Q8TB24Q76LB3Q8NF30Q8TEE8Q8WYP4Q9H6A5Q9HAG1RIN3_HUMANRas and Rab interactor 3Ras interaction/interference protein 3RIN3Homo sapiensHumanEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomoRIN3: a novel Rab5 GEF interacting with amphiphysin II involved in the early endocytic pathway.NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)FUNCTIONINTERACTION WITH BIN1 AND RAB5BSUBCELLULAR LOCATIONTISSUE SPECIFICITYThe DNA sequence and analysis of human chromosome 14.NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]Complete sequencing and characterization of 21,243 full-length human cDNAs.NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-167 AND 405-985 (ISOFORM 1)NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 485-985 (ISOFORM 4)VARIANT MET-425The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 328-985 (ISOFORM 1)A novel binding protein composed of homophilic tetramer exhibits unique properties for the small GTPase Rab5.NUCLEOTIDE SEQUENCE [MRNA] OF 435-959 (ISOFORM 1)Tyr-phosphorylation signals translocate RIN3, the small GTPase Rab5-GEF, to early endocytic vesicles.SUBCELLULAR LOCATIONPHOSPHORYLATIONCharacterization of RIN3 as a guanine nucleotide exchange factor for the Rab5 subfamily GTPase Rab31.FUNCTIONSUBCELLULAR LOCATIONMUTAGENESIS OF TYR-825 AND THR-828INTERACTION WITH RAB31Atomic resolution crystal structure of the 2nd SH3 domain from human CD2AP (CMS) in complex with a proline-rich peptide from human RIN3.X-RAY CRYSTALLOGRAPHY (1.11 ANGSTROMS) OF 452-467 IN COMPLEX WITH CD2APINTERACTION WITH CD2APRas effector protein that functions as a guanine nucleotide exchange (GEF) for RAB5B and RAB31, by exchanging bound GDP for free GTP. Required for normal RAB31 function.Interacts with CD2AP, RAB5B, RAB31 and BIN1.Q8TB24O00499false2Q8TB24Q9Y5K6false3Q8TB24P46108false2Q8TB24P16333false2Q8TB24P19174false3CytoplasmCytoplasmic vesicleEarly endosomeActivation of tyrosine phosphorylation signaling induces translocation to cytoplasmic vesicles.Q8TB24-11Q8TB24-44Widely expressed.Belongs to the RIN (Ras interaction/interference) family.Aberrant splicing.Truncated N-terminus.Intron retention.3D-structureAlternative splicingCytoplasmCytoplasmic vesicleEndosomeGTPase activationReference proteomeSH2 domainDFICVSYLEPEQQARTLASRADTQAQVRPESGRGPVGPCPRHHPCCLLAKEPEKHLHPHRTITMGAYATAIFMIRHAGAPARGDPTGPVPVVGKGEEEEEEDGMRLCLPANPKNCLPHRRGISILEKLIKTCPVWLQLSLGQAEVARILHRVVAGMFLVRRDSSSKQLVLCVHFPSLNESSAEVLEYTIKEEKSILYLEGSALVFEDIFRLIAFYCVSRDLLPFTLRLPQAILEASSFTDLETIANLGLGFWDSSLNPPQERGKPAEPPRDRAPGFPLVSSLRPTAHDANCACEIELSVGNDRLWFVNPIFIEDCSSALPTDQPPLGNCPARPLPPTSDATSPTSRWAPRRPPPPPPVLPLQPCSPAQPPVLPALAPAPACPLPTSPPVPAPHVTPHAPGPPDHPNQPPMMTCERLPCPTAGLGPLREEAMKPGAASSPLQQVPAPPLPAKKNLPTAPPRRRVSERVSLEDQSPGMAAEGDQLSLPPQGTSDGPEDTPRESTEQGQDTEVKASDPHSMPELPRTAKQPPVPPPRKKRISRQLASTLPAPLENAELCTQAMALETPTPGPPREGQSPASQAGTQHPPAQATAHSQSSPEFKGSLASLSDSLGVSVMATDQDSYSTSSTEEELEQFSSPSVKKKPSMILGKARHRLSFASFSSMFHAFLSNNRKLYKKVVELAQDKGSYFGSLVQDYKVYSLEMMARQTSSTEMLQEIRTMMTQLKSYLLQSTELKALVDPALHSEEELEAIVESALYKCVLKPLKEAINSCLHQIHSKDGSLQQLKENQLVILATTTTDLGVTTSVPEVPMMEKILQKFTSMHKAYSPEKKISILLKTCKLIYDSMALGNPGKPYGADDFLPVLMYVLARSNLTEMLLNVEYMMELMDPALQLGEGSYYLTTTYGALEHIKSYDKITVTRQLSVEVQDSIHRWERRRTLNKARASRSSVQDFICVSYLEPEQQARTLASRADTQAQALCAQCAEKFAVERPQAHRLFVLVDGRCFQLADDALPHCIKGYLLRSEPKRDFHFVYRPLDGGGGGGGGSPPCLVVREPNFL
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