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Q8TB61

- S35B2_HUMAN

UniProt

Q8TB61 - S35B2_HUMAN

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Protein

Adenosine 3'-phospho 5'-phosphosulfate transporter 1

Gene
SLC35B2, PAPST1, PSEC0149
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Mediates the transport of adenosine 3'-phospho 5'-phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal sulfuryl donor for sulfation events that take place in the Golgi. May indirectly participate in activation of the NF-kappa-B and MAPK pathways.1 Publication

Kineticsi

  1. KM=0.8 µM for PAPS1 Publication

GO - Molecular functioni

  1. 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity Source: UniProtKB
  2. signal transducer activity Source: UniProtKB

GO - Biological processi

  1. 3'-phospho-5'-adenylyl sulfate transmembrane transport Source: GOC
  2. 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process Source: Reactome
  3. 3'-phosphoadenosine 5'-phosphosulfate metabolic process Source: Reactome
  4. 3'-phosphoadenosine 5'-phosphosulfate transport Source: UniProtKB
  5. carbohydrate metabolic process Source: Reactome
  6. glycosaminoglycan metabolic process Source: Reactome
  7. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
  8. signal transduction Source: GOC
  9. small molecule metabolic process Source: Reactome
  10. transmembrane transport Source: Reactome
  11. xenobiotic metabolic process Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiREACT_22151. Transport of nucleotide sugars.
REACT_6840. Transport and synthesis of PAPS.

Protein family/group databases

TCDBi2.A.7.11.3. the drug/metabolite transporter (dmt) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosine 3'-phospho 5'-phosphosulfate transporter 1
Alternative name(s):
PAPS transporter 1
Putative MAPK-activating protein PM15
Putative NF-kappa-B-activating protein 48
Solute carrier family 35 member B2
Gene namesi
Name:SLC35B2
Synonyms:PAPST1
ORF Names:PSEC0149
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:16872. SLC35B2.

Subcellular locationi

Golgi apparatus membrane; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei5 – 2521Helical; Reviewed predictionAdd
BLAST
Transmembranei40 – 6021Helical; Reviewed predictionAdd
BLAST
Transmembranei109 – 12921Helical; Reviewed predictionAdd
BLAST
Transmembranei154 – 17421Helical; Reviewed predictionAdd
BLAST
Transmembranei238 – 25821Helical; Reviewed predictionAdd
BLAST
Transmembranei265 – 28521Helical; Reviewed predictionAdd
BLAST
Transmembranei299 – 31921Helical; Reviewed predictionAdd
BLAST
Transmembranei353 – 37321Helical; Reviewed predictionAdd
BLAST
Transmembranei387 – 40721Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB
  2. Golgi membrane Source: Reactome
  3. integral component of membrane Source: UniProtKB
  4. membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134927864.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 432432Adenosine 3'-phospho 5'-phosphosulfate transporter 1PRO_0000213374Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei427 – 4271Phosphoserine2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8TB61.
PaxDbiQ8TB61.
PRIDEiQ8TB61.

PTM databases

PhosphoSiteiQ8TB61.

Expressioni

Tissue specificityi

Highly expressed in the placenta, pancreas, mammary gland and skeletal muscle. Weakly or not expressed in colon, heart and prostate.1 Publication

Gene expression databases

BgeeiQ8TB61.
CleanExiHS_SLC35B2.
GenevestigatoriQ8TB61.

Organism-specific databases

HPAiHPA029638.

Interactioni

Protein-protein interaction databases

BioGridi131484. 2 interactions.
STRINGi9606.ENSP00000377401.

Structurei

3D structure databases

ProteinModelPortaliQ8TB61.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0697.
HOVERGENiHBG062347.
InParanoidiQ8TB61.
KOiK15276.
OMAiVLCKQPR.
PhylomeDBiQ8TB61.
TreeFamiTF105926.

