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Q8TAX0

- OSR1_HUMAN

UniProt

Q8TAX0 - OSR1_HUMAN

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Protein

Protein odd-skipped-related 1

Gene

OSR1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Transcription factor that plays a role in the regulation of embryonic heart and urogenital development.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri175 – 19723C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri203 – 22523C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri231 – 25323C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. nucleic acid binding Source: InterPro

GO - Biological processi

  1. cell differentiation Source: BHF-UCL
  2. cell proliferation involved in kidney development Source: UniProtKB
  3. cellular response to retinoic acid Source: Ensembl
  4. chondrocyte differentiation Source: BHF-UCL
  5. embryonic digit morphogenesis Source: BHF-UCL
  6. embryonic forelimb morphogenesis Source: BHF-UCL
  7. embryonic hindlimb morphogenesis Source: BHF-UCL
  8. embryonic skeletal joint development Source: BHF-UCL
  9. embryonic skeletal joint morphogenesis Source: BHF-UCL
  10. embryonic skeletal limb joint morphogenesis Source: BHF-UCL
  11. gonad development Source: Ensembl
  12. heart development Source: UniProtKB
  13. intermediate mesoderm development Source: Ensembl
  14. mesangial cell development Source: UniProtKB
  15. mesonephric duct morphogenesis Source: UniProtKB
  16. mesonephros development Source: UniProtKB
  17. metanephric cap mesenchymal cell proliferation involved in metanephros development Source: UniProtKB
  18. metanephric epithelium development Source: UniProtKB
  19. metanephric glomerulus vasculature development Source: UniProtKB
  20. metanephric interstitial fibroblast development Source: UniProtKB
  21. metanephric mesenchymal cell differentiation Source: UniProtKB
  22. metanephric mesenchyme development Source: UniProtKB
  23. metanephric mesenchyme morphogenesis Source: UniProtKB
  24. metanephric nephron tubule development Source: UniProtKB
  25. metanephric smooth muscle tissue development Source: UniProtKB
  26. middle ear morphogenesis Source: UniProtKB
  27. negative regulation of apoptotic process Source: UniProtKB
  28. negative regulation of epithelial cell differentiation Source: UniProtKB
  29. negative regulation of nephron tubule epithelial cell differentiation Source: UniProtKB
  30. negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  31. odontogenesis Source: UniProtKB
  32. palate development Source: UniProtKB
  33. pattern specification involved in metanephros development Source: UniProtKB
  34. positive regulation of bone mineralization Source: BHF-UCL
  35. positive regulation of epithelial cell proliferation Source: UniProtKB
  36. positive regulation of gastrulation Source: UniProtKB
  37. positive regulation of gene expression Source: UniProtKB
  38. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  39. posterior mesonephric tubule development Source: UniProtKB
  40. pronephros development Source: UniProtKB
  41. renal vesicle progenitor cell differentiation Source: UniProtKB
  42. specification of anterior mesonephric tubule identity Source: UniProtKB
  43. specification of posterior mesonephric tubule identity Source: UniProtKB
  44. stem cell differentiation Source: UniProtKB
  45. transcription, DNA-templated Source: UniProtKB-KW
  46. ureteric bud development Source: UniProtKB
  47. ureter urothelium development Source: UniProtKB
  48. urogenital system development Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein odd-skipped-related 1
Gene namesi
Name:OSR1
Synonyms:ODD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:8111. OSR1.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: LIFEdb
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164742217.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 266266Protein odd-skipped-related 1PRO_0000047004Add
BLAST

Proteomic databases

PaxDbiQ8TAX0.
PRIDEiQ8TAX0.

PTM databases

PhosphoSiteiQ8TAX0.

Expressioni

Tissue specificityi

Expressed in adult colon, small intestine, prostate, testis, and fetal lung.1 Publication

Gene expression databases

BgeeiQ8TAX0.
CleanExiHS_OSR1.
GenevestigatoriQ8TAX0.

Organism-specific databases

HPAiHPA015525.

Interactioni

Protein-protein interaction databases

BioGridi126234. 3 interactions.
MINTiMINT-4720561.
STRINGi9606.ENSP00000272223.

