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Protein

Spermatogenesis-associated protein 20

Gene

SPATA20

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in fertility regulation.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Spermatogenesis-associated protein 20
Alternative name(s):
Sperm-specific protein 411
Short name:
Ssp411
Gene namesi
Name:SPATA20
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:26125. SPATA20.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi64847.
OpenTargetsiENSG00000006282.
PharmGKBiPA142670885.

Polymorphism and mutation databases

BioMutaiSPATA20.
DMDMi311033529.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000027845023 – 786Spermatogenesis-associated protein 20Add BLAST764

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei649PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8TB22.
MaxQBiQ8TB22.
PaxDbiQ8TB22.
PeptideAtlasiQ8TB22.
PRIDEiQ8TB22.

PTM databases

iPTMnetiQ8TB22.
PhosphoSitePlusiQ8TB22.

Expressioni

Gene expression databases

BgeeiENSG00000006282.
CleanExiHS_SPATA20.
ExpressionAtlasiQ8TB22. baseline and differential.
GenevisibleiQ8TB22. HS.

Organism-specific databases

HPAiHPA027144.
HPA031442.

Interactioni

Protein-protein interaction databases

BioGridi122320. 38 interactors.
IntActiQ8TB22. 4 interactors.
STRINGi9606.ENSP00000006658.

Structurei

3D structure databases

ProteinModelPortaliQ8TB22.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2244. Eukaryota.
COG1331. LUCA.
GeneTreeiENSGT00390000004836.
HOGENOMiHOG000231201.
HOVERGENiHBG093992.
InParanoidiQ8TB22.
OMAiLFWDSQG.
OrthoDBiEOG091G02U2.
PhylomeDBiQ8TB22.
TreeFamiTF105663.

Family and domain databases

CDDicd02955. SSP411. 1 hit.
Gene3Di1.50.10.10. 2 hits.
3.40.30.10. 1 hit.
InterProiIPR008928. 6-hairpin_glycosidase-like.
IPR012341. 6hp_glycosidase.
IPR004879. DUF255.
IPR024705. Ssp411.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF03190. Thioredox_DsbH. 1 hit.
[Graphical view]
PIRSFiPIRSF006402. UCP006402_thioredoxin. 1 hit.
SUPFAMiSSF48208. SSF48208. 2 hits.
SSF52833. SSF52833. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TB22-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLGARAWLGR VLLLPRAGAG LAASRRGSSS RDKDRSATVS SSVPMPAGGK
60 70 80 90 100
GSHPSSTPQR VPNRLIHEKS PYLLQHAYNP VDWYPWGQEA FDKARKENKP
110 120 130 140 150
IFLSVGYSTC HWCHMMEEES FQNEEIGRLL SEDFVSVKVD REERPDVDKV
160 170 180 190 200
YMTFVQATSS GGGWPMNVWL TPNLQPFVGG TYFPPEDGLT RVGFRTVLLR
210 220 230 240 250
IREQWKQNKN TLLENSQRVT TALLARSEIS VGDRQLPPSA ATVNNRCFQQ
260 270 280 290 300
LDEGYDEEYG GFAEAPKFPT PVILSFLFSY WLSHRLTQDG SRAQQMALHT
310 320 330 340 350
LKMMANGGIR DHVGQGFHRY STDRQWHVPH FEKMLYDQAQ LAVAYSQAFQ
360 370 380 390 400
LSGDEFYSDV AKGILQYVAR SLSHRSGGFY SAEDADSPPE RGQRPKEGAY
410 420 430 440 450
YVWTVKEVQQ LLPEPVLGAT EPLTSGQLLM KHYGLTEAGN ISPSQDPKGE
460 470 480 490 500
LQGQNVLTVR YSLELTAARF GLDVEAVRTL LNSGLEKLFQ ARKHRPKPHL
510 520 530 540 550
DSKMLAAWNG LMVSGYAVTG AVLGQDRLIN YATNGAKFLK RHMFDVASGR
560 570 580 590 600
LMRTCYTGPG GTVEHSNPPC WGFLEDYAFV VRGLLDLYEA SQESAWLEWA
610 620 630 640 650
LRLQDTQDKL FWDSQGGGYF CSEAELGAGL PLRLKDDQDG AEPSANSVSA
660 670 680 690 700
HNLLRLHGFT GHKDWMDKCV CLLTAFSERM RRVPVALPEM VRALSAQQQT
710 720 730 740 750
LKQIVICGDR QAKDTKALVQ CVHSVYIPNK VLILADGDPS SFLSRQLPFL
760 770 780
STLRRLEDQA TAYVCENQAC SVPITDPCEL RKLLHP
Length:786
Mass (Da):87,899
Last modified:November 2, 2010 - v3
Checksum:i00C3CCE7C7BD8438
GO
Isoform 2 (identifier: Q8TB22-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     26-26: R → RCPGVWPRTWPHRSPSR

Note: No experimental confirmation available.
Show »
Length:802
Mass (Da):89,800
Checksum:iB5198C26A4BBD7FD
GO
Isoform 3 (identifier: Q8TB22-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-44: Missing.

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:742
Mass (Da):83,378
Checksum:i3FD77F6806458D03
GO
Isoform 4 (identifier: Q8TB22-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-25: MLGARAWLGRVLLLPRAGAGLAASR → MSHLSSPPKKHKGEHKGHSLPHGSE
     511-521: LMVSGYAVTGA → GAAHLRPSLSA
     522-786: Missing.

Note: No experimental confirmation available.
Show »
Length:521
Mass (Da):58,463
Checksum:i513594E2A330256A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti356F → L in BAB15051 (PubMed:14702039).Curated1
Sequence conflicti540K → E in BAB15051 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03077788Q → E.1 PublicationCorresponds to variant rs8076632dbSNPEnsembl.1
Natural variantiVAR_030778483S → T.1 PublicationCorresponds to variant rs9913430dbSNPEnsembl.1
Natural variantiVAR_030779609K → R.2 PublicationsCorresponds to variant rs8065903dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0232881 – 44Missing in isoform 3. 1 PublicationAdd BLAST44
Alternative sequenceiVSP_0232891 – 25MLGAR…LAASR → MSHLSSPPKKHKGEHKGHSL PHGSE in isoform 4. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_02329026R → RCPGVWPRTWPHRSPSR in isoform 2. 1 Publication1
Alternative sequenceiVSP_023291511 – 521LMVSGYAVTGA → GAAHLRPSLSA in isoform 4. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_023292522 – 786Missing in isoform 4. 1 PublicationAdd BLAST265

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ238597 mRNA. Translation: ABB54669.1.
AK025000 mRNA. Translation: BAB15051.1.
AC021491 Genomic DNA. No translation available.
BC017468 mRNA. Translation: AAH17468.1.
BC025255 mRNA. Translation: AAH25255.1.
BC111029 mRNA. Translation: AAI11030.1.
BC065526 mRNA. Translation: AAH65526.1.
CCDSiCCDS11571.1. [Q8TB22-2]
CCDS58563.1. [Q8TB22-1]
CCDS58564.1. [Q8TB22-3]
RefSeqiNP_001245301.1. NM_001258372.1. [Q8TB22-1]
NP_001245302.1. NM_001258373.1. [Q8TB22-3]
NP_073738.2. NM_022827.3. [Q8TB22-2]
UniGeneiHs.103147.

