.
Gene expression databases
ArrayExpress	Q8TBK6.
Bgee	Q8TBK6.
CleanEx	HS_ZCCHC10.
Genevestigator	Q8TBK6.
GermOnline	ENSG00000155329. Homo sapiens.
Family and domain databases
InterPro	IPR001878. Znf_CCHC. [Graphical view]
SMART	SM00343. ZnF_C2HC. 1 hit. [Graphical view]
PROSITE	PS50158. ZF_CCHC. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	57565.

Entry information

Entry name

ZCH10_HUMAN

Accession

Primary (citable) accession number: Q8TBK6
Secondary accession number(s): Q9NXR4

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 10, 2005
Last sequence update:	June 1, 2002
Last modified:	January 25, 2012
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.