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Protein

CKLF-like MARVEL transmembrane domain-containing protein 2

Gene

CMTM2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis

Names & Taxonomyi

Protein namesi
Recommended name:
CKLF-like MARVEL transmembrane domain-containing protein 2
Alternative name(s):
Chemokine-like factor superfamily member 2
Gene namesi
Name:CMTM2
Synonyms:CKLFSF2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:19173. CMTM2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei116 – 13621HelicalSequence analysisAdd
BLAST
Transmembranei147 – 16721HelicalSequence analysisAdd
BLAST
Transmembranei178 – 19821HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38812.

Polymorphism and mutation databases

BioMutaiCMTM2.
DMDMi34921873.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 248248CKLF-like MARVEL transmembrane domain-containing protein 2PRO_0000186098Add
BLAST

Proteomic databases

PaxDbiQ8TAZ6.
PRIDEiQ8TAZ6.

PTM databases

iPTMnetiQ8TAZ6.
PhosphoSiteiQ8TAZ6.

Expressioni

Tissue specificityi

Highly expressed in testis.1 Publication

Gene expression databases

BgeeiQ8TAZ6.
CleanExiHS_CMTM2.
ExpressionAtlasiQ8TAZ6. baseline and differential.
GenevisibleiQ8TAZ6. HS.

Organism-specific databases

HPAiHPA014719.
HPA014741.

Interactioni

Protein-protein interaction databases

BioGridi126973. 1 interaction.
IntActiQ8TAZ6. 1 interaction.
STRINGi9606.ENSP00000268595.

Structurei

3D structure databases

ProteinModelPortaliQ8TAZ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini82 – 204123MARVELPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the chemokine-like factor family.Curated
Contains 1 MARVEL domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4788. Eukaryota.
ENOG4111IAF. LUCA.
GeneTreeiENSGT00390000005715.
HOGENOMiHOG000111750.
HOVERGENiHBG050993.
InParanoidiQ8TAZ6.
OMAiLQRKHFK.
OrthoDBiEOG786H53.
PhylomeDBiQ8TAZ6.
TreeFamiTF338711.

Family and domain databases

InterProiIPR008253. Marvel.
[Graphical view]
PfamiPF01284. MARVEL. 1 hit.
[Graphical view]
PROSITEiPS51225. MARVEL. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TAZ6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPKAAKGAK PEPAPAPPPP GAKPEEDKKD GKEPSDKPQK AVQDHKEPSD
60 70 80 90 100
KPQKAVQPKH EVGTRRGCRR YRWELKDSNK EFWLLGHAEI KIRSLGCLIA
110 120 130 140 150
AMILLSSLTV HPILRLIITM EISFFSFFIL LYSFAIHRYI PFILWPISDL
160 170 180 190 200
FNDLIACAFL VGAVVFAVRS RRSMNLHYLL AVILIGAAGV FAFIDVCLQR
210 220 230 240
NHFRGKKAKK HMLVPPPGKE KGPQQGKGPE PAKPPEPGKP PGPAKGKK
Length:248
Mass (Da):27,496
Last modified:June 1, 2002 - v1
Checksum:i9E2E8FEB4554D84F
GO
Isoform 2 (identifier: Q8TAZ6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     96-148: Missing.

Show »
Length:195
Mass (Da):21,370
Checksum:i27E032F0F16E1DA0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti172 – 1721R → Q in BAC05345 (PubMed:15896670).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti122 – 1221I → T.
Corresponds to variant rs2290182 [ dbSNP | Ensembl ].
VAR_022154

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei96 – 14853Missing in isoform 2. 1 PublicationVSP_047061Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF479260 mRNA. Translation: AAN73038.1.
AY862139 mRNA. Translation: AAW51946.1.
AK098598 mRNA. Translation: BAC05345.1.
AC010542 Genomic DNA. No translation available.
BC025354 mRNA. Translation: AAH25354.1.
CCDSiCCDS10814.1. [Q8TAZ6-1]
CCDS56001.1. [Q8TAZ6-2]
RefSeqiNP_001186246.1. NM_001199317.1. [Q8TAZ6-2]
NP_653274.1. NM_144673.2. [Q8TAZ6-1]
UniGeneiHs.195685.

