Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Proline-rich protein 7

Gene

PRR7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Proline-rich protein 7
Alternative name(s):
Synaptic proline-rich membrane protein
Gene namesi
Name:PRR7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:28130. PRR7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 99ExtracellularSequence analysis
Transmembranei10 – 3021Helical; Signal-anchor for type III membrane proteinSequence analysisAdd
BLAST
Topological domaini31 – 274244CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134939770.

Polymorphism and mutation databases

BioMutaiPRR7.
DMDMi74730435.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 274274Proline-rich protein 7PRO_0000328649Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei64 – 641PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8TB68.
PRIDEiQ8TB68.

PTM databases

iPTMnetiQ8TB68.
PhosphoSiteiQ8TB68.

Expressioni

Gene expression databases

BgeeiENSG00000131188.
CleanExiHS_PRR7.
ExpressionAtlasiQ8TB68. baseline and differential.
GenevisibleiQ8TB68. HS.

Organism-specific databases

HPAiHPA046636.

Interactioni

Subunit structurei

Found in a postsynaptic membrane complex with DLG4 and GRIN1. Interacts with DLG4. Interacts preferentially to the PDZ3 domain of DLG4 and to lesser degree to PDZ2 but not to the PDZ1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi123292. 1 interaction.
IntActiQ8TB68. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ8TB68.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi272 – 2743PDZ-bindingSequence analysis

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi69 – 227159Pro-richAdd
BLAST

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWCG. Eukaryota.
ENOG410YRB8. LUCA.
GeneTreeiENSGT00390000001559.
HOGENOMiHOG000060177.
HOVERGENiHBG095664.
InParanoidiQ8TB68.
OMAiPLEHGAW.
OrthoDBiEOG091G0QN9.
PhylomeDBiQ8TB68.
TreeFamiTF332076.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TB68-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVMSQGTYTF LTCFAGFWLI WGLIVLLCCF CSFLRRRLKR RQEERLREQN
60 70 80 90 100
LRALELEPLE LEGSLAGSPP GLAPPQPPPH RSRLEAPAHA HSHPHVHVHP
110 120 130 140 150
LLHHGPAQPH AHAHPHPHHH ALPHPPPTHL SVPPRPWSYP RQAESDMSKP
160 170 180 190 200
PCYEEAVLMA EPPPPYSEVL TDTRGLYRKI VTPFLSRRDS AEKQEQPPPS
210 220 230 240 250
YKPLFLDRGY TSALHLPSAP RPAPPCPALC LQADRGRRVF PSWTDSELSS
260 270
REPLEHGAWR LPVSIPLFGR TTAV
Length:274
Mass (Da):30,930
Last modified:June 1, 2002 - v1
Checksum:i3F83198AD2F8032B
GO
Isoform 2 (identifier: Q8TB68-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     89-109: Missing.

Show »
Length:253
Mass (Da):28,605
Checksum:iD30A003C4F29CE71
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti127 – 1271P → H.1 Publication
Corresponds to variant rs17851889 [ dbSNP | Ensembl ].
VAR_042437

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei89 – 10921Missing in isoform 2. 1 PublicationVSP_032750Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471195 Genomic DNA. Translation: EAW84994.1.
BC004261 mRNA. Translation: AAH04261.1.
BC021240 mRNA. Translation: AAH21240.1.
BC024233 mRNA. Translation: AAH24233.2.
BC033649 mRNA. Translation: AAH33649.1.
CCDSiCCDS4419.1. [Q8TB68-1]
RefSeqiNP_001167572.1. NM_001174101.1. [Q8TB68-1]
NP_001167573.1. NM_001174102.1. [Q8TB68-1]
NP_085044.2. NM_030567.4. [Q8TB68-1]
XP_011532964.1. XM_011534662.1. [Q8TB68-1]
XP_011532965.1. XM_011534663.2. [Q8TB68-1]
UniGeneiHs.534492.

Genome annotation databases

EnsembliENST00000323249; ENSP00000327168; ENSG00000131188. [Q8TB68-1]
ENST00000502922; ENSP00000420872; ENSG00000131188. [Q8TB68-1]
ENST00000510492; ENSP00000421039; ENSG00000131188. [Q8TB68-1]
GeneIDi80758.
KEGGihsa:80758.
UCSCiuc003mgu.2. human. [Q8TB68-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471195 Genomic DNA. Translation: EAW84994.1.
BC004261 mRNA. Translation: AAH04261.1.
BC021240 mRNA. Translation: AAH21240.1.
BC024233 mRNA. Translation: AAH24233.2.
BC033649 mRNA. Translation: AAH33649.1.
CCDSiCCDS4419.1. [Q8TB68-1]
RefSeqiNP_001167572.1. NM_001174101.1. [Q8TB68-1]
NP_001167573.1. NM_001174102.1. [Q8TB68-1]
NP_085044.2. NM_030567.4. [Q8TB68-1]
XP_011532964.1. XM_011534662.1. [Q8TB68-1]
XP_011532965.1. XM_011534663.2. [Q8TB68-1]
UniGeneiHs.534492.

3D structure databases

ProteinModelPortaliQ8TB68.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123292. 1 interaction.
IntActiQ8TB68. 1 interaction.

PTM databases

iPTMnetiQ8TB68.
PhosphoSiteiQ8TB68.

Polymorphism and mutation databases

BioMutaiPRR7.
DMDMi74730435.

Proteomic databases

PaxDbiQ8TB68.
PRIDEiQ8TB68.

Protocols and materials databases

DNASUi80758.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000323249; ENSP00000327168; ENSG00000131188. [Q8TB68-1]
ENST00000502922; ENSP00000420872; ENSG00000131188. [Q8TB68-1]
ENST00000510492; ENSP00000421039; ENSG00000131188. [Q8TB68-1]
GeneIDi80758.
KEGGihsa:80758.
UCSCiuc003mgu.2. human. [Q8TB68-1]

Organism-specific databases

CTDi80758.
GeneCardsiPRR7.
HGNCiHGNC:28130. PRR7.
HPAiHPA046636.
neXtProtiNX_Q8TB68.
PharmGKBiPA134939770.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IWCG. Eukaryota.
ENOG410YRB8. LUCA.
GeneTreeiENSGT00390000001559.
HOGENOMiHOG000060177.
HOVERGENiHBG095664.
InParanoidiQ8TB68.
OMAiPLEHGAW.
OrthoDBiEOG091G0QN9.
PhylomeDBiQ8TB68.
TreeFamiTF332076.

Miscellaneous databases

GenomeRNAii80758.
PROiQ8TB68.

Gene expression databases

BgeeiENSG00000131188.
CleanExiHS_PRR7.
ExpressionAtlasiQ8TB68. baseline and differential.
GenevisibleiQ8TB68. HS.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiPRR7_HUMAN
AccessioniPrimary (citable) accession number: Q8TB68
Secondary accession number(s): Q8WU53, Q9BTA7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: June 1, 2002
Last modified: September 7, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.