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Protein

Fez family zinc finger protein 2

Gene

FEZF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Transcription repressor. Required for the specification of corticospinal motor neurons and other subcerebral projection neurons. May play a role in layer and neuronal subtype-specific patterning of subcortical projections and axonal fasciculation. Controls the development of dendritic arborization and spines of large layer V pyramidal neurons. May be involved in innate immunity (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri277 – 29923C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri305 – 32723C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri333 – 35523C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri361 – 38323C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri389 – 41123C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri417 – 44024C2H2-type 6PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Repressor

Keywords - Biological processi

Differentiation, Neurogenesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Fez family zinc finger protein 2
Alternative name(s):
Forebrain embryonic zinc finger-like protein 2
Zinc finger protein 312
Zinc finger protein Fez-like
Gene namesi
Name:FEZF2
Synonyms:FEZL, ZNF312
ORF Names:FKSG36
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:13506. FEZF2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162388420.

Polymorphism and mutation databases

BioMutaiFEZF2.
DMDMi152032462.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 459459Fez family zinc finger protein 2PRO_0000295119Add
BLAST

Proteomic databases

EPDiQ8TBJ5.
PaxDbiQ8TBJ5.
PRIDEiQ8TBJ5.

PTM databases

PhosphoSiteiQ8TBJ5.

Expressioni

Gene expression databases

BgeeiQ8TBJ5.
CleanExiHS_FEZF2.
GenevisibleiQ8TBJ5. HS.

Interactioni

Protein-protein interaction databases

BioGridi120394. 1 interaction.
STRINGi9606.ENSP00000283268.

Structurei

3D structure databases

ProteinModelPortaliQ8TBJ5.
SMRiQ8TBJ5. Positions 75-114, 240-440.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi27 – 4216Engrailed homology 1 repressorBy similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi102 – 12524Gly-richAdd
BLAST

Sequence similaritiesi

Contains 6 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri277 – 29923C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri305 – 32723C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri333 – 35523C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri361 – 38323C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri389 – 41123C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri417 – 44024C2H2-type 6PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00740000115096.
HOGENOMiHOG000013052.
HOVERGENiHBG098441.
InParanoidiQ8TBJ5.
OMAiNYSELWK.
OrthoDBiEOG7Z0JW5.
PhylomeDBiQ8TBJ5.
TreeFamiTF316780.

Family and domain databases

Gene3Di3.30.160.60. 6 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 2 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 6 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TBJ5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASSASLETM VPPACPRAGA SPATSKTLAF SIERIMAKTS EPRAPFEPRP
60 70 80 90 100
GALEADGSQG KKLLNLCSPL PCMIPLQPLG YEVPSKTLLS YSELWKSSLR
110 120 130 140 150
AGGGGGGGGG GGGGGGGAPV CGASGLCKTN CGVCCKAELG LAPSALPAGR
160 170 180 190 200
VIKPQVINQA VGLPASGSLY YFNYLDSTAY PPSELLSGHL FPSGLLNAQA
210 220 230 240 250
PAALAAHPKL FLLENAKLAG LAADKFPHPA PYPHKERLPA PLEQVLKENS
260 270 280 290 300
ALTAERGGVK GHSKLPGGSA DGKPKNFTCE VCGKVFNAHY NLTRHMPVHT
310 320 330 340 350
GARPFVCKVC GKGFRQASTL CRHKIIHTQE KPHKCNQCGK AFNRSSTLNT
360 370 380 390 400
HIRIHAGYKP FVCEFCGKGF HQKGNYKNHK LTHSGEKQYK CTICNKAFHQ
410 420 430 440 450
VYNLTFHMHT HNDKKPFTCA TCGKGFCRNF DLKKHVRKLH DSVGPAAPSA

KDLTRTVQS
Length:459
Mass (Da):48,811
Last modified:July 10, 2007 - v2
Checksum:iF1C9A512C7F0FEAF
GO
Isoform 2 (identifier: Q8TBJ5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     296-304: MPVHTGARP → LRQRVLQKL
     305-459: Missing.

