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Protein

UBA-like domain-containing protein 1

Gene

UBALD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
UBA-like domain-containing protein 1
Gene namesi
Name:UBALD1
Synonyms:FAM100A
ORF Names:PP11303
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:29576. UBALD1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671782.

Polymorphism and mutation databases

BioMutaiUBALD1.
DMDMi74730413.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 177177UBA-like domain-containing protein 1PRO_0000236079Add
BLAST

Proteomic databases

EPDiQ8TB05.
MaxQBiQ8TB05.
PaxDbiQ8TB05.
PeptideAtlasiQ8TB05.
PRIDEiQ8TB05.

PTM databases

iPTMnetiQ8TB05.
PhosphoSiteiQ8TB05.

Expressioni

Gene expression databases

BgeeiENSG00000153443.
CleanExiHS_FAM100A.
ExpressionAtlasiQ8TB05. baseline and differential.
GenevisibleiQ8TB05. HS.

Organism-specific databases

HPAiHPA066771.

Interactioni

Protein-protein interaction databases

IntActiQ8TB05. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ8TB05.
SMRiQ8TB05. Positions 3-59.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi107 – 17165Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the UBALD family.Curated

Phylogenomic databases

eggNOGiENOG410IXK9. Eukaryota.
ENOG4111XJX. LUCA.
GeneTreeiENSGT00390000008825.
HOGENOMiHOG000231197.
HOVERGENiHBG081490.
InParanoidiQ8TB05.
OMAiFATPSWP.
PhylomeDBiQ8TB05.
TreeFamiTF329433.

Family and domain databases

InterProiIPR009060. UBA-like.
[Graphical view]
SUPFAMiSSF46934. SSF46934. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TB05-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSVNMDELKH QVMINQFVLT AGCAADQAKQ LLQAAHWQFE TALSAFFQET
60 70 80 90 100
NIPYSHHHHQ MMCTPANTPA TPPNFPDALT MFSRLKASES FHSGGSGSPM
110 120 130 140 150
AATATSPPPH FPHAATSSSA ASSWPTAASP PGGPQHHQPQ PPLWTPTPPS
160 170
PASDWPPLAP QQATSEPRAH PAMEAER
Length:177
Mass (Da):18,954
Last modified:June 1, 2002 - v1
Checksum:i7CCC710752C42712
GO
Isoform 2 (identifier: Q8TB05-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-61: MSVNMDELKH...IPYSHHHHQM → MKLLTLQPPG...HPISPLFPSQ

Note: No experimental confirmation available.
Show »
Length:212
Mass (Da):22,394
Checksum:i33149EC30952283A
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 6161MSVNM…HHHQM → MKLLTLQPPGMLWLMERGGL GKPRGPRHRGLLRVRLGRFI SRLLLWEPLGGGQAWGSGEG TQSLPRMGQPRISPWEAVGA PPGRGAHPISPLFPSQ in isoform 2. 1 PublicationVSP_018573Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF447881 mRNA. Translation: AAQ04656.1.
AC023830 Genomic DNA. No translation available.
BC012018 mRNA. Translation: AAH12018.1.
BC025327 mRNA. Translation: AAH25327.1.
BC062534 mRNA. Translation: AAH62534.1.
CCDSiCCDS10518.1. [Q8TB05-1]
RefSeqiNP_660296.1. NM_145253.2. [Q8TB05-1]
UniGeneiHs.513313.

Genome annotation databases

EnsembliENST00000283474; ENSP00000283474; ENSG00000153443. [Q8TB05-1]
ENST00000590891; ENSP00000465706; ENSG00000153443. [Q8TB05-2]
GeneIDi124402.
KEGGihsa:124402.
UCSCiuc002cwx.2. human. [Q8TB05-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF447881 mRNA. Translation: AAQ04656.1.
AC023830 Genomic DNA. No translation available.
BC012018 mRNA. Translation: AAH12018.1.
BC025327 mRNA. Translation: AAH25327.1.
BC062534 mRNA. Translation: AAH62534.1.
CCDSiCCDS10518.1. [Q8TB05-1]
RefSeqiNP_660296.1. NM_145253.2. [Q8TB05-1]
UniGeneiHs.513313.

3D structure databases

ProteinModelPortaliQ8TB05.
SMRiQ8TB05. Positions 3-59.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8TB05. 2 interactions.

PTM databases

iPTMnetiQ8TB05.
PhosphoSiteiQ8TB05.

Polymorphism and mutation databases

BioMutaiUBALD1.
DMDMi74730413.

Proteomic databases

EPDiQ8TB05.
MaxQBiQ8TB05.
PaxDbiQ8TB05.
PeptideAtlasiQ8TB05.
PRIDEiQ8TB05.

Protocols and materials databases

DNASUi124402.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000283474; ENSP00000283474; ENSG00000153443. [Q8TB05-1]
ENST00000590891; ENSP00000465706; ENSG00000153443. [Q8TB05-2]
GeneIDi124402.
KEGGihsa:124402.
UCSCiuc002cwx.2. human. [Q8TB05-1]

Organism-specific databases

CTDi124402.
GeneCardsiUBALD1.
H-InvDBHIX0023252.
HGNCiHGNC:29576. UBALD1.
HPAiHPA066771.
neXtProtiNX_Q8TB05.
PharmGKBiPA142671782.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IXK9. Eukaryota.
ENOG4111XJX. LUCA.
GeneTreeiENSGT00390000008825.
HOGENOMiHOG000231197.
HOVERGENiHBG081490.
InParanoidiQ8TB05.
OMAiFATPSWP.
PhylomeDBiQ8TB05.
TreeFamiTF329433.

Miscellaneous databases

GenomeRNAii124402.
PROiQ8TB05.

Gene expression databases

BgeeiENSG00000153443.
CleanExiHS_FAM100A.
ExpressionAtlasiQ8TB05. baseline and differential.
GenevisibleiQ8TB05. HS.

Family and domain databases

InterProiIPR009060. UBA-like.
[Graphical view]
SUPFAMiSSF46934. SSF46934. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiUBAD1_HUMAN
AccessioniPrimary (citable) accession number: Q8TB05
Secondary accession number(s): Q71MF6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: June 1, 2002
Last modified: September 7, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.