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Protein

Proline-rich protein 7

Gene

PRR7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a synapse-to-nucleus messenger to promote NMDA receptor-mediated excitotoxicity in neurons in a JUN-dependent manner (By similarity). Inhibits ubiquitination-mediated degradation and promotes phosphorylation and transcriptional activity of transcription factor JUN (PubMed:27458189). Might play a redundant role in the regulation of T cell receptor signaling (PubMed:21460222). Might promote apoptosis in T cells (PubMed:21460222).By similarity2 Publications

GO - Biological processi

Keywordsi

Biological processAdaptive immunity, Immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Proline-rich protein 7
Alternative name(s):
Synaptic proline-rich membrane protein
Gene namesi
Name:PRR7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000131188.11.
HGNCiHGNC:28130. PRR7.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 9ExtracellularSequence analysis9
Transmembranei10 – 30Helical; Signal-anchor for type III membrane proteinSequence analysisAdd BLAST21
Topological domaini31 – 274CytoplasmicSequence analysisAdd BLAST244

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Membrane, Nucleus, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi139Y → F: Reduced induction of apoptosis; when associated with F-153; F-166; F-177; F-201 and F-210. 1 Publication1
Mutagenesisi153Y → F: Reduced induction of apoptosis; when associated with F-139; F-166; F-177; F-201 and F-210. 1 Publication1
Mutagenesisi166Y → F: Reduced induction of apoptosis; when associated with F-139; F-153; F-177; F-201 and F-210. 1 Publication1
Mutagenesisi177Y → F: Reduced induction of apoptosis; when associated with F-139; F-153; F-166; F-201 and F-210. 1 Publication1
Mutagenesisi201Y → F: Reduced induction of apoptosis; when associated with F-139; F-153; F-166; F-177 and F-210. 1 Publication1
Mutagenesisi210Y → F: Reduced induction of apoptosis; when associated with F-139; F-153; F-166; F-177 and F-201. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000131188.
PharmGKBiPA134939770.

Polymorphism and mutation databases

BioMutaiPRR7.
DMDMi74730435.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003286491 – 274Proline-rich protein 7Add BLAST274

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei64PhosphoserineBy similarity1

Post-translational modificationi

Palmitoylated.1 Publication
Tyrosine phosphorylated, possibly by SRC.1 Publication

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

MaxQBiQ8TB68.
PaxDbiQ8TB68.
PRIDEiQ8TB68.

PTM databases

iPTMnetiQ8TB68.
PhosphoSitePlusiQ8TB68.

Expressioni

Tissue specificityi

Strongly expressed in brain tissue including the hippocampus, and moderately expressed in esophagus, trachea, lung, ovary, cervix, prostate, testes, thyroid, thymus, lymph nodes and peripheral blood lymphocytes.1 Publication

Inductioni

Up-regulated in peripheral blood leukocytes in response to T-cell receptor stimulation.1 Publication

Gene expression databases

BgeeiENSG00000131188.
CleanExiHS_PRR7.
ExpressionAtlasiQ8TB68. baseline and differential.
GenevisibleiQ8TB68. HS.

Organism-specific databases

HPAiHPA046636.

Interactioni

Subunit structurei

Forms a complex with NMDA receptor zeta subunit GRIN1 and epsilon subunit GRIN2B (PubMed:27458189). Interacts with GRIN1 and GRIN2B (PubMed:27458189). The interaction with GRIN1 is reduced upon NMDA receptor activity (By similarity). Found in a postsynaptic membrane complex with DLG4 and GRIN1 (By similarity). Interacts with DLG4 (via PDZ3 domain and to lesser degree via PDZ2 domain) (By similarity). Found in a complex with JUN and FBXW7 (PubMed:27458189). Interacts with JUN and FBXW7; the interaction inhibits ubiquitination-mediated JUN degradation promoting its phosphorylation and transcriptional activity (PubMed:27458189). Interacts with SRC (PubMed:21460222).By similarity2 Publications

Protein-protein interaction databases

BioGridi123292. 1 interactor.
IntActiQ8TB68. 1 interactor.
STRINGi9606.ENSP00000327168.

