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Protein

THAP domain-containing protein 6

Gene

THAP6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1 – 89THAP-typePROSITE-ProRule annotationAdd BLAST89

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
THAP domain-containing protein 6
Gene namesi
Name:THAP6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000174796.12
HGNCiHGNC:23189 THAP6
MIMi612535 gene
neXtProtiNX_Q8TBB0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000174796
PharmGKBiPA134873449

Polymorphism and mutation databases

BioMutaiTHAP6
DMDMi29839572

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000686471 – 222THAP domain-containing protein 6Add BLAST222

Proteomic databases

PaxDbiQ8TBB0
PeptideAtlasiQ8TBB0
PRIDEiQ8TBB0

PTM databases

iPTMnetiQ8TBB0
PhosphoSitePlusiQ8TBB0

Expressioni

Gene expression databases

BgeeiENSG00000174796
CleanExiHS_THAP6
ExpressionAtlasiQ8TBB0 baseline and differential
GenevisibleiQ8TBB0 HS

Organism-specific databases

HPAiHPA035767

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi127466, 2 interactors
ELMiQ8TBB0
IntActiQ8TBB0, 10 interactors
STRINGi9606.ENSP00000309007

Structurei

3D structure databases

ProteinModelPortaliQ8TBB0
SMRiQ8TBB0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili149 – 194Sequence analysisAdd BLAST46

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi139 – 142HCFC1-binding motif (HBM)By similarity4

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1 – 89THAP-typePROSITE-ProRule annotationAdd BLAST89

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IVN3 Eukaryota
ENOG410YUA1 LUCA
GeneTreeiENSGT00530000063390
HOGENOMiHOG000294215
HOVERGENiHBG055966
InParanoidiQ8TBB0
OMAiRLEAFCW
OrthoDBiEOG091G0BYK
PhylomeDBiQ8TBB0
TreeFamiTF335838

Family and domain databases

Gene3Di3.30.40.180, 1 hit
InterProiView protein in InterPro
IPR006612 THAP_Znf
IPR038441 THAP_Znf_sf
PfamiView protein in Pfam
PF05485 THAP, 1 hit
SMARTiView protein in SMART
SM00692 DM3, 1 hit
SM00980 THAP, 1 hit
PROSITEiView protein in PROSITE
PS50950 ZF_THAP, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TBB0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVKCCSAIGC ASRCLPNSKL KGLTFHVFPT DENIKRKWVL AMKRLDVNAA
60 70 80 90 100
GIWEPKKGDV LCSRHFKKTD FDRSAPNIKL KPGVIPSIFD SPYHLQGKRE
110 120 130 140 150
KLHCRKNFTL KTVPATNYNH HLVGASSCIE EFQSQFIFEH SYSVMDSPKK
160 170 180 190 200
LKHKLDHVIG ELEDTKESLR NVLDREKRFQ KSLRKTIREL KDECLISQET
210 220
ANRLDTFCWD CCQESIEQDY IS
Length:222
Mass (Da):25,691
Last modified:June 1, 2002 - v1
Checksum:i4E039592D64C50FB
GO
Isoform 2 (identifier: Q8TBB0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     97-138: Missing.

Show »
Length:180
Mass (Da):20,828
Checksum:iBC13C7F1223939B2
GO
Isoform 3 (identifier: Q8TBB0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     139-220: EHSYSVMDSP...CCQESIEQDY → KHRKRKQEQEEEQKPRREKC

Note: No experimental confirmation available.
Show »
Length:160
Mass (Da):18,511
Checksum:i88E72EC61DAEF04F
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03907297 – 138Missing in isoform 2. 1 PublicationAdd BLAST42
Alternative sequenceiVSP_054378139 – 220EHSYS…IEQDY → KHRKRKQEQEEEQKPRREKC in isoform 3. 1 PublicationAdd BLAST82

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK303658 mRNA Translation: BAG64658.1
AK313765 mRNA Translation: BAG36503.1
AL833350 mRNA Translation: CAI46111.1
BX647579 mRNA Translation: CAI46093.1
AC096759 Genomic DNA No translation available.
CH471057 Genomic DNA Translation: EAX05731.1
BC022989 mRNA Translation: AAH22989.1
CCDSiCCDS3568.1 [Q8TBB0-1]
CCDS82932.1 [Q8TBB0-2]
RefSeqiNP_001304720.1, NM_001317791.1 [Q8TBB0-2]
NP_653322.1, NM_144721.5 [Q8TBB0-1]
XP_005262831.1, XM_005262774.3 [Q8TBB0-3]
XP_011529968.1, XM_011531666.2 [Q8TBB0-1]
XP_011529969.1, XM_011531667.2 [Q8TBB0-1]
XP_016863289.1, XM_017007800.1 [Q8TBB0-2]
UniGeneiHs.479971

Genome annotation databases

EnsembliENST00000311638; ENSP00000309007; ENSG00000174796 [Q8TBB0-1]
ENST00000380837; ENSP00000370217; ENSG00000174796 [Q8TBB0-2]
ENST00000507556; ENSP00000427651; ENSG00000174796 [Q8TBB0-3]
ENST00000514480; ENSP00000423720; ENSG00000174796 [Q8TBB0-1]
GeneIDi152815
KEGGihsa:152815
UCSCiuc003him.4 human [Q8TBB0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTHAP6_HUMAN
AccessioniPrimary (citable) accession number: Q8TBB0
Secondary accession number(s): B4E146, Q5HYJ7, Q5JPC6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: June 1, 2002
Last modified: March 28, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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