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Q8TB24

- RIN3_HUMAN

UniProt

Q8TB24 - RIN3_HUMAN

Protein

Ras and Rab interactor 3

Gene

RIN3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 4 (14 Oct 2008)
      Previous versions | rss
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    Functioni

    Ras effector protein that functions as a guanine nucleotide exchange (GEF) for RAB5B and RAB31, by exchanging bound GDP for free GTP. Required for normal RAB31 function.2 Publications

    GO - Molecular functioni

    1. GTPase activator activity Source: UniProtKB-KW
    2. protein binding Source: IntAct
    3. Rab GTPase binding Source: UniProtKB
    4. Rab guanyl-nucleotide exchange factor activity Source: UniProtKB

    GO - Biological processi

    1. endocytosis Source: UniProtKB
    2. positive regulation of Rab GTPase activity Source: GOC
    3. signal transduction Source: InterPro

    Keywords - Molecular functioni

    GTPase activation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ras and Rab interactor 3
    Alternative name(s):
    Ras interaction/interference protein 3
    Gene namesi
    Name:RIN3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:18751. RIN3.

    Subcellular locationi

    Cytoplasm. Cytoplasmic vesicle. Early endosome
    Note: Activation of tyrosine phosphorylation signaling induces translocation to cytoplasmic vesicles.

    GO - Cellular componenti

    1. cytoplasmic membrane-bounded vesicle Source: UniProtKB-SubCell
    2. cytoplasmic vesicle Source: UniProtKB
    3. early endosome Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Cytoplasmic vesicle, Endosome

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi825 – 8251Y → A: Strongly reduced guanine nucleotide exchange factor activity toward RAB31; when associated with A-828. 1 Publication
    Mutagenesisi828 – 8281T → A: Strongly reduced guanine nucleotide exchange factor activity toward RAB31; when associated with A-825. 1 Publication

    Organism-specific databases

    PharmGKBiPA38673.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 985985Ras and Rab interactor 3PRO_0000191322Add
    BLAST

    Proteomic databases

    PaxDbiQ8TB24.
    PRIDEiQ8TB24.

    PTM databases

    PhosphoSiteiQ8TB24.

    Expressioni

    Tissue specificityi

    Widely expressed.1 Publication

    Gene expression databases

    ArrayExpressiQ8TB24.
    BgeeiQ8TB24.
    CleanExiHS_RIN3.
    GenevestigatoriQ8TB24.

    Organism-specific databases

    HPAiHPA039836.

    Interactioni

    Subunit structurei

    Interacts with CD2AP, RAB5B, RAB31 and BIN1.3 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    NCK1P163332EBI-1570523,EBI-389883
    PLCG1P191743EBI-1570523,EBI-79387

    Protein-protein interaction databases

    BioGridi122974. 7 interactions.
    IntActiQ8TB24. 13 interactions.
    MINTiMINT-273957.
    STRINGi9606.ENSP00000216487.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3U23X-ray1.11B452-467[»]
    ProteinModelPortaliQ8TB24.
    SMRiQ8TB24. Positions 55-157, 738-846.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini63 – 15896SH2PROSITE-ProRule annotationAdd
    BLAST
    Domaini703 – 846144VPS9PROSITE-ProRule annotationAdd
    BLAST
    Domaini877 – 96387Ras-associatingPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni587 – 732146Interaction with RAB5BAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi24 – 296Poly-Glu
    Compositional biasi248 – 514267Pro-richAdd
    BLAST
    Compositional biasi722 – 7254Poly-Thr
    Compositional biasi965 – 9728Poly-Gly

    Sequence similaritiesi

    Contains 1 Ras-associating domain.PROSITE-ProRule annotation
    Contains 1 SH2 domain.PROSITE-ProRule annotation
    Contains 1 VPS9 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    SH2 domain

    Phylogenomic databases

    eggNOGiNOG295439.
    HOVERGENiHBG038998.
    InParanoidiQ8TB24.
    OMAiYTIKEEK.
    OrthoDBiEOG7PZRWP.
    PhylomeDBiQ8TB24.
    TreeFamiTF331067.

