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Q8TB40

- ABHD4_HUMAN

UniProt

Q8TB40 - ABHD4_HUMAN

Protein

Abhydrolase domain-containing protein 4

Gene

ABHD4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE). Contributes to the biosynthesis of N-acyl ethanolamines, including the endocannabinoid anandamide by hydrolyzing the sn-1 and sn-2 acyl chains from N-acyl phosphatidylethanolamine (NAPE) generating glycerophospho-N-acyl ethanolamine (GP-NAE), an intermediate for N-acyl ethanolamine biosynthesis. Hydrolyzes substrates bearing saturated, monounsaturated, polyunsaturated N-acyl chains. Shows no significant activity towards other lysophospholipids, including lysophosphatidylcholine, lysophosphatidylethanolamine and lysophosphatidylserine By similarity.By similarity

    GO - Molecular functioni

    1. hydrolase activity Source: UniProtKB-KW

    GO - Biological processi

    1. lipid catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Lipid degradation, Lipid metabolism

    Protein family/group databases

    MEROPSiS33.013.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Abhydrolase domain-containing protein 4 (EC:3.1.1.-)
    Alternative name(s):
    Alpha/beta-hydrolase 4
    Lyso-N-acylphosphatidylethanolamine lipase
    Gene namesi
    Name:ABHD4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:20154. ABHD4.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA128394705.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 342342Abhydrolase domain-containing protein 4PRO_0000080864Add
    BLAST

    Proteomic databases

    MaxQBiQ8TB40.
    PaxDbiQ8TB40.
    PRIDEiQ8TB40.

    PTM databases

    PhosphoSiteiQ8TB40.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8TB40.
    BgeeiQ8TB40.
    CleanExiHS_ABHD4.
    GenevestigatoriQ8TB40.

    Organism-specific databases

    HPAiHPA000600.

    Interactioni

    Protein-protein interaction databases

    BioGridi121967. 3 interactions.
    IntActiQ8TB40. 2 interactions.
    MINTiMINT-3044114.
    STRINGi9606.ENSP00000216327.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8TB40.
    SMRiQ8TB40. Positions 64-268.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0596.
    HOGENOMiHOG000007445.
    HOVERGENiHBG054445.
    InParanoidiQ8TB40.
    KOiK13698.
    OMAiGLFTMAD.
    OrthoDBiEOG751NG1.
    PhylomeDBiQ8TB40.
    TreeFamiTF314196.

    Family and domain databases

    Gene3Di3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR000073. AB_hydrolase_1.
    [Graphical view]
    PRINTSiPR00111. ABHYDROLASE.
    SUPFAMiSSF53474. SSF53474. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8TB40-1 [UniParc]FASTAAdd to Basket

    « Hide

    MADDLEQQSQ GWLSSWLPTW RPTSMSQLKN VEARILQCLQ NKFLARYVSL    50
    PNQNKIWTVT VSPEQNDRTP LVMVHGFGGG VGLWILNMDS LSARRTLHTF 100
    DLLGFGRSSR PAFPRDPEGA EDEFVTSIET WRETMGIPSM ILLGHSLGGF 150
    LATSYSIKYP DRVKHLILVD PWGFPLRPTN PSEIRAPPAW VKAVASVLGR 200
    SNPLAVLRVA GPWGPGLVQR FRPDFKRKFA DFFEDDTISE YIYHCNAQNP 250
    SGETAFKAMM ESFGWARRPM LERIHLIRKD VPITMIYGSD TWIDTSTGKK 300
    VKMQRPDSYV RDMEIKGASH HVYADQPHIF NAVVEEICDS VD 342
    Length:342
    Mass (Da):38,794
    Last modified:June 1, 2002 - v1
    Checksum:i867EA9E0092559CB
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti183 – 1853EIR → GIC in BAB14289. (PubMed:14702039)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK022878 mRNA. Translation: BAB14289.1.
    BC024779 mRNA. Translation: AAH24779.1.
    CCDSiCCDS9572.1.
    RefSeqiNP_071343.2. NM_022060.2.
    UniGeneiHs.445665.

    Genome annotation databases

    EnsembliENST00000428304; ENSP00000414558; ENSG00000100439.
    GeneIDi63874.
    KEGGihsa:63874.
    UCSCiuc001wgm.3. human.

    Polymorphism databases

    DMDMi74762601.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK022878 mRNA. Translation: BAB14289.1 .
    BC024779 mRNA. Translation: AAH24779.1 .
    CCDSi CCDS9572.1.
    RefSeqi NP_071343.2. NM_022060.2.
    UniGenei Hs.445665.

    3D structure databases

    ProteinModelPortali Q8TB40.
    SMRi Q8TB40. Positions 64-268.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121967. 3 interactions.
    IntActi Q8TB40. 2 interactions.
    MINTi MINT-3044114.
    STRINGi 9606.ENSP00000216327.

    Protein family/group databases

    MEROPSi S33.013.

    PTM databases

    PhosphoSitei Q8TB40.

    Polymorphism databases

    DMDMi 74762601.

    Proteomic databases

    MaxQBi Q8TB40.
    PaxDbi Q8TB40.
    PRIDEi Q8TB40.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000428304 ; ENSP00000414558 ; ENSG00000100439 .
    GeneIDi 63874.
    KEGGi hsa:63874.
    UCSCi uc001wgm.3. human.

    Organism-specific databases

    CTDi 63874.
    GeneCardsi GC14P023067.
    HGNCi HGNC:20154. ABHD4.
    HPAi HPA000600.
    neXtProti NX_Q8TB40.
    PharmGKBi PA128394705.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0596.
    HOGENOMi HOG000007445.
    HOVERGENi HBG054445.
    InParanoidi Q8TB40.
    KOi K13698.
    OMAi GLFTMAD.
    OrthoDBi EOG751NG1.
    PhylomeDBi Q8TB40.
    TreeFami TF314196.

    Miscellaneous databases

    ChiTaRSi ABHD4. human.
    GenomeRNAii 63874.
    NextBioi 65552.
    PROi Q8TB40.

    Gene expression databases

    ArrayExpressi Q8TB40.
    Bgeei Q8TB40.
    CleanExi HS_ABHD4.
    Genevestigatori Q8TB40.

    Family and domain databases

    Gene3Di 3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR000073. AB_hydrolase_1.
    [Graphical view ]
    PRINTSi PR00111. ABHYDROLASE.
    SUPFAMi SSF53474. SSF53474. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Cervix.

    Entry informationi

    Entry nameiABHD4_HUMAN
    AccessioniPrimary (citable) accession number: Q8TB40
    Secondary accession number(s): Q9H9E0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 27, 2005
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Thr-291 is present instead of the conserved His which is expected to be an active site residue.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3