Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Pumilio homolog 2

Gene

PUM2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE) (, PubMed:21397187). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation (PubMed:22955276). Also mediates deadenylation-independent repression by promoting accessibility of miRNAs (PubMed:18776931, PubMed:22345517). Acts as a post-transcriptional repressor of E2F3 mRNAs by binding to its 3'-UTR and facilitating miRNA regulation (PubMed:22345517). Plays a role in cytoplasmic sensing of viral infection (PubMed:25340845). Represses a program of genes necessary to maintain genomic stability such as key mitotic, DNA repair and DNA replication factors. Its ability to repress those target mRNAs is regulated by the lncRNA NORAD (non-coding RNA activated by DNA damage) which, due to its high abundance and multitude of PUMILIO binding sites, is able to sequester a significant fraction of PUM1 and PUM2 in the cytoplasm (PubMed:26724866). May regulate DCUN1D3 mRNA levels (PubMed:25349211). May support proliferation and self-renewal of stem cells.7 Publications

GO - Molecular functioni

  • mRNA 3'-UTR binding Source: UniProtKB
  • poly(A) RNA binding Source: UniProtKB
  • RNA binding Source: UniProtKB

GO - Biological processi

  • positive regulation of gene silencing by miRNA Source: UniProtKB
  • positive regulation of RIG-I signaling pathway Source: UniProtKB
  • posttranscriptional regulation of gene expression Source: MGI
  • regulation of chromosome segregation Source: UniProtKB
  • regulation of gene silencing by miRNA Source: UniProtKB
  • regulation of mRNA stability Source: UniProtKB
  • stress granule assembly Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Translation regulation

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Pumilio homolog 2
Short name:
Pumilio-2
Gene namesi
Name:PUM2
Synonyms:KIAA0235, PUMH2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:14958. PUM2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: HPA
  • cytoplasmic stress granule Source: UniProtKB
  • nuclear membrane Source: HPA
  • perinuclear region of cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi23369.
OpenTargetsiENSG00000055917.
PharmGKBiPA34043.

Polymorphism and mutation databases

DMDMi41688714.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000759191 – 1066Pumilio homolog 2Add BLAST1066

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei67PhosphoserineCombined sources1
Modified residuei82PhosphoserineCombined sources1
Modified residuei136PhosphoserineCombined sources1
Modified residuei178PhosphoserineCombined sources1
Modified residuei182PhosphoserineCombined sources1
Modified residuei184PhosphothreonineCombined sources1
Modified residuei396PhosphothreonineCombined sources1
Modified residuei587PhosphoserineCombined sources1
Modified residuei700PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8TB72.
MaxQBiQ8TB72.
PaxDbiQ8TB72.
PeptideAtlasiQ8TB72.
PRIDEiQ8TB72.

PTM databases

iPTMnetiQ8TB72.
PhosphoSitePlusiQ8TB72.

Expressioni

Tissue specificityi

Expressed in male germ cells of adult testis (at protein level). Highly expressed in testis and ovary. Predominantly expressed in stem cells and germ cells. Expressed at lower level in brain, heart, kidney, liver, muscle, placenta, intestine and stomach Expressed in cerebellum, corpus callosum, caudate nucleus, hippocampus, medulla oblongata and putamen. Expressed in all fetal tissues tested.3 Publications

Inductioni

Down-regulated in keratinocytes upon UVB irradiation.1 Publication

Gene expression databases

BgeeiENSG00000055917.
CleanExiHS_PUM2.
ExpressionAtlasiQ8TB72. baseline and differential.
GenevisibleiQ8TB72. HS.

Organism-specific databases

HPAiHPA030316.
HPA049670.

Interactioni

Subunit structurei

Homodimer; homodimerizes in vitro. Interacts with DAZ, DAZL and NANOS1 via its pumilio repeats. Interacts with NANOS3 (By similarity). Interacts with SNAPIN. Recruits the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation. Interacts with DDX20. In case of viral infection, interacts with DHX58 (PubMed:25340845).By similarity7 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
DAZ1Q9NQZ35EBI-311190,EBI-997955
ORFQ9Q2G43EBI-311190,EBI-6248094From a different organism.