Note: No experimental confirmation available.
Show »
Length:304
Mass (Da):31,326
Checksum:i7ED24FA0AEDB2E13
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti21 – 211S → L in BAA91464 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti164 – 1641P → T.1 Publication
Corresponds to variant rs17852031 [ dbSNP | Ensembl ].
VAR_033213
Natural varianti188 – 1881G → D in a patient with amyotrophic lateral sclerosis. 1 Publication
VAR_065740
Natural varianti250 – 2501S → W.1 Publication
Corresponds to variant rs17852032 [ dbSNP | Ensembl ].
VAR_033214

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei296 – 3049MPVHTGARP → LRQRVLQKL in isoform 2. 1 PublicationVSP_026734
Alternative sequencei305 – 459155Missing in isoform 2. 1 PublicationVSP_026735Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF332890 mRNA. Translation: AAG50287.1.
AK001004 mRNA. Translation: BAA91464.1.
AK290464 mRNA. Translation: BAF83153.1.
CH471055 Genomic DNA. Translation: EAW65404.1.
BC022464 mRNA. Translation: AAH22464.1.
CCDSiCCDS2897.1. [Q8TBJ5-1]
RefSeqiNP_060478.3. NM_018008.3. [Q8TBJ5-1]
UniGeneiHs.241523.

Genome annotation databases

EnsembliENST00000283268; ENSP00000283268; ENSG00000153266. [Q8TBJ5-1]
ENST00000475839; ENSP00000418804; ENSG00000153266. [Q8TBJ5-1]
ENST00000486811; ENSP00000418589; ENSG00000153266. [Q8TBJ5-1]
GeneIDi55079.
KEGGihsa:55079.
UCSCiuc003dlh.3. human. [Q8TBJ5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF332890 mRNA. Translation: AAG50287.1.
AK001004 mRNA. Translation: BAA91464.1.
AK290464 mRNA. Translation: BAF83153.1.
CH471055 Genomic DNA. Translation: EAW65404.1.
BC022464 mRNA. Translation: AAH22464.1.
CCDSiCCDS2897.1. [Q8TBJ5-1]
RefSeqiNP_060478.3. NM_018008.3. [Q8TBJ5-1]
UniGeneiHs.241523.

3D structure databases

ProteinModelPortaliQ8TBJ5.
SMRiQ8TBJ5. Positions 75-114, 240-440.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120394. 1 interaction.
STRINGi9606.ENSP00000283268.

PTM databases

PhosphoSiteiQ8TBJ5.

Polymorphism and mutation databases

BioMutaiFEZF2.
DMDMi152032462.

Proteomic databases

EPDiQ8TBJ5.
PaxDbiQ8TBJ5.
PRIDEiQ8TBJ5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000283268; ENSP00000283268; ENSG00000153266. [Q8TBJ5-1]
ENST00000475839; ENSP00000418804; ENSG00000153266. [Q8TBJ5-1]
ENST00000486811; ENSP00000418589; ENSG00000153266. [Q8TBJ5-1]
GeneIDi55079.
KEGGihsa:55079.
UCSCiuc003dlh.3. human. [Q8TBJ5-1]

Organism-specific databases

CTDi55079.
GeneCardsiFEZF2.
HGNCiHGNC:13506. FEZF2.
MIMi607414. gene.
neXtProtiNX_Q8TBJ5.
PharmGKBiPA162388420.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00740000115096.
HOGENOMiHOG000013052.
HOVERGENiHBG098441.
InParanoidiQ8TBJ5.
OMAiNYSELWK.
OrthoDBiEOG7Z0JW5.
PhylomeDBiQ8TBJ5.
TreeFamiTF316780.

Miscellaneous databases

GenomeRNAii55079.
NextBioi58618.
PROiQ8TBJ5.
SOURCEiSearch...

Gene expression databases

BgeeiQ8TBJ5.
CleanExiHS_FEZF2.
GenevisibleiQ8TBJ5. HS.

Family and domain databases

Gene3Di3.30.160.60. 6 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 2 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 6 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of FKSG36, a novel gene located on human chromosome 18p11."
    Wang Y.-G., Gong L.
    Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain and Embryo.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS THR-164 AND TRP-250.
    Tissue: Brain.
  5. "Resequencing of 29 candidate genes in patients with familial and sporadic amyotrophic lateral sclerosis."
    Daoud H., Valdmanis P.N., Gros-Louis F., Belzil V., Spiegelman D., Henrion E., Diallo O., Desjarlais A., Gauthier J., Camu W., Dion P.A., Rouleau G.A.
    Arch. Neurol. 68:587-593(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT ASP-188.

Entry informationi

Entry nameiFEZF2_HUMAN
AccessioniPrimary (citable) accession number: Q8TBJ5
Secondary accession number(s): A8K349, Q9BZ91, Q9NWB9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 10, 2007
Last modified: March 16, 2016
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.