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Protein

Phospholipid phosphatase-related protein type 1

Gene

PLPPR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

BRENDAi3.1.3.4 2681
ReactomeiR-HSA-419408 Lysosphingolipid and LPA receptors

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipid phosphatase-related protein type 1Curated
Alternative name(s):
Lipid phosphate phosphatase-related protein type 11 Publication
Plasticity-related gene 3 protein1 Publication
Short name:
PRG-31 Publication
Gene namesi
Name:PLPPR1Imported
Synonyms:LPPR11 Publication, PRG3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000148123.14
HGNCiHGNC:25993 PLPPR1
neXtProtiNX_Q8TBJ4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei13 – 33HelicalSequence analysisAdd BLAST21
Transmembranei67 – 87HelicalSequence analysisAdd BLAST21
Transmembranei127 – 147HelicalSequence analysisAdd BLAST21
Transmembranei201 – 218HelicalSequence analysisAdd BLAST18
Transmembranei230 – 247HelicalSequence analysisAdd BLAST18
Transmembranei257 – 277HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi54886
OpenTargetsiENSG00000148123

Polymorphism and mutation databases

BioMutaiLPPR1
DMDMi74751381

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003175321 – 325Phospholipid phosphatase-related protein type 1Add BLAST325

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi163N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei307PhosphoserineBy similarity1
Glycosylationi316N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ8TBJ4
PeptideAtlasiQ8TBJ4
PRIDEiQ8TBJ4

PTM databases

iPTMnetiQ8TBJ4
PhosphoSitePlusiQ8TBJ4

Expressioni

Gene expression databases

BgeeiENSG00000148123
CleanExiHS_PRG3
ExpressionAtlasiQ8TBJ4 baseline and differential
GenevisibleiQ8TBJ4 HS

Organism-specific databases

HPAiHPA014760
HPA014968
HPA014979

Interactioni

Protein-protein interaction databases

BioGridi120234, 12 interactors

Structurei

3D structure databases

ProteinModelPortaliQ8TBJ4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410ITB5 Eukaryota
ENOG410XYPV LUCA
GeneTreeiENSGT00620000087654
HOGENOMiHOG000286008
HOVERGENiHBG108093
InParanoidiQ8TBJ4
KOiK19581
OMAiCRAHHQF
OrthoDBiEOG091G0870
PhylomeDBiQ8TBJ4

Family and domain databases

InterProiView protein in InterPro
IPR028678 LPPR1
IPR036938 P_Acid_Pase_2/haloperoxi_sf
IPR000326 P_Acid_Pase_2/haloperoxidase
PANTHERiPTHR10165:SF41 PTHR10165:SF41, 1 hit
PfamiView protein in Pfam
PF01569 PAP2, 1 hit
SMARTiView protein in SMART
SM00014 acidPPc, 1 hit
SUPFAMiSSF48317 SSF48317, 1 hit

Sequencei

Sequence statusi: Complete.

Q8TBJ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVGNNTQRS YSIIPCFIFV ELVIMAGTVL LAYYFECTDT FQVHIQGFFC
60 70 80 90 100
QDGDLMKPYP GTEEESFITP LVLYCVLAAT PTAIIFIGEI SMYFIKSTRE
110 120 130 140 150
SLIAQEKTIL TGECCYLNPL LRRIIRFTGV FAFGLFATDI FVNAGQVVTG
160 170 180 190 200
HLTPYFLTVC KPNYTSADCQ AHHQFINNGN ICTGDLEVIE KARRSFPSKH
210 220 230 240 250
AALSIYSALY ATMYITSTIK TKSSRLAKPV LCLGTLCTAF LTGLNRVSEY
260 270 280 290 300
RNHCSDVIAG FILGTAVALF LGMCVVHNFK GTQGSPSKPK PEDPRGVPLM
310 320
AFPRIESPLE TLSAQNHSAS MTEVT
Length:325
Mass (Da):35,795
Last modified:June 1, 2002 - v1
Checksum:i5FC7B9381B78D116
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti105Q → R in BAA91072 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY337718 mRNA Translation: AAQ73539.1
AY304515 mRNA Translation: AAP72152.1
AK000307 mRNA Translation: BAA91072.1
AL359893 Genomic DNA No translation available.
AL161631 Genomic DNA No translation available.
CH471105 Genomic DNA Translation: EAW58938.1
BC022465 mRNA Translation: AAH22465.1
CCDSiCCDS6751.1
RefSeqiNP_060223.2, NM_017753.2
NP_997182.1, NM_207299.1
UniGeneiHs.382683

Genome annotation databases

EnsembliENST00000374874; ENSP00000364008; ENSG00000148123
ENST00000395056; ENSP00000378496; ENSG00000148123
ENST00000611695; ENSP00000478338; ENSG00000276539
ENST00000614834; ENSP00000477959; ENSG00000276539
GeneIDi54886
KEGGihsa:54886
UCSCiuc004bbb.4 human

Similar proteinsi

Entry informationi

Entry nameiPLPR1_HUMAN
AccessioniPrimary (citable) accession number: Q8TBJ4
Secondary accession number(s): Q5VX23, Q9NXE2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: June 1, 2002
Last modified: March 28, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health