Protein-protein interaction databases

BioGridi116949. 21 interactors.
IntActiQ8TB72. 8 interactors.
MINTiMINT-254513.
STRINGi9606.ENSP00000338173.

Structurei

Secondary structure

11066
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi709 – 715Combined sources7
Helixi724 – 727Combined sources4
Turni728 – 730Combined sources3
Helixi731 – 735Combined sources5
Helixi738 – 748Combined sources11
Helixi753 – 765Combined sources13
Helixi767 – 771Combined sources5
Turni774 – 776Combined sources3
Helixi777 – 786Combined sources10
Helixi789 – 799Combined sources11
Helixi803 – 808Combined sources6
Helixi812 – 822Combined sources11
Helixi828 – 835Combined sources8
Turni836 – 839Combined sources4
Helixi841 – 846Combined sources6
Helixi850 – 860Combined sources11
Helixi863 – 866Combined sources4
Helixi867 – 872Combined sources6
Turni873 – 876Combined sources4
Helixi877 – 881Combined sources5
Helixi886 – 896Combined sources11
Helixi899 – 911Combined sources13
Helixi913 – 916Combined sources4
Helixi922 – 932Combined sources11
Helixi935 – 945Combined sources11
Helixi949 – 953Combined sources5
Helixi958 – 968Combined sources11
Helixi971 – 982Combined sources12
Beta strandi987 – 989Combined sources3
Helixi991 – 996Combined sources6
Helixi1001 – 1011Combined sources11
Helixi1014 – 1024Combined sources11
Helixi1025 – 1027Combined sources3
Helixi1028 – 1033Combined sources6
Helixi1035 – 1037Combined sources3
Helixi1040 – 1045Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3Q0QX-ray2.00A706-1056[»]
3Q0RX-ray2.00A706-1056[»]
3Q0SX-ray2.00A706-1056[»]
ProteinModelPortaliQ8TB72.
SMRiQ8TB72.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8TB72.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini706 – 1048PUM-HDPROSITE-ProRule annotationAdd BLAST343
Repeati726 – 761Pumilio 1PROSITE-ProRule annotation1 PublicationAdd BLAST36
Repeati762 – 797Pumilio 2PROSITE-ProRule annotation1 PublicationAdd BLAST36
Repeati798 – 835Pumilio 3PROSITE-ProRule annotation1 PublicationAdd BLAST38
Repeati836 – 871Pumilio 4PROSITE-ProRule annotation1 PublicationAdd BLAST36
Repeati872 – 907Pumilio 5PROSITE-ProRule annotation1 PublicationAdd BLAST36
Repeati908 – 943Pumilio 6PROSITE-ProRule annotation1 PublicationAdd BLAST36
Repeati944 – 979Pumilio 7PROSITE-ProRule annotation1 PublicationAdd BLAST36
Repeati983 – 1022Pumilio 8PROSITE-ProRule annotation1 PublicationAdd BLAST40

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 260Interaction with SNAPIN1 PublicationAdd BLAST260
Regioni741 – 745Adenine-nucleotide binding in RNA targetBy similarity5
Regioni777 – 781Uracil-nucleotide binding in RNA targetBy similarity5
Regioni813 – 817Adenine-nucleotide binding in RNA targetBy similarity5
Regioni851 – 855Non-specific-nucleotide binding in RNA targetBy similarity5
Regioni887 – 891Adenine-nucleotide binding in RNA targetBy similarity5
Regioni923 – 927Uracil-nucleotide binding in RNA targetBy similarity5
Regioni959 – 963Guanine-nucleotide binding in RNA targetBy similarity5
Regioni1002 – 1006Uracil-nucleotide binding in RNA targetBy similarity5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi278 – 488Ala-richAdd BLAST211
Compositional biasi359 – 405Gln-richAdd BLAST47
Compositional biasi520 – 687Ser-richAdd BLAST168

Domaini

The pumilio repeats mediate the association with RNA by packing together to form a right-handed superhelix that approximates a half donut. RNA-binding occurs on the concave side of the surface (PubMed:21397187). PUM2 is composed of 8 pumilio repeats of 36 residues; each repeat binds a single nucleotide in its RNA target. Residues at positions 12 and 16 of the pumilio repeat bind each RNA base via hydrogen bonding or van der Waals contacts with the Watson-Crick edge, while the amino acid at position 13 makes a stacking interaction. The recognition of RNA by pumilio repeats is base specific: cysteine and glutamine at position 12 and 16, respectively, bind adenine; asparagine and glutamine bind uracil; and serine and glutamate bind guanine.By similarity1 Publication

