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Protein

Zinc finger CCHC-type and RNA-binding motif-containing protein 1

Gene

ZCRB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri105 – 12218CCHC-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • nucleotide binding Source: InterPro
  • poly(A) RNA binding Source: UniProtKB
  • RNA binding Source: GO_Central
  • zinc ion binding Source: InterPro

GO - Biological processi

  • mRNA splicing, via spliceosome Source: GO_Central
  • RNA splicing Source: HGNC
Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi

Metal-binding, RNA-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-72165. mRNA Splicing - Minor Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger CCHC-type and RNA-binding motif-containing protein 1
Alternative name(s):
U11/U12 small nuclear ribonucleoprotein 31 kDa protein
Short name:
U11/U12 snRNP 31 kDa protein
Short name:
U11/U12-31K
Gene namesi
Name:ZCRB1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:29620. ZCRB1.

Subcellular locationi

GO - Cellular componenti

  • nucleoplasm Source: Reactome
  • U12-type spliceosomal complex Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Nucleus, Spliceosome

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485674.

Polymorphism and mutation databases

BioMutaiZCRB1.
DMDMi158931154.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 217217Zinc finger CCHC-type and RNA-binding motif-containing protein 1PRO_0000252373Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei155 – 1551PhosphoserineCombined sources
Modified residuei210 – 2101PhosphoserineCombined sources
Modified residuei216 – 2161PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8TBF4.
MaxQBiQ8TBF4.
PaxDbiQ8TBF4.
PeptideAtlasiQ8TBF4.
PRIDEiQ8TBF4.

PTM databases

iPTMnetiQ8TBF4.
PhosphoSiteiQ8TBF4.

Expressioni

Inductioni

Up-regulated by morphine. Down-regulated at 30-36 degrees Celsius while it is up-regulated at 39 degrees Celsius.1 Publication

Gene expression databases

BgeeiENSG00000139168.
CleanExiHS_ZCRB1.
ExpressionAtlasiQ8TBF4. baseline and differential.
GenevisibleiQ8TBF4. HS.

Organism-specific databases

HPAiHPA038864.

Interactioni

Subunit structurei

Component of the U11/U12 snRNPs that are part of the U12-type spliceosome.1 Publication

Protein-protein interaction databases

BioGridi124524. 63 interactions.
IntActiQ8TBF4. 1 interaction.
MINTiMINT-5009522.
STRINGi9606.ENSP00000266529.

Structurei

Secondary structure

1
217
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi11 – 166Combined sources
Helixi23 – 297Combined sources
Turni30 – 334Combined sources
Beta strandi36 – 416Combined sources
Beta strandi45 – 473Combined sources
Beta strandi54 – 596Combined sources
Helixi61 – 7010Combined sources
Turni71 – 733Combined sources
Beta strandi74 – 763Combined sources
Beta strandi79 – 857Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2E5HNMR-A1-87[»]
ProteinModelPortaliQ8TBF4.
SMRiQ8TBF4. Positions 5-87.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8TBF4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 8879RRMPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi132 – 14110Poly-Lys

Sequence similaritiesi

Contains 1 CCHC-type zinc finger.PROSITE-ProRule annotation
Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri105 – 12218CCHC-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IQXP. Eukaryota.
ENOG4111IY7. LUCA.
GeneTreeiENSGT00730000111061.
HOGENOMiHOG000007632.
HOVERGENiHBG107480.
InParanoidiQ8TBF4.
KOiK13154.
OMAiRRNYTDK.
OrthoDBiEOG091G0NFT.
PhylomeDBiQ8TBF4.
TreeFamiTF106263.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
4.10.60.10. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR003954. RRM_dom_euk.
IPR001878. Znf_CCHC.
[Graphical view]
PfamiPF00076. RRM_1. 1 hit.
PF00098. zf-CCHC. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
SM00361. RRM_1. 1 hit.
SM00343. ZnF_C2HC. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
SSF57756. SSF57756. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
PS50158. ZF_CCHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TBF4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGGLAPSKS TVYVSNLPFS LTNNDLYRIF SKYGKVVKVT IMKDKDTRKS
60 70 80 90 100
KGVAFILFLD KDSAQNCTRA INNKQLFGRV IKASIAIDNG RAAEFIRRRN
110 120 130 140 150
YFDKSKCYEC GESGHLSYAC PKNMLGEREP PKKKEKKKKK KAPEPEEEIE
160 170 180 190 200
EVEESEDEGE DPALDSLSQA IAFQQAKIEE EQKKWKPSSG VPSTSDDSRR
210
PRIKKSTYFS DEEELSD
Length:217
Mass (Da):24,592
Last modified:October 2, 2007 - v2
Checksum:iCC0C2BB6D2E42444
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti131 – 1311P → Q.1 Publication
Corresponds to variant rs17852093 [ dbSNP | Ensembl ].
VAR_027845

