Q8TBH0 (ARRD2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Arrestin domain-containing protein 2

Gene names

Name:	ARRDC2
ORF Names:	PP2703

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	407 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the arrestin family.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8TBH0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8TBH0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-91: MLFDKVKAFS...VSHRATLLAP → MRSGGVRSFA...YLRRRQLLLR

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 407	407	Arrestin domain-containing protein 2		PRO_0000244347
Natural variations
	Alternative sequence	1 – 91	91	MLFDK…TLLAP → MRSGGVRSFALELARGPGGA YRGGERLCGRVLLEAAAPLR VRALEVKARGGAATHWLEGR SVGVNAVSSDYAAAETYLRR RQLLLR in isoform 2.		VSP_019544
	Natural variant	181	1	R → H. Ref.4 Corresponds to variant rs17852061 [ dbSNP | Ensembl ].		VAR_026895
	Natural variant	192	1	R → H. Ref.4 Corresponds to variant rs17852062 [ dbSNP | Ensembl ].		VAR_026896
	Natural variant	244	1	A → T. Corresponds to variant rs8110271 [ dbSNP | Ensembl ].		VAR_026897
	Natural variant	396	1	L → P. Ref.4 Corresponds to variant rs7259041 [ dbSNP | Ensembl ].		VAR_026898

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 27, 2006. Version 2. Checksum: AC11194410C31BD8	FASTA	407	44,379
	10 20 30 40 50 60 MLFDKVKAFS VQLDGATAGV EPVFSGGQAV AGRVLLELSS AARVGALRLR ARGRAHVHWT 70 80 90 100 110 120 ESRSAGSSTA YTQSYSERVE VVSHRATLLA PDTGETTTLP PGRHEFLFSF QLPPTLVTSF 130 140 150 160 170 180 EGKHGSVRYC IKATLHRPWV PARRARKVFT VIEPVDINTP ALLAPQAGAR EKVARSWYCN 190 200 210 220 230 240 RGLVSLSAKI DRKGYTPGEV IPVFAEIDNG STRPVLPRAA VVQTQTFMAR GARKQKRAVV 250 260 270 280 290 300 ASLAGEPVGP GQRALWQGRA LRIPPVGPSI LHCRVLHVDY ALKVCVDIPG TSKLLLELPL 310 320 330 340 350 360 VIGTIPLHPF GSRSSSVGSH ASFLLDWRLG ALPERPEAPP EYSEVVADTE EAALGQSPFP 370 380 390 400 LPQDPDMSLE GPFFAYIQEF RYRPPPLYSE EDPNPLLGDM RPRCMTC
	Isoform 2 [UniParc]. Checksum: 2795FAE9335D5ABF	FASTA	402	43,947
	10 20 30 40 50 60 MRSGGVRSFA LELARGPGGA YRGGERLCGR VLLEAAAPLR VRALEVKARG GAATHWLEGR 70 80 90 100 110 120 SVGVNAVSSD YAAAETYLRR RQLLLRDTGE TTTLPPGRHE FLFSFQLPPT LVTSFEGKHG 130 140 150 160 170 180 SVRYCIKATL HRPWVPARRA RKVFTVIEPV DINTPALLAP QAGAREKVAR SWYCNRGLVS 190 200 210 220 230 240 LSAKIDRKGY TPGEVIPVFA EIDNGSTRPV LPRAAVVQTQ TFMARGARKQ KRAVVASLAG 250 260 270 280 290 300 EPVGPGQRAL WQGRALRIPP VGPSILHCRV LHVDYALKVC VDIPGTSKLL LELPLVIGTI 310 320 330 340 350 360 PLHPFGSRSS SVGSHASFLL DWRLGALPER PEAPPEYSEV VADTEEAALG QSPFPLPQDP 370 380 390 400 DMSLEGPFFA YIQEFRYRPP PLYSEEDPNP LLGDMRPRCM TC

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Synovial cell and Tongue.
[2]	"Large-scale cDNA transfection screening for genes related to cancer development and progression." Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X. , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J. Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed: 15498874] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS HIS-181; HIS-192 AND PRO-396. Tissue: Brain.
[5]	Mei G., Yu W., Gibbs R.A. Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 110-407. Tissue: Brain.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK127940 mRNA. Translation: BAC87200.1. AK314657 mRNA. Translation: BAG37216.1. AF193051 mRNA. Translation: AAG22479.1. CH471106 Genomic DNA. Translation: EAW84650.1. BC022516 mRNA. Translation: AAH22516.1. AF131826 mRNA. Translation: AAD20053.1.
IPI	IPI00328155. IPI00619906.
RefSeq	NP_001020775.1. NM_001025604.1. NP_056498.1. NM_015683.1.
UniGene	Hs.515249.
3D structure databases
ProteinModelPortal	Q8TBH0.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8TBH0.
PTM databases
PhosphoSite	Q8TBH0.
Polymorphism databases
DMDM	109940307.
Proteomic databases
PRIDE	Q8TBH0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000222250; ENSP00000222250; ENSG00000105643.
GeneID	27106.
KEGG	hsa:27106.
UCSC	uc002nhu.1. human. uc002nhv.1. human.
Organism-specific databases
CTD	27106.
GeneCards	GC19P018111.
HGNC	HGNC:25225. ARRDC2.
neXtProt	NX_Q8TBH0.
PharmGKB	PA134945141.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG12127.
GeneTree	ENSGT00550000074356.
HOGENOM	HBG714698.
HOVERGEN	HBG066469.
InParanoid	Q8TBH0.
OMA	YTQSYSE.
PhylomeDB	Q8TBH0.
Gene expression databases
ArrayExpress	Q8TBH0.
Bgee	Q8TBH0.
CleanEx	HS_ARRDC2.
Genevestigator	Q8TBH0.
GermOnline	ENSG00000105643. Homo sapiens.
Family and domain databases
InterPro	IPR011021. Arrestin-like_N. IPR011022. Arrestin_C-like. IPR014756. Ig_E-set. [Graphical view]
Pfam	PF02752. Arrestin_C. 1 hit. PF00339. Arrestin_N. 1 hit. [Graphical view]
SMART	SM01017. Arrestin_C. 1 hit. [Graphical view]
SUPFAM	SSF81296. Ig_E-set. 2 hits.
ProtoNet	Search...
Other
NextBio	49768.

Entry information

Entry name

ARRD2_HUMAN

Accession

Primary (citable) accession number: Q8TBH0
Secondary accession number(s): B2RBG9 , O95895, Q6ZRV9, Q8WYG6

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	June 27, 2006
Last modified:	January 25, 2012
This is version 67 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.