Sequence similaritiesi

Contains 1 PUM-HD domain.PROSITE-ProRule annotation
Contains 8 pumilio repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1488. Eukaryota.
COG5099. LUCA.
GeneTreeiENSGT00390000017241.
HOGENOMiHOG000238461.
HOVERGENiHBG049462.
InParanoidiQ8TB72.
KOiK17943.
OMAiLFDYSSQ.
OrthoDBiEOG091G04QO.
PhylomeDBiQ8TB72.
TreeFamiTF318160.

Family and domain databases

CDDicd07920. Pumilio. 1 hit.
Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR033133. PUM-HD.
IPR033712. Pumilio_RNA-bd.
IPR001313. Pumilio_RNA-bd_rpt.
[Graphical view]
PfamiPF00806. PUF. 8 hits.
[Graphical view]
SMARTiSM00025. Pumilio. 8 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50302. PUM. 8 hits.
PS50303. PUM_HD. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TB72-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNHDFQALAL ESRGMGELLP TKKFWEPDDS TKDGQKGIFL GDDEWRETAW
60 70 80 90 100
GASHHSMSQP IMVQRRSGQG FHGNSEVNAI LSPRSESGGL GVSMVEYVLS
110 120 130 140 150
SSPADKLDSR FRKGNFGTRD AETDGPEKGD QKGKASPFEE DQNRDLKQGD
160 170 180 190 200
DDDSKINGRG LPNGMDADCK DFNRTPGSRQ ASPTEVVERL GPNTNPSEGL
210 220 230 240 250
GPLPNPTANK PLVEEFSNPE TQNLDAMEQV GLESLQFDYP GNQVPMDSSG
260 270 280 290 300
ATVGLFDYNS QQQLFQRTNA LTVQQLTAAQ QQQYALAAAQ QPHIAGVFSA
310 320 330 340 350
GLAPAAFVPN PYIISAAPPG TDPYTAAGLA AAATLAGPAV VPPQYYGVPW
360 370 380 390 400
GVYPANLFQQ QAAAAANNTA SQQAASQAQP GQQQVLRAGA GQRPLTPNQG
410 420 430 440 450
QQGQQAESLA AAAAANPTLA FGQGLATGMP GYQVLAPTAY YDQTGALVVG
460 470 480 490 500
PGARTGLGAP VRLMAPTPVL ISSAAAQAAA AAAAGGTASS LTGSTNGLFR
510 520 530 540 550
PIGTQPPQQQ QQQPSTNLQS NSFYGSSSLT NSSQSSSLFS HGPGQPGSTS
560 570 580 590 600
LGFGSGNSLG AAIGSALSGF GSSVGSSASS SATRRESLST SSDLYKRSSS
610 620 630 640 650
SLAPIGQPFY NSLGFSSSPS PIGMPLPSQT PGHSLTPPPS LSSHGSSSSL
660 670 680 690 700
HLGGLTNGSG RYISAAPGAE AKYRSASSTS SLFSSSSQLF PPSRLRYNRS
710 720 730 740 750
DIMPSGRSRL LEDFRNNRFP NLQLRDLIGH IVEFSQDQHG SRFIQQKLER
760 770 780 790 800
ATPAERQMVF NEILQAAYQL MTDVFGNYVI QKFFEFGSLD QKLALATRIR
810 820 830 840 850
GHVLPLALQM YGCRVIQKAL ESISSDQQVI SEMVKELDGH VLKCVKDQNG
860 870 880 890 900
NHVVQKCIEC VQPQSLQFII DAFKGQVFVL STHPYGCRVI QRILEHCTAE
910 920 930 940 950
QTLPILEELH QHTEQLVQDQ YGNYVIQHVL EHGRPEDKSK IVSEIRGKVL
960 970 980 990 1000
ALSQHKFASN VVEKCVTHAS RAERALLIDE VCCQNDGPHS ALYTMMKDQY
1010 1020 1030 1040 1050
ANYVVQKMID MAEPAQRKII MHKIRPHITT LRKYTYGKHI LAKLEKYYLK
1060
NSPDLGPIGG PPNGML
Length:1,066
Mass (Da):114,216
Last modified:February 2, 2004 - v2
Checksum:iCF6F9D7998CD5D9E
GO
Isoform 2 (identifier: Q8TB72-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     574-652: Missing.

