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Protein

Solute carrier family 35 member G2

Gene

SLC35G2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in cell proliferation.1 Publication

Protein family/group databases

TCDBi2.A.7.28.2. the drug/metabolite transporter (dmt) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 35 member G2Imported
Alternative name(s):
Transmembrane protein 221 Publication
Gene namesi
Name:SLC35G2Imported
Synonyms:TMEM221 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:28480. SLC35G2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 104Cytoplasmic1 PublicationAdd BLAST104
Transmembranei105 – 125Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini126 – 130Extracellular1 Publication5
Transmembranei131 – 151Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini152 – 168Cytoplasmic1 PublicationAdd BLAST17
Transmembranei169 – 189Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini190 – 193Extracellular1 Publication4
Transmembranei194 – 214Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini215 – 217Cytoplasmic1 Publication3
Transmembranei218 – 238Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini239 – 254Extracellular1 PublicationAdd BLAST16
Transmembranei255 – 275Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini276 – 285Cytoplasmic1 Publication10
Transmembranei286 – 306Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini307 – 318Extracellular1 PublicationAdd BLAST12
Transmembranei319 – 339Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini340 – 345Cytoplasmic1 Publication6
Transmembranei346 – 366Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini367Extracellular1 Publication1
Transmembranei368 – 388Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini389 – 412Cytoplasmic1 PublicationAdd BLAST24

GO - Cellular componenti

  • Golgi apparatus Source: LIFEdb
  • integral component of plasma membrane Source: UniProtKB
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi80723.
OpenTargetsiENSG00000168917.
PharmGKBiPA134946375.

Polymorphism and mutation databases

BioMutaiSLC35G2.
DMDMi317373497.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002444651 – 412Solute carrier family 35 member G2Add BLAST412

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei409PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8TBE7.
PaxDbiQ8TBE7.
PeptideAtlasiQ8TBE7.
PRIDEiQ8TBE7.

PTM databases

iPTMnetiQ8TBE7.
PhosphoSitePlusiQ8TBE7.

Expressioni

Gene expression databases

BgeeiENSG00000168917.
CleanExiHS_TMEM22.
GenevisibleiQ8TBE7. HS.

Organism-specific databases

HPAiHPA052054.
HPA064728.

Interactioni

Subunit structurei

Interacts with RAB37.1 Publication

Protein-protein interaction databases

BioGridi123273. 9 interactors.
IntActiQ8TBE7. 2 interactors.
MINTiMINT-1392191.

Structurei

3D structure databases

ProteinModelPortaliQ8TBE7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini119 – 237EamA 1Sequence analysisAdd BLAST119
Domaini268 – 388EamA 2Sequence analysisAdd BLAST121

Sequence similaritiesi

Belongs to the SLC35G solute transporter family.Curated
Contains 2 EamA domains.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJVP. Eukaryota.
ENOG410YGWG. LUCA.
GeneTreeiENSGT00730000110996.
HOGENOMiHOG000059600.
HOVERGENiHBG055114.
InParanoidiQ8TBE7.
OMAiKYTSHYP.
OrthoDBiEOG091G070D.
PhylomeDBiQ8TBE7.
TreeFamiTF331838.

Family and domain databases

InterProiIPR000620. EamA_dom.
[Graphical view]
PfamiPF00892. EamA. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TBE7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTSPSRKYP VKKRVKIHPN TVMVKYTSHY PQPGDDGYEE INEGYGNFME
60 70 80 90 100
ENPKKGLLSE MKKKGRAFFG TMDTLPPPTE DPMINEIGQF QSFAEKNIFQ
110 120 130 140 150
SRKMWIVLFG SALAHGCVAL ITRLVSDRSK VPSLELIFIR SVFQVLSVLV
160 170 180 190 200
VCYYQEAPFG PSGYRLRLFF YGVCNVISIT CAYTSFSIVP PSNGTTMWRA
210 220 230 240 250
TTTVFSAILA FLLVDEKMAY VDMATVVCSI LGVCLVMIPN IVDEDNSLLN
260 270 280 290 300
AWKEAFGYTM TVMAGLTTAL SMIVYRSIKE KISMWTALFT FGWTGTIWGI
310 320 330 340 350
STMFILQEPI IPLDGETWSY LIAICVCSTA AFLGVYYALD KFHPALVSTV
360 370 380 390 400
QHLEIVVAMV LQLLVLHIFP SIYDVFGGVI IMISVFVLAG YKLYWRNLRK
410
QDYQEILDSP IK
Length:412
Mass (Da):46,422
Last modified:January 11, 2011 - v3
Checksum:i94EB36A60A83355D
GO

