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Protein

Fez family zinc finger protein 2

Gene

FEZF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Transcription repressor. Required for the specification of corticospinal motor neurons and other subcerebral projection neurons. May play a role in layer and neuronal subtype-specific patterning of subcortical projections and axonal fasciculation. Controls the development of dendritic arborization and spines of large layer V pyramidal neurons. May be involved in innate immunity (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri277 – 299C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri305 – 327C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri333 – 355C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri361 – 383C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri389 – 411C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri417 – 440C2H2-type 6PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Repressor

Keywords - Biological processi

Differentiation, Neurogenesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000153266-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Fez family zinc finger protein 2
Alternative name(s):
Forebrain embryonic zinc finger-like protein 2
Zinc finger protein 312
Zinc finger protein Fez-like
Gene namesi
Name:FEZF2
Synonyms:FEZL, ZNF312
ORF Names:FKSG36
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:13506. FEZF2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi55079.
OpenTargetsiENSG00000153266.
PharmGKBiPA162388420.

Polymorphism and mutation databases

BioMutaiFEZF2.
DMDMi152032462.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002951191 – 459Fez family zinc finger protein 2Add BLAST459

Proteomic databases

PaxDbiQ8TBJ5.
PeptideAtlasiQ8TBJ5.
PRIDEiQ8TBJ5.

PTM databases

iPTMnetiQ8TBJ5.
PhosphoSitePlusiQ8TBJ5.

Expressioni

Gene expression databases

BgeeiENSG00000153266.
CleanExiHS_FEZF2.
ExpressionAtlasiQ8TBJ5. baseline and differential.
GenevisibleiQ8TBJ5. HS.

Interactioni

Protein-protein interaction databases

BioGridi120394. 1 interactor.
STRINGi9606.ENSP00000283268.

Structurei

3D structure databases

ProteinModelPortaliQ8TBJ5.
SMRiQ8TBJ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi27 – 42Engrailed homology 1 repressorBy similarityAdd BLAST16

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi102 – 125Gly-richAdd BLAST24

Sequence similaritiesi

Contains 6 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri277 – 299C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri305 – 327C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri333 – 355C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri361 – 383C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri389 – 411C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri417 – 440C2H2-type 6PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00740000115096.
HOGENOMiHOG000013052.
HOVERGENiHBG098441.
InParanoidiQ8TBJ5.
OMAiNYSELWK.
OrthoDBiEOG091G0ISJ.
PhylomeDBiQ8TBJ5.
TreeFamiTF316780.

Family and domain databases

Gene3Di3.30.160.60. 6 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 2 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 6 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TBJ5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASSASLETM VPPACPRAGA SPATSKTLAF SIERIMAKTS EPRAPFEPRP
60 70 80 90 100
GALEADGSQG KKLLNLCSPL PCMIPLQPLG YEVPSKTLLS YSELWKSSLR
110 120 130 140 150
AGGGGGGGGG GGGGGGGAPV CGASGLCKTN CGVCCKAELG LAPSALPAGR
160 170 180 190 200
VIKPQVINQA VGLPASGSLY YFNYLDSTAY PPSELLSGHL FPSGLLNAQA
210 220 230 240 250
PAALAAHPKL FLLENAKLAG LAADKFPHPA PYPHKERLPA PLEQVLKENS
260 270 280 290 300
ALTAERGGVK GHSKLPGGSA DGKPKNFTCE VCGKVFNAHY NLTRHMPVHT
310 320 330 340 350
GARPFVCKVC GKGFRQASTL CRHKIIHTQE KPHKCNQCGK AFNRSSTLNT
360 370 380 390 400
HIRIHAGYKP FVCEFCGKGF HQKGNYKNHK LTHSGEKQYK CTICNKAFHQ
410 420 430 440 450
VYNLTFHMHT HNDKKPFTCA TCGKGFCRNF DLKKHVRKLH DSVGPAAPSA

KDLTRTVQS
Length:459
Mass (Da):48,811
Last modified:July 10, 2007 - v2
Checksum:iF1C9A512C7F0FEAF
GO
Isoform 2 (identifier: Q8TBJ5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     296-304: MPVHTGARP → LRQRVLQKL
     305-459: Missing.

