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Protein

Arrestin domain-containing protein 2

Gene

ARRDC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Arrestin domain-containing protein 2
Gene namesi
Name:ARRDC2
ORF Names:PP2703
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:25225. ARRDC2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasmic vesicle Source: MGI
  • plasma membrane Source: MGI
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000105643.
PharmGKBiPA134945141.

Polymorphism and mutation databases

BioMutaiARRDC2.
DMDMi109940307.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002443471 – 407Arrestin domain-containing protein 2Add BLAST407

Proteomic databases

EPDiQ8TBH0.
PaxDbiQ8TBH0.
PRIDEiQ8TBH0.

PTM databases

iPTMnetiQ8TBH0.
PhosphoSitePlusiQ8TBH0.

Expressioni

Gene expression databases

BgeeiENSG00000105643.
CleanExiHS_ARRDC2.
ExpressionAtlasiQ8TBH0. baseline and differential.
GenevisibleiQ8TBH0. HS.

Organism-specific databases

HPAiHPA053788.

Interactioni

Protein-protein interaction databases

BioGridi118004. 1 interactor.
IntActiQ8TBH0. 2 interactors.
STRINGi9606.ENSP00000222250.

Structurei

3D structure databases

ProteinModelPortaliQ8TBH0.
SMRiQ8TBH0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the arrestin family.Curated

Phylogenomic databases

eggNOGiKOG3780. Eukaryota.
ENOG41102NY. LUCA.
GeneTreeiENSGT00550000074356.
HOGENOMiHOG000237328.
HOVERGENiHBG066469.
InParanoidiQ8TBH0.
OMAiARRPRCM.
OrthoDBiEOG091G0B0Y.
PhylomeDBiQ8TBH0.
TreeFamiTF313650.

Family and domain databases

Gene3Di2.60.40.640. 1 hit.
InterProiIPR011021. Arrestin-like_N.
IPR014752. Arrestin_C.
IPR011022. Arrestin_C-like.
IPR014756. Ig_E-set.
[Graphical view]
PfamiPF02752. Arrestin_C. 1 hit.
PF00339. Arrestin_N. 1 hit.
[Graphical view]
SMARTiSM01017. Arrestin_C. 1 hit.
[Graphical view]
SUPFAMiSSF81296. SSF81296. 2 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TBH0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLFDKVKAFS VQLDGATAGV EPVFSGGQAV AGRVLLELSS AARVGALRLR
60 70 80 90 100
ARGRAHVHWT ESRSAGSSTA YTQSYSERVE VVSHRATLLA PDTGETTTLP
110 120 130 140 150
PGRHEFLFSF QLPPTLVTSF EGKHGSVRYC IKATLHRPWV PARRARKVFT
160 170 180 190 200
VIEPVDINTP ALLAPQAGAR EKVARSWYCN RGLVSLSAKI DRKGYTPGEV
210 220 230 240 250
IPVFAEIDNG STRPVLPRAA VVQTQTFMAR GARKQKRAVV ASLAGEPVGP
260 270 280 290 300
GQRALWQGRA LRIPPVGPSI LHCRVLHVDY ALKVCVDIPG TSKLLLELPL
310 320 330 340 350
VIGTIPLHPF GSRSSSVGSH ASFLLDWRLG ALPERPEAPP EYSEVVADTE
360 370 380 390 400
EAALGQSPFP LPQDPDMSLE GPFFAYIQEF RYRPPPLYSE EDPNPLLGDM

RPRCMTC
Length:407
Mass (Da):44,379
Last modified:June 27, 2006 - v2
Checksum:iAC11194410C31BD8
GO
Isoform 2 (identifier: Q8TBH0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-91: MLFDKVKAFS...VSHRATLLAP → MRSGGVRSFA...YLRRRQLLLR

Show »
Length:402
Mass (Da):43,947
Checksum:i2795FAE9335D5ABF
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_026895181R → H.1 PublicationCorresponds to variant rs17852061dbSNPEnsembl.1
Natural variantiVAR_026896192R → H.1 PublicationCorresponds to variant rs17852062dbSNPEnsembl.1
Natural variantiVAR_026897244A → T.Corresponds to variant rs8110271dbSNPEnsembl.1
Natural variantiVAR_026898396L → P.1 PublicationCorresponds to variant rs7259041dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0195441 – 91MLFDK…TLLAP → MRSGGVRSFALELARGPGGA YRGGERLCGRVLLEAAAPLR VRALEVKARGGAATHWLEGR SVGVNAVSSDYAAAETYLRR RQLLLR in isoform 2. 1 PublicationAdd BLAST91

