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Protein

Synaptoporin

Gene

SYNPR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Intrinsic membrane protein of small synaptic vesicles. Probable vesicular channel protein (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptoporin
Gene namesi
Name:SYNPR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:16507. SYNPR.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 44CytoplasmicSequence analysis
Transmembranei5 – 2521HelicalSequence analysisAdd
BLAST
Topological domaini26 – 8156VesicularSequence analysisAdd
BLAST
Transmembranei82 – 10221HelicalSequence analysisAdd
BLAST
Topological domaini103 – 11412CytoplasmicSequence analysisAdd
BLAST
Transmembranei115 – 13521HelicalSequence analysisAdd
BLAST
Topological domaini136 – 17742VesicularSequence analysisAdd
BLAST
Transmembranei178 – 19821HelicalSequence analysisAdd
BLAST
Topological domaini199 – 26567CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse, Synaptosome

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38154.

Polymorphism and mutation databases

BioMutaiSYNPR.
DMDMi48474879.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 265265SynaptoporinPRO_0000179157Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi33 – 331N-linked (GlcNAc...)Sequence analysis
Glycosylationi38 – 381N-linked (GlcNAc...)Sequence analysis
Modified residuei212 – 2121PhosphoserineBy similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ8TBG9.
PRIDEiQ8TBG9.

PTM databases

iPTMnetiQ8TBG9.
PhosphoSiteiQ8TBG9.

Expressioni

Gene expression databases

BgeeiQ8TBG9.
CleanExiHS_SYNPR.
ExpressionAtlasiQ8TBG9. baseline and differential.
GenevisibleiQ8TBG9. HS.

Organism-specific databases

HPAiHPA051368.
HPA061671.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
FATE1Q969F03EBI-10273251,EBI-743099

Protein-protein interaction databases

BioGridi126311. 2 interactions.
IntActiQ8TBG9. 1 interaction.
MINTiMINT-4724528.
STRINGi9606.ENSP00000418994.

Structurei

3D structure databases

ProteinModelPortaliQ8TBG9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 202202MARVELPROSITE-ProRule annotationAdd
BLAST
Repeati210 – 21451
Repeati222 – 22652
Repeati227 – 23153
Repeati232 – 23654
Repeati238 – 24255

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni210 – 242335 X approximate repeatsAdd
BLAST

Sequence similaritiesi

Belongs to the synaptophysin/synaptobrevin family.Curated
Contains 1 MARVEL domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IDYC. Eukaryota.
ENOG4111J4N. LUCA.
GeneTreeiENSGT00390000010039.
HOGENOMiHOG000252913.
HOVERGENiHBG006681.
InParanoidiQ8TBG9.
OMAiIXVFGFL.
OrthoDBiEOG7WT43S.
PhylomeDBiQ8TBG9.
TreeFamiTF315804.

Family and domain databases

InterProiIPR008253. Marvel.
IPR001285. Synaptophysin/porin.
[Graphical view]
PANTHERiPTHR10306. PTHR10306. 1 hit.
PfamiPF01284. MARVEL. 1 hit.
[Graphical view]
PRINTSiPR00220. SYNAPTOPHYSN.
PROSITEiPS51225. MARVEL. 1 hit.
PS00604. SYNAPTOP. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TBG9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MCMVIFAPLF AIFAFATCGG YSGGLRLSVD CVNKTESNLS IDIAFAYPFR
60 70 80 90 100
LHQVTFEVPT CEGKERQKLA LIGDSSSSAE FFVTVAVFAF LYSLAATVVY
110 120 130 140 150
IFFQNKYREN NRGPLIDFIV TVVFSFLWLV GSSAWAKGLS DVKVATDPKE
160 170 180 190 200
VLLLMSACKQ PSNKCMAIHS PVMSSLNTSV VFGFLNFILW AGNIWFVFKE
210 220 230 240 250
TGWHSSGQRY LSDPMEKHSS SYNQGGYNQD SYGSSSGYSQ QASLGPTSDE
260
FGQQPTGPTS FTNQI
Length:265
Mass (Da):29,166
Last modified:June 1, 2002 - v1
Checksum:i2A9DEC870A70F947
GO
Isoform 2 (identifier: Q8TBG9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-8: MCMVIFAP → MDPVSQLASAGTFRVLKEPLAFLRALEL

Note: No experimental confirmation available.
Show »
Length:285
Mass (Da):31,329
Checksum:i3F251FBBAA1B5B04
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 88MCMVIFAP → MDPVSQLASAGTFRVLKEPL AFLRALEL in isoform 2. 1 PublicationVSP_046199

