Reviewed, UniProtKB/Swiss-Prot Q8TBH0 (ARRD2_HUMAN)

Names and origin

Protein names

Recommended name:
    Arrestin domain-containing protein 2

Gene names

Name:	ARRDC2
ORF Names:	PP2703

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	407 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Sequence similarities

Belongs to the arrestin family.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Technical term	Complete proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8TBH0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8TBH0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-91: MLFDKVKAFS...VSHRATLLAP → MRSGGVRSFA...YLRRRQLLLR

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 407	407	Arrestin domain-containing protein 2		PRO_0000244347
Natural variations
	Alternative sequence	1 – 91	91	MLFDK…TLLAP → MRSGGVRSFALELARGPGGA YRGGERLCGRVLLEAAAPLR VRALEVKARGGAATHWLEGR SVGVNAVSSDYAAAETYLRR RQLLLR in isoform 2.		VSP_019544
	Natural variant	181	1	R → H: dbSNP rs17852061. Ref.4		VAR_026895
	Natural variant	192	1	R → H: dbSNP rs17852062. Ref.4		VAR_026896
	Natural variant	244	1	A → T: dbSNP rs8110271.		VAR_026897
	Natural variant	396	1	L → P: dbSNP rs7259041. Ref.4		VAR_026898

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 27, 2006. Version 2. Checksum: AC11194410C31BD8	FASTA	407	44,379
	10 20 30 40 50 60 MLFDKVKAFS VQLDGATAGV EPVFSGGQAV AGRVLLELSS AARVGALRLR ARGRAHVHWT 70 80 90 100 110 120 ESRSAGSSTA YTQSYSERVE VVSHRATLLA PDTGETTTLP PGRHEFLFSF QLPPTLVTSF 130 140 150 160 170 180 EGKHGSVRYC IKATLHRPWV PARRARKVFT VIEPVDINTP ALLAPQAGAR EKVARSWYCN 190 200 210 220 230 240 RGLVSLSAKI DRKGYTPGEV IPVFAEIDNG STRPVLPRAA VVQTQTFMAR GARKQKRAVV 250 260 270 280 290 300 ASLAGEPVGP GQRALWQGRA LRIPPVGPSI LHCRVLHVDY ALKVCVDIPG TSKLLLELPL 310 320 330 340 350 360 VIGTIPLHPF GSRSSSVGSH ASFLLDWRLG ALPERPEAPP EYSEVVADTE EAALGQSPFP 370 380 390 400 LPQDPDMSLE GPFFAYIQEF RYRPPPLYSE EDPNPLLGDM RPRCMTC
	Isoform 2. Checksum: 2795FAE9335D5ABF	FASTA	402	43,947
	10 20 30 40 50 60 MRSGGVRSFA LELARGPGGA YRGGERLCGR VLLEAAAPLR VRALEVKARG GAATHWLEGR 70 80 90 100 110 120 SVGVNAVSSD YAAAETYLRR RQLLLRDTGE TTTLPPGRHE FLFSFQLPPT LVTSFEGKHG 130 140 150 160 170 180 SVRYCIKATL HRPWVPARRA RKVFTVIEPV DINTPALLAP QAGAREKVAR SWYCNRGLVS 190 200 210 220 230 240 LSAKIDRKGY TPGEVIPVFA EIDNGSTRPV LPRAAVVQTQ TFMARGARKQ KRAVVASLAG 250 260 270 280 290 300 EPVGPGQRAL WQGRALRIPP VGPSILHCRV LHVDYALKVC VDIPGTSKLL LELPLVIGTI 310 320 330 340 350 360 PLHPFGSRSS SVGSHASFLL DWRLGALPER PEAPPEYSEV VADTEEAALG QSPFPLPQDP 370 380 390 400 DMSLEGPFFA YIQEFRYRPP PLYSEEDPNP LLGDMRPRCM TC

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Synovial cell and Tongue.
[2]	"Large-scale cDNA transfection screening for genes related to cancer development and progression." Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X. , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J. Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed: 15498874] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS HIS-181; HIS-192 AND PRO-396. Tissue: Brain.
[5]	Mei G., Yu W., Gibbs R.A. Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 110-407. Tissue: Brain.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AK127940 mRNA. Translation: BAC87200.1. AK314657 mRNA. Translation: BAG37216.1. AF193051 mRNA. Translation: AAG22479.1. CH471106 Genomic DNA. Translation: EAW84650.1. BC022516 mRNA. Translation: AAH22516.1. AF131826 mRNA. Translation: AAD20053.1.
IPI	IPI00328155. IPI00619906.
RefSeq	NP_001020775.1. NP_056498.1.
UniGene	Hs.515249
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	Q8TBH0.
Genome annotation databases
Ensembl	ENST00000222250; ENSP00000222250; ENSG00000105643; Homo sapiens. [Genome view]
GeneID	27106.
KEGG	hsa:27106.
UCSC	uc002nhu.1. human. uc002nhv.1. human.
Organism-specific databases
CTD	27106.
GeneCards	GC19P017979.
HGNC	HGNC:25225. ARRDC2.
PharmGKB	PA134945141.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q8TBH0.
HOVERGEN	Q8TBH0.
Gene expression databases
ArrayExpress	Q8TBH0.
Bgee	Q8TBH0.
CleanEx	HS_ARRDC2.
Genevestigator	Q8TBH0.
GermOnline	ENSG00000105643. Homo sapiens.
Family and domain databases
InterPro	IPR011022. Arrestin-like_C. IPR011021. Arrestin-like_N. IPR014756. Ig_E-set. [Graphical view]
Pfam	PF02752. Arrestin_C. 1 hit. PF00339. Arrestin_N. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	49768.

Entry information

Entry name

ARRD2_HUMAN

Accession

Primary (citable) accession number: Q8TBH0
Secondary accession number(s): B2RBG9 , O95895, Q6ZRV9, Q8WYG6

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	June 27, 2006
Last modified:	November 24, 2009
This is version 51 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.