Structurei

3D structure databases

ProteinModelPortaliQ8TB68.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 44Required for interaction with NMDA receptors1 PublicationAdd BLAST44
Regioni2 – 39Required for membrane localization1 PublicationAdd BLAST38
Regioni151 – 274Required for apoptosis induction1 PublicationAdd BLAST124
Regioni151 – 171Required for internalization1 PublicationAdd BLAST21

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi272 – 274PDZ-bindingSequence analysis3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi69 – 227Pro-richAdd BLAST159

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWCG. Eukaryota.
ENOG410YRB8. LUCA.
GeneTreeiENSGT00390000001559.
HOGENOMiHOG000060177.
HOVERGENiHBG095664.
InParanoidiQ8TB68.
OMAiCFAGFWL.
OrthoDBiEOG091G0QN9.
PhylomeDBiQ8TB68.
TreeFamiTF332076.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TB68-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVMSQGTYTF LTCFAGFWLI WGLIVLLCCF CSFLRRRLKR RQEERLREQN
60 70 80 90 100
LRALELEPLE LEGSLAGSPP GLAPPQPPPH RSRLEAPAHA HSHPHVHVHP
110 120 130 140 150
LLHHGPAQPH AHAHPHPHHH ALPHPPPTHL SVPPRPWSYP RQAESDMSKP
160 170 180 190 200
PCYEEAVLMA EPPPPYSEVL TDTRGLYRKI VTPFLSRRDS AEKQEQPPPS
210 220 230 240 250
YKPLFLDRGY TSALHLPSAP RPAPPCPALC LQADRGRRVF PSWTDSELSS
260 270
REPLEHGAWR LPVSIPLFGR TTAV
Length:274
Mass (Da):30,930
Last modified:June 1, 2002 - v1
Checksum:i3F83198AD2F8032B
GO
Isoform 2 (identifier: Q8TB68-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     89-109: Missing.

Show »
Length:253
Mass (Da):28,605
Checksum:iD30A003C4F29CE71
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_042437127P → H1 PublicationCorresponds to variant dbSNP:rs17851889Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03275089 – 109Missing in isoform 2. 1 PublicationAdd BLAST21

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471195 Genomic DNA. Translation: EAW84994.1.
BC004261 mRNA. Translation: AAH04261.1.
BC021240 mRNA. Translation: AAH21240.1.
BC024233 mRNA. Translation: AAH24233.2.
BC033649 mRNA. Translation: AAH33649.1.
CCDSiCCDS4419.1. [Q8TB68-1]
RefSeqiNP_001167572.1. NM_001174101.1. [Q8TB68-1]
NP_001167573.1. NM_001174102.2. [Q8TB68-1]
NP_085044.2. NM_030567.4. [Q8TB68-1]
XP_011532964.1. XM_011534662.1. [Q8TB68-1]
XP_011532965.1. XM_011534663.2. [Q8TB68-1]
XP_016865385.1. XM_017009896.1. [Q8TB68-1]
XP_016865386.1. XM_017009897.1. [Q8TB68-1]
UniGeneiHs.534492.

Genome annotation databases

EnsembliENST00000323249; ENSP00000327168; ENSG00000131188. [Q8TB68-1]
ENST00000502922; ENSP00000420872; ENSG00000131188. [Q8TB68-1]
ENST00000510492; ENSP00000421039; ENSG00000131188. [Q8TB68-1]
GeneIDi80758.
KEGGihsa:80758.
UCSCiuc003mgu.2. human. [Q8TB68-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPRR7_HUMAN
AccessioniPrimary (citable) accession number: Q8TB68
Secondary accession number(s): Q8WU53, Q9BTA7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: June 1, 2002
Last modified: November 22, 2017
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations