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Protein

THAP domain-containing protein 6

Gene

THAP6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1 – 8989THAP-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
THAP domain-containing protein 6
Gene namesi
Name:THAP6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:23189. THAP6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134873449.

Polymorphism and mutation databases

BioMutaiTHAP6.
DMDMi29839572.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 222222THAP domain-containing protein 6PRO_0000068647Add
BLAST

Proteomic databases

EPDiQ8TBB0.
PaxDbiQ8TBB0.
PRIDEiQ8TBB0.

PTM databases

iPTMnetiQ8TBB0.
PhosphoSiteiQ8TBB0.

Expressioni

Gene expression databases

BgeeiQ8TBB0.
CleanExiHS_THAP6.
ExpressionAtlasiQ8TBB0. baseline and differential.
GenevisibleiQ8TBB0. HS.

Organism-specific databases

HPAiHPA035767.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KRTAP10-7P604093EBI-3925505,EBI-10172290

Protein-protein interaction databases

BioGridi127466. 2 interactions.
IntActiQ8TBB0. 2 interactions.
MINTiMINT-4720720.
STRINGi9606.ENSP00000309007.

Structurei

3D structure databases

ProteinModelPortaliQ8TBB0.
SMRiQ8TBB0. Positions 1-89.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili149 – 19446Sequence analysisAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi139 – 1424HCFC1-binding motif (HBM)By similarity

Sequence similaritiesi

Contains 1 THAP-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1 – 8989THAP-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IVN3. Eukaryota.
ENOG410YUA1. LUCA.
GeneTreeiENSGT00530000063390.
HOGENOMiHOG000294215.
HOVERGENiHBG055966.
InParanoidiQ8TBB0.
OMAiRLEAFCW.
PhylomeDBiQ8TBB0.
TreeFamiTF335838.

Family and domain databases

InterProiIPR006612. Znf_C2CH.
[Graphical view]
PfamiPF05485. THAP. 1 hit.
[Graphical view]
SMARTiSM00692. DM3. 1 hit.
SM00980. THAP. 1 hit.
[Graphical view]
PROSITEiPS50950. ZF_THAP. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TBB0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVKCCSAIGC ASRCLPNSKL KGLTFHVFPT DENIKRKWVL AMKRLDVNAA
60 70 80 90 100
GIWEPKKGDV LCSRHFKKTD FDRSAPNIKL KPGVIPSIFD SPYHLQGKRE
110 120 130 140 150
KLHCRKNFTL KTVPATNYNH HLVGASSCIE EFQSQFIFEH SYSVMDSPKK
160 170 180 190 200
LKHKLDHVIG ELEDTKESLR NVLDREKRFQ KSLRKTIREL KDECLISQET
210 220
ANRLDTFCWD CCQESIEQDY IS
Length:222
Mass (Da):25,691
Last modified:June 1, 2002 - v1
Checksum:i4E039592D64C50FB
GO
Isoform 2 (identifier: Q8TBB0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     97-138: Missing.

Show »
Length:180
Mass (Da):20,828
Checksum:iBC13C7F1223939B2
GO
Isoform 3 (identifier: Q8TBB0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     139-220: EHSYSVMDSP...CCQESIEQDY → KHRKRKQEQEEEQKPRREKC

Note: No experimental confirmation available.
Show »
Length:160
Mass (Da):18,511
Checksum:i88E72EC61DAEF04F
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei97 – 13842Missing in isoform 2. 1 PublicationVSP_039072Add
BLAST
Alternative sequencei139 – 22082EHSYS…IEQDY → KHRKRKQEQEEEQKPRREKC in isoform 3. 1 PublicationVSP_054378Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK303658 mRNA. Translation: BAG64658.1.
AK313765 mRNA. Translation: BAG36503.1.
AL833350 mRNA. Translation: CAI46111.1.
BX647579 mRNA. Translation: CAI46093.1.
AC096759 Genomic DNA. No translation available.
CH471057 Genomic DNA. Translation: EAX05731.1.
BC022989 mRNA. Translation: AAH22989.1.
CCDSiCCDS3568.1. [Q8TBB0-1]
RefSeqiNP_001304720.1. NM_001317791.1. [Q8TBB0-2]
NP_653322.1. NM_144721.5. [Q8TBB0-1]
XP_005262831.1. XM_005262774.2. [Q8TBB0-3]
XP_011529968.1. XM_011531666.1. [Q8TBB0-1]
XP_011529969.1. XM_011531667.1. [Q8TBB0-1]
UniGeneiHs.479971.

