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Protein

T-cell immunomodulatory protein

Gene

ITFG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Modulator of T-cell function. Has a protective effect in graft versus host disease model (By similarity).By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell immunomodulatory protein
Short name:
Protein TIP
Alternative name(s):
Integrin-alpha FG-GAP repeat-containing protein 1
Linkin1 Publication
Gene namesi
Name:ITFG1Imported
Synonyms:LNKN-11 Publication, TIPImported
ORF Names:CDA08
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:30697. ITFG1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei567 – 58721HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485506.

Polymorphism and mutation databases

BioMutaiITFG1.
DMDMi45477238.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3333Sequence analysisAdd
BLAST
Chaini34 – 612579T-cell immunomodulatory proteinPRO_0000034354Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi36 – 361N-linked (GlcNAc...)Sequence analysis
Glycosylationi95 – 951N-linked (GlcNAc...)Sequence analysis
Glycosylationi139 – 1391N-linked (GlcNAc...)Sequence analysis
Glycosylationi146 – 1461N-linked (GlcNAc...)Sequence analysis
Glycosylationi151 – 1511N-linked (GlcNAc...)Sequence analysis
Glycosylationi176 – 1761N-linked (GlcNAc...)Sequence analysis
Glycosylationi188 – 1881N-linked (GlcNAc...)1 Publication
Glycosylationi226 – 2261N-linked (GlcNAc...)Sequence analysis
Glycosylationi243 – 2431N-linked (GlcNAc...)Sequence analysis
Glycosylationi353 – 3531N-linked (GlcNAc...)Sequence analysis
Glycosylationi371 – 3711N-linked (GlcNAc...)Sequence analysis
Glycosylationi482 – 4821N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ8TB96.
MaxQBiQ8TB96.
PaxDbiQ8TB96.
PeptideAtlasiQ8TB96.
PRIDEiQ8TB96.

PTM databases

iPTMnetiQ8TB96.
PhosphoSiteiQ8TB96.

Expressioni

Tissue specificityi

Ubiquitously expressed.

Gene expression databases

BgeeiQ8TB96.
CleanExiHS_ITFG1.
ExpressionAtlasiQ8TB96. baseline and differential.
GenevisibleiQ8TB96. HS.

Organism-specific databases

HPAiHPA015590.
HPA019728.

Interactioni

Subunit structurei

Interacts with RUVBL1, RUVBL2 and alpha-tubulin.1 Publication

Protein-protein interaction databases

BioGridi123507. 16 interactions.
IntActiQ8TB96. 8 interactions.
MINTiMINT-3044187.
STRINGi9606.ENSP00000319918.

Structurei

3D structure databases

ProteinModelPortaliQ8TB96.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati258 – 29336FG-GAP; atypicalAdd
BLAST

Sequence similaritiesi

Belongs to the TIP family.Curated
Contains 1 FG-GAP repeat.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4550. Eukaryota.
ENOG410XPFB. LUCA.
GeneTreeiENSGT00390000013367.
HOGENOMiHOG000045462.
HOVERGENiHBG050269.
InParanoidiQ8TB96.
KOiK17257.
OMAiFYDFYQD.
OrthoDBiEOG7BW0HZ.
PhylomeDBiQ8TB96.
TreeFamiTF105620.

Family and domain databases

InterProiIPR024881. Tip.
[Graphical view]
PANTHERiPTHR13412. PTHR13412. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8TB96-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAGRLPSS WALFSPLLAG LALLGVGPVP ARALHNVTAE LFGAEAWGTL
60 70 80 90 100
AAFGDLNSDK QTDLFVLRER NDLIVFLADQ NAPYFKPKVK VSFKNHSALI
110 120 130 140 150
TSVVPGDYDG DSQMDVLLTY LPKNYAKSEL GAVIFWGQNQ TLDPNNMTIL
160 170 180 190 200
NRTFQDEPLI MDFNGDLIPD IFGITNESNQ PQILLGGNLS WHPALTTTSK
210 220 230 240 250
MRIPHSHAFI DLTEDFTADL FLTTLNATTS TFQFEIWENL DGNFSVSTIL
260 270 280 290 300
EKPQNMMVVG QSAFADFDGD GHMDHLLPGC EDKNCQKSTI YLVRSGMKQW
310 320 330 340 350
VPVLQDFSNK GTLWGFVPFV DEQQPTEIPI PITLHIGDYN MDGYPDALVI
360 370 380 390 400
LKNTSGSNQQ AFLLENVPCN NASCEEARRM FKVYWELTDL NQIKDAMVAT
410 420 430 440 450
FFDIYEDGIL DIVVLSKGYT KNDFAIHTLK NNFEADAYFV KVIVLSGLCS
460 470 480 490 500
NDCPRKITPF GVNQPGPYIM YTTVDANGYL KNGSAGQLSQ SAHLALQLPY
510 520 530 540 550
NVLGLGRSAN FLDHLYVGIP RPSGEKSIRK QEWTAIIPNS QLIVIPYPHN
560 570 580 590 600
VPRSWSAKLY LTPSNIVLLT AIALIGVCVF ILAIIGILHW QEKKADDREK
610
RQEAHRFHFD AM
Length:612
Mass (Da):68,108
Last modified:June 1, 2002 - v1
Checksum:iCF01ECDCEBB3292A
GO