Genome annotation databases

EnsembliENST00000268595; ENSP00000268595; ENSG00000140932. [Q8TAZ6-1]
ENST00000379486; ENSP00000368800; ENSG00000140932. [Q8TAZ6-2]
GeneIDi146225.
KEGGihsa:146225.
UCSCiuc002ept.4. human. [Q8TAZ6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF479260 mRNA. Translation: AAN73038.1.
AY862139 mRNA. Translation: AAW51946.1.
AK098598 mRNA. Translation: BAC05345.1.
AC010542 Genomic DNA. No translation available.
BC025354 mRNA. Translation: AAH25354.1.
CCDSiCCDS10814.1. [Q8TAZ6-1]
CCDS56001.1. [Q8TAZ6-2]
RefSeqiNP_001186246.1. NM_001199317.1. [Q8TAZ6-2]
NP_653274.1. NM_144673.2. [Q8TAZ6-1]
UniGeneiHs.195685.

3D structure databases

ProteinModelPortaliQ8TAZ6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126973. 1 interaction.
IntActiQ8TAZ6. 1 interaction.
STRINGi9606.ENSP00000268595.

PTM databases

iPTMnetiQ8TAZ6.
PhosphoSiteiQ8TAZ6.

Polymorphism and mutation databases

BioMutaiCMTM2.
DMDMi34921873.

Proteomic databases

PaxDbiQ8TAZ6.
PRIDEiQ8TAZ6.

Protocols and materials databases

DNASUi146225.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000268595; ENSP00000268595; ENSG00000140932. [Q8TAZ6-1]
ENST00000379486; ENSP00000368800; ENSG00000140932. [Q8TAZ6-2]
GeneIDi146225.
KEGGihsa:146225.
UCSCiuc002ept.4. human. [Q8TAZ6-1]

Organism-specific databases

CTDi146225.
GeneCardsiCMTM2.
HGNCiHGNC:19173. CMTM2.
HPAiHPA014719.
HPA014741.
MIMi607885. gene.
neXtProtiNX_Q8TAZ6.
PharmGKBiPA38812.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4788. Eukaryota.
ENOG4111IAF. LUCA.
GeneTreeiENSGT00390000005715.
HOGENOMiHOG000111750.
HOVERGENiHBG050993.
InParanoidiQ8TAZ6.
OMAiLQRKHFK.
OrthoDBiEOG786H53.
PhylomeDBiQ8TAZ6.
TreeFamiTF338711.

Miscellaneous databases

GeneWikiiCMTM2.
GenomeRNAii146225.
PROiQ8TAZ6.
SOURCEiSearch...

Gene expression databases

BgeeiQ8TAZ6.
CleanExiHS_CMTM2.
ExpressionAtlasiQ8TAZ6. baseline and differential.
GenevisibleiQ8TAZ6. HS.

Family and domain databases

InterProiIPR008253. Marvel.
[Graphical view]
PfamiPF01284. MARVEL. 1 hit.
[Graphical view]
PROSITEiPS51225. MARVEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of eight genes encoding chemokine-like factor superfamily members 1-8 (CKLFSF1-8) by in silico cloning and experimental validation."
    Han W., Ding P., Xu M., Wang L., Rui M., Shi S., Liu Y., Zheng Y., Chen Y., Yang T., Ma D.
    Genomics 81:609-617(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    Tissue: Testis.
  2. "CKLFSF2 is highly expressed in testis and can be secreted into the seminiferous tubules."
    Shi S., Rui M., Han W., Wang Y., Qiu X., Ding P., Zhang P., Zhu X., Zhang Y., Gan Q., Ma D.
    Int. J. Biochem. Cell Biol. 37:1633-1640(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  4. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Muscle.

Entry informationi

Entry nameiCKLF2_HUMAN
AccessioniPrimary (citable) accession number: Q8TAZ6
Secondary accession number(s): Q5I2A4, Q8N7E5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: June 1, 2002
Last modified: June 8, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.