    Family and domain databases

    Gene3Di3.30.505.10. 1 hit.
    InterProiIPR000159. Ras-assoc.
    IPR000980. SH2.
    IPR003123. VPS9.
    IPR013995. VPS9_subgr.
    [Graphical view]
    PfamiPF02204. VPS9. 1 hit.
    [Graphical view]
    SMARTiSM00314. RA. 1 hit.
    SM00252. SH2. 1 hit.
    SM00167. VPS9. 1 hit.
    [Graphical view]
    SUPFAMiSSF55550. SSF55550. 1 hit.
    PROSITEiPS50200. RA. 1 hit.
    PS50001. SH2. 1 hit.
    PS51205. VPS9. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8TB24-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MIRHAGAPAR GDPTGPVPVV GKGEEEEEED GMRLCLPANP KNCLPHRRGI    50
    SILEKLIKTC PVWLQLSLGQ AEVARILHRV VAGMFLVRRD SSSKQLVLCV 100
    HFPSLNESSA EVLEYTIKEE KSILYLEGSA LVFEDIFRLI AFYCVSRDLL 150
    PFTLRLPQAI LEASSFTDLE TIANLGLGFW DSSLNPPQER GKPAEPPRDR 200
    APGFPLVSSL RPTAHDANCA CEIELSVGND RLWFVNPIFI EDCSSALPTD 250
    QPPLGNCPAR PLPPTSDATS PTSRWAPRRP PPPPPVLPLQ PCSPAQPPVL 300
    PALAPAPACP LPTSPPVPAP HVTPHAPGPP DHPNQPPMMT CERLPCPTAG 350
    LGPLREEAMK PGAASSPLQQ VPAPPLPAKK NLPTAPPRRR VSERVSLEDQ 400
    SPGMAAEGDQ LSLPPQGTSD GPEDTPREST EQGQDTEVKA SDPHSMPELP 450
    RTAKQPPVPP PRKKRISRQL ASTLPAPLEN AELCTQAMAL ETPTPGPPRE 500
    GQSPASQAGT QHPPAQATAH SQSSPEFKGS LASLSDSLGV SVMATDQDSY 550
    STSSTEEELE QFSSPSVKKK PSMILGKARH RLSFASFSSM FHAFLSNNRK 600
    LYKKVVELAQ DKGSYFGSLV QDYKVYSLEM MARQTSSTEM LQEIRTMMTQ 650
    LKSYLLQSTE LKALVDPALH SEEELEAIVE SALYKCVLKP LKEAINSCLH 700
    QIHSKDGSLQ QLKENQLVIL ATTTTDLGVT TSVPEVPMME KILQKFTSMH 750
    KAYSPEKKIS ILLKTCKLIY DSMALGNPGK PYGADDFLPV LMYVLARSNL 800
    TEMLLNVEYM MELMDPALQL GEGSYYLTTT YGALEHIKSY DKITVTRQLS 850
    VEVQDSIHRW ERRRTLNKAR ASRSSVQDFI CVSYLEPEQQ ARTLASRADT 900
    QAQALCAQCA EKFAVERPQA HRLFVLVDGR CFQLADDALP HCIKGYLLRS 950
    EPKRDFHFVY RPLDGGGGGG GGSPPCLVVR EPNFL 985
    Length:985
    Mass (Da):107,854
    Last modified:October 14, 2008 - v4
    Checksum:iA8949EA0D61570BB
    GO
    Isoform 4 (identifier: Q8TB24-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         878-903: DFICVSYLEPEQQARTLASRADTQAQ → VRPESGRGPVGPCPRHHPCCLLAKEP
         904-985: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:903
    Mass (Da):98,739
    Checksum:i562A82ADCBD13127
    GO

