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Protein

T-cell immunomodulatory protein

Gene

ITFG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Modulator of T-cell function. Has a protective effect in graft versus host disease model (By similarity).By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell immunomodulatory protein
Short name:
Protein TIP
Alternative name(s):
Integrin-alpha FG-GAP repeat-containing protein 1
Linkin1 Publication
Gene namesi
Name:ITFG1Imported
Synonyms:LNKN-11 Publication, TIPImported
ORF Names:CDA08
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000129636.12
HGNCiHGNC:30697 ITFG1
MIMi611803 gene
neXtProtiNX_Q8TB96

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei567 – 587HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi81533
OpenTargetsiENSG00000129636
PharmGKBiPA143485506

Polymorphism and mutation databases

BioMutaiITFG1
DMDMi45477238

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 33Sequence analysisAdd BLAST33
ChainiPRO_000003435434 – 612T-cell immunomodulatory proteinAdd BLAST579

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi36N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi95N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi139N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi146N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi151N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi176N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi188N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi226N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi243N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi353N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi371N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi482N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ8TB96
MaxQBiQ8TB96
PaxDbiQ8TB96
PeptideAtlasiQ8TB96
PRIDEiQ8TB96

PTM databases

iPTMnetiQ8TB96
PhosphoSitePlusiQ8TB96

Expressioni

Tissue specificityi

Ubiquitously expressed.

Gene expression databases

BgeeiENSG00000129636
CleanExiHS_ITFG1
ExpressionAtlasiQ8TB96 baseline and differential
GenevisibleiQ8TB96 HS

Organism-specific databases

HPAiHPA015590
HPA019728

Interactioni

Subunit structurei

Interacts with RUVBL1, RUVBL2 and alpha-tubulin.1 Publication

Protein-protein interaction databases

BioGridi12350724 interactors.
IntActiQ8TB96 9 interactors.
MINTiQ8TB96
STRINGi9606.ENSP00000319918

Structurei

3D structure databases

ProteinModelPortaliQ8TB96
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati258 – 293FG-GAP; atypicalAdd BLAST36

Sequence similaritiesi

Belongs to the TIP family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4550 Eukaryota
ENOG410XPFB LUCA
GeneTreeiENSGT00390000013367
HOGENOMiHOG000045462
HOVERGENiHBG050269
InParanoidiQ8TB96
KOiK17257
OMAiFYDFYQD
OrthoDBiEOG091G05G7
PhylomeDBiQ8TB96
TreeFamiTF105620

Family and domain databases

InterProiView protein in InterPro
IPR024881 Tip
PANTHERiPTHR13412 PTHR13412, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8TB96-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAGRLPSS WALFSPLLAG LALLGVGPVP ARALHNVTAE LFGAEAWGTL
60 70 80 90 100
AAFGDLNSDK QTDLFVLRER NDLIVFLADQ NAPYFKPKVK VSFKNHSALI
110 120 130 140 150
TSVVPGDYDG DSQMDVLLTY LPKNYAKSEL GAVIFWGQNQ TLDPNNMTIL
160 170 180 190 200
NRTFQDEPLI MDFNGDLIPD IFGITNESNQ PQILLGGNLS WHPALTTTSK
210 220 230 240 250
MRIPHSHAFI DLTEDFTADL FLTTLNATTS TFQFEIWENL DGNFSVSTIL
260 270 280 290 300
EKPQNMMVVG QSAFADFDGD GHMDHLLPGC EDKNCQKSTI YLVRSGMKQW
310 320 330 340 350
VPVLQDFSNK GTLWGFVPFV DEQQPTEIPI PITLHIGDYN MDGYPDALVI
360 370 380 390 400
LKNTSGSNQQ AFLLENVPCN NASCEEARRM FKVYWELTDL NQIKDAMVAT
410 420 430 440 450
FFDIYEDGIL DIVVLSKGYT KNDFAIHTLK NNFEADAYFV KVIVLSGLCS
460 470 480 490 500
NDCPRKITPF GVNQPGPYIM YTTVDANGYL KNGSAGQLSQ SAHLALQLPY
510 520 530 540 550
NVLGLGRSAN FLDHLYVGIP RPSGEKSIRK QEWTAIIPNS QLIVIPYPHN
560 570 580 590 600
VPRSWSAKLY LTPSNIVLLT AIALIGVCVF ILAIIGILHW QEKKADDREK
610
RQEAHRFHFD AM
Length:612
Mass (Da):68,108
Last modified:June 1, 2002 - v1
Checksum:iCF01ECDCEBB3292A
GO

Sequence cautioni

The sequence AAG41782 differs from that shown. Reason: Frameshift at several positions.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF503339 mRNA Translation: AAN31655.1
AF212247 mRNA Translation: AAG41782.1 Frameshift.
AK027596 mRNA Translation: BAB55220.1
BC006321 mRNA Translation: AAH06321.2
BC024162 mRNA Translation: AAH24162.1
CCDSiCCDS10728.1
RefSeqiNP_001291931.1, NM_001305002.1
NP_110417.2, NM_030790.4
UniGeneiHs.42217
Hs.592539

Genome annotation databases

EnsembliENST00000320640; ENSP00000319918; ENSG00000129636
GeneIDi81533
KEGGihsa:81533
UCSCiuc002eet.4 human

Similar proteinsi

Entry informationi

Entry nameiTIP_HUMAN
AccessioniPrimary (citable) accession number: Q8TB96
Secondary accession number(s): Q96SR4, Q9BRE2, Q9H2V9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: June 1, 2002
Last modified: February 28, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome