p21 protein (Cdc42/Rac)-activated kinase 7 - Homo sapiens (Human)

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Unreviewed, UniProtKB/TrEMBL Q8TB93 (Q8TB93_HUMAN)

Last modified March 24, 2009. Version 56. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequences · References · Cross-references · Entry information

Names and origin

Protein names

Submitted name:
p21 protein (Cdc42/Rac)-activated kinase 7 EMBL AAH24179.1

Gene names

Name:

PAK7 EMBL AAH24179.1

Organism

Homo sapiens (Human) EMBL AAH24179.1

Taxonomic identifier

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	719 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity

ATP + a protein = ADP + a phosphoprotein. Spearmint SPM000095

Sequence similarities

Contains 1 CRIB domain. Spearmint SPM000095

Contains 1 protein kinase domain. Spearmint SPM000095

Ontologies

Keywords
Ligand	ATP-binding RuleBase RU000304V2 Spearmint SPM000095 Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Spearmint SPM000095 Transferase
Gene Ontology (GO)
Biological process	anti-apoptosis Inferred from electronic annotation. Source: Compara protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro
Cellular component	mitochondrion Inferred from electronic annotation. Source: Compara
Molecular function	ATP binding Inferred from electronic annotation. Source: InterPro protein serine/threonine kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

Sequence

Length

Mass (Da)

Tools

Q8TB93-1 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: 536CB5DE65DA9FC3
Show »

719

80,795

        10         20         30         40         50         60 
MFGKKKKKIE ISGPSNFEHR VHTGFDAQEQ KFTGLPQQWH SLLADTANRP KPMVDPSCIT 

        70         80         90        100        110        120 
PIQLAPMKTI VRGNKPCKET SINGLLEDFD NISVTRSNSL RKESPPTPDQ GASSHGPGHA 

       130        140        150        160        170        180 
EENGFITFSQ YSSESDTTAD YTTEKYREKS LYGDDLDPYY RGSHAAKQNG HVMKMKHGEA 

       190        200        210        220        230        240 
YYSEVKPLKS DFARFSADYH SHLDSLSKPS EYSDLKWEYQ RASSSSPLDY SFQFTPSRTA 

       250        260        270        280        290        300 
GTSGCSKESL AYSESEWGPS LDDYDRRPKS SYLNQTSPQP TMRQRSRSGS GLQEPMMPFG 

       310        320        330        340        350        360 
ASAFKTHPQG HSYNSYTYPR LSEPTMCIPK VDYDRAQMVL SPPLSGSDTY PRGPAKLPQS 

       370        380        390        400        410        420 
QSKSGYSSSS HQYPSGYHKA TLYHHPSLQS SSQYISTASY LSYLSLSSST YPPPSWGSSS 

       430        440        450        460        470        480 
DQQPSRVSHE QFRAALQLVV SPGDPREYLA NFIKIGEGST GIVCIATEKH TGKQVAVKKM 

       490        500        510        520        530        540 
DLRKQQRREL LFNEVVIMRD YHHDNVVDMY SSYLVGDELW VVMEFLEGGA LTDIVTHTRM 

       550        560        570        580        590        600 
NEEQIATVCL SVLRALSYLH NQGVIHRDIK SDSILLTSDG RIKLSDFGFC AQVSKEVPKR 

       610        620        630        640        650        660 
KSLVGTPYWM APEVISRLPY GTEVDIWSLG IMVIEMIDGE PPYFNEPPLQ AMRRIRDSLP 

       670        680        690        700        710 
PRVKDLHKVS SVLRGFLDLM LVREPSQRAT AQELLGHPFL KLAGPPSCIV PLMRQYRHH

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain EMBL AAH24179.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
	BC024179 mRNA. Translation: AAH24179.1.
IPI	IPI00001814.
UniGene	Hs.32539
3D structure databases
HSSP	HSSP built from PDB template 1F3M based on UniProtKB Q13153.
SMR	Q8TB93. Positions 422-718.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8TB93. 4 interactions.
Genome annotation databases
Ensembl	ENSG00000101349. Homo sapiens. [Contig view]
Organism-specific databases
HGNC	HGNC:15916. PAK7.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q8TB93.
Gene expression databases
ArrayExpress	Q8TB93.
Bgee	Q8TB93.
Family and domain databases
InterPro	IPR000095. PAK_box_Rho_bd. IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_pkinase-rel. IPR015750. Ser/Thr_Kinase_Pak-rel. IPR002290. Ser_thr_pkinase. [Graphical view]
PANTHER	PTHR22986:SF84. Pak_like. 1 hit.
Pfam	PF00786. PBD. 1 hit. PF00069. Pkinase. 1 hit. [Graphical view]
ProDom	PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00285. PBD. 1 hit. SM00220. S_TKc. 1 hit. [Graphical view]
PROSITE	PS50108. CRIB. 1 hit. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q8TB93_HUMAN

Accession

Primary (citable) accession number: Q8TB93

Entry history

Integrated into UniProtKB/TrEMBL:	June 1, 2002
Last sequence update:	June 1, 2002
Last modified:	March 24, 2009
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequences · References · Cross-references · Entry information