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Protein

Phospholipid phosphatase-related protein type 1

Gene

PLPPR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BRENDAi3.1.3.4. 2681.
ReactomeiR-HSA-419408. Lysosphingolipid and LPA receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipid phosphatase-related protein type 1Curated
Alternative name(s):
Lipid phosphate phosphatase-related protein type 11 Publication
Plasticity-related gene 3 protein1 Publication
Short name:
PRG-31 Publication
Gene namesi
Name:PLPPR1Imported
Synonyms:LPPR11 Publication, PRG3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:25993. PLPPR1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei13 – 3321HelicalSequence analysisAdd
BLAST
Transmembranei67 – 8721HelicalSequence analysisAdd
BLAST
Transmembranei127 – 14721HelicalSequence analysisAdd
BLAST
Transmembranei201 – 21818HelicalSequence analysisAdd
BLAST
Transmembranei230 – 24718HelicalSequence analysisAdd
BLAST
Transmembranei257 – 27721HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Polymorphism and mutation databases

BioMutaiLPPR1.
DMDMi74751381.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 325325Phospholipid phosphatase-related protein type 1PRO_0000317532Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence analysis
Glycosylationi163 – 1631N-linked (GlcNAc...)Sequence analysis
Modified residuei307 – 3071PhosphoserineBy similarity
Glycosylationi316 – 3161N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ8TBJ4.
PRIDEiQ8TBJ4.

PTM databases

iPTMnetiQ8TBJ4.
PhosphoSiteiQ8TBJ4.

Expressioni

Gene expression databases

BgeeiQ8TBJ4.
CleanExiHS_PRG3.
ExpressionAtlasiQ8TBJ4. baseline and differential.
GenevisibleiQ8TBJ4. HS.

Organism-specific databases

HPAiHPA014968.

Interactioni

Protein-protein interaction databases

BioGridi120234. 12 interactions.
STRINGi9606.ENSP00000364005.

Structurei

3D structure databases

ProteinModelPortaliQ8TBJ4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410ITB5. Eukaryota.
ENOG410XYPV. LUCA.
GeneTreeiENSGT00620000087654.
HOGENOMiHOG000286008.
HOVERGENiHBG108093.
InParanoidiQ8TBJ4.
KOiK19581.
OMAiRAHHQFI.
PhylomeDBiQ8TBJ4.

Family and domain databases

Gene3Di1.20.144.10. 1 hit.
InterProiIPR028678. LPPR1.
IPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view]
PANTHERiPTHR10165:SF41. PTHR10165:SF41. 1 hit.
PfamiPF01569. PAP2. 1 hit.
[Graphical view]
SMARTiSM00014. acidPPc. 1 hit.
[Graphical view]
SUPFAMiSSF48317. SSF48317. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8TBJ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVGNNTQRS YSIIPCFIFV ELVIMAGTVL LAYYFECTDT FQVHIQGFFC
60 70 80 90 100
QDGDLMKPYP GTEEESFITP LVLYCVLAAT PTAIIFIGEI SMYFIKSTRE
110 120 130 140 150
SLIAQEKTIL TGECCYLNPL LRRIIRFTGV FAFGLFATDI FVNAGQVVTG
160 170 180 190 200
HLTPYFLTVC KPNYTSADCQ AHHQFINNGN ICTGDLEVIE KARRSFPSKH
210 220 230 240 250
AALSIYSALY ATMYITSTIK TKSSRLAKPV LCLGTLCTAF LTGLNRVSEY
260 270 280 290 300
RNHCSDVIAG FILGTAVALF LGMCVVHNFK GTQGSPSKPK PEDPRGVPLM
310 320
AFPRIESPLE TLSAQNHSAS MTEVT
Length:325
Mass (Da):35,795
Last modified:June 1, 2002 - v1
Checksum:i5FC7B9381B78D116
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti105 – 1051Q → R in BAA91072 (PubMed:14702039).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY337718 mRNA. Translation: AAQ73539.1.
AY304515 mRNA. Translation: AAP72152.1.
AK000307 mRNA. Translation: BAA91072.1.
AL359893, AL161631 Genomic DNA. Translation: CAH72990.1.
AL161631, AL359893 Genomic DNA. Translation: CAI16478.1.
AL359893, AL161631 Genomic DNA. Translation: CAH72991.1.
AL161631, AL359893 Genomic DNA. Translation: CAI16479.1.
CH471105 Genomic DNA. Translation: EAW58938.1.
BC022465 mRNA. Translation: AAH22465.1.
CCDSiCCDS6751.1.
RefSeqiNP_060223.2. NM_017753.2.
NP_997182.1. NM_207299.1.
UniGeneiHs.382683.

