Q8TB93 (Q8TB93_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
p21 protein (Cdc42/Rac)-activated kinase 7 EMBL AAH24179.1

Gene names

Name:

PAK7 EMBL AAH24179.1

Organism

Homo sapiens (Human) EMBL AAH24179.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	719 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	ATP + a protein = ADP + a phosphoprotein. SAAS SAAS000095
Sequence similarities	Contains 1 CRIB domain. SAAS SAAS000095 Contains 1 protein kinase domain. SAAS SAAS000095

Ontologies

Keywords
Ligand	ATP-binding RuleBase RU000304 SAAS SAAS000095 Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase SAAS SAAS000095 Transferase
Gene Ontology (GO)
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8TB93 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: 536CB5DE65DA9FC3	FASTA	719	80,795
	10 20 30 40 50 60 MFGKKKKKIE ISGPSNFEHR VHTGFDAQEQ KFTGLPQQWH SLLADTANRP KPMVDPSCIT 70 80 90 100 110 120 PIQLAPMKTI VRGNKPCKET SINGLLEDFD NISVTRSNSL RKESPPTPDQ GASSHGPGHA 130 140 150 160 170 180 EENGFITFSQ YSSESDTTAD YTTEKYREKS LYGDDLDPYY RGSHAAKQNG HVMKMKHGEA 190 200 210 220 230 240 YYSEVKPLKS DFARFSADYH SHLDSLSKPS EYSDLKWEYQ RASSSSPLDY SFQFTPSRTA 250 260 270 280 290 300 GTSGCSKESL AYSESEWGPS LDDYDRRPKS SYLNQTSPQP TMRQRSRSGS GLQEPMMPFG 310 320 330 340 350 360 ASAFKTHPQG HSYNSYTYPR LSEPTMCIPK VDYDRAQMVL SPPLSGSDTY PRGPAKLPQS 370 380 390 400 410 420 QSKSGYSSSS HQYPSGYHKA TLYHHPSLQS SSQYISTASY LSYLSLSSST YPPPSWGSSS 430 440 450 460 470 480 DQQPSRVSHE QFRAALQLVV SPGDPREYLA NFIKIGEGST GIVCIATEKH TGKQVAVKKM 490 500 510 520 530 540 DLRKQQRREL LFNEVVIMRD YHHDNVVDMY SSYLVGDELW VVMEFLEGGA LTDIVTHTRM 550 560 570 580 590 600 NEEQIATVCL SVLRALSYLH NQGVIHRDIK SDSILLTSDG RIKLSDFGFC AQVSKEVPKR 610 620 630 640 650 660 KSLVGTPYWM APEVISRLPY GTEVDIWSLG IMVIEMIDGE PPYFNEPPLQ AMRRIRDSLP 670 680 690 700 710 PRVKDLHKVS SVLRGFLDLM LVREPSQRAT AQELLGHPFL KLAGPPSCIV PLMRQYRHH

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain EMBL AAH24179.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC024179 mRNA. Translation: AAH24179.1.
IPI	IPI00001814.
UniGene	Hs.32539.
3D structure databases
HSSP	HSSP built from PDB template 1F3M based on UniProtKB Q13153.
ProteinModelPortal	Q8TB93.
SMR	Q8TB93. Positions 10-43, 422-718.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8TB93. 5 interactions.
STRING	Q8TB93.
Proteomic databases
PRIDE	Q8TB93.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG108518.
Gene expression databases
ArrayExpress	Q8TB93.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000095. PAK_box_Rho-bd. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_kinase-like_dom. IPR002290. Ser/Thr_kinase_dom. [Graphical view]
Pfam	PF00786. PBD. 1 hit. PF00069. Pkinase. 1 hit. [Graphical view]
SMART	SM00285. PBD. 1 hit. SM00220. S_TKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS50108. CRIB. 1 hit. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q8TB93_HUMAN

Accession

Primary (citable) accession number: Q8TB93

Entry history

Integrated into UniProtKB/TrEMBL:	June 1, 2002
Last sequence update:	June 1, 2002
Last modified:	November 16, 2011
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.