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Protein

Arrestin domain-containing protein 2

Gene

ARRDC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Arrestin domain-containing protein 2
Gene namesi
Name:ARRDC2
ORF Names:PP2703
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:25225. ARRDC2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasmic vesicle Source: MGI
  • plasma membrane Source: MGI
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134945141.

Polymorphism and mutation databases

BioMutaiARRDC2.
DMDMi109940307.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 407407Arrestin domain-containing protein 2PRO_0000244347Add
BLAST

Proteomic databases

EPDiQ8TBH0.
PaxDbiQ8TBH0.
PRIDEiQ8TBH0.

PTM databases

iPTMnetiQ8TBH0.
PhosphoSiteiQ8TBH0.

Expressioni

Gene expression databases

BgeeiQ8TBH0.
CleanExiHS_ARRDC2.
ExpressionAtlasiQ8TBH0. baseline and differential.
GenevisibleiQ8TBH0. HS.

Organism-specific databases

HPAiHPA053788.

Interactioni

Protein-protein interaction databases

BioGridi118004. 1 interaction.
STRINGi9606.ENSP00000222250.

Structurei

3D structure databases

ProteinModelPortaliQ8TBH0.
SMRiQ8TBH0. Positions 5-304.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the arrestin family.Curated

Phylogenomic databases

eggNOGiKOG3780. Eukaryota.
ENOG41102NY. LUCA.
GeneTreeiENSGT00550000074356.
HOGENOMiHOG000237328.
HOVERGENiHBG066469.
InParanoidiQ8TBH0.
OMAiNCERIVF.
OrthoDBiEOG7P02HT.
PhylomeDBiQ8TBH0.
TreeFamiTF313650.

Family and domain databases

Gene3Di2.60.40.640. 1 hit.
InterProiIPR011021. Arrestin-like_N.
IPR014752. Arrestin_C.
IPR011022. Arrestin_C-like.
IPR014756. Ig_E-set.
[Graphical view]
PfamiPF02752. Arrestin_C. 1 hit.
PF00339. Arrestin_N. 1 hit.
[Graphical view]
SMARTiSM01017. Arrestin_C. 1 hit.
[Graphical view]
SUPFAMiSSF81296. SSF81296. 2 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TBH0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLFDKVKAFS VQLDGATAGV EPVFSGGQAV AGRVLLELSS AARVGALRLR
60 70 80 90 100
ARGRAHVHWT ESRSAGSSTA YTQSYSERVE VVSHRATLLA PDTGETTTLP
110 120 130 140 150
PGRHEFLFSF QLPPTLVTSF EGKHGSVRYC IKATLHRPWV PARRARKVFT
160 170 180 190 200
VIEPVDINTP ALLAPQAGAR EKVARSWYCN RGLVSLSAKI DRKGYTPGEV
210 220 230 240 250
IPVFAEIDNG STRPVLPRAA VVQTQTFMAR GARKQKRAVV ASLAGEPVGP
260 270 280 290 300
GQRALWQGRA LRIPPVGPSI LHCRVLHVDY ALKVCVDIPG TSKLLLELPL
310 320 330 340 350
VIGTIPLHPF GSRSSSVGSH ASFLLDWRLG ALPERPEAPP EYSEVVADTE
360 370 380 390 400
EAALGQSPFP LPQDPDMSLE GPFFAYIQEF RYRPPPLYSE EDPNPLLGDM

RPRCMTC
Length:407
Mass (Da):44,379
Last modified:June 27, 2006 - v2
Checksum:iAC11194410C31BD8
GO
Isoform 2 (identifier: Q8TBH0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-91: MLFDKVKAFS...VSHRATLLAP → MRSGGVRSFA...YLRRRQLLLR

Show »
Length:402
Mass (Da):43,947
Checksum:i2795FAE9335D5ABF
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti181 – 1811R → H.1 Publication
Corresponds to variant rs17852061 [ dbSNP | Ensembl ].
VAR_026895
Natural varianti192 – 1921R → H.1 Publication
Corresponds to variant rs17852062 [ dbSNP | Ensembl ].
VAR_026896
Natural varianti244 – 2441A → T.
Corresponds to variant rs8110271 [ dbSNP | Ensembl ].
VAR_026897
Natural varianti396 – 3961L → P.1 Publication
Corresponds to variant rs7259041 [ dbSNP | Ensembl ].
VAR_026898