Family and domain databases

InterProiIPR013657. UAA.
[Graphical view]
PfamiPF08449. UAA. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8TB61-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MDARWWAVVV LAAFPSLGAG GETPEAPPES WTQLWFFRFV VNAAGYASFM    50
VPGYLLVQYF RRKNYLETGR GLCFPLVKAC VFGNEPKASD EVPLAPRTEA 100
AETTPMWQAL KLLFCATGLQ VSYLTWGVLQ ERVMTRSYGA TATSPGERFT 150
DSQFLVLMNR VLALIVAGLS CVLCKQPRHG APMYRYSFAS LSNVLSSWCQ 200
YEALKFVSFP TQVLAKASKV IPVMLMGKLV SRRSYEHWEY LTATLISIGV 250
SMFLLSSGPE PRSSPATTLS GLILLAGYIA FDSFTSNWQD ALFAYKMSSV 300
QMMFGVNFFS CLFTVGSLLE QGALLEGTRF MGRHSEFAAH ALLLSICSAC 350
GQLFIFYTIG QFGAAVFTII MTLRQAFAIL LSCLLYGHTV TVVGGLGVAV 400
VFAALLLRVY ARGRLKQRGK KAVPVESPVQ KV 432
Length:432
Mass (Da):47,515
Last modified:June 1, 2002 - v1
Checksum:i7E4E9E87231072FB
GO
Isoform 2 (identifier: Q8TB61-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     272-311: Missing.

Show »
Length:392
Mass (Da):42,967
Checksum:i9B7BACC7F3F670DD
GO
Isoform 3 (identifier: Q8TB61-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-49: Missing.

Note: No experimental confirmation available.

Show »
Length:383
Mass (Da):42,128
Checksum:i49A2443E2C37F263
GO
Isoform 4 (identifier: Q8TB61-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-27: MDARWWAVVVLAAFPSLGAGGETPEAP → MLLAMPALWYLATSWCSTSGGRTTWRP
     28-120: Missing.

Note: No experimental confirmation available.

Show »
Length:339
Mass (Da):37,235
Checksum:iBD3CA2176C9D31C8
GO

Sequence cautioni

The sequence CAI20100.2 differs from that shown. Reason: Erroneous gene model prediction.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti342 – 3421L → V.1 Publication
Corresponds to variant rs3734707 [ dbSNP | Ensembl ].
VAR_022657

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 4949Missing in isoform 3. VSP_026949Add
BLAST
Alternative sequencei1 – 2727MDARW…TPEAP → MLLAMPALWYLATSWCSTSG GRTTWRP in isoform 4. VSP_054696Add
BLAST
Alternative sequencei28 – 12093Missing in isoform 4. VSP_054697Add
BLAST
Alternative sequencei272 – 31140Missing in isoform 2. VSP_014084Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti214 – 2141L → P in BAD96748. 1 Publication
Sequence conflicti336 – 3361E → G in BAC11631. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB106538 mRNA. Translation: BAC79117.1.
AY491520 mRNA. Translation: AAS79661.1.
AB097021 mRNA. Translation: BAC77374.1.
AB097039 mRNA. Translation: BAC77392.1.
AK293344 mRNA. Translation: BAG56860.1.
AK075456 mRNA. Translation: BAC11631.1.
AL139392 Genomic DNA. Translation: CAI20100.2. Sequence problems.
AL139392 Genomic DNA. Translation: CAI20101.2.
BC016839 mRNA. Translation: AAH16839.1.
BC024288 mRNA. Translation: AAH24288.1.
AK223028 mRNA. Translation: BAD96748.1.
CCDSiCCDS34462.1. [Q8TB61-1]
CCDS69127.1. [Q8TB61-4]
RefSeqiNP_001273438.1. NM_001286509.1.
NP_001273439.1. NM_001286510.1.
NP_001273440.1. NM_001286511.1. [Q8TB61-3]
NP_001273441.1. NM_001286512.1. [Q8TB61-3]
NP_001273442.1. NM_001286513.1. [Q8TB61-4]
NP_001273446.1. NM_001286517.1.
NP_001273448.1. NM_001286519.1.
NP_001273449.1. NM_001286520.1.
NP_835361.1. NM_178148.3. [Q8TB61-1]
UniGeneiHs.182885.

Genome annotation databases

EnsembliENST00000393812; ENSP00000377401; ENSG00000157593. [Q8TB61-1]
ENST00000538577; ENSP00000443845; ENSG00000157593.
GeneIDi347734.
KEGGihsa:347734.
UCSCiuc003oxd.3. human. [Q8TB61-1]