Show »
Length:987
Mass (Da):106,215
Checksum:i99F119F5E3CFCCCF
GO
Isoform 3 (identifier: Q8TB72-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     829-830: Missing.

Show »
Length:1,064
Mass (Da):114,003
Checksum:i99BC2A2711306F18
GO
Isoform 4 (identifier: Q8TB72-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-56: Missing.
     829-830: Missing.

Note: No experimental confirmation available.
Show »
Length:1,008
Mass (Da):107,646
Checksum:i44DA760E31DD5F62
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_057100367N → S.Corresponds to variant rs34032508dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0537051 – 56Missing in isoform 4. 1 PublicationAdd BLAST56
Alternative sequenceiVSP_009319574 – 652Missing in isoform 2. 1 PublicationAdd BLAST79
Alternative sequenceiVSP_009320829 – 830Missing in isoform 3 and isoform 4. 4 Publications2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF315591 mRNA. Translation: AAG31806.1.
D87078 mRNA. Translation: BAA19665.3.
AK093847 mRNA. Translation: BAG52772.1.
AK304198 mRNA. Translation: BAG65078.1.
AC007041 Genomic DNA. Translation: AAY15026.1.
CH471053 Genomic DNA. Translation: EAX00821.1.
CH471053 Genomic DNA. Translation: EAX00823.1.
BC024218 mRNA. Translation: AAH24218.2.
BC112046 mRNA. Translation: AAI12047.1.
BC112048 mRNA. Translation: AAI12049.1.
AF272350 mRNA. Translation: AAL36981.1.
CCDSiCCDS1698.1. [Q8TB72-3]
CCDS74487.1. [Q8TB72-4]
RefSeqiNP_001269681.1. NM_001282752.1. [Q8TB72-4]
NP_001269719.1. NM_001282790.1.
NP_001269720.1. NM_001282791.1.
NP_056132.1. NM_015317.2. [Q8TB72-3]
XP_005262664.1. XM_005262607.1. [Q8TB72-1]
XP_005262666.1. XM_005262609.1. [Q8TB72-2]
XP_006712036.1. XM_006711973.1. [Q8TB72-1]
XP_006712037.1. XM_006711974.2. [Q8TB72-1]
XP_011531021.1. XM_011532719.1. [Q8TB72-1]
XP_011531022.1. XM_011532720.2. [Q8TB72-1]
XP_011531023.1. XM_011532721.2. [Q8TB72-1]
XP_016859190.1. XM_017003701.1. [Q8TB72-3]
XP_016859191.1. XM_017003702.1. [Q8TB72-3]
XP_016859196.1. XM_017003707.1. [Q8TB72-2]
XP_016859197.1. XM_017003708.1. [Q8TB72-2]
UniGeneiHs.467824.

