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Q8TB40

- ABHD4_HUMAN

UniProt

Q8TB40 - ABHD4_HUMAN

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Protein

Abhydrolase domain-containing protein 4

Gene

ABHD4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE). Contributes to the biosynthesis of N-acyl ethanolamines, including the endocannabinoid anandamide by hydrolyzing the sn-1 and sn-2 acyl chains from N-acyl phosphatidylethanolamine (NAPE) generating glycerophospho-N-acyl ethanolamine (GP-NAE), an intermediate for N-acyl ethanolamine biosynthesis. Hydrolyzes substrates bearing saturated, monounsaturated, polyunsaturated N-acyl chains. Shows no significant activity towards other lysophospholipids, including lysophosphatidylcholine, lysophosphatidylethanolamine and lysophosphatidylserine (By similarity).By similarity

GO - Molecular functioni

  1. hydrolase activity Source: UniProtKB-KW

GO - Biological processi

  1. lipid catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Protein family/group databases

MEROPSiS33.013.

Names & Taxonomyi

Protein namesi
Recommended name:
Abhydrolase domain-containing protein 4 (EC:3.1.1.-)
Alternative name(s):
Alpha/beta-hydrolase 4
Lyso-N-acylphosphatidylethanolamine lipase
Gene namesi
Name:ABHD4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:20154. ABHD4.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA128394705.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 342342Abhydrolase domain-containing protein 4PRO_0000080864Add
BLAST

Proteomic databases

MaxQBiQ8TB40.
PaxDbiQ8TB40.
PRIDEiQ8TB40.

PTM databases

PhosphoSiteiQ8TB40.

Expressioni

Gene expression databases

BgeeiQ8TB40.
CleanExiHS_ABHD4.
ExpressionAtlasiQ8TB40. baseline and differential.
GenevestigatoriQ8TB40.

Organism-specific databases

HPAiHPA000600.

Interactioni

Protein-protein interaction databases

BioGridi121967. 3 interactions.
IntActiQ8TB40. 2 interactions.
MINTiMINT-3044114.
STRINGi9606.ENSP00000216327.

Structurei

3D structure databases

ProteinModelPortaliQ8TB40.
SMRiQ8TB40. Positions 64-268.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0596.
GeneTreeiENSGT00390000016277.
HOGENOMiHOG000007445.
HOVERGENiHBG054445.
InParanoidiQ8TB40.
KOiK13698.
OMAiGLFTMAD.
OrthoDBiEOG751NG1.
PhylomeDBiQ8TB40.
TreeFamiTF314196.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
[Graphical view]
PRINTSiPR00111. ABHYDROLASE.
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8TB40-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MADDLEQQSQ GWLSSWLPTW RPTSMSQLKN VEARILQCLQ NKFLARYVSL
60 70 80 90 100
PNQNKIWTVT VSPEQNDRTP LVMVHGFGGG VGLWILNMDS LSARRTLHTF
110 120 130 140 150
DLLGFGRSSR PAFPRDPEGA EDEFVTSIET WRETMGIPSM ILLGHSLGGF
160 170 180 190 200
LATSYSIKYP DRVKHLILVD PWGFPLRPTN PSEIRAPPAW VKAVASVLGR
210 220 230 240 250
SNPLAVLRVA GPWGPGLVQR FRPDFKRKFA DFFEDDTISE YIYHCNAQNP
260 270 280 290 300
SGETAFKAMM ESFGWARRPM LERIHLIRKD VPITMIYGSD TWIDTSTGKK
310 320 330 340
VKMQRPDSYV RDMEIKGASH HVYADQPHIF NAVVEEICDS VD
Length:342
Mass (Da):38,794
Last modified:June 1, 2002 - v1
Checksum:i867EA9E0092559CB
GO
Isoform 2 (identifier: Q8TB40-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     163-181: VKHLILVDPWGFPLRPTNP → AWSGAAIPAGLQTQVCRLL
     182-342: Missing.

Note: No experimental confirmation available

Show »
Length:181
Mass (Da):20,239
Checksum:iABBBF26B35E97C0A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti183 – 1853EIR → GIC in BAB14289. (PubMed:14702039)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei163 – 18119VKHLI…RPTNP → AWSGAAIPAGLQTQVCRLL in isoform 2. 1 PublicationVSP_056924Add
BLAST
Alternative sequencei182 – 342161Missing in isoform 2. 1 PublicationVSP_056925Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022878 mRNA. Translation: BAB14289.1.
AK293198 mRNA. Translation: BAG56738.1.
AL160314 Genomic DNA. No translation available.
BC024779 mRNA. Translation: AAH24779.1.
CCDSiCCDS9572.1.
RefSeqiNP_071343.2. NM_022060.2.
UniGeneiHs.445665.

Genome annotation databases

EnsembliENST00000418446; ENSP00000388751; ENSG00000100439. [Q8TB40-2]
ENST00000428304; ENSP00000414558; ENSG00000100439. [Q8TB40-1]
GeneIDi63874.
KEGGihsa:63874.
UCSCiuc001wgm.3. human. [Q8TB40-1]

Polymorphism databases

DMDMi74762601.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022878 mRNA. Translation: BAB14289.1 .
AK293198 mRNA. Translation: BAG56738.1 .
AL160314 Genomic DNA. No translation available.
BC024779 mRNA. Translation: AAH24779.1 .
CCDSi CCDS9572.1.
RefSeqi NP_071343.2. NM_022060.2.
UniGenei Hs.445665.

3D structure databases

ProteinModelPortali Q8TB40.
SMRi Q8TB40. Positions 64-268.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121967. 3 interactions.
IntActi Q8TB40. 2 interactions.
MINTi MINT-3044114.
STRINGi 9606.ENSP00000216327.

Protein family/group databases

MEROPSi S33.013.

PTM databases

PhosphoSitei Q8TB40.

Polymorphism databases

DMDMi 74762601.

Proteomic databases

MaxQBi Q8TB40.
PaxDbi Q8TB40.
PRIDEi Q8TB40.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000418446 ; ENSP00000388751 ; ENSG00000100439 . [Q8TB40-2 ]
ENST00000428304 ; ENSP00000414558 ; ENSG00000100439 . [Q8TB40-1 ]
GeneIDi 63874.
KEGGi hsa:63874.
UCSCi uc001wgm.3. human. [Q8TB40-1 ]

Organism-specific databases

CTDi 63874.
GeneCardsi GC14P023067.
HGNCi HGNC:20154. ABHD4.
HPAi HPA000600.
neXtProti NX_Q8TB40.
PharmGKBi PA128394705.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0596.
GeneTreei ENSGT00390000016277.
HOGENOMi HOG000007445.
HOVERGENi HBG054445.
InParanoidi Q8TB40.
KOi K13698.
OMAi GLFTMAD.
OrthoDBi EOG751NG1.
PhylomeDBi Q8TB40.
TreeFami TF314196.

Miscellaneous databases

ChiTaRSi ABHD4. human.
GenomeRNAii 63874.
NextBioi 65552.
PROi Q8TB40.

Gene expression databases

Bgeei Q8TB40.
CleanExi HS_ABHD4.
ExpressionAtlasi Q8TB40. baseline and differential.
Genevestigatori Q8TB40.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
[Graphical view ]
PRINTSi PR00111. ABHYDROLASE.
SUPFAMi SSF53474. SSF53474. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Adrenal gland.
  2. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Cervix.

Entry informationi

Entry nameiABHD4_HUMAN
AccessioniPrimary (citable) accession number: Q8TB40
Secondary accession number(s): B4DDH7, Q9H9E0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: June 1, 2002
Last modified: November 26, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3