    Sequence cautioni

    The sequence BAB13888.1 differs from that shown. Reason: Aberrant splicing.
    The sequence BAC03432.1 differs from that shown. Reason: Intron retention.
    The sequence BAB15357.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti742 – 7421I → F in AAH25248. (PubMed:15489334)Curated
    Sequence conflicti965 – 9651Missing in BAB15357. (PubMed:14702039)Curated
    Sequence conflicti965 – 9651Missing in AAH25248. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti111 – 1111E → K.
    Corresponds to variant rs2274542 [ dbSNP | Ensembl ].
    VAR_046645
    Natural varianti215 – 2151H → L.
    Corresponds to variant rs3829947 [ dbSNP | Ensembl ].
    VAR_059960
    Natural varianti215 – 2151H → P.
    Corresponds to variant rs3829947 [ dbSNP | Ensembl ].
    VAR_046646
    Natural varianti215 – 2151H → R.
    Corresponds to variant rs3829947 [ dbSNP | Ensembl ].
    VAR_059961
    Natural varianti425 – 4251T → I.
    Corresponds to variant rs3742717 [ dbSNP | Ensembl ].
    VAR_052946
    Natural varianti425 – 4251T → M.1 Publication
    Corresponds to variant rs3742717 [ dbSNP | Ensembl ].
    VAR_046647
    Natural varianti613 – 6131G → A.
    Corresponds to variant rs12434929 [ dbSNP | Ensembl ].
    VAR_046648

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei878 – 90326DFICV…DTQAQ → VRPESGRGPVGPCPRHHPCC LLAKEP in isoform 4. 1 PublicationVSP_007587Add
    BLAST
    Alternative sequencei904 – 98582Missing in isoform 4. 1 PublicationVSP_007588Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB081753 mRNA. Translation: BAC16513.1.
    AL136332 Genomic DNA. No translation available.
    AL159141 Genomic DNA. No translation available.
    AK021762 mRNA. Translation: BAB13888.1. Sequence problems.
    AK026092 mRNA. Translation: BAB15357.1. Different initiation.
    AK074176 mRNA. Translation: BAB85002.1.
    AK090451 mRNA. Translation: BAC03432.1. Sequence problems.
    BC025248 mRNA. Translation: AAH25248.2.
    AB060338 mRNA. Translation: BAB84316.1.
    CCDSiCCDS32144.1. [Q8TB24-1]
    PIRiT50623.
    RefSeqiNP_079108.3. NM_024832.3. [Q8TB24-1]
    UniGeneiHs.326822.

    Genome annotation databases

    EnsembliENST00000216487; ENSP00000216487; ENSG00000100599. [Q8TB24-1]
    GeneIDi79890.
    KEGGihsa:79890.
    UCSCiuc001yap.3. human. [Q8TB24-1]
    uc001yas.1. human. [Q8TB24-4]

    Polymorphism databases

    DMDMi209572780.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB081753 mRNA. Translation: BAC16513.1 .
    AL136332 Genomic DNA. No translation available.
    AL159141 Genomic DNA. No translation available.
    AK021762 mRNA. Translation: BAB13888.1 . Sequence problems.
    AK026092 mRNA. Translation: BAB15357.1 . Different initiation.
    AK074176 mRNA. Translation: BAB85002.1 .
    AK090451 mRNA. Translation: BAC03432.1 . Sequence problems.
    BC025248 mRNA. Translation: AAH25248.2 .
    AB060338 mRNA. Translation: BAB84316.1 .
    CCDSi CCDS32144.1. [Q8TB24-1 ]
    PIRi T50623.
    RefSeqi NP_079108.3. NM_024832.3. [Q8TB24-1 ]
    UniGenei Hs.326822.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3U23 X-ray 1.11 B 452-467 [» ]
    ProteinModelPortali Q8TB24.
    SMRi Q8TB24. Positions 55-157, 738-846.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122974. 7 interactions.
    IntActi Q8TB24. 13 interactions.
    MINTi MINT-273957.
    STRINGi 9606.ENSP00000216487.

    PTM databases

    PhosphoSitei Q8TB24.

    Polymorphism databases

    DMDMi 209572780.