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF411860 mRNA. Translation: AAN03681.2.
AK312465 mRNA. Translation: BAG35372.1.
AL834457 mRNA. Translation: CAD39117.1.
CR936762 mRNA. No translation available.
AC099056 Genomic DNA. No translation available.
AC099545 Genomic DNA. No translation available.
AC104436 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW65413.1.
CH471055 Genomic DNA. Translation: EAW65414.1.
BC022518 mRNA. Translation: AAH22518.1.
CCDSiCCDS46859.1. [Q8TBG9-2]
CCDS46860.1. [Q8TBG9-1]
RefSeqiNP_001123475.1. NM_001130003.1. [Q8TBG9-2]
NP_653243.1. NM_144642.4. [Q8TBG9-1]
UniGeneiHs.648668.

Genome annotation databases

EnsembliENST00000295894; ENSP00000295894; ENSG00000163630. [Q8TBG9-1]
ENST00000478300; ENSP00000418994; ENSG00000163630. [Q8TBG9-2]
GeneIDi132204.
KEGGihsa:132204.
UCSCiuc003dlp.4. human. [Q8TBG9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF411860 mRNA. Translation: AAN03681.2.
AK312465 mRNA. Translation: BAG35372.1.
AL834457 mRNA. Translation: CAD39117.1.
CR936762 mRNA. No translation available.
AC099056 Genomic DNA. No translation available.
AC099545 Genomic DNA. No translation available.
AC104436 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW65413.1.
CH471055 Genomic DNA. Translation: EAW65414.1.
BC022518 mRNA. Translation: AAH22518.1.
CCDSiCCDS46859.1. [Q8TBG9-2]
CCDS46860.1. [Q8TBG9-1]
RefSeqiNP_001123475.1. NM_001130003.1. [Q8TBG9-2]
NP_653243.1. NM_144642.4. [Q8TBG9-1]
UniGeneiHs.648668.

3D structure databases

ProteinModelPortaliQ8TBG9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126311. 2 interactions.
IntActiQ8TBG9. 1 interaction.
MINTiMINT-4724528.
STRINGi9606.ENSP00000418994.

PTM databases

iPTMnetiQ8TBG9.
PhosphoSiteiQ8TBG9.

Polymorphism and mutation databases

BioMutaiSYNPR.
DMDMi48474879.

Proteomic databases

PaxDbiQ8TBG9.
PRIDEiQ8TBG9.

Protocols and materials databases

DNASUi132204.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295894; ENSP00000295894; ENSG00000163630. [Q8TBG9-1]
ENST00000478300; ENSP00000418994; ENSG00000163630. [Q8TBG9-2]
GeneIDi132204.
KEGGihsa:132204.
UCSCiuc003dlp.4. human. [Q8TBG9-1]

Organism-specific databases

CTDi132204.
GeneCardsiSYNPR.
HGNCiHGNC:16507. SYNPR.
HPAiHPA051368.
HPA061671.
neXtProtiNX_Q8TBG9.
PharmGKBiPA38154.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IDYC. Eukaryota.
ENOG4111J4N. LUCA.
GeneTreeiENSGT00390000010039.
HOGENOMiHOG000252913.
HOVERGENiHBG006681.
InParanoidiQ8TBG9.
OMAiIXVFGFL.
OrthoDBiEOG7WT43S.
PhylomeDBiQ8TBG9.
TreeFamiTF315804.

Miscellaneous databases

ChiTaRSiSYNPR. human.
GeneWikiiSYNPR.
GenomeRNAii132204.
NextBioi83046.
PROiQ8TBG9.

Gene expression databases

BgeeiQ8TBG9.
CleanExiHS_SYNPR.
ExpressionAtlasiQ8TBG9. baseline and differential.
GenevisibleiQ8TBG9. HS.

Family and domain databases

InterProiIPR008253. Marvel.
IPR001285. Synaptophysin/porin.
[Graphical view]
PANTHERiPTHR10306. PTHR10306. 1 hit.
PfamiPF01284. MARVEL. 1 hit.
[Graphical view]
PRINTSiPR00220. SYNAPTOPHYSN.
PROSITEiPS51225. MARVEL. 1 hit.
PS00604. SYNAPTOP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of a novel human synaptophysin-like protein."
    Mao Y., Xie Y., Cheng C.
    Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Hippocampus.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain and Retina.
  4. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.

Entry informationi

Entry nameiSYNPR_HUMAN
AccessioniPrimary (citable) accession number: Q8TBG9
Secondary accession number(s): B2R675, G5E9W4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: June 1, 2002
Last modified: March 16, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.