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Protein

Protein FAM81A

Gene

FAM81A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM81A
Gene namesi
Name:FAM81A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:28379. FAM81A.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671846.

Polymorphism and mutation databases

BioMutaiFAM81A.
DMDMi341941102.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 368368Protein FAM81APRO_0000265119Add
BLAST

Proteomic databases

PaxDbiQ8TBF8.
PRIDEiQ8TBF8.

PTM databases

iPTMnetiQ8TBF8.
PhosphoSiteiQ8TBF8.

Expressioni

Gene expression databases

BgeeiQ8TBF8.
CleanExiHS_FAM81A.
ExpressionAtlasiQ8TBF8. baseline and differential.
GenevisibleiQ8TBF8. HS.

Organism-specific databases

HPAiHPA001847.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000288228.

Structurei

3D structure databases

ProteinModelPortaliQ8TBF8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili78 – 11033Sequence analysisAdd
BLAST
Coiled coili161 – 19232Sequence analysisAdd
BLAST
Coiled coili236 – 29055Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the FAM81 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IH95. Eukaryota.
ENOG4111JK9. LUCA.
GeneTreeiENSGT00390000004985.
HOGENOMiHOG000112480.
HOVERGENiHBG081513.
InParanoidiQ8TBF8.
OMAiIQQMQKP.
PhylomeDBiQ8TBF8.
TreeFamiTF335682.

Family and domain databases

InterProiIPR029619. FAM81.
IPR029622. FAM81A.
[Graphical view]
PANTHERiPTHR22420. PTHR22420. 1 hit.
PTHR22420:SF2. PTHR22420:SF2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8TBF8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENMHLRRVR TMPRHSQSLT MAPYSSVSLV EQLEDRILCH EKTTAALVEH
60 70 80 90 100
AFRIKDDIVN SLQKMQNKGG GDRLARLFLE EHIRNITAIV KQLNRDIEVL
110 120 130 140 150
QEQIRARDNI SYGTNSALKT LEMRQLSGLG DLRGRVARCD ASIARLSAEH
160 170 180 190 200
KTTYEGLQHL NKEQQAAKLI LETKIKDAEG QISQLLNRVD LSISEQSTKL
210 220 230 240 250
KMSHRDSNHQ LQLLDTKFKG TVEELSNQIL SARSWLQQEQ ERIEKELLQK
260 270 280 290 300
IDQLSLIVKE NSGASERDME KKLSQMSARL DKIEEGQKKT FDGQRTRQEE
310 320 330 340 350
EKMHGRITKL ELQMNQNIKE MKAEVNAGFT AVYESIGSLR QVLEAKMKLD
360
RDQLQKQIQL MQKPETPM
Length:368
Mass (Da):42,392
Last modified:July 27, 2011 - v3
Checksum:iB4A41A79F5714233
GO

Sequence cautioni

The sequence AAH22537.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti339 – 3391L → I in AAH22537 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC091748 Genomic DNA. No translation available.
AC092754 Genomic DNA. No translation available.
BC022537 mRNA. Translation: AAH22537.1. Different initiation.
CCDSiCCDS45269.1.
RefSeqiNP_689663.2. NM_152450.2.
XP_006720461.1. XM_006720398.2.
XP_006720462.1. XM_006720399.1.
XP_011519551.1. XM_011521249.1.
XP_011519552.1. XM_011521250.1.
XP_011519553.1. XM_011521251.1.
UniGeneiHs.531168.

Genome annotation databases

EnsembliENST00000288228; ENSP00000288228; ENSG00000157470.
GeneIDi145773.
KEGGihsa:145773.
UCSCiuc002agc.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC091748 Genomic DNA. No translation available.
AC092754 Genomic DNA. No translation available.
BC022537 mRNA. Translation: AAH22537.1. Different initiation.
CCDSiCCDS45269.1.
RefSeqiNP_689663.2. NM_152450.2.
XP_006720461.1. XM_006720398.2.
XP_006720462.1. XM_006720399.1.
XP_011519551.1. XM_011521249.1.
XP_011519552.1. XM_011521250.1.
XP_011519553.1. XM_011521251.1.
UniGeneiHs.531168.

3D structure databases

ProteinModelPortaliQ8TBF8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000288228.

PTM databases

iPTMnetiQ8TBF8.
PhosphoSiteiQ8TBF8.

Polymorphism and mutation databases

BioMutaiFAM81A.
DMDMi341941102.

Proteomic databases

PaxDbiQ8TBF8.
PRIDEiQ8TBF8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000288228; ENSP00000288228; ENSG00000157470.
GeneIDi145773.
KEGGihsa:145773.
UCSCiuc002agc.3. human.

Organism-specific databases

CTDi145773.
GeneCardsiFAM81A.
HGNCiHGNC:28379. FAM81A.
HPAiHPA001847.
neXtProtiNX_Q8TBF8.
PharmGKBiPA142671846.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IH95. Eukaryota.
ENOG4111JK9. LUCA.
GeneTreeiENSGT00390000004985.
HOGENOMiHOG000112480.
HOVERGENiHBG081513.
InParanoidiQ8TBF8.
OMAiIQQMQKP.
PhylomeDBiQ8TBF8.
TreeFamiTF335682.

Miscellaneous databases

ChiTaRSiFAM81A. human.
GenomeRNAii145773.
NextBioi85166.
PROiQ8TBF8.

Gene expression databases

BgeeiQ8TBF8.
CleanExiHS_FAM81A.
ExpressionAtlasiQ8TBF8. baseline and differential.
GenevisibleiQ8TBF8. HS.

Family and domain databases

InterProiIPR029619. FAM81.
IPR029622. FAM81A.
[Graphical view]
PANTHERiPTHR22420. PTHR22420. 1 hit.
PTHR22420:SF2. PTHR22420:SF2. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiFA81A_HUMAN
AccessioniPrimary (citable) accession number: Q8TBF8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: July 27, 2011
Last modified: March 16, 2016
This is version 91 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-4 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.