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK127940 mRNA. Translation: BAC87200.1.
AK314657 mRNA. Translation: BAG37216.1.
AF193051 mRNA. Translation: AAG22479.1.
CH471106 Genomic DNA. Translation: EAW84650.1.
BC022516 mRNA. Translation: AAH22516.1.
AF131826 mRNA. Translation: AAD20053.1.
CCDSiCCDS12370.1. [Q8TBH0-1]
CCDS32956.1. [Q8TBH0-2]
RefSeqiNP_001020775.1. NM_001025604.2. [Q8TBH0-2]
NP_001273755.1. NM_001286826.1.
NP_056498.1. NM_015683.1. [Q8TBH0-1]
UniGeneiHs.515249.

Genome annotation databases

EnsembliENST00000222250; ENSP00000222250; ENSG00000105643. [Q8TBH0-1]
ENST00000379656; ENSP00000368977; ENSG00000105643. [Q8TBH0-2]
GeneIDi27106.
KEGGihsa:27106.
UCSCiuc002nhu.4. human. [Q8TBH0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK127940 mRNA. Translation: BAC87200.1.
AK314657 mRNA. Translation: BAG37216.1.
AF193051 mRNA. Translation: AAG22479.1.
CH471106 Genomic DNA. Translation: EAW84650.1.
BC022516 mRNA. Translation: AAH22516.1.
AF131826 mRNA. Translation: AAD20053.1.
CCDSiCCDS12370.1. [Q8TBH0-1]
CCDS32956.1. [Q8TBH0-2]
RefSeqiNP_001020775.1. NM_001025604.2. [Q8TBH0-2]
NP_001273755.1. NM_001286826.1.
NP_056498.1. NM_015683.1. [Q8TBH0-1]
UniGeneiHs.515249.

3D structure databases

ProteinModelPortaliQ8TBH0.
SMRiQ8TBH0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118004. 1 interactor.
IntActiQ8TBH0. 2 interactors.
STRINGi9606.ENSP00000222250.

PTM databases

iPTMnetiQ8TBH0.
PhosphoSitePlusiQ8TBH0.

Polymorphism and mutation databases

BioMutaiARRDC2.
DMDMi109940307.

Proteomic databases

EPDiQ8TBH0.
PaxDbiQ8TBH0.
PRIDEiQ8TBH0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000222250; ENSP00000222250; ENSG00000105643. [Q8TBH0-1]
ENST00000379656; ENSP00000368977; ENSG00000105643. [Q8TBH0-2]
GeneIDi27106.
KEGGihsa:27106.
UCSCiuc002nhu.4. human. [Q8TBH0-1]

Organism-specific databases

CTDi27106.
GeneCardsiARRDC2.
HGNCiHGNC:25225. ARRDC2.
HPAiHPA053788.
neXtProtiNX_Q8TBH0.
OpenTargetsiENSG00000105643.
PharmGKBiPA134945141.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3780. Eukaryota.
ENOG41102NY. LUCA.
GeneTreeiENSGT00550000074356.
HOGENOMiHOG000237328.
HOVERGENiHBG066469.
InParanoidiQ8TBH0.
OMAiARRPRCM.
OrthoDBiEOG091G0B0Y.
PhylomeDBiQ8TBH0.
TreeFamiTF313650.

Miscellaneous databases

ChiTaRSiARRDC2. human.
GenomeRNAii27106.
PROiQ8TBH0.

Gene expression databases

BgeeiENSG00000105643.
CleanExiHS_ARRDC2.
ExpressionAtlasiQ8TBH0. baseline and differential.
GenevisibleiQ8TBH0. HS.

Family and domain databases

Gene3Di2.60.40.640. 1 hit.
InterProiIPR011021. Arrestin-like_N.
IPR014752. Arrestin_C.
IPR011022. Arrestin_C-like.
IPR014756. Ig_E-set.
[Graphical view]
PfamiPF02752. Arrestin_C. 1 hit.
PF00339. Arrestin_N. 1 hit.
[Graphical view]
SMARTiSM01017. Arrestin_C. 1 hit.
[Graphical view]
SUPFAMiSSF81296. SSF81296. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiARRD2_HUMAN
AccessioniPrimary (citable) accession number: Q8TBH0
Secondary accession number(s): B2RBG9
, O95895, Q6ZRV9, Q8WYG6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: November 30, 2016
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.