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Protein

Golgin subfamily A member 5

Gene

GOLGA5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport.2 Publications

GO - Molecular functioni

  • protein homodimerization activity Source: UniProtKB
  • Rab GTPase binding Source: UniProtKB

GO - Biological processi

  • Golgi organization Source: UniProtKB
  • Golgi vesicle transport Source: UniProtKB
  • retrograde transport, vesicle recycling within Golgi Source: GO_Central
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Golgin subfamily A member 5
Alternative name(s):
Cell proliferation-inducing gene 31 protein
Golgin-84
Protein Ret-II
RET-fused gene 5 protein
Gene namesi
Name:GOLGA5
Synonyms:RETII, RFG5
ORF Names:PIG31
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:4428. GOLGA5.

Subcellular locationi

  • Golgi apparatus membrane 1 Publication; Single-pass type IV membrane protein 1 Publication

  • Note: Found throughout the Golgi, both on cisternae and, at higher abundance, on the tubulo-vesicular structures of the cis-Golgi network.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 698697CytoplasmicSequence analysisAdd
BLAST
Transmembranei699 – 71921Helical; Anchor for type IV membrane proteinSequence analysisAdd
BLAST
Topological domaini720 – 73112LumenalSequence analysisAdd
BLAST

GO - Cellular componenti

  • cis-Golgi network Source: UniProtKB
  • COPI-coated vesicle membrane Source: Ensembl
  • Golgi apparatus Source: UniProtKB
  • Golgi cis cisterna Source: Ensembl
  • Golgi cisterna Source: UniProtKB
  • Golgi medial cisterna Source: Ensembl
  • Golgi membrane Source: GO_Central
  • Golgi trans cisterna Source: Ensembl
  • integral component of membrane Source: UniProtKB
  • membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving GOLGA5 is found in papillary thyroid carcinomas (PTCs). Translocation t(10;14)(q11;q32) with RET. The translocation generates the RET/GOLGA5 (PTC5) oncogene.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei497 – 4982Breakpoint for translocation to form RET-GOLGA5 oncogene

Organism-specific databases

MalaCardsiGOLGA5.
Orphaneti146. Papillary or follicular thyroid carcinoma.
PharmGKBiPA28809.

Polymorphism and mutation databases

DMDMi296439337.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 731730Golgin subfamily A member 5PRO_0000190061Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineCombined sources
Modified residuei89 – 891Dimethylated arginine; alternateBy similarity
Modified residuei89 – 891Omega-N-methylated arginine; alternateBy similarity
Modified residuei116 – 1161PhosphoserineCombined sources

Post-translational modificationi

Highly phosphorylated during mitosis. Phosphorylation is barely detectable during interphase.1 Publication

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiQ8TBA6.
MaxQBiQ8TBA6.
PaxDbiQ8TBA6.
PRIDEiQ8TBA6.

PTM databases

iPTMnetiQ8TBA6.
PhosphoSiteiQ8TBA6.

Expressioni

Tissue specificityi

Ubiquitous. Highly expressed in seminiferous tubules and Leydig cells in testis, and detected at much lower levels in the other tissues tested. Expression is very low or not detectable in spermatozoa.1 Publication

Gene expression databases

BgeeiQ8TBA6.
CleanExiHS_GOLGA5.
ExpressionAtlasiQ8TBA6. baseline and differential.
GenevisibleiQ8TBA6. HS.

Organism-specific databases

HPAiHPA000992.
HPA063876.

Interactioni

Subunit structurei

Homodimer. Interacts with RAB1A that has been activated by GTP-binding, and possibly also with OCRL1. Interacts with isoform CASP of CUX1.3 Publications

GO - Molecular functioni

  • protein homodimerization activity Source: UniProtKB
  • Rab GTPase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi115275. 43 interactions.
IntActiQ8TBA6. 10 interactions.
STRINGi9606.ENSP00000163416.

Structurei

3D structure databases

ProteinModelPortaliQ8TBA6.
SMRiQ8TBA6. Positions 589-624.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili216 – 632417Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4677. Eukaryota.
ENOG410XR4F. LUCA.
GeneTreeiENSGT00390000018470.
HOGENOMiHOG000273871.
HOVERGENiHBG051755.
InParanoidiQ8TBA6.
OMAiNRVDQGA.
OrthoDBiEOG74BJRQ.
PhylomeDBiQ8TBA6.
TreeFamiTF319468.

