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Protein

F-box only protein 30

Gene

FBXO30

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Required for muscle atrophy following denervation.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri48 – 109TRAF-typePROSITE-ProRule annotationAdd BLAST62

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000118496-MONOMER.
ZFISH:ENSG00000132879-MONOMER.
ReactomeiR-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 30
Gene namesi
Name:FBXO30
Synonyms:FBX30
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:15600. FBXO30.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000118496.
PharmGKBiPA28041.

Polymorphism and mutation databases

BioMutaiFBXO30.
DMDMi51704325.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001199181 – 745F-box only protein 30Add BLAST745

Post-translational modificationi

Auto-ubiquitinated.By similarity
May be neddylated. Neddylation may be required for E3 ligase activity (By similarity).By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

EPDiQ8TB52.
MaxQBiQ8TB52.
PaxDbiQ8TB52.
PeptideAtlasiQ8TB52.
PRIDEiQ8TB52.

PTM databases

iPTMnetiQ8TB52.
PhosphoSitePlusiQ8TB52.

Expressioni

Gene expression databases

BgeeiENSG00000118496.
CleanExiHS_FBXO30.
GenevisibleiQ8TB52. HS.

Organism-specific databases

HPAiHPA012583.

Interactioni

Subunit structurei

Part of a SCF (SKP1-cullin-F-box) protein ligase complex. Interacts with SKP1, CUL1 and RBX1/ROC1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi123879. 22 interactors.
IntActiQ8TB52. 9 interactors.
STRINGi9606.ENSP00000237281.

Structurei

Secondary structure

1745
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi10 – 12Combined sources3
Turni24 – 26Combined sources3
Beta strandi30 – 32Combined sources3
Beta strandi40 – 42Combined sources3
Helixi43 – 52Combined sources10
Beta strandi54 – 59Combined sources6
Turni61 – 65Combined sources5
Beta strandi70 – 74Combined sources5
Helixi76 – 81Combined sources6
Helixi84 – 86Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YRENMR-A1-87[»]
ProteinModelPortaliQ8TB52.
SMRiQ8TB52.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8TB52.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini373 – 409F-boxPROSITE-ProRule annotationAdd BLAST37

Sequence similaritiesi

Contains 1 F-box domain.PROSITE-ProRule annotation
Contains 1 TRAF-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri48 – 109TRAF-typePROSITE-ProRule annotationAdd BLAST62

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IH36. Eukaryota.
ENOG410XQPH. LUCA.
GeneTreeiENSGT00410000025582.
HOGENOMiHOG000059618.
HOVERGENiHBG051574.
InParanoidiQ8TB52.
KOiK10307.
OMAiRNKVAEH.
OrthoDBiEOG091G06SE.
PhylomeDBiQ8TB52.
TreeFamiTF343227.

Family and domain databases

Gene3Di3.90.890.10. 1 hit.
InterProiIPR001810. F-box_dom.
IPR031890. Fbxo30/Fbxo40.
IPR013323. SIAH-type.
IPR008974. TRAF-like.
IPR001293. Znf_TRAF.
[Graphical view]
PANTHERiPTHR15933. PTHR15933. 3 hits.
PfamiPF15966. F-box_4. 1 hit.
PF15965. zf-TRAF_2. 1 hit.
[Graphical view]
SUPFAMiSSF49599. SSF49599. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
PS50145. ZF_TRAF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TB52-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEELQHSHC VNCVSRRCMT RPEPGISCDL IGCPLVCGAV FHSCKADEHR
60 70 80 90 100
LLCPFERVPC LNSDFGCPFT MARNKVAEHL EMCPASVVCC TMEWNRWPVS
110 120 130 140 150
YADRKSYENL SRDVDEVAQL DMALALQDQR MLLESLKVAT MMSKATDKVS
160 170 180 190 200
KPREQISVKS SVPEIPHANG LVSVDEESYG ALYQATVETT RSLAAALDIL
210 220 230 240 250
NTATRDIGML NTSVPNDMDE QQNARESLED QNLKDQDHLY EEEIGAVGGI
260 270 280 290 300
DYNDTNQNAQ SEQNGSSDLL CDLNTSSYDT SALCNGFPLE NICTQVIDQN
310 320 330 340 350
QNLHGDSKQS NLTNGDCVAS SDGTSKPSSS LAVAAQLREI IPSSALPNGT
360 370 380 390 400
VQHILMPDDE GEGELCWKKV DLGDVKNVDV LSFSHAPSFN FLSNSCWSKP
410 420 430 440 450
KEDKAVDTSD LEVAEDPMGL QGIDLITAAL LFCLGDSPGG RGISDSRMAD
460 470 480 490 500
IYHIDVGTQT FSLPSAILAT STMVGEIASA SACDHANPQL SNPSPFQTLG
510 520 530 540 550
LDLVLECVAR YQPKQRSMFT FVCGQLFRRK EFSSHFKNVH GDIHAGLNGW
560 570 580 590 600
MEQRCPLAYY GCTYSQRRFC PSIQGAKIIH DRHLRSFGVQ PCVSTVLVEP
610 620 630 640 650
ARNCVLGLHN DHLSSLPFEV LQHIAGFLDG FSLCQLSCVS KLMRDVCGSL
660 670 680 690 700
LQSRGMVILQ WGKRKYPEGN SSWQIKEKVW RFSTAFCSVN EWKFADILSM
710 720 730 740
ADHLKKCSYN VVEKREEAIP LPCMCVTREL TKEGRSLRSV LKPVL
Length:745
Mass (Da):82,304
Last modified:August 31, 2004 - v3
Checksum:iC2C010CF28568F9F
GO

