Q8TB05 (F100A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein FAM100A

Gene names

Name:	FAM100A
ORF Names:	PP11303

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	177 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the FAM100 family.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8TB05-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8TB05-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-61: MSVNMDELKH...IPYSHHHHQM → MKLLTLQPPG...HPISPLFPSQ

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 177	177	Protein FAM100A		PRO_0000236079
Regions
	Compositional bias	107 – 171	65	Pro-rich
Natural variations
	Alternative sequence	1 – 61	61	MSVNM…HHHQM → MKLLTLQPPGMLWLMERGGL GKPRGPRHRGLLRVRLGRFI SRLLLWEPLGGGQAWGSGEG TQSLPRMGQPRISPWEAVGA PPGRGAHPISPLFPSQ in isoform 2.		VSP_018573

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: 7CCC710752C42712	FASTA	177	18,954
	10 20 30 40 50 60 MSVNMDELKH QVMINQFVLT AGCAADQAKQ LLQAAHWQFE TALSAFFQET NIPYSHHHHQ 70 80 90 100 110 120 MMCTPANTPA TPPNFPDALT MFSRLKASES FHSGGSGSPM AATATSPPPH FPHAATSSSA 130 140 150 160 170 ASSWPTAASP PGGPQHHQPQ PPLWTPTPPS PASDWPPLAP QQATSEPRAH PAMEAER
	Isoform 2 [UniParc]. Checksum: 33149EC30952283A	FASTA	212	22,394
	10 20 30 40 50 60 MKLLTLQPPG MLWLMERGGL GKPRGPRHRG LLRVRLGRFI SRLLLWEPLG GGQAWGSGEG 70 80 90 100 110 120 TQSLPRMGQP RISPWEAVGA PPGRGAHPIS PLFPSQMCTP ANTPATPPNF PDALTMFSRL 130 140 150 160 170 180 KASESFHSGG SGSPMAATAT SPPPHFPHAA TSSSAASSWP TAASPPGGPQ HHQPQPPLWT 190 200 210 PTPPSPASDW PPLAPQQATS EPRAHPAMEA ER

References

[1]

"Large-scale cDNA transfection screening for genes related to cancer development and progression." Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X. , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J. Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed: 15498874] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).

[2]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Cervix adenocarcinoma, Lung and Melanoma.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF447881 mRNA. Translation: AAQ04656.1. BC012018 mRNA. Translation: AAH12018.1. BC025327 mRNA. Translation: AAH25327.1. BC062534 mRNA. Translation: AAH62534.1.
IPI	IPI00152091. IPI00434706.
RefSeq	NP_660296.1. NM_145253.2.
UniGene	Hs.513313.
3D structure databases
ProteinModelPortal	Q8TB05.
SMR	Q8TB05. Positions 3-59.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8TB05. 2 interactions.
Polymorphism databases
DMDM	74730413.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000283474; ENSP00000283474; ENSG00000153443.
GeneID	124402.
KEGG	hsa:124402.
UCSC	uc002cwx.2. human.
Organism-specific databases
CTD	124402.
GeneCards	GC16M004625.
H-InvDB	HIX0023252. HIX0027326. HIX0038573.
HGNC	HGNC:29576. FAM100A.
neXtProt	NX_Q8TB05.
PharmGKB	PA142671782.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG18461.
GeneTree	ENSGT00390000008825.
HOGENOM	HBG715196.
HOVERGEN	HBG081490.
InParanoid	Q8TB05.
OMA	GSPMATT.
OrthoDB	EOG4N5VZH.
PhylomeDB	Q8TB05.
Gene expression databases
ArrayExpress	Q8TB05.
Bgee	Q8TB05.
CleanEx	HS_FAM100A.
Genevestigator	Q8TB05.
GermOnline	ENSG00000153443. Homo sapiens.
Family and domain databases
InterPro	IPR009060. UBA-like. [Graphical view]
SUPFAM	SSF46934. UBA_like. 1 hit.
ProtoNet	Search...
Other
NextBio	81265.

Entry information

Entry name

F100A_HUMAN

Accession

Primary (citable) accession number: Q8TB05
Secondary accession number(s): Q71MF6

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 16, 2006
Last sequence update:	June 1, 2002
Last modified:	December 14, 2011
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.