Sequence cautioni

The sequence AAH00111 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti155Q → E in AAH22557 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_026907400K → R.Combined sources3 PublicationsCorresponds to variant rs1052618dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136661 mRNA. Translation: CAB66596.1.
AK314079 mRNA. Translation: BAG36777.1.
AC011597 Genomic DNA. No translation available.
AC096992 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79111.1.
CH471052 Genomic DNA. Translation: EAW79112.1.
CH471052 Genomic DNA. Translation: EAW79113.1.
BC000111 mRNA. Translation: AAH00111.1. Different initiation.
BC022557 mRNA. Translation: AAH22557.1.
CCDSiCCDS3091.1.
RefSeqiNP_001091068.1. NM_001097599.1.
NP_001091069.1. NM_001097600.1.
NP_079522.2. NM_025246.2.
XP_006713836.1. XM_006713773.3.
XP_011511516.1. XM_011513214.2.
XP_016862778.1. XM_017007289.1.
XP_016862779.1. XM_017007290.1.
XP_016862780.1. XM_017007291.1.
UniGeneiHs.477692.
Hs.655019.

Genome annotation databases

EnsembliENST00000393079; ENSP00000376794; ENSG00000168917.
ENST00000446465; ENSP00000400839; ENSG00000168917.
GeneIDi80723.
KEGGihsa:80723.
UCSCiuc003erf.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136661 mRNA. Translation: CAB66596.1.
AK314079 mRNA. Translation: BAG36777.1.
AC011597 Genomic DNA. No translation available.
AC096992 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79111.1.
CH471052 Genomic DNA. Translation: EAW79112.1.
CH471052 Genomic DNA. Translation: EAW79113.1.
BC000111 mRNA. Translation: AAH00111.1. Different initiation.
BC022557 mRNA. Translation: AAH22557.1.
CCDSiCCDS3091.1.
RefSeqiNP_001091068.1. NM_001097599.1.
NP_001091069.1. NM_001097600.1.
NP_079522.2. NM_025246.2.
XP_006713836.1. XM_006713773.3.
XP_011511516.1. XM_011513214.2.
XP_016862778.1. XM_017007289.1.
XP_016862779.1. XM_017007290.1.
XP_016862780.1. XM_017007291.1.
UniGeneiHs.477692.
Hs.655019.

3D structure databases

ProteinModelPortaliQ8TBE7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123273. 9 interactors.
IntActiQ8TBE7. 2 interactors.
MINTiMINT-1392191.

Protein family/group databases

TCDBi2.A.7.28.2. the drug/metabolite transporter (dmt) superfamily.

PTM databases

iPTMnetiQ8TBE7.
PhosphoSitePlusiQ8TBE7.

Polymorphism and mutation databases

BioMutaiSLC35G2.
DMDMi317373497.

Proteomic databases

MaxQBiQ8TBE7.
PaxDbiQ8TBE7.
PeptideAtlasiQ8TBE7.
PRIDEiQ8TBE7.

Protocols and materials databases

DNASUi80723.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000393079; ENSP00000376794; ENSG00000168917.
ENST00000446465; ENSP00000400839; ENSG00000168917.
GeneIDi80723.
KEGGihsa:80723.
UCSCiuc003erf.5. human.

Organism-specific databases

CTDi80723.
DisGeNETi80723.
GeneCardsiSLC35G2.
HGNCiHGNC:28480. SLC35G2.
HPAiHPA052054.
HPA064728.
neXtProtiNX_Q8TBE7.
OpenTargetsiENSG00000168917.
PharmGKBiPA134946375.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJVP. Eukaryota.
ENOG410YGWG. LUCA.
GeneTreeiENSGT00730000110996.
HOGENOMiHOG000059600.
HOVERGENiHBG055114.
InParanoidiQ8TBE7.
OMAiKYTSHYP.
OrthoDBiEOG091G070D.
PhylomeDBiQ8TBE7.
TreeFamiTF331838.

Miscellaneous databases

GeneWikiiTMEM22.
GenomeRNAii80723.
PROiQ8TBE7.

Gene expression databases

BgeeiENSG00000168917.
CleanExiHS_TMEM22.
GenevisibleiQ8TBE7. HS.

Family and domain databases

InterProiIPR000620. EamA_dom.
[Graphical view]
PfamiPF00892. EamA. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS35G2_HUMAN
AccessioniPrimary (citable) accession number: Q8TBE7
Secondary accession number(s): B2RA80
, D3DNE1, Q9BWN4, Q9H0S6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: January 11, 2011
Last modified: November 2, 2016
This is version 102 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.