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Protein

Adenosine 3'-phospho 5'-phosphosulfate transporter 1

Gene

SLC35B2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mediates the transport of adenosine 3'-phospho 5'-phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal sulfuryl donor for sulfation events that take place in the Golgi. May indirectly participate in activation of the NF-kappa-B and MAPK pathways.1 Publication

Kineticsi

  1. KM=0.8 µM for PAPS1 Publication

    GO - Molecular functioni

    • 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity Source: UniProtKB
    • signal transducer activity Source: UniProtKB

    GO - Biological processi

    Complete GO annotation...

    Keywords - Biological processi

    Transport

    Enzyme and pathway databases

    ReactomeiREACT_22151. Transport of nucleotide sugars.
    REACT_6840. Transport and synthesis of PAPS.

    Protein family/group databases

    TCDBi2.A.7.11.3. the drug/metabolite transporter (dmt) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Adenosine 3'-phospho 5'-phosphosulfate transporter 1
    Alternative name(s):
    PAPS transporter 1
    Putative MAPK-activating protein PM15
    Putative NF-kappa-B-activating protein 48
    Solute carrier family 35 member B2
    Gene namesi
    Name:SLC35B2
    Synonyms:PAPST1
    ORF Names:PSEC0149
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640 Componenti: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:16872. SLC35B2.

    Subcellular locationi

    Topology

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei5 – 2521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei40 – 6021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei109 – 12921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei154 – 17421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei238 – 25821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei265 – 28521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei299 – 31921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei353 – 37321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei387 – 40721HelicalSequence AnalysisAdd
    BLAST

    GO - Cellular componenti

    • Golgi apparatus Source: UniProtKB
    • Golgi membrane Source: Reactome
    • integral component of membrane Source: UniProtKB
    • membrane Source: UniProtKB
    Complete GO annotation...

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134927864.

    Polymorphism and mutation databases

    DMDMi67461576.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 432432Adenosine 3'-phospho 5'-phosphosulfate transporter 1PRO_0000213374Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei427 – 4271Phosphoserine2 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ8TB61.
    PaxDbiQ8TB61.
    PRIDEiQ8TB61.

    PTM databases

    PhosphoSiteiQ8TB61.

    Expressioni

    Tissue specificityi

    Highly expressed in the placenta, pancreas, mammary gland and skeletal muscle. Weakly or not expressed in colon, heart and prostate.1 Publication

    Gene expression databases

    BgeeiQ8TB61.
    CleanExiHS_SLC35B2.
    ExpressionAtlasiQ8TB61. baseline.
    GenevisibleiQ8TB61. HS.

    Organism-specific databases

    HPAiHPA029638.

    Interactioni

    Protein-protein interaction databases

    BioGridi131484. 14 interactions.
    STRINGi9606.ENSP00000377401.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8TB61.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0697.
    GeneTreeiENSGT00530000063090.
    HOVERGENiHBG062347.
    KOiK15276.
    OMAiYEYWEYF.
    OrthoDBiEOG79CXZC.
    PhylomeDBiQ8TB61.
    TreeFamiTF105926.

    Family and domain databases

    InterProiIPR013657. UAA.
    [Graphical view]
    PfamiPF08449. UAA. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

    Isoform 1 (identifier: Q8TB61-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

            10         20         30         40         50
    MDARWWAVVV LAAFPSLGAG GETPEAPPES WTQLWFFRFV VNAAGYASFM
    60 70 80 90 100
    VPGYLLVQYF RRKNYLETGR GLCFPLVKAC VFGNEPKASD EVPLAPRTEA
    110 120 130 140 150
    AETTPMWQAL KLLFCATGLQ VSYLTWGVLQ ERVMTRSYGA TATSPGERFT
    160 170 180 190 200
    DSQFLVLMNR VLALIVAGLS CVLCKQPRHG APMYRYSFAS LSNVLSSWCQ
    210 220 230 240 250
    YEALKFVSFP TQVLAKASKV IPVMLMGKLV SRRSYEHWEY LTATLISIGV
    260 270 280 290 300
    SMFLLSSGPE PRSSPATTLS GLILLAGYIA FDSFTSNWQD ALFAYKMSSV
    310 320 330 340 350
    QMMFGVNFFS CLFTVGSLLE QGALLEGTRF MGRHSEFAAH ALLLSICSAC
    360 370 380 390 400
    GQLFIFYTIG QFGAAVFTII MTLRQAFAIL LSCLLYGHTV TVVGGLGVAV
    410 420 430
    VFAALLLRVY ARGRLKQRGK KAVPVESPVQ KV
    Length:432
    Mass (Da):47,515
    Last modified:June 1, 2002 - v1
    Checksum:i7E4E9E87231072FB
    GO
    Isoform 2 (identifier: Q8TB61-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         272-311: Missing.

    Show »
    Length:392
    Mass (Da):42,967
    Checksum:i9B7BACC7F3F670DD
    GO
    Isoform 3 (identifier: Q8TB61-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-49: Missing.