Genome annotation databases

EnsembliENST00000006658; ENSP00000006658; ENSG00000006282. [Q8TB22-2]
ENST00000356488; ENSP00000348878; ENSG00000006282. [Q8TB22-1]
ENST00000511937; ENSP00000489476; ENSG00000006282. [Q8TB22-4]
ENST00000619622; ENSP00000483295; ENSG00000006282. [Q8TB22-3]
GeneIDi64847.
KEGGihsa:64847.
UCSCiuc002ird.4. human. [Q8TB22-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ238597 mRNA. Translation: ABB54669.1.
AK025000 mRNA. Translation: BAB15051.1.
AC021491 Genomic DNA. No translation available.
BC017468 mRNA. Translation: AAH17468.1.
BC025255 mRNA. Translation: AAH25255.1.
BC111029 mRNA. Translation: AAI11030.1.
BC065526 mRNA. Translation: AAH65526.1.
CCDSiCCDS11571.1. [Q8TB22-2]
CCDS58563.1. [Q8TB22-1]
CCDS58564.1. [Q8TB22-3]
RefSeqiNP_001245301.1. NM_001258372.1. [Q8TB22-1]
NP_001245302.1. NM_001258373.1. [Q8TB22-3]
NP_073738.2. NM_022827.3. [Q8TB22-2]
UniGeneiHs.103147.

3D structure databases

ProteinModelPortaliQ8TB22.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122320. 38 interactors.
IntActiQ8TB22. 4 interactors.
STRINGi9606.ENSP00000006658.

PTM databases

iPTMnetiQ8TB22.
PhosphoSitePlusiQ8TB22.

Polymorphism and mutation databases

BioMutaiSPATA20.
DMDMi311033529.

Proteomic databases

EPDiQ8TB22.
MaxQBiQ8TB22.
PaxDbiQ8TB22.
PeptideAtlasiQ8TB22.
PRIDEiQ8TB22.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000006658; ENSP00000006658; ENSG00000006282. [Q8TB22-2]
ENST00000356488; ENSP00000348878; ENSG00000006282. [Q8TB22-1]
ENST00000511937; ENSP00000489476; ENSG00000006282. [Q8TB22-4]
ENST00000619622; ENSP00000483295; ENSG00000006282. [Q8TB22-3]
GeneIDi64847.
KEGGihsa:64847.
UCSCiuc002ird.4. human. [Q8TB22-1]

Organism-specific databases

CTDi64847.
DisGeNETi64847.
GeneCardsiSPATA20.
HGNCiHGNC:26125. SPATA20.
HPAiHPA027144.
HPA031442.
MIMi613939. gene.
neXtProtiNX_Q8TB22.
OpenTargetsiENSG00000006282.
PharmGKBiPA142670885.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2244. Eukaryota.
COG1331. LUCA.
GeneTreeiENSGT00390000004836.
HOGENOMiHOG000231201.
HOVERGENiHBG093992.
InParanoidiQ8TB22.
OMAiLFWDSQG.
OrthoDBiEOG091G02U2.
PhylomeDBiQ8TB22.
TreeFamiTF105663.

Miscellaneous databases

ChiTaRSiSPATA20. human.
GenomeRNAii64847.
PROiQ8TB22.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000006282.
CleanExiHS_SPATA20.
ExpressionAtlasiQ8TB22. baseline and differential.
GenevisibleiQ8TB22. HS.

Family and domain databases

CDDicd02955. SSP411. 1 hit.
Gene3Di1.50.10.10. 2 hits.
3.40.30.10. 1 hit.
InterProiIPR008928. 6-hairpin_glycosidase-like.
IPR012341. 6hp_glycosidase.
IPR004879. DUF255.
IPR024705. Ssp411.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF03190. Thioredox_DsbH. 1 hit.
[Graphical view]
PIRSFiPIRSF006402. UCP006402_thioredoxin. 1 hit.
SUPFAMiSSF48208. SSF48208. 2 hits.
SSF52833. SSF52833. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSPT20_HUMAN
AccessioniPrimary (citable) accession number: Q8TB22
Secondary accession number(s): Q2TA99
, Q2XUZ6, Q6P0P1, Q8WVW3, Q9H747
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: November 2, 2010
Last modified: November 2, 2016
This is version 116 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.