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Q8TAX0 (OSR1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein odd-skipped-related 1
Gene names
Name:OSR1
Synonyms:ODD
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length266 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Transcription factor that plays a role in the regulation of embryonic heart and urogenital development By similarity.

Subcellular location

Nucleus Potential.

Tissue specificity

Expressed in adult colon, small intestine, prostate, testis, and fetal lung. Ref.1

Sequence similarities

Belongs to the Odd C2H2-type zinc-finger protein family.

Contains 3 C2H2-type zinc fingers.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainRepeat
Zinc-finger
   LigandMetal-binding
Zinc
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell differentiation

Inferred from sequence or structural similarity. Source: BHF-UCL

cell proliferation involved in kidney development

Inferred from sequence or structural similarity. Source: UniProtKB

cellular response to retinoic acid

Inferred from electronic annotation. Source: Ensembl

chondrocyte differentiation

Inferred from sequence or structural similarity. Source: BHF-UCL

embryonic digit morphogenesis

Inferred from sequence or structural similarity. Source: BHF-UCL

embryonic forelimb morphogenesis

Inferred from sequence or structural similarity. Source: BHF-UCL

embryonic hindlimb morphogenesis

Inferred from sequence or structural similarity. Source: BHF-UCL

embryonic skeletal joint development

Inferred from sequence or structural similarity. Source: BHF-UCL

embryonic skeletal joint morphogenesis

Inferred from sequence or structural similarity. Source: BHF-UCL

embryonic skeletal limb joint morphogenesis

Inferred from sequence or structural similarity. Source: BHF-UCL

gonad development

Inferred from electronic annotation. Source: Ensembl

heart development

Inferred from sequence or structural similarity. Source: UniProtKB

intermediate mesoderm development

Inferred from electronic annotation. Source: Ensembl

mesangial cell development

Inferred from sequence or structural similarity. Source: UniProtKB

mesonephric duct morphogenesis

Inferred from sequence or structural similarity. Source: UniProtKB

mesonephros development

Inferred from sequence or structural similarity. Source: UniProtKB

metanephric cap mesenchymal cell proliferation involved in metanephros development

Inferred from sequence or structural similarity. Source: UniProtKB

metanephric epithelium development

Inferred from sequence or structural similarity. Source: UniProtKB

metanephric glomerulus vasculature development

Inferred from sequence or structural similarity. Source: UniProtKB

metanephric interstitial cell development

Inferred from sequence or structural similarity. Source: UniProtKB

metanephric mesenchymal cell differentiation

Inferred from sequence or structural similarity. Source: UniProtKB

metanephric mesenchyme development

Inferred from sequence or structural similarity. Source: UniProtKB

metanephric mesenchyme morphogenesis

Inferred from sequence or structural similarity. Source: UniProtKB

metanephric nephron tubule development

Inferred from sequence or structural similarity. Source: UniProtKB

metanephric smooth muscle tissue development

Inferred from sequence or structural similarity. Source: UniProtKB

middle ear morphogenesis

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of apoptotic process

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of epithelial cell differentiation

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of nephron tubule epithelial cell differentiation

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of transcription from RNA polymerase II promoter

Inferred from sequence or structural similarity. Source: BHF-UCL

odontogenesis

Inferred from sequence or structural similarity. Source: UniProtKB

palate development

Inferred from sequence or structural similarity. Source: UniProtKB

pattern specification involved in metanephros development

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of bone mineralization

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of epithelial cell proliferation

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of gastrulation

Inferred from mutant phenotype PubMed 21281489. Source: UniProtKB

positive regulation of gene expression

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of transcription from RNA polymerase II promoter

Inferred from sequence or structural similarity. Source: BHF-UCL

posterior mesonephric tubule development

Inferred from sequence or structural similarity. Source: UniProtKB

pronephros development

Inferred from mutant phenotype PubMed 21281489. Source: UniProtKB

renal vesicle progenitor cell differentiation

Inferred from sequence or structural similarity. Source: UniProtKB

specification of anterior mesonephric tubule identity

Inferred from sequence or structural similarity. Source: UniProtKB

specification of posterior mesonephric tubule identity

Inferred from sequence or structural similarity. Source: UniProtKB

stem cell differentiation

Inferred from sequence or structural similarity. Source: UniProtKB

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

ureter urothelium development

Inferred from sequence or structural similarity. Source: UniProtKB

ureteric bud development

Inferred from sequence or structural similarity. Source: UniProtKB

urogenital system development

Inferred from sequence or structural similarity. Source: UniProtKB

   Cellular_componentnucleus

Inferred from direct assay. Source: LIFEdb

   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

nucleic acid binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 266266Protein odd-skipped-related 1
PRO_0000047004

