Q8TAX7 (MUC7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mucin-7
Short name=MUC-7

Alternative name(s):
Apo-MG2
Salivary mucin-7

Gene names

Name:	MUC7
Synonyms:	MG2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	377 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May function in a protective capacity by promoting the clearance of bacteria in the oral cavity and aiding in mastication, speech, and swallowing. Binds P.aeruginosa pili. Ref.5 Ref.6
Subunit structure	Monomer.
Subcellular location	Secreted Ref.1.
Tissue specificity	Expressed in salivary gland tissues and only in those that contain mucous acinar cells (e.g. sublingual and submandibular glands) and not in salivary glands containing only serous acinar cells (e.g. parotid gland). Ref.1 Ref.4
Post-translational modification	N- and O-glycosylated. Contains fucose, mannose, galactose, N-acetylglucosamine and N-acetylgalactosamine. Ref.5
Polymorphism	The most common allele, MUC7*6, contains a tandem repeat domain comprising 6 repeats (shown here) each composed of 23 amino acids. These repeats are very similar but not identical. In a large cohort of 375 individuals from a variety of ethnic backgrounds, three different alleles were detected, MUC7*6 being the most common, in all populations studied, followed by MUC7*5 (5 repeats), with frequency varying from 0.05 in Africans to 0.22 in East Asians. The MUC7*5 allele is less prevalent in patients with asthma than in controls, and seems to have a protective role in respiratory function. MUC7*8 (8 repeats), a novel rare allele, was identified in 1 Northern European individual.
Involvement in disease	Asthma (ASTHMA) [MIM:600807]: The most common chronic disease affecting children and young adults. It is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. It is characterized by recurrent attacks of paroxysmal dyspnea, with weezing due to spasmodic contraction of the bronchi. Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. Ref.6

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Disease	Asthma
Domain	Repeat Signal
PTM	Glycoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	O-glycan processing Traceable author statement. Source: Reactome post-translational protein modification Traceable author statement. Source: Reactome
Cellular_component	Golgi lumen Traceable author statement. Source: Reactome extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
AMY1C	P04745	2	EBI-738582,EBI-738586
HTN1	P15515	2	EBI-738582,EBI-738638
PRH2	P02810	2	EBI-738582,EBI-738601
STATH	P02808	2	EBI-738582,EBI-738687

