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Q8TAX0

- OSR1_HUMAN

UniProt

Q8TAX0 - OSR1_HUMAN

Protein

Protein odd-skipped-related 1

Gene

OSR1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    Transcription factor that plays a role in the regulation of embryonic heart and urogenital development.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri175 – 19723C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri203 – 22523C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri231 – 25323C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. nucleic acid binding Source: InterPro

    GO - Biological processi

    1. cell differentiation Source: BHF-UCL
    2. cell proliferation involved in kidney development Source: UniProtKB
    3. cellular response to retinoic acid Source: Ensembl
    4. chondrocyte differentiation Source: BHF-UCL
    5. embryonic digit morphogenesis Source: BHF-UCL
    6. embryonic forelimb morphogenesis Source: BHF-UCL
    7. embryonic hindlimb morphogenesis Source: BHF-UCL
    8. embryonic skeletal joint development Source: BHF-UCL
    9. embryonic skeletal joint morphogenesis Source: BHF-UCL
    10. embryonic skeletal limb joint morphogenesis Source: BHF-UCL
    11. gonad development Source: Ensembl
    12. heart development Source: UniProtKB
    13. intermediate mesoderm development Source: Ensembl
    14. mesangial cell development Source: UniProtKB
    15. mesonephric duct morphogenesis Source: UniProtKB
    16. mesonephros development Source: UniProtKB
    17. metanephric cap mesenchymal cell proliferation involved in metanephros development Source: UniProtKB
    18. metanephric epithelium development Source: UniProtKB
    19. metanephric glomerulus vasculature development Source: UniProtKB
    20. metanephric interstitial fibroblast development Source: UniProtKB
    21. metanephric mesenchymal cell differentiation Source: UniProtKB
    22. metanephric mesenchyme development Source: UniProtKB
    23. metanephric mesenchyme morphogenesis Source: UniProtKB
    24. metanephric nephron tubule development Source: UniProtKB
    25. metanephric smooth muscle tissue development Source: UniProtKB
    26. middle ear morphogenesis Source: UniProtKB
    27. negative regulation of apoptotic process Source: UniProtKB
    28. negative regulation of epithelial cell differentiation Source: UniProtKB
    29. negative regulation of nephron tubule epithelial cell differentiation Source: UniProtKB
    30. negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
    31. odontogenesis Source: UniProtKB
    32. palate development Source: UniProtKB
    33. pattern specification involved in metanephros development Source: UniProtKB
    34. positive regulation of bone mineralization Source: BHF-UCL
    35. positive regulation of epithelial cell proliferation Source: UniProtKB
    36. positive regulation of gastrulation Source: UniProtKB
    37. positive regulation of gene expression Source: UniProtKB
    38. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
    39. posterior mesonephric tubule development Source: UniProtKB
    40. pronephros development Source: UniProtKB
    41. renal vesicle progenitor cell differentiation Source: UniProtKB
    42. specification of anterior mesonephric tubule identity Source: UniProtKB
    43. specification of posterior mesonephric tubule identity Source: UniProtKB
    44. stem cell differentiation Source: UniProtKB
    45. transcription, DNA-templated Source: UniProtKB-KW
    46. ureteric bud development Source: UniProtKB
    47. ureter urothelium development Source: UniProtKB
    48. urogenital system development Source: UniProtKB

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein odd-skipped-related 1
    Gene namesi
    Name:OSR1
    Synonyms:ODD
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:8111. OSR1.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: LIFEdb

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA164742217.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 266266Protein odd-skipped-related 1PRO_0000047004Add
    BLAST

    Proteomic databases

    PaxDbiQ8TAX0.
    PRIDEiQ8TAX0.

    PTM databases

    PhosphoSiteiQ8TAX0.

    Expressioni

    Tissue specificityi

    Expressed in adult colon, small intestine, prostate, testis, and fetal lung.1 Publication

    Gene expression databases

    BgeeiQ8TAX0.
    CleanExiHS_OSR1.
    GenevestigatoriQ8TAX0.

    Organism-specific databases

    HPAiHPA015525.

    Interactioni

    Protein-protein interaction databases

    BioGridi126234. 3 interactions.
    MINTiMINT-4720561.
    STRINGi9606.ENSP00000272223.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8TAX0.
    SMRiQ8TAX0. Positions 166-255.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri175 – 19723C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri203 – 22523C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri231 – 25323C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000013107.
    HOVERGENiHBG054398.
    InParanoidiQ8TAX0.
    KOiK09215.
    OMAiAKPRFDF.
    OrthoDBiEOG754HQ2.
    PhylomeDBiQ8TAX0.
    TreeFamiTF350876.

    Family and domain databases

    Gene3Di3.30.160.60. 3 hits.
    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 3 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
    PS50157. ZINC_FINGER_C2H2_2. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8TAX0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGSKTLPAPV PIHPSLQLTN YSFLQAVNGL PTVPSDHLPN LYGFSALHAV    50
    HLHQWTLGYP AMHLPRSSFS KVPGTVSSLV DARFQLPAFP WFPHVIQPKP 100
    EITAGGSVPA LKTKPRFDFA NLALAATQED PAKLGRGEGP GSPAGGLGAL 150
    LDVTKLSPEK KPTRGRLPSK TKKEFVCKFC GRHFTKSYNL LIHERTHTDE 200
    RPYTCDICHK AFRRQDHLRD HRYIHSKEKP FKCQECGKGF CQSRTLAVHK 250
    TLHSQVKELK TSKIKC 266
    Length:266
    Mass (Da):29,611
    Last modified:June 1, 2002 - v1
    Checksum:i3D15ED2565C954E3
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti214 – 2141R → G in BAG53709. (PubMed:14702039)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB082568 mRNA. Translation: BAB92079.1.
    AK074591 mRNA. Translation: BAC11079.1.
    AK122756 mRNA. Translation: BAG53709.1.
    DQ021502 Genomic DNA. Translation: AAY26397.1.
    AC018741 Genomic DNA. Translation: AAY14760.1.
    CH471053 Genomic DNA. Translation: EAX00846.1.
    CH471053 Genomic DNA. Translation: EAX00848.1.
    BC025712 mRNA. Translation: AAH25712.1.
    CCDSiCCDS1694.1.
    RefSeqiNP_660303.1. NM_145260.2.
    XP_006712005.1. XM_006711942.1.
    UniGeneiHs.123933.

    Genome annotation databases

    EnsembliENST00000272223; ENSP00000272223; ENSG00000143867.
    GeneIDi130497.
    KEGGihsa:130497.
    UCSCiuc002rdc.3. human.

    Polymorphism databases

    DMDMi74762600.

    Cross-referencesi

    Web resourcesi

    NIEHS-SNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB082568 mRNA. Translation: BAB92079.1 .
    AK074591 mRNA. Translation: BAC11079.1 .
    AK122756 mRNA. Translation: BAG53709.1 .
    DQ021502 Genomic DNA. Translation: AAY26397.1 .
    AC018741 Genomic DNA. Translation: AAY14760.1 .
    CH471053 Genomic DNA. Translation: EAX00846.1 .
    CH471053 Genomic DNA. Translation: EAX00848.1 .
    BC025712 mRNA. Translation: AAH25712.1 .
    CCDSi CCDS1694.1.
    RefSeqi NP_660303.1. NM_145260.2.
    XP_006712005.1. XM_006711942.1.
    UniGenei Hs.123933.

    3D structure databases

    ProteinModelPortali Q8TAX0.
    SMRi Q8TAX0. Positions 166-255.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 126234. 3 interactions.
    MINTi MINT-4720561.
    STRINGi 9606.ENSP00000272223.

    PTM databases

    PhosphoSitei Q8TAX0.

    Polymorphism databases

    DMDMi 74762600.

    Proteomic databases

    PaxDbi Q8TAX0.
    PRIDEi Q8TAX0.

    Protocols and materials databases

    DNASUi 130497.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000272223 ; ENSP00000272223 ; ENSG00000143867 .
    GeneIDi 130497.
    KEGGi hsa:130497.
    UCSCi uc002rdc.3. human.

    Organism-specific databases

    CTDi 130497.
    GeneCardsi GC02M019551.
    HGNCi HGNC:8111. OSR1.
    HPAi HPA015525.
    MIMi 608891. gene.
    neXtProti NX_Q8TAX0.
    PharmGKBi PA164742217.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000013107.
    HOVERGENi HBG054398.
    InParanoidi Q8TAX0.
    KOi K09215.
    OMAi AKPRFDF.
    OrthoDBi EOG754HQ2.
    PhylomeDBi Q8TAX0.
    TreeFami TF350876.

    Miscellaneous databases

    GeneWikii OSR1.
    GenomeRNAii 130497.
    NextBioi 82746.
    PROi Q8TAX0.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8TAX0.
    CleanExi HS_OSR1.
    Genevestigatori Q8TAX0.

    Family and domain databases

    Gene3Di 3.30.160.60. 3 hits.
    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 3 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 3 hits.
    PS50157. ZINC_FINGER_C2H2_2. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterization of OSR1 on human chromosome 2p24."
      Katoh M.
      Int. J. Mol. Med. 10:221-225(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    3. NIEHS SNPs program
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Pancreas.

    Entry informationi

    Entry nameiOSR1_HUMAN
    AccessioniPrimary (citable) accession number: Q8TAX0
    Secondary accession number(s): B3KV97, D6W521
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 24, 2006
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3