Q8TBJ0 (Q8TBJ0_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Malic enzyme RuleBase RU003426

Gene names

Name:

ME3 EMBL AAH22472.1

Organism

Homo sapiens (Human) EMBL AAH22472.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	604 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the malic enzymes family. RuleBase RU003426

Ontologies

Keywords
Ligand	Metal-binding RuleBase RU003426
Molecular function	Oxidoreductase RuleBase RU003426
Gene Ontology (GO)
Biological process	malate metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	NAD binding Inferred from electronic annotation. Source: InterPro malate dehydrogenase (oxaloacetate-decarboxylating) activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8TBJ0 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: 43E75A34F19BC0A4	FASTA	604	66,925
	10 20 30 40 50 60 MGAALGTGTR LAPWPGRACG ALPRWTPTAP AQGCHSKPGP ARPVPLKKRG YDVTRNPHLN 70 80 90 100 110 120 KGMAFTLEER LQLGIHGLIP PCFLGQDVQL LRIMGYYERQ QSDLDKYIIL MTLQDRNEKL 130 140 150 160 170 180 FYRVLTSDVE KFMPIVYTPT VGLACQHYGL TFRRPRGLFI TIHDKGHLAT MLNSWPEDNI 190 200 210 220 230 240 KAVVVTDGER ILGLGDLGCY GMGIPVGKLA LYTACGGVNP QQCLPVLLDV GTNNEELLRD 250 260 270 280 290 300 PLYIGLKHQR VHGKAYDDLL DEFMQAVTDK FGINCLIQFE DFANANAFRL LNKYRNKYCM 310 320 330 340 350 360 FNDDIQGTAS VAVAGILAAL RITNNKLSNH VFVFQGAGEA AMGIAHLLVM ALEKEGVPKA 370 380 390 400 410 420 EATRKIWMVD SKGLIVKGRS HLNHEKEMFA QDHPEVNSLE EVVRLVKPTA IIGVAAIAGA 430 440 450 460 470 480 FTEQILRDMA SFHERPIIFA LSNPTSKAEC TAEKCYRVTE GRGIFASGSP FKSVTLEDGK 490 500 510 520 530 540 TFIPGQGNNA YVFPGVALGV IAGGIRHIPD EIFLLTAEQI AQEVSEQHLS QGRLYPPLST 550 560 570 580 590 600 IRDVSLRIAI KVLDYAYKHN LASYYPEPKD KEAFVRSLVY TPDYDSFTLD SYTWPKEAMN VQTV

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain EMBL AAH22472.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC022472 mRNA. Translation: AAH22472.1.
IPI	IPI00003970.
RefSeq	NP_001014811.1. NM_001014811.1. NP_006671.2. NM_006680.2.
UniGene	Hs.199743.
3D structure databases
HSSP	HSSP built from PDB template 1GQ2 based on UniProtKB P40927.
ProteinModelPortal	Q8TBJ0.
SMR	Q8TBJ0. Positions 48-602.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8TBJ0.
Proteomic databases
PRIDE	Q8TBJ0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	10873.
KEGG	hsa:10873.
Organism-specific databases
CTD	10873.
Phylogenomic databases
GeneTree	ENSGT00390000000754.
HOVERGEN	HBG000746.
Gene expression databases
ArrayExpress	Q8TBJ0.
Family and domain databases
InterPro	IPR015884. Malic_enzyme_CS. IPR012301. Malic_N. IPR012302. Malic_NAD-bd. IPR001891. Malic_OxRdtase. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.10380. G3DSA:3.40.50.10380. 1 hit. G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00029.
Pfam	PF00390. malic. 1 hit. PF03949. Malic_M. 1 hit. [Graphical view]
PIRSF	PIRSF000106. ME. 1 hit.
PRINTS	PR00072. MALOXRDTASE.
SMART	SM00919. Malic_M. 1 hit. [Graphical view]
PROSITE	PS00331. MALIC_ENZYMES. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	41285.

Entry information

Entry name

Q8TBJ0_HUMAN

Accession

Primary (citable) accession number: Q8TBJ0

Entry history

Integrated into UniProtKB/TrEMBL:	June 1, 2002
Last sequence update:	June 1, 2002
Last modified:	November 16, 2011
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.