Structurei

3D structure databases

ProteinModelPortaliQ8TAX0.
SMRiQ8TAX0. Positions 166-255.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri175 – 19723C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri203 – 22523C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri231 – 25323C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00760000119344.
HOGENOMiHOG000013107.
HOVERGENiHBG054398.
InParanoidiQ8TAX0.
KOiK09215.
OMAiAKPRFDF.
OrthoDBiEOG754HQ2.
PhylomeDBiQ8TAX0.
TreeFamiTF350876.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TAX0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGSKTLPAPV PIHPSLQLTN YSFLQAVNGL PTVPSDHLPN LYGFSALHAV
60 70 80 90 100
HLHQWTLGYP AMHLPRSSFS KVPGTVSSLV DARFQLPAFP WFPHVIQPKP
110 120 130 140 150
EITAGGSVPA LKTKPRFDFA NLALAATQED PAKLGRGEGP GSPAGGLGAL
160 170 180 190 200
LDVTKLSPEK KPTRGRLPSK TKKEFVCKFC GRHFTKSYNL LIHERTHTDE
210 220 230 240 250
RPYTCDICHK AFRRQDHLRD HRYIHSKEKP FKCQECGKGF CQSRTLAVHK
260
TLHSQVKELK TSKIKC
Length:266
Mass (Da):29,611
Last modified:June 1, 2002 - v1
Checksum:i3D15ED2565C954E3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti214 – 2141R → G in BAG53709. (PubMed:14702039)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB082568 mRNA. Translation: BAB92079.1.
AK074591 mRNA. Translation: BAC11079.1.
AK122756 mRNA. Translation: BAG53709.1.
DQ021502 Genomic DNA. Translation: AAY26397.1.
AC018741 Genomic DNA. Translation: AAY14760.1.
CH471053 Genomic DNA. Translation: EAX00846.1.
CH471053 Genomic DNA. Translation: EAX00848.1.
BC025712 mRNA. Translation: AAH25712.1.
CCDSiCCDS1694.1.
RefSeqiNP_660303.1. NM_145260.2.
XP_006712005.1. XM_006711942.1.
UniGeneiHs.123933.

Genome annotation databases

EnsembliENST00000272223; ENSP00000272223; ENSG00000143867.
GeneIDi130497.
KEGGihsa:130497.
UCSCiuc002rdc.3. human.

Polymorphism databases

DMDMi74762600.

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB082568 mRNA. Translation: BAB92079.1 .
AK074591 mRNA. Translation: BAC11079.1 .
AK122756 mRNA. Translation: BAG53709.1 .
DQ021502 Genomic DNA. Translation: AAY26397.1 .
AC018741 Genomic DNA. Translation: AAY14760.1 .
CH471053 Genomic DNA. Translation: EAX00846.1 .
CH471053 Genomic DNA. Translation: EAX00848.1 .
BC025712 mRNA. Translation: AAH25712.1 .
CCDSi CCDS1694.1.
RefSeqi NP_660303.1. NM_145260.2.
XP_006712005.1. XM_006711942.1.
UniGenei Hs.123933.

3D structure databases

ProteinModelPortali Q8TAX0.
SMRi Q8TAX0. Positions 166-255.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 126234. 3 interactions.
MINTi MINT-4720561.
STRINGi 9606.ENSP00000272223.

PTM databases

PhosphoSitei Q8TAX0.

Polymorphism databases

DMDMi 74762600.

Proteomic databases

PaxDbi Q8TAX0.
PRIDEi Q8TAX0.

Protocols and materials databases

DNASUi 130497.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000272223 ; ENSP00000272223 ; ENSG00000143867 .
GeneIDi 130497.
KEGGi hsa:130497.
UCSCi uc002rdc.3. human.

Organism-specific databases

CTDi 130497.
GeneCardsi GC02M019551.
HGNCi HGNC:8111. OSR1.
HPAi HPA015525.
MIMi 608891. gene.
neXtProti NX_Q8TAX0.
PharmGKBi PA164742217.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
GeneTreei ENSGT00760000119344.
HOGENOMi HOG000013107.
HOVERGENi HBG054398.
InParanoidi Q8TAX0.
KOi K09215.
OMAi AKPRFDF.
OrthoDBi EOG754HQ2.
PhylomeDBi Q8TAX0.
TreeFami TF350876.

Miscellaneous databases

GeneWikii OSR1.
GenomeRNAii 130497.
NextBioi 82746.
PROi Q8TAX0.
SOURCEi Search...

Gene expression databases

Bgeei Q8TAX0.
CleanExi HS_OSR1.
Genevestigatori Q8TAX0.

Family and domain databases

Gene3Di 3.30.160.60. 3 hits.
InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 3 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of OSR1 on human chromosome 2p24."
    Katoh M.
    Int. J. Mol. Med. 10:221-225(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. NIEHS SNPs program
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pancreas.

Entry informationi

Entry nameiOSR1_HUMAN
AccessioniPrimary (citable) accession number: Q8TAX0
Secondary accession number(s): B3KV97, D6W521
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: June 1, 2002
Last modified: October 29, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3