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Protein

Phospholipid phosphatase-related protein type 1

Gene

PLPPR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000148123-MONOMER.
BRENDAi3.1.3.4. 2681.
ReactomeiR-HSA-419408. Lysosphingolipid and LPA receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipid phosphatase-related protein type 1Curated
Alternative name(s):
Lipid phosphate phosphatase-related protein type 11 Publication
Plasticity-related gene 3 protein1 Publication
Short name:
PRG-31 Publication
Gene namesi
Name:PLPPR1Imported
Synonyms:LPPR11 Publication, PRG3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:25993. PLPPR1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei13 – 33HelicalSequence analysisAdd BLAST21
Transmembranei67 – 87HelicalSequence analysisAdd BLAST21
Transmembranei127 – 147HelicalSequence analysisAdd BLAST21
Transmembranei201 – 218HelicalSequence analysisAdd BLAST18
Transmembranei230 – 247HelicalSequence analysisAdd BLAST18
Transmembranei257 – 277HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi54886.
OpenTargetsiENSG00000148123.
ENSG00000276539.

Polymorphism and mutation databases

BioMutaiLPPR1.
DMDMi74751381.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003175321 – 325Phospholipid phosphatase-related protein type 1Add BLAST325

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Glycosylationi163N-linked (GlcNAc...)Sequence analysis1
Modified residuei307PhosphoserineBy similarity1
Glycosylationi316N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ8TBJ4.
PeptideAtlasiQ8TBJ4.
PRIDEiQ8TBJ4.

PTM databases

iPTMnetiQ8TBJ4.
PhosphoSitePlusiQ8TBJ4.

Expressioni

Gene expression databases

BgeeiENSG00000148123.
CleanExiHS_PRG3.
ExpressionAtlasiQ8TBJ4. baseline and differential.
GenevisibleiQ8TBJ4. HS.

Organism-specific databases

HPAiHPA014968.

Interactioni

Protein-protein interaction databases

BioGridi120234. 12 interactors.
STRINGi9606.ENSP00000364005.

Structurei

3D structure databases

ProteinModelPortaliQ8TBJ4.
SMRiQ8TBJ4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410ITB5. Eukaryota.
ENOG410XYPV. LUCA.
GeneTreeiENSGT00620000087654.
HOGENOMiHOG000286008.
HOVERGENiHBG108093.
InParanoidiQ8TBJ4.
KOiK19581.
OMAiRAHHQFI.
OrthoDBiEOG091G0870.
PhylomeDBiQ8TBJ4.

Family and domain databases

Gene3Di1.20.144.10. 1 hit.
InterProiIPR028678. LPPR1.
IPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view]
PANTHERiPTHR10165:SF41. PTHR10165:SF41. 1 hit.
PfamiPF01569. PAP2. 1 hit.
[Graphical view]
SMARTiSM00014. acidPPc. 1 hit.
[Graphical view]
SUPFAMiSSF48317. SSF48317. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8TBJ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVGNNTQRS YSIIPCFIFV ELVIMAGTVL LAYYFECTDT FQVHIQGFFC
60 70 80 90 100
QDGDLMKPYP GTEEESFITP LVLYCVLAAT PTAIIFIGEI SMYFIKSTRE
110 120 130 140 150
SLIAQEKTIL TGECCYLNPL LRRIIRFTGV FAFGLFATDI FVNAGQVVTG
160 170 180 190 200
HLTPYFLTVC KPNYTSADCQ AHHQFINNGN ICTGDLEVIE KARRSFPSKH
210 220 230 240 250
AALSIYSALY ATMYITSTIK TKSSRLAKPV LCLGTLCTAF LTGLNRVSEY
260 270 280 290 300
RNHCSDVIAG FILGTAVALF LGMCVVHNFK GTQGSPSKPK PEDPRGVPLM
310 320
AFPRIESPLE TLSAQNHSAS MTEVT
Length:325
Mass (Da):35,795
Last modified:June 1, 2002 - v1
Checksum:i5FC7B9381B78D116
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti105Q → R in BAA91072 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY337718 mRNA. Translation: AAQ73539.1.
AY304515 mRNA. Translation: AAP72152.1.
AK000307 mRNA. Translation: BAA91072.1.
AL359893, AL161631 Genomic DNA. Translation: CAH72990.1.
AL161631, AL359893 Genomic DNA. Translation: CAI16478.1.
AL359893, AL161631 Genomic DNA. Translation: CAH72991.1.
AL161631, AL359893 Genomic DNA. Translation: CAI16479.1.
CH471105 Genomic DNA. Translation: EAW58938.1.
BC022465 mRNA. Translation: AAH22465.1.
CCDSiCCDS6751.1.
RefSeqiNP_060223.2. NM_017753.2.
NP_997182.1. NM_207299.1.
UniGeneiHs.382683.