Genome annotation databases

EnsembliENST00000374874; ENSP00000364008; ENSG00000148123.
ENST00000395056; ENSP00000378496; ENSG00000148123.
ENST00000611695; ENSP00000478338; ENSG00000276539.
ENST00000614834; ENSP00000477959; ENSG00000276539.
GeneIDi54886.
KEGGihsa:54886.
UCSCiuc004bbb.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY337718 mRNA. Translation: AAQ73539.1.
AY304515 mRNA. Translation: AAP72152.1.
AK000307 mRNA. Translation: BAA91072.1.
AL359893, AL161631 Genomic DNA. Translation: CAH72990.1.
AL161631, AL359893 Genomic DNA. Translation: CAI16478.1.
AL359893, AL161631 Genomic DNA. Translation: CAH72991.1.
AL161631, AL359893 Genomic DNA. Translation: CAI16479.1.
CH471105 Genomic DNA. Translation: EAW58938.1.
BC022465 mRNA. Translation: AAH22465.1.
CCDSiCCDS6751.1.
RefSeqiNP_060223.2. NM_017753.2.
NP_997182.1. NM_207299.1.
UniGeneiHs.382683.

3D structure databases

ProteinModelPortaliQ8TBJ4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120234. 12 interactions.
STRINGi9606.ENSP00000364005.

PTM databases

iPTMnetiQ8TBJ4.
PhosphoSiteiQ8TBJ4.

Polymorphism and mutation databases

BioMutaiLPPR1.
DMDMi74751381.

Proteomic databases

PaxDbiQ8TBJ4.
PRIDEiQ8TBJ4.

Protocols and materials databases

DNASUi54886.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374874; ENSP00000364008; ENSG00000148123.
ENST00000395056; ENSP00000378496; ENSG00000148123.
ENST00000611695; ENSP00000478338; ENSG00000276539.
ENST00000614834; ENSP00000477959; ENSG00000276539.
GeneIDi54886.
KEGGihsa:54886.
UCSCiuc004bbb.4. human.

Organism-specific databases

CTDi54886.
GeneCardsiLPPR1.
HGNCiHGNC:25993. PLPPR1.
HPAiHPA014968.
neXtProtiNX_Q8TBJ4.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ITB5. Eukaryota.
ENOG410XYPV. LUCA.
GeneTreeiENSGT00620000087654.
HOGENOMiHOG000286008.
HOVERGENiHBG108093.
InParanoidiQ8TBJ4.
KOiK19581.
OMAiRAHHQFI.
PhylomeDBiQ8TBJ4.

Enzyme and pathway databases

BRENDAi3.1.3.4. 2681.
ReactomeiR-HSA-419408. Lysosphingolipid and LPA receptors.

Miscellaneous databases

ChiTaRSiLPPR1. human.
GenomeRNAii54886.
PROiQ8TBJ4.

Gene expression databases

BgeeiQ8TBJ4.
CleanExiHS_PRG3.
ExpressionAtlasiQ8TBJ4. baseline and differential.
GenevisibleiQ8TBJ4. HS.

Family and domain databases

Gene3Di1.20.144.10. 1 hit.
InterProiIPR028678. LPPR1.
IPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view]
PANTHERiPTHR10165:SF41. PTHR10165:SF41. 1 hit.
PfamiPF01569. PAP2. 1 hit.
[Graphical view]
SMARTiSM00014. acidPPc. 1 hit.
[Graphical view]
SUPFAMiSSF48317. SSF48317. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and expression regulation of PRG-3, a new member of the plasticity-related gene family."
    Savaskan N.E., Brauer A.U., Nitsch R.
    Eur. J. Neurosci. 19:212-220(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Lipid phosphate phosphatase related proteins."
    Morris A.J., Sigal Y.J., McDermott M., Sciorra V.A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiPLPR1_HUMAN
AccessioniPrimary (citable) accession number: Q8TBJ4
Secondary accession number(s): Q5VX23, Q9NXE2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: June 1, 2002
Last modified: June 8, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.