Family and domain databases

InterProiIPR019177. Golgin_subfamily_A_member_5.
[Graphical view]
PfamiPF09787. Golgin_A5. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TBA6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSWFVDLAGK AEDLLNRVDQ GAATALSRKD NASNIYSKNT DYTELHQQNT
60 70 80 90 100
DLIYQTGPKS TYISSAADNI RNQKATILAG TANVKVGSRT PVEASHPVEN
110 120 130 140 150
ASVPRPSSHF VRRKKSEPDD ELLFDFLNSS QKEPTGRVEI RKEKGKTPVF
160 170 180 190 200
QSSQTSSVSS VNPSVTTIKT IEENSFGSQT HEAASNSDSS HEGQEESSKE
210 220 230 240 250
NVSSNAACPD HTPTPNDDGK SHELSNLRLE NQLLRNEVQS LNQEMASLLQ
260 270 280 290 300
RSKETQEELN KARARVEKWN ADHSKSDRMT RGLRAQVDDL TEAVAAKDSQ
310 320 330 340 350
LAVLKVRLQE ADQLLSTRTE ALEALQSEKS RIMQDQSEGN SLQNQALQTF
360 370 380 390 400
QERLHEADAT LKREQESYKQ MQSEFAARLN KVEMERQNLA EAITLAERKY
410 420 430 440 450
SDEKKRVDEL QQQVKLYKLN LESSKQELID YKQKATRILQ SKEKLINSLK
460 470 480 490 500
EGSGFEGLDS STASSMELEE LRHEKEMQRE EIQKLMGQIH QLRSELQDME
510 520 530 540 550
AQQVNEAESA REQLQDLHDQ IAGQKASKQE LETELERLKQ EFHYIEEDLY
560 570 580 590 600
RTKNTLQSRI KDRDEEIQKL RNQLTNKTLS NSSQSELENR LHQLTETLIQ
610 620 630 640 650
KQTMLESLST EKNSLVFQLE RLEQQMNSAS GSSSNGSSIN MSGIDNGEGT
660 670 680 690 700
RLRNVPVLFN DTETNLAGMY GKVRKAASSI DQFSIRLGIF LRRYPIARVF
710 720 730
VIIYMALLHL WVMIVLLTYT PEMHHDQPYG K
Length:731
Mass (Da):83,024
Last modified:May 18, 2010 - v3
Checksum:i650B5D46096A2DDE
GO
Isoform 2 (identifier: Q8TBA6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     684-691: SIRLGIFL → RLCFTSGS
     692-731: Missing.

Note: No experimental confirmation available.
Show »
Length:691
Mass (Da):78,108
Checksum:iB5E3CED3DE0F96CC
GO

Sequence cautioni

The sequence CAA33787.1 differs from that shown.Chimeric cDNA. A chimeric cDNA originating from chromosomes 14 and 10.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti350 – 3501F → L in AAD09753 (PubMed:9915833).Curated
Sequence conflicti350 – 3501F → L in AAV85456 (Ref. 2) Curated
Sequence conflicti350 – 3501F → L in EAW81502 (Ref. 4) Curated
Sequence conflicti350 – 3501F → L in AAH23021 (PubMed:15489334).Curated
Sequence conflicti350 – 3501F → L in CAA33787 (PubMed:2734021).Curated
Sequence conflicti350 – 3501F → L in CAB36967 (PubMed:9443391).Curated
Sequence conflicti584 – 5852QS → PV in CAB36967 (PubMed:9443391).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti67 – 671A → G.1 Publication
Corresponds to variant rs17128572 [ dbSNP | Ensembl ].
VAR_055859
Natural varianti486 – 4861M → V.
Corresponds to variant rs34139657 [ dbSNP | Ensembl ].
VAR_055860

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei684 – 6918SIRLGIFL → RLCFTSGS in isoform 2. 1 PublicationVSP_007731
Alternative sequencei692 – 73140Missing in isoform 2. 1 PublicationVSP_007732Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF085199 mRNA. Translation: AAD09753.1.
AY644768 mRNA. Translation: AAV85456.1.
AL132987 Genomic DNA. No translation available.
CH471061 Genomic DNA. Translation: EAW81502.1.
BC023021 mRNA. Translation: AAH23021.1.
X15786 mRNA. Translation: CAA33787.1. Sequence problems.
AJ132949 mRNA. Translation: CAB36967.1.
BX248744 mRNA. Translation: CAD66551.1.
CCDSiCCDS9905.1. [Q8TBA6-1]
PIRiI38153.
RefSeqiNP_005104.3. NM_005113.3.
XP_011535722.1. XM_011537420.1. [Q8TBA6-2]
UniGeneiHs.104320.

Genome annotation databases

EnsembliENST00000163416; ENSP00000163416; ENSG00000066455. [Q8TBA6-1]
GeneIDi9950.
KEGGihsa:9950.
UCSCiuc001yaz.3. human. [Q8TBA6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF085199 mRNA. Translation: AAD09753.1.
AY644768 mRNA. Translation: AAV85456.1.
AL132987 Genomic DNA. No translation available.
CH471061 Genomic DNA. Translation: EAW81502.1.
BC023021 mRNA. Translation: AAH23021.1.
X15786 mRNA. Translation: CAA33787.1. Sequence problems.
AJ132949 mRNA. Translation: CAB36967.1.
BX248744 mRNA. Translation: CAD66551.1.
CCDSiCCDS9905.1. [Q8TBA6-1]
PIRiI38153.
RefSeqiNP_005104.3. NM_005113.3.
XP_011535722.1. XM_011537420.1. [Q8TBA6-2]
UniGeneiHs.104320.

