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Protein

Arrestin domain-containing protein 2

Gene

ARRDC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Arrestin domain-containing protein 2
Gene namesi
Name:ARRDC2
ORF Names:PP2703
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000105643.9
HGNCiHGNC:25225 ARRDC2
neXtProtiNX_Q8TBH0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000105643
PharmGKBiPA134945141

Polymorphism and mutation databases

BioMutaiARRDC2
DMDMi109940307

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002443471 – 407Arrestin domain-containing protein 2Add BLAST407

Proteomic databases

EPDiQ8TBH0
PaxDbiQ8TBH0
PeptideAtlasiQ8TBH0
PRIDEiQ8TBH0

PTM databases

iPTMnetiQ8TBH0
PhosphoSitePlusiQ8TBH0

Expressioni

Gene expression databases

BgeeiENSG00000105643
CleanExiHS_ARRDC2
ExpressionAtlasiQ8TBH0 baseline and differential
GenevisibleiQ8TBH0 HS

Organism-specific databases

HPAiHPA053788

Interactioni

Subunit structurei

Interacts with WWP1 (via WW domains).1 Publication

Protein-protein interaction databases

BioGridi118004, 1 interactor
IntActiQ8TBH0, 2 interactors
STRINGi9606.ENSP00000222250

Structurei

3D structure databases

ProteinModelPortaliQ8TBH0
SMRiQ8TBH0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the arrestin family.Curated

Phylogenomic databases

eggNOGiKOG3780 Eukaryota
ENOG41102NY LUCA
GeneTreeiENSGT00550000074356
HOGENOMiHOG000237328
HOVERGENiHBG066469
InParanoidiQ8TBH0
OMAiPGRHEFP
OrthoDBiEOG091G0B0Y
PhylomeDBiQ8TBH0
TreeFamiTF313650

Family and domain databases

Gene3Di2.60.40.640, 2 hits
InterProiView protein in InterPro
IPR011021 Arrestin-like_N
IPR014752 Arrestin_C
IPR011022 Arrestin_C-like
IPR014756 Ig_E-set
PfamiView protein in Pfam
PF02752 Arrestin_C, 1 hit
PF00339 Arrestin_N, 1 hit
SMARTiView protein in SMART
SM01017 Arrestin_C, 1 hit
SUPFAMiSSF81296 SSF81296, 2 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TBH0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLFDKVKAFS VQLDGATAGV EPVFSGGQAV AGRVLLELSS AARVGALRLR
60 70 80 90 100
ARGRAHVHWT ESRSAGSSTA YTQSYSERVE VVSHRATLLA PDTGETTTLP
110 120 130 140 150
PGRHEFLFSF QLPPTLVTSF EGKHGSVRYC IKATLHRPWV PARRARKVFT
160 170 180 190 200
VIEPVDINTP ALLAPQAGAR EKVARSWYCN RGLVSLSAKI DRKGYTPGEV
210 220 230 240 250
IPVFAEIDNG STRPVLPRAA VVQTQTFMAR GARKQKRAVV ASLAGEPVGP
260 270 280 290 300
GQRALWQGRA LRIPPVGPSI LHCRVLHVDY ALKVCVDIPG TSKLLLELPL
310 320 330 340 350
VIGTIPLHPF GSRSSSVGSH ASFLLDWRLG ALPERPEAPP EYSEVVADTE
360 370 380 390 400
EAALGQSPFP LPQDPDMSLE GPFFAYIQEF RYRPPPLYSE EDPNPLLGDM

RPRCMTC
Length:407
Mass (Da):44,379
Last modified:June 27, 2006 - v2
Checksum:iAC11194410C31BD8
GO
Isoform 2 (identifier: Q8TBH0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-91: MLFDKVKAFS...VSHRATLLAP → MRSGGVRSFA...YLRRRQLLLR

Show »
Length:402
Mass (Da):43,947
Checksum:i2795FAE9335D5ABF
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_026895181R → H1 PublicationCorresponds to variant dbSNP:rs17852061Ensembl.1
Natural variantiVAR_026896192R → H1 PublicationCorresponds to variant dbSNP:rs17852062Ensembl.1
Natural variantiVAR_026897244A → T. Corresponds to variant dbSNP:rs8110271Ensembl.1
Natural variantiVAR_026898396L → P1 PublicationCorresponds to variant dbSNP:rs7259041Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0195441 – 91MLFDK…TLLAP → MRSGGVRSFALELARGPGGA YRGGERLCGRVLLEAAAPLR VRALEVKARGGAATHWLEGR SVGVNAVSSDYAAAETYLRR RQLLLR in isoform 2. 1 PublicationAdd BLAST91

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK127940 mRNA Translation: BAC87200.1
AK314657 mRNA Translation: BAG37216.1
AF193051 mRNA Translation: AAG22479.1
CH471106 Genomic DNA Translation: EAW84650.1
BC022516 mRNA Translation: AAH22516.1
AF131826 mRNA Translation: AAD20053.1
CCDSiCCDS12370.1 [Q8TBH0-1]
CCDS32956.1 [Q8TBH0-2]
RefSeqiNP_001020775.1, NM_001025604.2 [Q8TBH0-2]
NP_001273755.1, NM_001286826.1
NP_056498.1, NM_015683.1 [Q8TBH0-1]
UniGeneiHs.515249

Genome annotation databases

EnsembliENST00000222250; ENSP00000222250; ENSG00000105643 [Q8TBH0-1]
ENST00000379656; ENSP00000368977; ENSG00000105643 [Q8TBH0-2]
GeneIDi27106
KEGGihsa:27106
UCSCiuc002nhu.4 human [Q8TBH0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiARRD2_HUMAN
AccessioniPrimary (citable) accession number: Q8TBH0
Secondary accession number(s): B2RBG9
, O95895, Q6ZRV9, Q8WYG6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: March 28, 2018
This is version 111 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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