Regions

Zinc finger175 – 19723C2H2-type 1
Zinc finger203 – 22523C2H2-type 2
Zinc finger231 – 25323C2H2-type 3

Experimental info

Sequence conflict2141R → G in BAG53709. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q8TAX0 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: 3D15ED2565C954E3

FASTA26629,611
        10         20         30         40         50         60 
MGSKTLPAPV PIHPSLQLTN YSFLQAVNGL PTVPSDHLPN LYGFSALHAV HLHQWTLGYP 

        70         80         90        100        110        120 
AMHLPRSSFS KVPGTVSSLV DARFQLPAFP WFPHVIQPKP EITAGGSVPA LKTKPRFDFA 

       130        140        150        160        170        180 
NLALAATQED PAKLGRGEGP GSPAGGLGAL LDVTKLSPEK KPTRGRLPSK TKKEFVCKFC 

       190        200        210        220        230        240 
GRHFTKSYNL LIHERTHTDE RPYTCDICHK AFRRQDHLRD HRYIHSKEKP FKCQECGKGF 

       250        260 
CQSRTLAVHK TLHSQVKELK TSKIKC 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning and characterization of OSR1 on human chromosome 2p24."
Katoh M.
Int. J. Mol. Med. 10:221-225(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[3]NIEHS SNPs program
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Pancreas.
+Additional computationally mapped references.

Web resources

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB082568 mRNA. Translation: BAB92079.1.
AK074591 mRNA. Translation: BAC11079.1.
AK122756 mRNA. Translation: BAG53709.1.
DQ021502 Genomic DNA. Translation: AAY26397.1.
AC018741 Genomic DNA. Translation: AAY14760.1.
CH471053 Genomic DNA. Translation: EAX00846.1.
CH471053 Genomic DNA. Translation: EAX00848.1.
BC025712 mRNA. Translation: AAH25712.1.
CCDSCCDS1694.1.
RefSeqNP_660303.1. NM_145260.2.
XP_006712005.1. XM_006711942.1.
UniGeneHs.123933.

3D structure databases

ProteinModelPortalQ8TAX0.
SMRQ8TAX0. Positions 166-255.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid126234. 3 interactions.
MINTMINT-4720561.
STRING9606.ENSP00000272223.

PTM databases

PhosphoSiteQ8TAX0.

Polymorphism databases

DMDM74762600.

Proteomic databases

PaxDbQ8TAX0.
PRIDEQ8TAX0.

Protocols and materials databases

DNASU130497.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000272223; ENSP00000272223; ENSG00000143867.
ENST00000536433; ENSP00000441801; ENSG00000143867.
GeneID130497.
KEGGhsa:130497.
UCSCuc002rdc.3. human.

Organism-specific databases

CTD130497.
GeneCardsGC02M019551.
HGNCHGNC:8111. OSR1.
HPAHPA015525.
MIM608891. gene.
neXtProtNX_Q8TAX0.
PharmGKBPA164742217.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5048.
HOGENOMHOG000013107.
HOVERGENHBG054398.
InParanoidQ8TAX0.
KOK09215.
OMAAKPRFDF.
OrthoDBEOG754HQ2.
PhylomeDBQ8TAX0.
TreeFamTF350876.

Gene expression databases

BgeeQ8TAX0.
CleanExHS_OSR1.
GenevestigatorQ8TAX0.

Family and domain databases

Gene3D3.30.160.60. 3 hits.
InterProIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOSR1.
GenomeRNAi130497.
NextBio82746.
PROQ8TAX0.
SOURCESearch...

Entry information

Entry nameOSR1_HUMAN
AccessionPrimary (citable) accession number: Q8TAX0
Secondary accession number(s): B3KV97, D6W521
Entry history
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: June 1, 2002
Last modified: July 9, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM