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Q8TAX7

- MUC7_HUMAN

UniProt

Q8TAX7 - MUC7_HUMAN

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Protein

Mucin-7

Gene

MUC7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May function in a protective capacity by promoting the clearance of bacteria in the oral cavity and aiding in mastication, speech, and swallowing. Binds P.aeruginosa pili.2 Publications

GO - Biological processi

  1. cellular protein metabolic process Source: Reactome
  2. O-glycan processing Source: Reactome
  3. post-translational protein modification Source: Reactome
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_115606. O-linked glycosylation of mucins.
REACT_115835. Termination of O-glycan biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Mucin-7
Short name:
MUC-7
Alternative name(s):
Apo-MG2
Salivary mucin-7
Gene namesi
Name:MUC7
Synonyms:MG2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:7518. MUC7.

Subcellular locationi

Secreted 1 Publication

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
  2. Golgi lumen Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Involvement in diseasei

Asthma (ASTHMA) [MIM:600807]: The most common chronic disease affecting children and young adults. It is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. It is characterized by recurrent attacks of paroxysmal dyspnea, with wheezing due to spasmodic contraction of the bronchi.1 Publication
Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.

Keywords - Diseasei

Asthma

Organism-specific databases

MIMi600807. phenotype.
PharmGKBiPA31323.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Chaini23 – 377355Mucin-7PRO_0000239228Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi97 – 971N-linked (GlcNAc...)Sequence Analysis
Glycosylationi128 – 1281N-linked (GlcNAc...)Sequence Analysis
Glycosylationi135 – 1351N-linked (GlcNAc...)Sequence Analysis
Glycosylationi146 – 1461N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

N- and O-glycosylated. Contains fucose, mannose, galactose, N-acetylglucosamine and N-acetylgalactosamine.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8TAX7.
PRIDEiQ8TAX7.

Miscellaneous databases

PMAP-CutDBQ8TAX7.

Expressioni

Tissue specificityi

Expressed in salivary gland tissues and only in those that contain mucous acinar cells (e.g. sublingual and submandibular glands) and not in salivary glands containing only serous acinar cells (e.g. parotid gland).2 Publications

Gene expression databases

BgeeiQ8TAX7.
CleanExiHS_MUC7.
ExpressionAtlasiQ8TAX7. baseline and differential.
GenevestigatoriQ8TAX7.

Organism-specific databases

HPAiHPA006411.

Interactioni

Subunit structurei

Monomer.

Binary interactionsi

WithEntry#Exp.IntActNotes
AMY1CP047452EBI-738582,EBI-738586
HTN1P155152EBI-738582,EBI-738638
PRH2P028102EBI-738582,EBI-738601
STATHP028082EBI-738582,EBI-738687

Protein-protein interaction databases

BioGridi110676. 8 interactions.
IntActiQ8TAX7. 10 interactions.
STRINGi9606.ENSP00000302021.

Structurei

3D structure databases

ProteinModelPortaliQ8TAX7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati165 – 187231Add
BLAST
Repeati188 – 210232Add
BLAST
Repeati211 – 233233Add
BLAST
Repeati234 – 256234Add
BLAST
Repeati257 – 279235Add
BLAST
Repeati280 – 302236Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi104 – 348245Thr-richAdd
BLAST

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG138316.
GeneTreeiENSGT00730000111663.
HOGENOMiHOG000169238.
InParanoidiQ8TAX7.
KOiK13909.
OMAiKSHFELP.
PhylomeDBiQ8TAX7.
TreeFamiTF341506.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8TAX7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKTLPLFVCI CALSACFSFS EGRERDHELR HRRHHHQSPK SHFELPHYPG
60 70 80 90 100
LLAHQKPFIR KSYKCLHKRC RPKLPPSPNN PPKFPNPHQP PKHPDKNSSV
110 120 130 140 150
VNPTLVATTQ IPSVTFPSAS TKITTLPNVT FLPQNATTIS SRENVNTSSS
160 170 180 190 200
VATLAPVNSP APQDTTAAPP TPSATTPAPP SSSAPPETTA APPTPSATTQ
210 220 230 240 250
APPSSSAPPE TTAAPPTPPA TTPAPPSSSA PPETTAAPPT PSATTPAPLS
260 270 280 290 300
SSAPPETTAV PPTPSATTLD PSSASAPPET TAAPPTPSAT TPAPPSSPAP
310 320 330 340 350
QETTAAPITT PNSSPTTLAP DTSETSAAPT HQTTTSVTTQ TTTTKQPTSA
360 370
PGQNKISRFL LYMKNLLNRI IDDMVEQ
Length:377
Mass (Da):39,159
Last modified:May 18, 2010 - v2
Checksum:i1BF92D1855C13F4A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti70 – 701C → S AA sequence (PubMed:1445223)Curated
Sequence conflicti92 – 921K → P AA sequence (PubMed:1445223)Curated
Sequence conflicti162 – 1621P → A AA sequence (PubMed:1445223)Curated
Sequence conflicti162 – 1621P → A AA sequence (PubMed:8104046)Curated
Sequence conflicti334 – 3341T → I in AAH25688. (PubMed:15489334)Curated

Polymorphismi

The most common allele, MUC7*6, contains a tandem repeat domain comprising 6 repeats (shown here) each composed of 23 amino acids. These repeats are very similar but not identical. In a large cohort of 375 individuals from a variety of ethnic backgrounds, three different alleles were detected, MUC7*6 being the most common, in all populations studied, followed by MUC7*5 (5 repeats), with frequency varying from 0.05 in Africans to 0.22 in East Asians. The MUC7*5 allele is less prevalent in patients with asthma than in controls, and seems to have a protective role in respiratory function. MUC7*8 (8 repeats), a novel rare allele, was identified in 1 Northern European individual.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti80 – 801N → K.
Corresponds to variant rs6826961 [ dbSNP | Ensembl ].
VAR_050451

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC106884 Genomic DNA. No translation available.
AC108518 Genomic DNA. No translation available.
BC025688 mRNA. Translation: AAH25688.1.
CCDSiCCDS3541.1.
PIRiA48018.
RefSeqiNP_001138478.1. NM_001145006.1.
NP_001138479.1. NM_001145007.1.
NP_689504.2. NM_152291.2.
UniGeneiHs.631946.

Genome annotation databases

EnsembliENST00000304887; ENSP00000302021; ENSG00000171195.
ENST00000413702; ENSP00000407422; ENSG00000171195.
ENST00000456088; ENSP00000400585; ENSG00000171195.
GeneIDi4589.
KEGGihsa:4589.
UCSCiuc003hfj.3. human.

Polymorphism databases

DMDMi296439230.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Mucin database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC106884 Genomic DNA. No translation available.
AC108518 Genomic DNA. No translation available.
BC025688 mRNA. Translation: AAH25688.1 .
CCDSi CCDS3541.1.
PIRi A48018.
RefSeqi NP_001138478.1. NM_001145006.1.
NP_001138479.1. NM_001145007.1.
NP_689504.2. NM_152291.2.
UniGenei Hs.631946.

3D structure databases

ProteinModelPortali Q8TAX7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110676. 8 interactions.
IntActi Q8TAX7. 10 interactions.
STRINGi 9606.ENSP00000302021.

Polymorphism databases

DMDMi 296439230.

Proteomic databases

PaxDbi Q8TAX7.
PRIDEi Q8TAX7.

Protocols and materials databases

DNASUi 4589.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000304887 ; ENSP00000302021 ; ENSG00000171195 .
ENST00000413702 ; ENSP00000407422 ; ENSG00000171195 .
ENST00000456088 ; ENSP00000400585 ; ENSG00000171195 .
GeneIDi 4589.
KEGGi hsa:4589.
UCSCi uc003hfj.3. human.

Organism-specific databases

CTDi 4589.
GeneCardsi GC04P071372.
H-InvDB HIX0004265.
HIX0205079.
HGNCi HGNC:7518. MUC7.
HPAi HPA006411.
MIMi 158375. gene.
600807. phenotype.
neXtProti NX_Q8TAX7.
PharmGKBi PA31323.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG138316.
GeneTreei ENSGT00730000111663.
HOGENOMi HOG000169238.
InParanoidi Q8TAX7.
KOi K13909.
OMAi KSHFELP.
PhylomeDBi Q8TAX7.
TreeFami TF341506.

Enzyme and pathway databases

Reactomei REACT_115606. O-linked glycosylation of mucins.
REACT_115835. Termination of O-glycan biosynthesis.

Miscellaneous databases

ChiTaRSi MUC7. human.
GeneWikii MUC7.
GenomeRNAii 4589.
NextBioi 17644.
PMAP-CutDB Q8TAX7.
PROi Q8TAX7.
SOURCEi Search...

Gene expression databases

Bgeei Q8TAX7.
CleanExi HS_MUC7.
ExpressionAtlasi Q8TAX7. baseline and differential.
Genevestigatori Q8TAX7.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning, sequence, and specificity of expression of the gene encoding the low molecular weight human salivary mucin (MUC7)."
    Bobek L.A., Tsai H., Biesbrock A.R., Levine M.J.
    J. Biol. Chem. 268:20563-20569(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Submandibular gland.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  4. "Structural features of the low-molecular-mass human salivary mucin."
    Reddy M.S., Bobek L.A., Haraszthy G.G., Biesbrock A.R., Levine M.J.
    Biochem. J. 287:639-643(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 70-92 AND 143-168, TISSUE SPECIFICITY.
    Tissue: Saliva.
  5. "Low-molecular-mass human salivary mucin, MG2: structure and binding of Pseudomonas aeruginosa."
    Reddy M.S., Levine M.J., Paranchych W.
    Crit. Rev. Oral Biol. Med. 4:315-323(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 93-112 AND 143-168, FUNCTION, GLYCOSYLATION.
    Tissue: Saliva.
  6. "Genetic polymorphism of MUC7: allele frequencies and association with asthma."
    Kirkbride H.J., Bolscher J.G., Nazmi K., Vinall L.E., Nash M.W., Moss F.M., Mitchell D.M., Swallow D.M.
    Eur. J. Hum. Genet. 9:347-354(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, POLYMORPHISM, INVOLVEMENT IN SUSCEPTIBILITY TO ASTHMA.

Entry informationi

Entry nameiMUC7_HUMAN
AccessioniPrimary (citable) accession number: Q8TAX7
Secondary accession number(s): Q9UCD7, Q9UCD8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: May 18, 2010
Last modified: October 29, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3