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB062361 mRNA. Translation: BAB56132.1.
CH471111 Genomic DNA. Translation: EAW57842.1.
BC010177 mRNA. Translation: AAH10177.1.
BC022543 mRNA. Translation: AAH22543.1.
BK005200 mRNA. Translation: DAA05498.1.
CCDSiCCDS8740.1.
RefSeqiNP_149105.3. NM_033114.3.
UniGeneiHs.496279.

Genome annotation databases

EnsembliENST00000266529; ENSP00000266529; ENSG00000139168.
GeneIDi85437.
KEGGihsa:85437.
UCSCiuc001rmz.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB062361 mRNA. Translation: BAB56132.1.
CH471111 Genomic DNA. Translation: EAW57842.1.
BC010177 mRNA. Translation: AAH10177.1.
BC022543 mRNA. Translation: AAH22543.1.
BK005200 mRNA. Translation: DAA05498.1.
CCDSiCCDS8740.1.
RefSeqiNP_149105.3. NM_033114.3.
UniGeneiHs.496279.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2E5HNMR-A1-87[»]
ProteinModelPortaliQ8TBF4.
SMRiQ8TBF4. Positions 5-87.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124524. 63 interactions.
IntActiQ8TBF4. 1 interaction.
MINTiMINT-5009522.
STRINGi9606.ENSP00000266529.

PTM databases

iPTMnetiQ8TBF4.
PhosphoSiteiQ8TBF4.

Polymorphism and mutation databases

BioMutaiZCRB1.
DMDMi158931154.

Proteomic databases

EPDiQ8TBF4.
MaxQBiQ8TBF4.
PaxDbiQ8TBF4.
PeptideAtlasiQ8TBF4.
PRIDEiQ8TBF4.

Protocols and materials databases

DNASUi85437.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000266529; ENSP00000266529; ENSG00000139168.
GeneIDi85437.
KEGGihsa:85437.
UCSCiuc001rmz.4. human.

Organism-specific databases

CTDi85437.
GeneCardsiZCRB1.
HGNCiHGNC:29620. ZCRB1.
HPAiHPA038864.
MIMi610750. gene.
neXtProtiNX_Q8TBF4.
PharmGKBiPA143485674.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IQXP. Eukaryota.
ENOG4111IY7. LUCA.
GeneTreeiENSGT00730000111061.
HOGENOMiHOG000007632.
HOVERGENiHBG107480.
InParanoidiQ8TBF4.
KOiK13154.
OMAiRRNYTDK.
OrthoDBiEOG091G0NFT.
PhylomeDBiQ8TBF4.
TreeFamiTF106263.

Enzyme and pathway databases

ReactomeiR-HSA-72165. mRNA Splicing - Minor Pathway.

Miscellaneous databases

ChiTaRSiZCRB1. human.
EvolutionaryTraceiQ8TBF4.
GenomeRNAii85437.
PROiQ8TBF4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000139168.
CleanExiHS_ZCRB1.
ExpressionAtlasiQ8TBF4. baseline and differential.
GenevisibleiQ8TBF4. HS.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
4.10.60.10. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR003954. RRM_dom_euk.
IPR001878. Znf_CCHC.
[Graphical view]
PfamiPF00076. RRM_1. 1 hit.
PF00098. zf-CCHC. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
SM00361. RRM_1. 1 hit.
SM00343. ZnF_C2HC. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
SSF57756. SSF57756. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
PS50158. ZF_CCHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZCRB1_HUMAN
AccessioniPrimary (citable) accession number: Q8TBF4
Secondary accession number(s): Q6PJX0, Q96TA6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: October 2, 2007
Last modified: September 7, 2016
This is version 137 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.