    Proteomic databases

    PaxDbi Q8TB24.
    PRIDEi Q8TB24.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000216487 ; ENSP00000216487 ; ENSG00000100599 . [Q8TB24-1 ]
    GeneIDi 79890.
    KEGGi hsa:79890.
    UCSCi uc001yap.3. human. [Q8TB24-1 ]
    uc001yas.1. human. [Q8TB24-4 ]

    Organism-specific databases

    CTDi 79890.
    GeneCardsi GC14P092980.
    H-InvDB HIX0011904.
    HGNCi HGNC:18751. RIN3.
    HPAi HPA039836.
    MIMi 610223. gene.
    neXtProti NX_Q8TB24.
    PharmGKBi PA38673.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG295439.
    HOVERGENi HBG038998.
    InParanoidi Q8TB24.
    OMAi YTIKEEK.
    OrthoDBi EOG7PZRWP.
    PhylomeDBi Q8TB24.
    TreeFami TF331067.

    Miscellaneous databases

    ChiTaRSi RIN3. human.
    GenomeRNAii 79890.
    NextBioi 69706.
    PROi Q8TB24.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8TB24.
    Bgeei Q8TB24.
    CleanExi HS_RIN3.
    Genevestigatori Q8TB24.

    Family and domain databases

    Gene3Di 3.30.505.10. 1 hit.
    InterProi IPR000159. Ras-assoc.
    IPR000980. SH2.
    IPR003123. VPS9.
    IPR013995. VPS9_subgr.
    [Graphical view ]
    Pfami PF02204. VPS9. 1 hit.
    [Graphical view ]
    SMARTi SM00314. RA. 1 hit.
    SM00252. SH2. 1 hit.
    SM00167. VPS9. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55550. SSF55550. 1 hit.
    PROSITEi PS50200. RA. 1 hit.
    PS50001. SH2. 1 hit.
    PS51205. VPS9. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "RIN3: a novel Rab5 GEF interacting with amphiphysin II involved in the early endocytic pathway."
      Kajiho H., Saito K., Tsujita K., Kontani K., Araki Y., Kurosu H., Katada T.
      J. Cell Sci. 116:4159-4168(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INTERACTION WITH BIN1 AND RAB5B, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    2. "The DNA sequence and analysis of human chromosome 14."
      Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
      , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
      Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-167 AND 405-985 (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 485-985 (ISOFORM 4), VARIANT MET-425.
      Tissue: Embryo.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 328-985 (ISOFORM 1).
      Tissue: Eye.
    5. "A novel binding protein composed of homophilic tetramer exhibits unique properties for the small GTPase Rab5."
      Saito K., Murai J., Kajiho H., Kontani K., Kurosu H., Katada T.
      J. Biol. Chem. 277:3412-3418(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 435-959 (ISOFORM 1).
      Tissue: Leukocyte and Spleen.
    6. "Tyr-phosphorylation signals translocate RIN3, the small GTPase Rab5-GEF, to early endocytic vesicles."
      Yoshikawa M., Kajiho H., Sakurai K., Minoda T., Nakagawa S., Kontani K., Katada T.
      Biochem. Biophys. Res. Commun. 372:168-172(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, PHOSPHORYLATION.
    7. "Characterization of RIN3 as a guanine nucleotide exchange factor for the Rab5 subfamily GTPase Rab31."
      Kajiho H., Sakurai K., Minoda T., Yoshikawa M., Nakagawa S., Fukushima S., Kontani K., Katada T.
      J. Biol. Chem. 286:24364-24373(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, MUTAGENESIS OF TYR-825 AND THR-828, INTERACTION WITH RAB31.
    8. "Atomic resolution crystal structure of the 2nd SH3 domain from human CD2AP (CMS) in complex with a proline-rich peptide from human RIN3."
      Structural genomics consortium (SGC)
      Submitted (DEC-2011) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.11 ANGSTROMS) OF 452-467 IN COMPLEX WITH CD2AP, INTERACTION WITH CD2AP.

    Entry informationi

    Entry nameiRIN3_HUMAN
    AccessioniPrimary (citable) accession number: Q8TB24
    Secondary accession number(s): Q76LB3
    , Q8NF30, Q8TEE8, Q8WYP4, Q9H6A5, Q9HAG1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 2003
    Last sequence update: October 14, 2008
    Last modified: October 1, 2014
    This is version 111 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3