Q8TAX0 (OSR1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein odd-skipped-related 1

Gene names

Name:	OSR1
Synonyms:	ODD

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	266 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Transcription factor that plays a role in the regulation of embryonic heart and urogenital development By similarity.
Subcellular location	Nucleus Potential.
Tissue specificity	Expressed in adult colon, small intestine, prostate, testis, and fetal lung. Ref.1
Sequence similarities	Belongs to the Odd C2H2-type zinc-finger protein family. Contains 3 C2H2-type zinc fingers.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Repeat Zinc-finger
Ligand	Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular response to retinoic acid Inferred from electronic annotation. Source: Compara chondrocyte differentiation Inferred from sequence or structural similarity. Source: BHF-UCL embryonic digit morphogenesis Inferred from sequence or structural similarity. Source: BHF-UCL embryonic forelimb morphogenesis Inferred from sequence or structural similarity. Source: BHF-UCL embryonic hindlimb morphogenesis Inferred from sequence or structural similarity. Source: BHF-UCL embryonic skeletal limb joint morphogenesis Inferred from sequence or structural similarity. Source: BHF-UCL gonad development Inferred from electronic annotation. Source: Compara heart development Inferred from sequence or structural similarity. Source: UniProtKB intermediate mesoderm development Inferred from electronic annotation. Source: Compara mesangial cell development Inferred from sequence or structural similarity. Source: UniProtKB mesonephric duct morphogenesis Inferred from sequence or structural similarity. Source: UniProtKB metanephric cap mesenchymal cell proliferation involved in metanephros development Inferred from sequence or structural similarity. Source: UniProtKB metanephric glomerulus vasculature development Inferred from sequence or structural similarity. Source: UniProtKB metanephric interstitial cell development Inferred from sequence or structural similarity. Source: UniProtKB metanephric mesenchymal cell differentiation Inferred from sequence or structural similarity. Source: UniProtKB metanephric nephron tubule development Inferred from sequence or structural similarity. Source: UniProtKB metanephric smooth muscle tissue development Inferred from sequence or structural similarity. Source: UniProtKB middle ear morphogenesis Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of apoptotic process Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of nephron tubule epithelial cell differentiation Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of transcription from RNA polymerase II promoter Inferred from sequence or structural similarity. Source: BHF-UCL odontogenesis Inferred from sequence or structural similarity. Source: UniProtKB palate development Inferred from sequence or structural similarity. Source: UniProtKB pattern specification involved in metanephros development Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of bone mineralization Inferred from sequence or structural similarity. Source: BHF-UCL positive regulation of epithelial cell proliferation Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of gastrulation Inferred from mutant phenotype PubMed 21281489. Source: UniProtKB positive regulation of transcription from RNA polymerase II promoter Inferred from sequence or structural similarity. Source: BHF-UCL pronephros development Inferred from mutant phenotype PubMed 21281489. Source: UniProtKB renal vesicle progenitor cell differentiation Inferred from sequence or structural similarity. Source: UniProtKB specification of anterior mesonephric tubule identity Inferred from sequence or structural similarity. Source: UniProtKB specification of posterior mesonephric tubule identity Inferred from sequence or structural similarity. Source: UniProtKB stem cell differentiation Inferred from sequence or structural similarity. Source: UniProtKB transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW ureter urothelium development Inferred from sequence or structural similarity. Source: UniProtKB ureteric bud development Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	nucleolus Inferred from direct assay. Source: HPA
Molecular_function	nucleic acid binding Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 266	266	Protein odd-skipped-related 1		PRO_0000047004
Regions
	Zinc finger	175 – 197	23	C2H2-type 1
	Zinc finger	203 – 225	23	C2H2-type 2
	Zinc finger	231 – 253	23	C2H2-type 3
Experimental info
	Sequence conflict	214	1	R → G in BAG53709. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q8TAX0 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: 3D15ED2565C954E3	FASTA	266	29,611
	10 20 30 40 50 60 MGSKTLPAPV PIHPSLQLTN YSFLQAVNGL PTVPSDHLPN LYGFSALHAV HLHQWTLGYP 70 80 90 100 110 120 AMHLPRSSFS KVPGTVSSLV DARFQLPAFP WFPHVIQPKP EITAGGSVPA LKTKPRFDFA 130 140 150 160 170 180 NLALAATQED PAKLGRGEGP GSPAGGLGAL LDVTKLSPEK KPTRGRLPSK TKKEFVCKFC 190 200 210 220 230 240 GRHFTKSYNL LIHERTHTDE RPYTCDICHK AFRRQDHLRD HRYIHSKEKP FKCQECGKGF 250 260 CQSRTLAVHK TLHSQVKELK TSKIKC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and characterization of OSR1 on human chromosome 2p24." Katoh M. Int. J. Mol. Med. 10:221-225(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[3]	NIEHS SNPs program Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Pancreas.
+	Additional computationally mapped references.

Web resources

NIEHS-SNPs

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB082568 mRNA. Translation: BAB92079.1. AK074591 mRNA. Translation: BAC11079.1. AK122756 mRNA. Translation: BAG53709.1. DQ021502 Genomic DNA. Translation: AAY26397.1. AC018741 Genomic DNA. Translation: AAY14760.1. CH471053 Genomic DNA. Translation: EAX00846.1. CH471053 Genomic DNA. Translation: EAX00848.1. BC025712 mRNA. Translation: AAH25712.1.
IPI	IPI00152145.
RefSeq	NP_660303.1. NM_145260.2.
UniGene	Hs.123933.
3D structure databases
ProteinModelPortal	Q8TAX0.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000272223.
PTM databases
PhosphoSite	Q8TAX0.
Polymorphism databases
DMDM	74762600.
Proteomic databases
PaxDb	Q8TAX0.
PRIDE	Q8TAX0.
Protocols and materials databases
DNASU	130497.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000272223; ENSP00000272223; ENSG00000143867. ENST00000536433; ENSP00000441801; ENSG00000143867.
GeneID	130497.
KEGG	hsa:130497.
UCSC	uc002rdc.3. human.
Organism-specific databases
CTD	130497.
GeneCards	GC02M019551.
HGNC	HGNC:8111. OSR1.
HPA	HPA015525.
MIM	608891. gene.
neXtProt	NX_Q8TAX0.
PharmGKB	PA164742217.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5048.
HOGENOM	HOG000013107.
HOVERGEN	HBG054398.
InParanoid	Q8TAX0.
KO	K09215.
OMA	AKPRFDF.
OrthoDB	EOG4DFPP5.
PhylomeDB	Q8TAX0.
Gene expression databases
Bgee	Q8TAX0.
CleanEx	HS_OSR1.
Genevestigator	Q8TAX0.
GermOnline	ENSG00000143867. Homo sapiens.
Family and domain databases
Gene3D	3.30.160.60. 3 hits.
InterPro	IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
SMART	SM00355. ZnF_C2H2. 3 hits. [Graphical view]
PROSITE	PS00028. ZINC_FINGER_C2H2_1. 3 hits. PS50157. ZINC_FINGER_C2H2_2. 3 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	130497.
NextBio	82746.
SOURCE	Search...

Entry information

Entry name

OSR1_HUMAN

Accession

Primary (citable) accession number: Q8TAX0
Secondary accession number(s): B3KV97, D6W521

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 24, 2006
Last sequence update:	June 1, 2002
Last modified:	May 1, 2013
This is version 99 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.