Q8TBB0 (THAP6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
THAP domain-containing protein 6

Gene names

Name:

THAP6

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	222 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 THAP-type zinc finger.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Domain	Coiled coil Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	microtubule cytoskeleton Inferred from direct assay. Source: LIFEdb
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8TBB0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8TBB0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     97-138: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 222	222	THAP domain-containing protein 6		PRO_0000068647
Regions
	Zinc finger	1 – 89	89	THAP-type
	Coiled coil	149 – 194	46	Potential
	Motif	139 – 142	4	HCFC1-binding motif (HBM) By similarity
Natural variations
	Alternative sequence	97 – 138	42	Missing in isoform 2.		VSP_039072

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: 4E039592D64C50FB	FASTA	222	25,691
	10 20 30 40 50 60 MVKCCSAIGC ASRCLPNSKL KGLTFHVFPT DENIKRKWVL AMKRLDVNAA GIWEPKKGDV 70 80 90 100 110 120 LCSRHFKKTD FDRSAPNIKL KPGVIPSIFD SPYHLQGKRE KLHCRKNFTL KTVPATNYNH 130 140 150 160 170 180 HLVGASSCIE EFQSQFIFEH SYSVMDSPKK LKHKLDHVIG ELEDTKESLR NVLDREKRFQ 190 200 210 220 KSLRKTIREL KDECLISQET ANRLDTFCWD CCQESIEQDY IS
	Isoform 2 [UniParc]. Checksum: BC13C7F1223939B2	FASTA	180	20,828
	10 20 30 40 50 60 MVKCCSAIGC ASRCLPNSKL KGLTFHVFPT DENIKRKWVL AMKRLDVNAA GIWEPKKGDV 70 80 90 100 110 120 LCSRHFKKTD FDRSAPNIKL KPGVIPSIFD SPYHLQEHSY SVMDSPKKLK HKLDHVIGEL 130 140 150 160 170 180 EDTKESLRNV LDREKRFQKS LRKTIRELKD ECLISQETAN RLDTFCWDCC QESIEQDYIS

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Testis.
[2]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Heart and Testis.
[3]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Cervix.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK313765 mRNA. Translation: BAG36503.1. AL833350 mRNA. Translation: CAI46111.1. BX647579 mRNA. Translation: CAI46093.1. CH471057 Genomic DNA. Translation: EAX05731.1. BC022989 mRNA. Translation: AAH22989.1.
IPI	IPI00152180. IPI00552789.
RefSeq	NP_653322.1. NM_144721.4.
UniGene	Hs.479971.
3D structure databases
ProteinModelPortal	Q8TBB0.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8TBB0. 1 interaction.
MINT	MINT-4720720.
STRING	9606.ENSP00000309007.
PTM databases
PhosphoSite	Q8TBB0.
Polymorphism databases
DMDM	29839572.
Proteomic databases
PaxDb	Q8TBB0.
PRIDE	Q8TBB0.
Protocols and materials databases
DNASU	152815.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000311638; ENSP00000309007; ENSG00000174796. ENST00000380837; ENSP00000370217; ENSG00000174796. ENST00000514480; ENSP00000423720; ENSG00000174796.
GeneID	152815.
KEGG	hsa:152815.
UCSC	uc003him.3. human. uc003hin.3. human.
Organism-specific databases
CTD	152815.
GeneCards	GC04P076439.
HGNC	HGNC:23189. THAP6.
HPA	HPA035767.
MIM	612535. gene.
neXtProt	NX_Q8TBB0.
PharmGKB	PA134873449.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG84798.
HOGENOM	HOG000294215.
HOVERGEN	HBG055966.
InParanoid	Q8TBB0.
OMA	RLEAFCW.
Gene expression databases
ArrayExpress	Q8TBB0.
Bgee	Q8TBB0.
CleanEx	HS_THAP6.
Genevestigator	Q8TBB0.
GermOnline	ENSG00000174796. Homo sapiens.
Family and domain databases
InterPro	IPR026517. THAP6. IPR006612. Znf_C2CH. [Graphical view]
PANTHER	PTHR23080:SF9. PTHR23080:SF9. 1 hit.
Pfam	PF05485. THAP. 1 hit. [Graphical view]
SMART	SM00692. DM3. 1 hit. SM00980. THAP. 1 hit. [Graphical view]
PROSITE	PS50950. ZF_THAP. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	152815.
NextBio	87035.
SOURCE	Search...

Entry information

Entry name

THAP6_HUMAN

Accession

Primary (citable) accession number: Q8TBB0
Secondary accession number(s): Q5HYJ7, Q5JPC6

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 11, 2003
Last sequence update:	June 1, 2002
Last modified:	May 29, 2013
This is version 90 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.