Polymorphism databases

DMDMi67461576.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

GGDB

GlycoGene database

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB106538 mRNA. Translation: BAC79117.1 .
AY491520 mRNA. Translation: AAS79661.1 .
AB097021 mRNA. Translation: BAC77374.1 .
AB097039 mRNA. Translation: BAC77392.1 .
AK293344 mRNA. Translation: BAG56860.1 .
AK075456 mRNA. Translation: BAC11631.1 .
AL139392 Genomic DNA. Translation: CAI20100.2 . Sequence problems.
AL139392 Genomic DNA. Translation: CAI20101.2 .
BC016839 mRNA. Translation: AAH16839.1 .
BC024288 mRNA. Translation: AAH24288.1 .
AK223028 mRNA. Translation: BAD96748.1 .
CCDSi CCDS34462.1. [Q8TB61-1 ]
CCDS69127.1. [Q8TB61-4 ]
RefSeqi NP_001273438.1. NM_001286509.1.
NP_001273439.1. NM_001286510.1.
NP_001273440.1. NM_001286511.1. [Q8TB61-3 ]
NP_001273441.1. NM_001286512.1. [Q8TB61-3 ]
NP_001273442.1. NM_001286513.1. [Q8TB61-4 ]
NP_001273446.1. NM_001286517.1.
NP_001273448.1. NM_001286519.1.
NP_001273449.1. NM_001286520.1.
NP_835361.1. NM_178148.3. [Q8TB61-1 ]
UniGenei Hs.182885.

3D structure databases

ProteinModelPortali Q8TB61.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 131484. 2 interactions.
STRINGi 9606.ENSP00000377401.

Protein family/group databases

TCDBi 2.A.7.11.3. the drug/metabolite transporter (dmt) superfamily.

PTM databases

PhosphoSitei Q8TB61.

Polymorphism databases

DMDMi 67461576.

Proteomic databases

MaxQBi Q8TB61.
PaxDbi Q8TB61.
PRIDEi Q8TB61.

Protocols and materials databases

DNASUi 347734.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000393812 ; ENSP00000377401 ; ENSG00000157593 . [Q8TB61-1 ]
ENST00000538577 ; ENSP00000443845 ; ENSG00000157593 .
GeneIDi 347734.
KEGGi hsa:347734.
UCSCi uc003oxd.3. human. [Q8TB61-1 ]

Organism-specific databases

CTDi 347734.
GeneCardsi GC06M044221.
HGNCi HGNC:16872. SLC35B2.
HPAi HPA029638.
MIMi 610788. gene.
neXtProti NX_Q8TB61.
PharmGKBi PA134927864.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0697.
HOVERGENi HBG062347.
InParanoidi Q8TB61.
KOi K15276.
OMAi VLCKQPR.
PhylomeDBi Q8TB61.
TreeFami TF105926.

Enzyme and pathway databases

Reactomei REACT_22151. Transport of nucleotide sugars.
REACT_6840. Transport and synthesis of PAPS.

Miscellaneous databases

ChiTaRSi SLC35B2. human.
GeneWikii SLC35B2.
GenomeRNAii 347734.
NextBioi 35471032.
PROi Q8TB61.
SOURCEi Search...

Gene expression databases

Bgeei Q8TB61.
CleanExi HS_SLC35B2.
Genevestigatori Q8TB61.

Family and domain databases

InterProi IPR013657. UAA.
[Graphical view ]
Pfami PF08449. UAA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and identification of 3'-phosphoadenosine 5'-phosphosulfate transporter."
    Kamiyama S., Suda T., Ueda R., Suzuki M., Okubo R., Kikuchi N., Chiba Y., Goto S., Toyoda H., Saigo K., Watanabe M., Narimatsu H., Jigami Y., Nishihara S.
    J. Biol. Chem. 278:25958-25963(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Colon.
  2. "Identification of a splicing variant of solute carrier family 35, member B2 (SLC35B2)."
    Xu J., Xie Y., Mao Y.
    Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
  3. "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways."
    Matsuda A., Suzuki Y., Honda G., Muramatsu S., Matsuzaki O., Nagano Y., Doi T., Shimotohno K., Harada T., Nishida E., Hayashi H., Sugano S.
    Oncogene 22:3307-3318(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Lung fibroblast.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), VARIANT VAL-342.
  5. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
    Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
    , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
    DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Placenta.
  6. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lung carcinoma and Neuroblastoma.
  8. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 64-432 (ISOFORMS 1/3).
    Tissue: Thyroid.
  9. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-427, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-427, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiS35B2_HUMAN
AccessioniPrimary (citable) accession number: Q8TB61
Secondary accession number(s): B4DDU9
, F5H7Y9, Q2VY06, Q53GA3, Q5T9W1, Q5T9W2, Q7Z2G3, Q8NBK6, Q96AR6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 1, 2002
Last modified: September 3, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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