    Note: No experimental confirmation available.
    Show »
    Length:383
    Mass (Da):42,128
    Checksum:i49A2443E2C37F263
    GO
    Isoform 4 (identifier: Q8TB61-4) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-27: MDARWWAVVVLAAFPSLGAGGETPEAP → MLLAMPALWYLATSWCSTSGGRTTWRP
         28-120: Missing.

    Note: No experimental confirmation available.
    Show »
    Length:339
    Mass (Da):37,235
    Checksum:iBD3CA2176C9D31C8
    GO
    Isoform 5 (identifier: Q8TB61-5) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-133: Missing.

    Note: No experimental confirmation available.
    Show »
    Length:299
    Mass (Da):32,664
    Checksum:iC2DB27B67918AABB
    GO

    Sequence cautioni

    The sequence CAI20100.2 differs from that shown. Reason: Erroneous gene model prediction. Curated

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti214 – 2141L → P in BAD96748 (Ref. 8) Curated
    Sequence conflicti336 – 3361E → G in BAC11631 (PubMed:16303743).Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti342 – 3421L → V.1 Publication
    Corresponds to variant rs3734707 [ dbSNP | Ensembl ].
    VAR_022657

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 133133Missing in isoform 5. 1 PublicationVSP_057436Add
    BLAST
    Alternative sequencei1 – 4949Missing in isoform 3. 1 PublicationVSP_026949Add
    BLAST
    Alternative sequencei1 – 2727MDARW…TPEAP → MLLAMPALWYLATSWCSTSG GRTTWRP in isoform 4. 1 PublicationVSP_054696Add
    BLAST
    Alternative sequencei28 – 12093Missing in isoform 4. 1 PublicationVSP_054697Add
    BLAST
    Alternative sequencei272 – 31140Missing in isoform 2. 1 PublicationVSP_014084Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AB106538 mRNA. Translation: BAC79117.1.
    AY491520 mRNA. Translation: AAS79661.1.
    AB097021 mRNA. Translation: BAC77374.1.
    AB097039 mRNA. Translation: BAC77392.1.
    AK293251 mRNA. Translation: BAG56783.1.
    AK293344 mRNA. Translation: BAG56860.1.
    AK075456 mRNA. Translation: BAC11631.1.
    AL139392 Genomic DNA. Translation: CAI20100.2. Sequence problems.
    AL139392 Genomic DNA. Translation: CAI20101.2.
    BC016839 mRNA. Translation: AAH16839.1.
    BC024288 mRNA. Translation: AAH24288.1.
    AK223028 mRNA. Translation: BAD96748.1.
    CCDSiCCDS34462.1. [Q8TB61-1]
    CCDS69127.1. [Q8TB61-4]
    CCDS75462.1. [Q8TB61-5]
    CCDS75463.1. [Q8TB61-3]
    RefSeqiNP_001273438.1. NM_001286509.1.
    NP_001273439.1. NM_001286510.1.
    NP_001273440.1. NM_001286511.1. [Q8TB61-3]
    NP_001273441.1. NM_001286512.1. [Q8TB61-3]
    NP_001273442.1. NM_001286513.1. [Q8TB61-4]
    NP_001273446.1. NM_001286517.1.
    NP_001273448.1. NM_001286519.1. [Q8TB61-5]
    NP_001273449.1. NM_001286520.1. [Q8TB61-5]
    NP_835361.1. NM_178148.3. [Q8TB61-1]
    UniGeneiHs.182885.

    Genome annotation databases

    EnsembliENST00000393812; ENSP00000377401; ENSG00000157593.
    ENST00000537814; ENSP00000440340; ENSG00000157593. [Q8TB61-5]
    ENST00000538577; ENSP00000443845; ENSG00000157593. [Q8TB61-4]
    ENST00000615337; ENSP00000480681; ENSG00000157593. [Q8TB61-3]
    ENST00000619636; ENSP00000483181; ENSG00000157593. [Q8TB61-3]
    GeneIDi347734.
    KEGGihsa:347734.
    UCSCiuc003oxd.3. human. [Q8TB61-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    GGDB

    GlycoGene database

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AB106538 mRNA. Translation: BAC79117.1.
    AY491520 mRNA. Translation: AAS79661.1.
    AB097021 mRNA. Translation: BAC77374.1.
    AB097039 mRNA. Translation: BAC77392.1.
    AK293251 mRNA. Translation: BAG56783.1.
    AK293344 mRNA. Translation: BAG56860.1.
    AK075456 mRNA. Translation: BAC11631.1.
    AL139392 Genomic DNA. Translation: CAI20100.2. Sequence problems.
    AL139392 Genomic DNA. Translation: CAI20101.2.
    BC016839 mRNA. Translation: AAH16839.1.
    BC024288 mRNA. Translation: AAH24288.1.
    AK223028 mRNA. Translation: BAD96748.1.
    CCDSiCCDS34462.1. [Q8TB61-1]
    CCDS69127.1. [Q8TB61-4]
    CCDS75462.1. [Q8TB61-5]
    CCDS75463.1. [Q8TB61-3]
    RefSeqiNP_001273438.1. NM_001286509.1.
    NP_001273439.1. NM_001286510.1.
    NP_001273440.1. NM_001286511.1. [Q8TB61-3]
    NP_001273441.1. NM_001286512.1. [Q8TB61-3]
    NP_001273442.1. NM_001286513.1. [Q8TB61-4]
    NP_001273446.1. NM_001286517.1.
    NP_001273448.1. NM_001286519.1. [Q8TB61-5]
    NP_001273449.1. NM_001286520.1. [Q8TB61-5]
    NP_835361.1. NM_178148.3. [Q8TB61-1]
    UniGeneiHs.182885.