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	Potential
	Chain	23 – 377	355	Mucin-7		PRO_0000239228
Regions
	Repeat	165 – 187	23	1
	Repeat	188 – 210	23	2
	Repeat	211 – 233	23	3
	Repeat	234 – 256	23	4
	Repeat	257 – 279	23	5
	Repeat	280 – 302	23	6
	Compositional bias	104 – 348	245	Thr-rich
Amino acid modifications
	Glycosylation	97	1	N-linked (GlcNAc...) Potential
	Glycosylation	128	1	N-linked (GlcNAc...) Potential
	Glycosylation	135	1	N-linked (GlcNAc...) Potential
	Glycosylation	146	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	80	1	N → K. Corresponds to variant rs6826961 [ dbSNP | Ensembl ].		VAR_050451
Experimental info
	Sequence conflict	70	1	C → S AA sequence Ref.4
	Sequence conflict	92	1	K → P AA sequence Ref.4
	Sequence conflict	162	1	P → A AA sequence Ref.4
	Sequence conflict	162	1	P → A AA sequence Ref.5
	Sequence conflict	334	1	T → I in AAH25688. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q8TAX7 [UniParc]. Last modified May 18, 2010. Version 2. Checksum: 1BF92D1855C13F4A	FASTA	377	39,159
	10 20 30 40 50 60 MKTLPLFVCI CALSACFSFS EGRERDHELR HRRHHHQSPK SHFELPHYPG LLAHQKPFIR 70 80 90 100 110 120 KSYKCLHKRC RPKLPPSPNN PPKFPNPHQP PKHPDKNSSV VNPTLVATTQ IPSVTFPSAS 130 140 150 160 170 180 TKITTLPNVT FLPQNATTIS SRENVNTSSS VATLAPVNSP APQDTTAAPP TPSATTPAPP 190 200 210 220 230 240 SSSAPPETTA APPTPSATTQ APPSSSAPPE TTAAPPTPPA TTPAPPSSSA PPETTAAPPT 250 260 270 280 290 300 PSATTPAPLS SSAPPETTAV PPTPSATTLD PSSASAPPET TAAPPTPSAT TPAPPSSPAP 310 320 330 340 350 360 QETTAAPITT PNSSPTTLAP DTSETSAAPT HQTTTSVTTQ TTTTKQPTSA PGQNKISRFL 370 LYMKNLLNRI IDDMVEQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning, sequence, and specificity of expression of the gene encoding the low molecular weight human salivary mucin (MUC7)." Bobek L.A., Tsai H., Biesbrock A.R., Levine M.J. J. Biol. Chem. 268:20563-20569(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY. Tissue: Submandibular gland.
[2]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
[4]	"Structural features of the low-molecular-mass human salivary mucin." Reddy M.S., Bobek L.A., Haraszthy G.G., Biesbrock A.R., Levine M.J. Biochem. J. 287:639-643(1992) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 70-92 AND 143-168, TISSUE SPECIFICITY. Tissue: Saliva.
[5]	"Low-molecular-mass human salivary mucin, MG2: structure and binding of Pseudomonas aeruginosa." Reddy M.S., Levine M.J., Paranchych W. Crit. Rev. Oral Biol. Med. 4:315-323(1993) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 93-112 AND 143-168, FUNCTION, GLYCOSYLATION. Tissue: Saliva.
[6]	"Genetic polymorphism of MUC7: allele frequencies and association with asthma." Kirkbride H.J., Bolscher J.G., Nazmi K., Vinall L.E., Nash M.W., Moss F.M., Mitchell D.M., Swallow D.M. Eur. J. Hum. Genet. 9:347-354(2001) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, POLYMORPHISM, INVOLVEMENT IN SUSCEPTIBILITY TO ASTHMA.
+	Additional computationally mapped references.

Web resources

Mucin database

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC106884 Genomic DNA. No translation available. AC108518 Genomic DNA. No translation available. BC025688 mRNA. Translation: AAH25688.1.
IPI	IPI00152154.
PIR	A48018.
RefSeq	NP_001138478.1. NM_001145006.1. NP_001138479.1. NM_001145007.1. NP_689504.2. NM_152291.2.
UniGene	Hs.631946.
3D structure databases
ProteinModelPortal	Q8TAX7.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8TAX7. 10 interactions.
STRING	9606.ENSP00000302021.
Polymorphism databases
DMDM	296439230.
Proteomic databases
PaxDb	Q8TAX7.
PRIDE	Q8TAX7.
Protocols and materials databases
DNASU	4589.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000304887; ENSP00000302021; ENSG00000171195. ENST00000413702; ENSP00000407422; ENSG00000171195. ENST00000456088; ENSP00000400585; ENSG00000171195.
GeneID	4589.
KEGG	hsa:4589.
UCSC	uc003hfj.3. human.
Organism-specific databases
CTD	4589.
GeneCards	GC04P071372.
H-InvDB	HIX0004265. HIX0205079.
HGNC	HGNC:7518. MUC7.
HPA	HPA006411.
MIM	158375. gene. 600807. phenotype.
neXtProt	NX_Q8TAX7.
PharmGKB	PA31323.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG138316.
HOGENOM	HOG000169238.
InParanoid	Q8TAX7.
KO	K13909.
OMA	TKQPTSA.
Enzyme and pathway databases
Reactome	REACT_17015. Metabolism of proteins.
Gene expression databases
ArrayExpress	Q8TAX7.
Bgee	Q8TAX7.
CleanEx	HS_MUC7.
Genevestigator	Q8TAX7.
GermOnline	ENSG00000171195. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other
ChiTaRS	MUC7. human.
GenomeRNAi	4589.
NextBio	17644.
PMAP-CutDB	Q8TAX7.
SOURCE	Search...

Entry information

Entry name

MUC7_HUMAN

Accession

Primary (citable) accession number: Q8TAX7
Secondary accession number(s): Q9UCD7, Q9UCD8

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2006
Last sequence update:	May 18, 2010
Last modified:	May 1, 2013
This is version 81 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.