Sequence cautioni

The sequence AAK30299 differs from that shown. Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated
The sequence AAK30299 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0360728S → C in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_024443375V → M.1 PublicationCorresponds to variant rs9373475dbSNPEnsembl.1
Natural variantiVAR_049044382S → C.Corresponds to variant rs17075385dbSNPEnsembl.1
Natural variantiVAR_020410583H → Q.1 PublicationCorresponds to variant rs3811102dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL356599 Genomic DNA. Translation: CAI41119.1.
BC024326 mRNA. Translation: AAH24326.3.
AF248640 mRNA. Translation: AAK30299.1. Different initiation.
CCDSiCCDS5208.1.
RefSeqiNP_115521.3. NM_032145.4.
XP_005267216.1. XM_005267159.3.
XP_011534479.1. XM_011536177.2.
XP_016866842.1. XM_017011353.1.
UniGeneiHs.421095.

Genome annotation databases

EnsembliENST00000237281; ENSP00000237281; ENSG00000118496.
GeneIDi84085.
KEGGihsa:84085.
UCSCiuc003qla.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL356599 Genomic DNA. Translation: CAI41119.1.
BC024326 mRNA. Translation: AAH24326.3.
AF248640 mRNA. Translation: AAK30299.1. Different initiation.
CCDSiCCDS5208.1.
RefSeqiNP_115521.3. NM_032145.4.
XP_005267216.1. XM_005267159.3.
XP_011534479.1. XM_011536177.2.
XP_016866842.1. XM_017011353.1.
UniGeneiHs.421095.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YRENMR-A1-87[»]
ProteinModelPortaliQ8TB52.
SMRiQ8TB52.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123879. 22 interactors.
IntActiQ8TB52. 9 interactors.
STRINGi9606.ENSP00000237281.

PTM databases

iPTMnetiQ8TB52.
PhosphoSitePlusiQ8TB52.

Polymorphism and mutation databases

BioMutaiFBXO30.
DMDMi51704325.

Proteomic databases

EPDiQ8TB52.
MaxQBiQ8TB52.
PaxDbiQ8TB52.
PeptideAtlasiQ8TB52.
PRIDEiQ8TB52.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000237281; ENSP00000237281; ENSG00000118496.
GeneIDi84085.
KEGGihsa:84085.
UCSCiuc003qla.4. human.

Organism-specific databases

CTDi84085.
GeneCardsiFBXO30.
HGNCiHGNC:15600. FBXO30.
HPAiHPA012583.
MIMi609101. gene.
neXtProtiNX_Q8TB52.
OpenTargetsiENSG00000118496.
PharmGKBiPA28041.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IH36. Eukaryota.
ENOG410XQPH. LUCA.
GeneTreeiENSGT00410000025582.
HOGENOMiHOG000059618.
HOVERGENiHBG051574.
InParanoidiQ8TB52.
KOiK10307.
OMAiRNKVAEH.
OrthoDBiEOG091G06SE.
PhylomeDBiQ8TB52.
TreeFamiTF343227.

Enzyme and pathway databases

UniPathwayiUPA00143.
BioCyciZFISH:ENSG00000118496-MONOMER.
ZFISH:ENSG00000132879-MONOMER.
ReactomeiR-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

EvolutionaryTraceiQ8TB52.
GenomeRNAii84085.
PROiQ8TB52.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000118496.
CleanExiHS_FBXO30.
GenevisibleiQ8TB52. HS.

Family and domain databases

Gene3Di3.90.890.10. 1 hit.
InterProiIPR001810. F-box_dom.
IPR031890. Fbxo30/Fbxo40.
IPR013323. SIAH-type.
IPR008974. TRAF-like.
IPR001293. Znf_TRAF.
[Graphical view]
PANTHERiPTHR15933. PTHR15933. 3 hits.
PfamiPF15966. F-box_4. 1 hit.
PF15965. zf-TRAF_2. 1 hit.
[Graphical view]
SUPFAMiSSF49599. SSF49599. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
PS50145. ZF_TRAF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFBX30_HUMAN
AccessioniPrimary (citable) accession number: Q8TB52
Secondary accession number(s): Q9BXZ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: August 31, 2004
Last modified: November 30, 2016
This is version 133 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.