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Protein

Protein FAM81A

Gene

FAM81A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM81A
Gene namesi
Name:FAM81A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000157470.11.
HGNCiHGNC:28379. FAM81A.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000157470.
PharmGKBiPA142671846.

Polymorphism and mutation databases

BioMutaiFAM81A.
DMDMi341941102.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002651191 – 368Protein FAM81AAdd BLAST368

Proteomic databases

PaxDbiQ8TBF8.
PeptideAtlasiQ8TBF8.
PRIDEiQ8TBF8.

PTM databases

iPTMnetiQ8TBF8.
PhosphoSitePlusiQ8TBF8.

Expressioni

Gene expression databases

BgeeiENSG00000157470.
CleanExiHS_FAM81A.
ExpressionAtlasiQ8TBF8. baseline and differential.
GenevisibleiQ8TBF8. HS.

Organism-specific databases

HPAiHPA001847.
HPA065797.

Interactioni

Protein-protein interaction databases

BioGridi126935. 2 interactors.
IntActiQ8TBF8. 2 interactors.
STRINGi9606.ENSP00000288228.

Structurei

3D structure databases

ProteinModelPortaliQ8TBF8.
SMRiQ8TBF8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili78 – 110Sequence analysisAdd BLAST33
Coiled coili161 – 192Sequence analysisAdd BLAST32
Coiled coili236 – 290Sequence analysisAdd BLAST55

Sequence similaritiesi

Belongs to the FAM81 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IH95. Eukaryota.
ENOG4111JK9. LUCA.
GeneTreeiENSGT00390000004985.
HOGENOMiHOG000112480.
HOVERGENiHBG081513.
InParanoidiQ8TBF8.
OMAiVHGRISK.
OrthoDBiEOG091G0CNY.
PhylomeDBiQ8TBF8.
TreeFamiTF335682.

Family and domain databases

InterProiView protein in InterPro
IPR029619. FAM81.
IPR029622. FAM81A.
PANTHERiPTHR22420. PTHR22420. 1 hit.
PTHR22420:SF6. PTHR22420:SF6. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8TBF8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENMHLRRVR TMPRHSQSLT MAPYSSVSLV EQLEDRILCH EKTTAALVEH
60 70 80 90 100
AFRIKDDIVN SLQKMQNKGG GDRLARLFLE EHIRNITAIV KQLNRDIEVL
110 120 130 140 150
QEQIRARDNI SYGTNSALKT LEMRQLSGLG DLRGRVARCD ASIARLSAEH
160 170 180 190 200
KTTYEGLQHL NKEQQAAKLI LETKIKDAEG QISQLLNRVD LSISEQSTKL
210 220 230 240 250
KMSHRDSNHQ LQLLDTKFKG TVEELSNQIL SARSWLQQEQ ERIEKELLQK
260 270 280 290 300
IDQLSLIVKE NSGASERDME KKLSQMSARL DKIEEGQKKT FDGQRTRQEE
310 320 330 340 350
EKMHGRITKL ELQMNQNIKE MKAEVNAGFT AVYESIGSLR QVLEAKMKLD
360
RDQLQKQIQL MQKPETPM
Length:368
Mass (Da):42,392
Last modified:July 27, 2011 - v3
Checksum:iB4A41A79F5714233
GO

Sequence cautioni

The sequence AAH22537 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti339L → I in AAH22537 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC091748 Genomic DNA. No translation available.
AC092754 Genomic DNA. No translation available.
BC022537 mRNA. Translation: AAH22537.1. Different initiation.
CCDSiCCDS45269.1.
RefSeqiNP_689663.2. NM_152450.2.
XP_006720461.1. XM_006720398.3.
XP_006720462.1. XM_006720399.2.
XP_011519551.1. XM_011521249.2.
XP_011519552.1. XM_011521250.2.
UniGeneiHs.531168.

Genome annotation databases

EnsembliENST00000288228; ENSP00000288228; ENSG00000157470.
GeneIDi145773.
KEGGihsa:145773.
UCSCiuc002agc.3. human.

Similar proteinsi

Entry informationi

Entry nameiFA81A_HUMAN
AccessioniPrimary (citable) accession number: Q8TBF8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: July 27, 2011
Last modified: September 27, 2017
This is version 102 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-4 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families