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Q8TB40

- ABHD4_HUMAN

UniProt

Q8TB40 - ABHD4_HUMAN

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Protein
Abhydrolase domain-containing protein 4
Gene
ABHD4
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE). Contributes to the biosynthesis of N-acyl ethanolamines, including the endocannabinoid anandamide by hydrolyzing the sn-1 and sn-2 acyl chains from N-acyl phosphatidylethanolamine (NAPE) generating glycerophospho-N-acyl ethanolamine (GP-NAE), an intermediate for N-acyl ethanolamine biosynthesis. Hydrolyzes substrates bearing saturated, monounsaturated, polyunsaturated N-acyl chains. Shows no significant activity towards other lysophospholipids, including lysophosphatidylcholine, lysophosphatidylethanolamine and lysophosphatidylserine By similarity.

GO - Molecular functioni

  1. hydrolase activity Source: UniProtKB-KW

GO - Biological processi

  1. lipid catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Protein family/group databases

MEROPSiS33.013.

Names & Taxonomyi

Protein namesi
Recommended name:
Abhydrolase domain-containing protein 4 (EC:3.1.1.-)
Alternative name(s):
Alpha/beta-hydrolase 4
Lyso-N-acylphosphatidylethanolamine lipase
Gene namesi
Name:ABHD4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:20154. ABHD4.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA128394705.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 342342Abhydrolase domain-containing protein 4
PRO_0000080864Add
BLAST

Proteomic databases

MaxQBiQ8TB40.
PaxDbiQ8TB40.
PRIDEiQ8TB40.

PTM databases

PhosphoSiteiQ8TB40.

Expressioni

Gene expression databases

ArrayExpressiQ8TB40.
BgeeiQ8TB40.
CleanExiHS_ABHD4.
GenevestigatoriQ8TB40.

Organism-specific databases

HPAiHPA000600.

Interactioni

Protein-protein interaction databases

BioGridi121967. 3 interactions.
IntActiQ8TB40. 2 interactions.
MINTiMINT-3044114.
STRINGi9606.ENSP00000216327.

Structurei

3D structure databases

ProteinModelPortaliQ8TB40.
SMRiQ8TB40. Positions 64-268.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0596.
HOGENOMiHOG000007445.
HOVERGENiHBG054445.
InParanoidiQ8TB40.
KOiK13698.
OMAiGLFTMAD.
OrthoDBiEOG751NG1.
PhylomeDBiQ8TB40.
TreeFamiTF314196.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
[Graphical view]
PRINTSiPR00111. ABHYDROLASE.
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8TB40-1 [UniParc]FASTAAdd to Basket

« Hide

MADDLEQQSQ GWLSSWLPTW RPTSMSQLKN VEARILQCLQ NKFLARYVSL    50
PNQNKIWTVT VSPEQNDRTP LVMVHGFGGG VGLWILNMDS LSARRTLHTF 100
DLLGFGRSSR PAFPRDPEGA EDEFVTSIET WRETMGIPSM ILLGHSLGGF 150
LATSYSIKYP DRVKHLILVD PWGFPLRPTN PSEIRAPPAW VKAVASVLGR 200
SNPLAVLRVA GPWGPGLVQR FRPDFKRKFA DFFEDDTISE YIYHCNAQNP 250
SGETAFKAMM ESFGWARRPM LERIHLIRKD VPITMIYGSD TWIDTSTGKK 300
VKMQRPDSYV RDMEIKGASH HVYADQPHIF NAVVEEICDS VD 342
Length:342
Mass (Da):38,794
Last modified:June 1, 2002 - v1
Checksum:i867EA9E0092559CB
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti183 – 1853EIR → GIC in BAB14289. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK022878 mRNA. Translation: BAB14289.1.
BC024779 mRNA. Translation: AAH24779.1.
CCDSiCCDS9572.1.
RefSeqiNP_071343.2. NM_022060.2.
UniGeneiHs.445665.

Genome annotation databases

EnsembliENST00000428304; ENSP00000414558; ENSG00000100439.
GeneIDi63874.
KEGGihsa:63874.
UCSCiuc001wgm.3. human.

Polymorphism databases

DMDMi74762601.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK022878 mRNA. Translation: BAB14289.1 .
BC024779 mRNA. Translation: AAH24779.1 .
CCDSi CCDS9572.1.
RefSeqi NP_071343.2. NM_022060.2.
UniGenei Hs.445665.

3D structure databases

ProteinModelPortali Q8TB40.
SMRi Q8TB40. Positions 64-268.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121967. 3 interactions.
IntActi Q8TB40. 2 interactions.
MINTi MINT-3044114.
STRINGi 9606.ENSP00000216327.

Protein family/group databases

MEROPSi S33.013.

PTM databases

PhosphoSitei Q8TB40.

Polymorphism databases

DMDMi 74762601.

Proteomic databases

MaxQBi Q8TB40.
PaxDbi Q8TB40.
PRIDEi Q8TB40.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000428304 ; ENSP00000414558 ; ENSG00000100439 .
GeneIDi 63874.
KEGGi hsa:63874.
UCSCi uc001wgm.3. human.

Organism-specific databases

CTDi 63874.
GeneCardsi GC14P023067.
HGNCi HGNC:20154. ABHD4.
HPAi HPA000600.
neXtProti NX_Q8TB40.
PharmGKBi PA128394705.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0596.
HOGENOMi HOG000007445.
HOVERGENi HBG054445.
InParanoidi Q8TB40.
KOi K13698.
OMAi GLFTMAD.
OrthoDBi EOG751NG1.
PhylomeDBi Q8TB40.
TreeFami TF314196.

Miscellaneous databases

ChiTaRSi ABHD4. human.
GenomeRNAii 63874.
NextBioi 65552.
PROi Q8TB40.

Gene expression databases

ArrayExpressi Q8TB40.
Bgeei Q8TB40.
CleanExi HS_ABHD4.
Genevestigatori Q8TB40.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
[Graphical view ]
PRINTSi PR00111. ABHYDROLASE.
SUPFAMi SSF53474. SSF53474. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cervix.

Entry informationi

Entry nameiABHD4_HUMAN
AccessioniPrimary (citable) accession number: Q8TB40
Secondary accession number(s): Q9H9E0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: June 1, 2002
Last modified: July 9, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Thr-291 is present instead of the conserved His which is expected to be an active site residue.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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