Genome annotation databases

EnsembliENST00000374874; ENSP00000364008; ENSG00000148123.
ENST00000395056; ENSP00000378496; ENSG00000148123.
ENST00000611695; ENSP00000478338; ENSG00000276539.
ENST00000614834; ENSP00000477959; ENSG00000276539.
GeneIDi54886.
KEGGihsa:54886.
UCSCiuc004bbb.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY337718 mRNA. Translation: AAQ73539.1.
AY304515 mRNA. Translation: AAP72152.1.
AK000307 mRNA. Translation: BAA91072.1.
AL359893, AL161631 Genomic DNA. Translation: CAH72990.1.
AL161631, AL359893 Genomic DNA. Translation: CAI16478.1.
AL359893, AL161631 Genomic DNA. Translation: CAH72991.1.
AL161631, AL359893 Genomic DNA. Translation: CAI16479.1.
CH471105 Genomic DNA. Translation: EAW58938.1.
BC022465 mRNA. Translation: AAH22465.1.
CCDSiCCDS6751.1.
RefSeqiNP_060223.2. NM_017753.2.
NP_997182.1. NM_207299.1.
UniGeneiHs.382683.

3D structure databases

ProteinModelPortaliQ8TBJ4.
SMRiQ8TBJ4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120234. 12 interactors.
STRINGi9606.ENSP00000364005.

PTM databases

iPTMnetiQ8TBJ4.
PhosphoSitePlusiQ8TBJ4.

Polymorphism and mutation databases

BioMutaiLPPR1.
DMDMi74751381.

Proteomic databases

PaxDbiQ8TBJ4.
PeptideAtlasiQ8TBJ4.
PRIDEiQ8TBJ4.

Protocols and materials databases

DNASUi54886.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374874; ENSP00000364008; ENSG00000148123.
ENST00000395056; ENSP00000378496; ENSG00000148123.
ENST00000611695; ENSP00000478338; ENSG00000276539.
ENST00000614834; ENSP00000477959; ENSG00000276539.
GeneIDi54886.
KEGGihsa:54886.
UCSCiuc004bbb.4. human.

Organism-specific databases

CTDi54886.
DisGeNETi54886.
GeneCardsiLPPR1.
HGNCiHGNC:25993. PLPPR1.
HPAiHPA014968.
neXtProtiNX_Q8TBJ4.
OpenTargetsiENSG00000148123.
ENSG00000276539.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ITB5. Eukaryota.
ENOG410XYPV. LUCA.
GeneTreeiENSGT00620000087654.
HOGENOMiHOG000286008.
HOVERGENiHBG108093.
InParanoidiQ8TBJ4.
KOiK19581.
OMAiRAHHQFI.
OrthoDBiEOG091G0870.
PhylomeDBiQ8TBJ4.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000148123-MONOMER.
BRENDAi3.1.3.4. 2681.
ReactomeiR-HSA-419408. Lysosphingolipid and LPA receptors.

Miscellaneous databases

ChiTaRSiLPPR1. human.
GenomeRNAii54886.
PROiQ8TBJ4.

Gene expression databases

BgeeiENSG00000148123.
CleanExiHS_PRG3.
ExpressionAtlasiQ8TBJ4. baseline and differential.
GenevisibleiQ8TBJ4. HS.

Family and domain databases

Gene3Di1.20.144.10. 1 hit.
InterProiIPR028678. LPPR1.
IPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view]
PANTHERiPTHR10165:SF41. PTHR10165:SF41. 1 hit.
PfamiPF01569. PAP2. 1 hit.
[Graphical view]
SMARTiSM00014. acidPPc. 1 hit.
[Graphical view]
SUPFAMiSSF48317. SSF48317. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPLPR1_HUMAN
AccessioniPrimary (citable) accession number: Q8TBJ4
Secondary accession number(s): Q5VX23, Q9NXE2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: June 1, 2002
Last modified: November 2, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.