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Protein

Zinc finger protein 519

Gene

ZNF519

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri181 – 203C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri292 – 314C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri320 – 342C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri348 – 370C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri376 – 398C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri404 – 426C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri432 – 454C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri460 – 482C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri488 – 510C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri516 – 538C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 519
Gene namesi
Name:ZNF519
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

HGNCiHGNC:30574. ZNF519.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi162655.
OpenTargetsiENSG00000175322.
PharmGKBiPA134863605.

Polymorphism and mutation databases

BioMutaiZNF519.
DMDMi296453045.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000476371 – 540Zinc finger protein 519Add BLAST540

Proteomic databases

EPDiQ8TB69.
PaxDbiQ8TB69.
PeptideAtlasiQ8TB69.
PRIDEiQ8TB69.

PTM databases

iPTMnetiQ8TB69.
PhosphoSitePlusiQ8TB69.

Expressioni

Gene expression databases

BgeeiENSG00000175322.
CleanExiHS_ZNF519.
ExpressionAtlasiQ8TB69. baseline and differential.

Organism-specific databases

HPAiHPA028982.

Interactioni

Protein-protein interaction databases

BioGridi127827. 1 interactor.
STRINGi9606.ENSP00000464872.

Structurei

3D structure databases

ProteinModelPortaliQ8TB69.
SMRiQ8TB69.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 78KRABPROSITE-ProRule annotationAdd BLAST75

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri181 – 203C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri292 – 314C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri320 – 342C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri348 – 370C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri376 – 398C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri404 – 426C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri432 – 454C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri460 – 482C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri488 – 510C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri516 – 538C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00860000134064.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8TB69.
KOiK09228.
OMAiFNRGSYL.
OrthoDBiEOG091G02KC.
PhylomeDBiQ8TB69.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.40.10. 1 hit.
InterProiView protein in InterPro
IPR001909. KRAB.
IPR013087. Znf_C2H2_type.
IPR013083. Znf_RING/FYVE/PHD.
PfamiView protein in Pfam
PF01352. KRAB. 1 hit.
SMARTiView protein in SMART
SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 10 hits.
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF57667. SSF57667. 7 hits.
PROSITEiView protein in PROSITE
PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.

Sequencei

Sequence statusi: Complete.

Q8TB69-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELLTFRDVA IEFSPEEWKC LDPAQQNLYR DVMLENYRNL VSLAVYSYYN
60 70 80 90 100
QGILPEQGIQ DSFKKATLGR YGSCGLENIC LWKNWESIGE GEGQKECYNL
110 120 130 140 150
CSQYLTTSHN KHLTVKGDKE YRIFQKKPQF LSAAPTEPCI PMNKYQHKFL
160 170 180 190 200
KSVFCNKNQI NFNHDSNISK HHSTHFLENY YNCNECEKVF YQSSKLIFPE
210 220 230 240 250
NIHIQKKPYN SNECGETSDP FSKLTQHQRI YIGESSQRCN KKCIIVFSQS
260 270 280 290 300
HLKGHKIINT GEKSVKYKER GKAFTRGLHL GHQKIHTGEK PYKCKKCDKA
310 320 330 340 350
FNKSSHLAQH QRIHTGEKPF KCKECGKAFN RGSYLTQHQR IHTGERAFKC
360 370 380 390 400
EECGKAFNRG SYLTQHQRIH TGEKPFRCKE CGKAFNRSSY VTQHQRMHTG
410 420 430 440 450
EKPFKCKECG KAFNRASHLT QHQRIHTGEK HFKCKECGKA FNRGSHLTRH
460 470 480 490 500
QRIHTGEKSF KCEECGKAFI WGSHLTQHQR VHTGEKFFKC KECGKAFTRS
510 520 530 540
SHLTQHQRIH TGEKPFKCKE CGKAFNRRST LTQHQIIHTR
Length:540
Mass (Da):63,020
Last modified:May 18, 2010 - v2
Checksum:iD3212C320B418C3C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti167N → D in AAH24227 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05285418W → R. Corresponds to variant dbSNP:rs16941623Ensembl.1
Natural variantiVAR_05285589G → S. Corresponds to variant dbSNP:rs10221432Ensembl.1
Natural variantiVAR_052856206K → E1 PublicationCorresponds to variant dbSNP:rs2159940Ensembl.1
Natural variantiVAR_052857229R → I. Corresponds to variant dbSNP:rs8094412Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006557 Genomic DNA. No translation available.
BC024227 mRNA. Translation: AAH24227.1.
CCDSiCCDS32797.1.
RefSeqiNP_660330.2. NM_145287.3.
XP_016881051.1. XM_017025562.1.
XP_016881052.1. XM_017025563.1.
XP_016881053.1. XM_017025564.1.
XP_016881054.1. XM_017025565.1.
UniGeneiHs.352635.

Genome annotation databases

EnsembliENST00000590202; ENSP00000464872; ENSG00000175322.
GeneIDi162655.
KEGGihsa:162655.
UCSCiuc002kst.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiZN519_HUMAN
AccessioniPrimary (citable) accession number: Q8TB69
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 18, 2010
Last modified: May 10, 2017
This is version 125 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families