Genome annotation databases

EnsembliENST00000338086; ENSP00000338173; ENSG00000055917. [Q8TB72-3]
ENST00000361078; ENSP00000354370; ENSG00000055917. [Q8TB72-4]
ENST00000403432; ENSP00000385992; ENSG00000055917. [Q8TB72-3]
GeneIDi23369.
KEGGihsa:23369.
UCSCiuc002rdt.2. human. [Q8TB72-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF315591 mRNA. Translation: AAG31806.1.
D87078 mRNA. Translation: BAA19665.3.
AK093847 mRNA. Translation: BAG52772.1.
AK304198 mRNA. Translation: BAG65078.1.
AC007041 Genomic DNA. Translation: AAY15026.1.
CH471053 Genomic DNA. Translation: EAX00821.1.
CH471053 Genomic DNA. Translation: EAX00823.1.
BC024218 mRNA. Translation: AAH24218.2.
BC112046 mRNA. Translation: AAI12047.1.
BC112048 mRNA. Translation: AAI12049.1.
AF272350 mRNA. Translation: AAL36981.1.
CCDSiCCDS1698.1. [Q8TB72-3]
CCDS74487.1. [Q8TB72-4]
RefSeqiNP_001269681.1. NM_001282752.1. [Q8TB72-4]
NP_001269719.1. NM_001282790.1.
NP_001269720.1. NM_001282791.1.
NP_056132.1. NM_015317.2. [Q8TB72-3]
XP_005262664.1. XM_005262607.1. [Q8TB72-1]
XP_005262666.1. XM_005262609.1. [Q8TB72-2]
XP_006712036.1. XM_006711973.1. [Q8TB72-1]
XP_006712037.1. XM_006711974.2. [Q8TB72-1]
XP_011531021.1. XM_011532719.1. [Q8TB72-1]
XP_011531022.1. XM_011532720.2. [Q8TB72-1]
XP_011531023.1. XM_011532721.2. [Q8TB72-1]
XP_016859190.1. XM_017003701.1. [Q8TB72-3]
XP_016859191.1. XM_017003702.1. [Q8TB72-3]
XP_016859196.1. XM_017003707.1. [Q8TB72-2]
XP_016859197.1. XM_017003708.1. [Q8TB72-2]
UniGeneiHs.467824.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3Q0QX-ray2.00A706-1056[»]
3Q0RX-ray2.00A706-1056[»]
3Q0SX-ray2.00A706-1056[»]
ProteinModelPortaliQ8TB72.
SMRiQ8TB72.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116949. 21 interactors.
IntActiQ8TB72. 8 interactors.
MINTiMINT-254513.
STRINGi9606.ENSP00000338173.

PTM databases

iPTMnetiQ8TB72.
PhosphoSitePlusiQ8TB72.

Polymorphism and mutation databases

DMDMi41688714.

Proteomic databases

EPDiQ8TB72.
MaxQBiQ8TB72.
PaxDbiQ8TB72.
PeptideAtlasiQ8TB72.
PRIDEiQ8TB72.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000338086; ENSP00000338173; ENSG00000055917. [Q8TB72-3]
ENST00000361078; ENSP00000354370; ENSG00000055917. [Q8TB72-4]
ENST00000403432; ENSP00000385992; ENSG00000055917. [Q8TB72-3]
GeneIDi23369.
KEGGihsa:23369.
UCSCiuc002rdt.2. human. [Q8TB72-1]

Organism-specific databases

CTDi23369.
DisGeNETi23369.
GeneCardsiPUM2.
HGNCiHGNC:14958. PUM2.
HPAiHPA030316.
HPA049670.
MIMi607205. gene.
neXtProtiNX_Q8TB72.
OpenTargetsiENSG00000055917.
PharmGKBiPA34043.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1488. Eukaryota.
COG5099. LUCA.
GeneTreeiENSGT00390000017241.
HOGENOMiHOG000238461.
HOVERGENiHBG049462.
InParanoidiQ8TB72.
KOiK17943.
OMAiLFDYSSQ.
OrthoDBiEOG091G04QO.
PhylomeDBiQ8TB72.
TreeFamiTF318160.

Miscellaneous databases

ChiTaRSiPUM2. human.
EvolutionaryTraceiQ8TB72.
GeneWikiiPUM2.
GenomeRNAii23369.
PROiQ8TB72.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000055917.
CleanExiHS_PUM2.
ExpressionAtlasiQ8TB72. baseline and differential.
GenevisibleiQ8TB72. HS.

Family and domain databases

CDDicd07920. Pumilio. 1 hit.
Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR033133. PUM-HD.
IPR033712. Pumilio_RNA-bd.
IPR001313. Pumilio_RNA-bd_rpt.
[Graphical view]
PfamiPF00806. PUF. 8 hits.
[Graphical view]
SMARTiSM00025. Pumilio. 8 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50302. PUM. 8 hits.
PS50303. PUM_HD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPUM2_HUMAN
AccessioniPrimary (citable) accession number: Q8TB72
Secondary accession number(s): B3KSL0
, B4E2B6, D6W527, O00234, Q53TV7, Q8WY43, Q9HAN2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: February 2, 2004
Last modified: November 2, 2016
This is version 140 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.