Genome annotation databases

EnsembliENST00000311638; ENSP00000309007; ENSG00000174796. [Q8TBB0-1]
ENST00000380837; ENSP00000370217; ENSG00000174796. [Q8TBB0-2]
ENST00000507556; ENSP00000427651; ENSG00000174796. [Q8TBB0-3]
ENST00000514480; ENSP00000423720; ENSG00000174796. [Q8TBB0-1]
GeneIDi152815.
KEGGihsa:152815.
UCSCiuc003him.4. human. [Q8TBB0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK303658 mRNA. Translation: BAG64658.1.
AK313765 mRNA. Translation: BAG36503.1.
AL833350 mRNA. Translation: CAI46111.1.
BX647579 mRNA. Translation: CAI46093.1.
AC096759 Genomic DNA. No translation available.
CH471057 Genomic DNA. Translation: EAX05731.1.
BC022989 mRNA. Translation: AAH22989.1.
CCDSiCCDS3568.1. [Q8TBB0-1]
RefSeqiNP_001304720.1. NM_001317791.1. [Q8TBB0-2]
NP_653322.1. NM_144721.5. [Q8TBB0-1]
XP_005262831.1. XM_005262774.2. [Q8TBB0-3]
XP_011529968.1. XM_011531666.1. [Q8TBB0-1]
XP_011529969.1. XM_011531667.1. [Q8TBB0-1]
UniGeneiHs.479971.

3D structure databases

ProteinModelPortaliQ8TBB0.
SMRiQ8TBB0. Positions 1-89.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127466. 2 interactions.
IntActiQ8TBB0. 2 interactions.
MINTiMINT-4720720.
STRINGi9606.ENSP00000309007.

PTM databases

iPTMnetiQ8TBB0.
PhosphoSiteiQ8TBB0.

Polymorphism and mutation databases

BioMutaiTHAP6.
DMDMi29839572.

Proteomic databases

EPDiQ8TBB0.
PaxDbiQ8TBB0.
PRIDEiQ8TBB0.

Protocols and materials databases

DNASUi152815.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311638; ENSP00000309007; ENSG00000174796. [Q8TBB0-1]
ENST00000380837; ENSP00000370217; ENSG00000174796. [Q8TBB0-2]
ENST00000507556; ENSP00000427651; ENSG00000174796. [Q8TBB0-3]
ENST00000514480; ENSP00000423720; ENSG00000174796. [Q8TBB0-1]
GeneIDi152815.
KEGGihsa:152815.
UCSCiuc003him.4. human. [Q8TBB0-1]

Organism-specific databases

CTDi152815.
GeneCardsiTHAP6.
HGNCiHGNC:23189. THAP6.
HPAiHPA035767.
MIMi612535. gene.
neXtProtiNX_Q8TBB0.
PharmGKBiPA134873449.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVN3. Eukaryota.
ENOG410YUA1. LUCA.
GeneTreeiENSGT00530000063390.
HOGENOMiHOG000294215.
HOVERGENiHBG055966.
InParanoidiQ8TBB0.
OMAiRLEAFCW.
PhylomeDBiQ8TBB0.
TreeFamiTF335838.

Miscellaneous databases

GeneWikiiTHAP6.
GenomeRNAii152815.
NextBioi35476930.
PROiQ8TBB0.
SOURCEiSearch...

Gene expression databases

BgeeiQ8TBB0.
CleanExiHS_THAP6.
ExpressionAtlasiQ8TBB0. baseline and differential.
GenevisibleiQ8TBB0. HS.

Family and domain databases

InterProiIPR006612. Znf_C2CH.
[Graphical view]
PfamiPF05485. THAP. 1 hit.
[Graphical view]
SMARTiSM00692. DM3. 1 hit.
SM00980. THAP. 1 hit.
[Graphical view]
PROSITEiPS50950. ZF_THAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Tissue: Testis and Thymus.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Heart and Testis.
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Cervix.

Entry informationi

Entry nameiTHAP6_HUMAN
AccessioniPrimary (citable) accession number: Q8TBB0
Secondary accession number(s): B4E146, Q5HYJ7, Q5JPC6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: June 1, 2002
Last modified: April 13, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.