Sequence cautioni

The sequence AAG41782.1 differs from that shown. Reason: Frameshift at several positions. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF503339 mRNA. Translation: AAN31655.1.
AF212247 mRNA. Translation: AAG41782.1. Frameshift.
AK027596 mRNA. Translation: BAB55220.1.
BC006321 mRNA. Translation: AAH06321.2.
BC024162 mRNA. Translation: AAH24162.1.
CCDSiCCDS10728.1.
RefSeqiNP_001291931.1. NM_001305002.1.
NP_110417.2. NM_030790.4.
UniGeneiHs.42217.
Hs.592539.

Genome annotation databases

EnsembliENST00000320640; ENSP00000319918; ENSG00000129636.
GeneIDi81533.
KEGGihsa:81533.
UCSCiuc002eet.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF503339 mRNA. Translation: AAN31655.1.
AF212247 mRNA. Translation: AAG41782.1. Frameshift.
AK027596 mRNA. Translation: BAB55220.1.
BC006321 mRNA. Translation: AAH06321.2.
BC024162 mRNA. Translation: AAH24162.1.
CCDSiCCDS10728.1.
RefSeqiNP_001291931.1. NM_001305002.1.
NP_110417.2. NM_030790.4.
UniGeneiHs.42217.
Hs.592539.

3D structure databases

ProteinModelPortaliQ8TB96.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123507. 16 interactions.
IntActiQ8TB96. 8 interactions.
MINTiMINT-3044187.
STRINGi9606.ENSP00000319918.

PTM databases

iPTMnetiQ8TB96.
PhosphoSiteiQ8TB96.

Polymorphism and mutation databases

BioMutaiITFG1.
DMDMi45477238.

Proteomic databases

EPDiQ8TB96.
MaxQBiQ8TB96.
PaxDbiQ8TB96.
PeptideAtlasiQ8TB96.
PRIDEiQ8TB96.

Protocols and materials databases

DNASUi81533.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000320640; ENSP00000319918; ENSG00000129636.
GeneIDi81533.
KEGGihsa:81533.
UCSCiuc002eet.4. human.

Organism-specific databases

CTDi81533.
GeneCardsiITFG1.
HGNCiHGNC:30697. ITFG1.
HPAiHPA015590.
HPA019728.
MIMi611803. gene.
neXtProtiNX_Q8TB96.
PharmGKBiPA143485506.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4550. Eukaryota.
ENOG410XPFB. LUCA.
GeneTreeiENSGT00390000013367.
HOGENOMiHOG000045462.
HOVERGENiHBG050269.
InParanoidiQ8TB96.
KOiK17257.
OMAiFYDFYQD.
OrthoDBiEOG7BW0HZ.
PhylomeDBiQ8TB96.
TreeFamiTF105620.

Miscellaneous databases

ChiTaRSiITFG1. human.
GenomeRNAii81533.
NextBioi71759.
PROiQ8TB96.
SOURCEiSearch...

Gene expression databases

BgeeiQ8TB96.
CleanExiHS_ITFG1.
ExpressionAtlasiQ8TB96. baseline and differential.
GenevisibleiQ8TB96. HS.

Family and domain databases

InterProiIPR024881. Tip.
[Graphical view]
PANTHERiPTHR13412. PTHR13412. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION.
  2. "A novel gene expressed in human pheochromocytoma."
    Li Y., Huang Q., Peng Y., Song H., Yu Y., Xu S., Ren S., Chen Z., Han Z.
    Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pheochromocytoma.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Muscle and Skin.
  5. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-188.
    Tissue: Liver.
  6. "LINKIN, a new transmembrane protein necessary for cell adhesion."
    Kato M., Chou T.F., Yu C.Z., DeModena J., Sternberg P.W.
    Elife 3:E04449-E04449(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RUVBL1; RUVBL2 AND ALPHA-TUBULIN.

Entry informationi

Entry nameiTIP_HUMAN
AccessioniPrimary (citable) accession number: Q8TB96
Secondary accession number(s): Q96SR4, Q9BRE2, Q9H2V9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: June 1, 2002
Last modified: March 16, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.