    3D structure databases

    ProteinModelPortaliQ8TB61.
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi131484. 14 interactions.
    STRINGi9606.ENSP00000377401.

    Protein family/group databases

    TCDBi2.A.7.11.3. the drug/metabolite transporter (dmt) superfamily.

    PTM databases

    PhosphoSiteiQ8TB61.

    Polymorphism and mutation databases

    DMDMi67461576.

    Proteomic databases

    MaxQBiQ8TB61.
    PaxDbiQ8TB61.
    PRIDEiQ8TB61.

    Protocols and materials databases

    DNASUi347734.
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000393812; ENSP00000377401; ENSG00000157593.
    ENST00000537814; ENSP00000440340; ENSG00000157593. [Q8TB61-5]
    ENST00000538577; ENSP00000443845; ENSG00000157593. [Q8TB61-4]
    ENST00000615337; ENSP00000480681; ENSG00000157593. [Q8TB61-3]
    ENST00000619636; ENSP00000483181; ENSG00000157593. [Q8TB61-3]
    GeneIDi347734.
    KEGGihsa:347734.
    UCSCiuc003oxd.3. human. [Q8TB61-1]

    Organism-specific databases

    CTDi347734.
    GeneCardsiGC06M044221.
    HGNCiHGNC:16872. SLC35B2.
    HPAiHPA029638.
    MIMi610788. gene.
    neXtProtiNX_Q8TB61.
    PharmGKBiPA134927864.
    GenAtlasiSearch...

    Phylogenomic databases

    eggNOGiCOG0697.
    GeneTreeiENSGT00530000063090.
    HOVERGENiHBG062347.
    KOiK15276.
    OMAiYEYWEYF.
    OrthoDBiEOG79CXZC.
    PhylomeDBiQ8TB61.
    TreeFamiTF105926.

    Enzyme and pathway databases

    ReactomeiREACT_22151. Transport of nucleotide sugars.
    REACT_6840. Transport and synthesis of PAPS.

    Miscellaneous databases

    ChiTaRSiSLC35B2. human.
    GeneWikiiSLC35B2.
    GenomeRNAii347734.
    NextBioi35470972.
    PROiQ8TB61.
    SOURCEiSearch...

    Gene expression databases

    BgeeiQ8TB61.
    CleanExiHS_SLC35B2.
    ExpressionAtlasiQ8TB61. baseline.
    GenevisibleiQ8TB61. HS.

    Family and domain databases

    InterProiIPR013657. UAA.
    [Graphical view]
    PfamiPF08449. UAA. 1 hit.
    [Graphical view]
    ProtoNetiSearch...

    Publicationsi

    « Hide 'large scale' publications
    1. "Molecular cloning and identification of 3'-phosphoadenosine 5'-phosphosulfate transporter."
      Kamiyama S., Suda T., Ueda R., Suzuki M., Okubo R., Kikuchi N., Chiba Y., Goto S., Toyoda H., Saigo K., Watanabe M., Narimatsu H., Jigami Y., Nishihara S.
      J. Biol. Chem. 278:25958-25963(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Tissue: Colon.
    2. "Identification of a splicing variant of solute carrier family 35, member B2 (SLC35B2)."
      Xu J., Xie Y., Mao Y.
      Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
    3. "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways."
      Matsuda A., Suzuki Y., Honda G., Muramatsu S., Matsuzaki O., Nagano Y., Doi T., Shimotohno K., Harada T., Nishida E., Hayashi H., Sugano S.
      Oncogene 22:3307-3318(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Lung fibroblast.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4 AND 5), VARIANT VAL-342.
    5. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
      Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
      , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
      DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Placenta.
    6. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Lung carcinoma and Neuroblastoma.
    8. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 64-432 (ISOFORMS 1/3).
      Tissue: Thyroid.
    9. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-427, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-427, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiS35B2_HUMAN
    AccessioniPrimary (citable) accession number: Q8TB61
    Secondary accession number(s): B4DDM2
    , B4DDU9, F5H7Y9, Q2VY06, Q53GA3, Q5T9W1, Q5T9W2, Q7Z2G3, Q8NBK6, Q96AR6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2005
    Last sequence update: June 1, 2002
    Last modified: July 22, 2015
    This is version 117 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

    Similar proteinsi

    Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
    100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
    90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
    50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.