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 9191MLFDK…TLLAP → MRSGGVRSFALELARGPGGA YRGGERLCGRVLLEAAAPLR VRALEVKARGGAATHWLEGR SVGVNAVSSDYAAAETYLRR RQLLLR in isoform 2. 1 PublicationVSP_019544Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK127940 mRNA. Translation: BAC87200.1.
AK314657 mRNA. Translation: BAG37216.1.
AF193051 mRNA. Translation: AAG22479.1.
CH471106 Genomic DNA. Translation: EAW84650.1.
BC022516 mRNA. Translation: AAH22516.1.
AF131826 mRNA. Translation: AAD20053.1.
CCDSiCCDS12370.1. [Q8TBH0-1]
CCDS32956.1. [Q8TBH0-2]
RefSeqiNP_001020775.1. NM_001025604.2. [Q8TBH0-2]
NP_001273755.1. NM_001286826.1.
NP_056498.1. NM_015683.1. [Q8TBH0-1]
UniGeneiHs.515249.

Genome annotation databases

EnsembliENST00000222250; ENSP00000222250; ENSG00000105643. [Q8TBH0-1]
ENST00000379656; ENSP00000368977; ENSG00000105643. [Q8TBH0-2]
GeneIDi27106.
KEGGihsa:27106.
UCSCiuc002nhu.4. human. [Q8TBH0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK127940 mRNA. Translation: BAC87200.1.
AK314657 mRNA. Translation: BAG37216.1.
AF193051 mRNA. Translation: AAG22479.1.
CH471106 Genomic DNA. Translation: EAW84650.1.
BC022516 mRNA. Translation: AAH22516.1.
AF131826 mRNA. Translation: AAD20053.1.
CCDSiCCDS12370.1. [Q8TBH0-1]
CCDS32956.1. [Q8TBH0-2]
RefSeqiNP_001020775.1. NM_001025604.2. [Q8TBH0-2]
NP_001273755.1. NM_001286826.1.
NP_056498.1. NM_015683.1. [Q8TBH0-1]
UniGeneiHs.515249.

3D structure databases

ProteinModelPortaliQ8TBH0.
SMRiQ8TBH0. Positions 5-304.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118004. 1 interaction.
STRINGi9606.ENSP00000222250.

PTM databases

iPTMnetiQ8TBH0.
PhosphoSiteiQ8TBH0.

Polymorphism and mutation databases

BioMutaiARRDC2.
DMDMi109940307.

Proteomic databases

EPDiQ8TBH0.
PaxDbiQ8TBH0.
PRIDEiQ8TBH0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000222250; ENSP00000222250; ENSG00000105643. [Q8TBH0-1]
ENST00000379656; ENSP00000368977; ENSG00000105643. [Q8TBH0-2]
GeneIDi27106.
KEGGihsa:27106.
UCSCiuc002nhu.4. human. [Q8TBH0-1]

Organism-specific databases

CTDi27106.
GeneCardsiARRDC2.
HGNCiHGNC:25225. ARRDC2.
HPAiHPA053788.
neXtProtiNX_Q8TBH0.
PharmGKBiPA134945141.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3780. Eukaryota.
ENOG41102NY. LUCA.
GeneTreeiENSGT00550000074356.
HOGENOMiHOG000237328.
HOVERGENiHBG066469.
InParanoidiQ8TBH0.
OMAiNCERIVF.
OrthoDBiEOG7P02HT.
PhylomeDBiQ8TBH0.
TreeFamiTF313650.

Miscellaneous databases

ChiTaRSiARRDC2. human.
GenomeRNAii27106.
PROiQ8TBH0.

Gene expression databases

BgeeiQ8TBH0.
CleanExiHS_ARRDC2.
ExpressionAtlasiQ8TBH0. baseline and differential.
GenevisibleiQ8TBH0. HS.

Family and domain databases

Gene3Di2.60.40.640. 1 hit.
InterProiIPR011021. Arrestin-like_N.
IPR014752. Arrestin_C.
IPR011022. Arrestin_C-like.
IPR014756. Ig_E-set.
[Graphical view]
PfamiPF02752. Arrestin_C. 1 hit.
PF00339. Arrestin_N. 1 hit.
[Graphical view]
SMARTiSM01017. Arrestin_C. 1 hit.
[Graphical view]
SUPFAMiSSF81296. SSF81296. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Synovial cell and Tongue.
  2. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
    Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
    , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
    Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS HIS-181; HIS-192 AND PRO-396.
    Tissue: Brain.
  5. Mei G., Yu W., Gibbs R.A.
    Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 110-407.
    Tissue: Brain.

Entry informationi

Entry nameiARRD2_HUMAN
AccessioniPrimary (citable) accession number: Q8TBH0
Secondary accession number(s): B2RBG9
, O95895, Q6ZRV9, Q8WYG6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: June 8, 2016
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.