3D structure databases

ProteinModelPortaliQ8TBA6.
SMRiQ8TBA6. Positions 589-624.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115275. 43 interactions.
IntActiQ8TBA6. 10 interactions.
STRINGi9606.ENSP00000163416.

PTM databases

iPTMnetiQ8TBA6.
PhosphoSiteiQ8TBA6.

Polymorphism and mutation databases

DMDMi296439337.

Proteomic databases

EPDiQ8TBA6.
MaxQBiQ8TBA6.
PaxDbiQ8TBA6.
PRIDEiQ8TBA6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000163416; ENSP00000163416; ENSG00000066455. [Q8TBA6-1]
GeneIDi9950.
KEGGihsa:9950.
UCSCiuc001yaz.3. human. [Q8TBA6-1]

Organism-specific databases

CTDi9950.
GeneCardsiGOLGA5.
H-InvDBHIX0011907.
HGNCiHGNC:4428. GOLGA5.
HPAiHPA000992.
HPA063876.
MalaCardsiGOLGA5.
MIMi606918. gene.
neXtProtiNX_Q8TBA6.
Orphaneti146. Papillary or follicular thyroid carcinoma.
PharmGKBiPA28809.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4677. Eukaryota.
ENOG410XR4F. LUCA.
GeneTreeiENSGT00390000018470.
HOGENOMiHOG000273871.
HOVERGENiHBG051755.
InParanoidiQ8TBA6.
OMAiNRVDQGA.
OrthoDBiEOG74BJRQ.
PhylomeDBiQ8TBA6.
TreeFamiTF319468.

Miscellaneous databases

ChiTaRSiGOLGA5. human.
GeneWikiiGOLGA5.
GenomeRNAii9950.
NextBioi37546.
PROiQ8TBA6.
SOURCEiSearch...

Gene expression databases

BgeeiQ8TBA6.
CleanExiHS_GOLGA5.
ExpressionAtlasiQ8TBA6. baseline and differential.
GenevisibleiQ8TBA6. HS.

Family and domain databases

InterProiIPR019177. Golgin_subfamily_A_member_5.
[Graphical view]
PfamiPF09787. Golgin_A5. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of golgin-84, a novel Golgi integral membrane protein with a cytoplasmic coiled-coil domain."
    Bascom R.A., Srinivasan S., Nussbaum R.L.
    J. Biol. Chem. 274:2953-2962(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TOPOLOGY, DIMERIZATION, INTERACTION WITH OCRL1, TISSUE SPECIFICITY.
    Tissue: Testis.
  2. "Identification of a human cell proliferation gene."
    Kim J.W.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT GLY-67.
    Tissue: Placenta.
  6. "Activation of the ret-II oncogene without a sequence encoding a transmembrane domain and transforming activity of two ret-II oncogene products differing in carboxy-termini due to alternative splicing."
    Ishizaka Y., Ochiai M., Tahira T., Suhimura T., Nahao M.
    Oncogene 4:789-794(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-497 (ISOFORM 1), CHROMOSOMAL TRANSLOCATION WITH RET.
    Tissue: Fibroblast.
  7. Erratum
    Ishizaka Y., Ochiai M., Tahira T., Suhimura T., Nahao M.
    Oncogene 4:1415-1415(1989)
  8. "Detection of a novel type of Ret rearrangement (PTC5) in thyroid carcinomas after Chernobyl and analysis of the involved Ret-fused gene RFG5."
    Klugbauer S., Demidchik E.P., Lengfelder E., Rabes H.M.
    Cancer Res. 58:198-203(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-585, CHROMOSOMAL TRANSLOCATION WITH RET.
    Tissue: Thyroid.
  9. "Full-length cDNA libraries and normalization."
    Li W.B., Gruber C., Jessee J., Polayes D.
    Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 576-731 (ISOFORM 2).
    Tissue: Neuroblastoma.
  10. "The coiled-coil membrane protein golgin-84 is a novel rab effector required for Golgi ribbon formation."
    Diao A., Rahman D., Pappin D.J.C., Lucocq J., Lowe M.
    J. Cell Biol. 160:201-212(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, PHOSPHORYLATION, INTERACTION WITH RAB1A.
  11. "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."
    Brill L.M., Salomon A.R., Ficarro S.B., Mukherji M., Stettler-Gill M., Peters E.C.
    Anal. Chem. 76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  12. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
    Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J.
    Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "Golgin tethers define subpopulations of COPI vesicles."
    Malsam J., Satoh A., Pelletier L., Warren G.
    Science 307:1095-1098(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH CUX1.
  14. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-116, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  15. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-116, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  16. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  17. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-116, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  18. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS], IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  19. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-116, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiGOGA5_HUMAN
AccessioniPrimary (citable) accession number: Q8TBA6
Secondary accession number(s): C9JRU1
, O95287, Q03962, Q2TS49, Q9UQQ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 3, 2003
Last sequence update: May 18, 2010
Last modified: April 13, 2016
This is version 128 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.