Note: No experimental confirmation available.
Show »
Length:304
Mass (Da):31,326
Checksum:i7ED24FA0AEDB2E13
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti21S → L in BAA91464 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033213164P → T.1 PublicationCorresponds to variant rs17852031dbSNPEnsembl.1
Natural variantiVAR_065740188G → D in a patient with amyotrophic lateral sclerosis. 1 PublicationCorresponds to variant rs199850439dbSNPEnsembl.1
Natural variantiVAR_033214250S → W.1 PublicationCorresponds to variant rs17852032dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_026734296 – 304MPVHTGARP → LRQRVLQKL in isoform 2. 1 Publication9
Alternative sequenceiVSP_026735305 – 459Missing in isoform 2. 1 PublicationAdd BLAST155

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF332890 mRNA. Translation: AAG50287.1.
AK001004 mRNA. Translation: BAA91464.1.
AK290464 mRNA. Translation: BAF83153.1.
CH471055 Genomic DNA. Translation: EAW65404.1.
BC022464 mRNA. Translation: AAH22464.1.
CCDSiCCDS2897.1. [Q8TBJ5-1]
RefSeqiNP_060478.3. NM_018008.3. [Q8TBJ5-1]
UniGeneiHs.241523.

Genome annotation databases

EnsembliENST00000283268; ENSP00000283268; ENSG00000153266. [Q8TBJ5-1]
ENST00000475839; ENSP00000418804; ENSG00000153266. [Q8TBJ5-1]
ENST00000486811; ENSP00000418589; ENSG00000153266. [Q8TBJ5-1]
GeneIDi55079.
KEGGihsa:55079.
UCSCiuc003dlh.3. human. [Q8TBJ5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF332890 mRNA. Translation: AAG50287.1.
AK001004 mRNA. Translation: BAA91464.1.
AK290464 mRNA. Translation: BAF83153.1.
CH471055 Genomic DNA. Translation: EAW65404.1.
BC022464 mRNA. Translation: AAH22464.1.
CCDSiCCDS2897.1. [Q8TBJ5-1]
RefSeqiNP_060478.3. NM_018008.3. [Q8TBJ5-1]
UniGeneiHs.241523.

3D structure databases

ProteinModelPortaliQ8TBJ5.
SMRiQ8TBJ5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120394. 1 interactor.
STRINGi9606.ENSP00000283268.

PTM databases

iPTMnetiQ8TBJ5.
PhosphoSitePlusiQ8TBJ5.

Polymorphism and mutation databases

BioMutaiFEZF2.
DMDMi152032462.

Proteomic databases

PaxDbiQ8TBJ5.
PeptideAtlasiQ8TBJ5.
PRIDEiQ8TBJ5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000283268; ENSP00000283268; ENSG00000153266. [Q8TBJ5-1]
ENST00000475839; ENSP00000418804; ENSG00000153266. [Q8TBJ5-1]
ENST00000486811; ENSP00000418589; ENSG00000153266. [Q8TBJ5-1]
GeneIDi55079.
KEGGihsa:55079.
UCSCiuc003dlh.3. human. [Q8TBJ5-1]

Organism-specific databases

CTDi55079.
DisGeNETi55079.
GeneCardsiFEZF2.
HGNCiHGNC:13506. FEZF2.
MIMi607414. gene.
neXtProtiNX_Q8TBJ5.
OpenTargetsiENSG00000153266.
PharmGKBiPA162388420.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00740000115096.
HOGENOMiHOG000013052.
HOVERGENiHBG098441.
InParanoidiQ8TBJ5.
OMAiNYSELWK.
OrthoDBiEOG091G0ISJ.
PhylomeDBiQ8TBJ5.
TreeFamiTF316780.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000153266-MONOMER.

Miscellaneous databases

GenomeRNAii55079.
PROiQ8TBJ5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000153266.
CleanExiHS_FEZF2.
ExpressionAtlasiQ8TBJ5. baseline and differential.
GenevisibleiQ8TBJ5. HS.

Family and domain databases

Gene3Di3.30.160.60. 6 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 2 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 6 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFEZF2_HUMAN
AccessioniPrimary (citable) accession number: Q8TBJ5
Secondary accession number(s): A8K349, Q9BZ91, Q9NWB9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 10, 2007
Last modified: November 30, 2016
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.