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Protein

Protein odd-skipped-related 1

Gene

OSR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Transcription factor that plays a role in the regulation of embryonic heart and urogenital development.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri175 – 19723C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri203 – 22523C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri231 – 25323C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein odd-skipped-related 1
Gene namesi
Name:OSR1
Synonyms:ODD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:8111. OSR1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164742217.

Polymorphism and mutation databases

BioMutaiOSR1.
DMDMi74762600.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 266266Protein odd-skipped-related 1PRO_0000047004Add
BLAST

Proteomic databases

PaxDbiQ8TAX0.
PRIDEiQ8TAX0.

PTM databases

PhosphoSiteiQ8TAX0.

Expressioni

Tissue specificityi

Expressed in adult colon, small intestine, prostate, testis, and fetal lung.1 Publication

Gene expression databases

BgeeiQ8TAX0.
CleanExiHS_OSR1.
GenevisibleiQ8TAX0. HS.

Organism-specific databases

HPAiHPA015525.

Interactioni

Protein-protein interaction databases

BioGridi126234. 3 interactions.
MINTiMINT-4720561.
STRINGi9606.ENSP00000272223.

Structurei

3D structure databases

ProteinModelPortaliQ8TAX0.
SMRiQ8TAX0. Positions 166-255.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri175 – 19723C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri203 – 22523C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri231 – 25323C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00760000119344.
HOGENOMiHOG000013107.
HOVERGENiHBG054398.
InParanoidiQ8TAX0.
KOiK09215.
OMAiYPAVHLP.
OrthoDBiEOG754HQ2.
PhylomeDBiQ8TAX0.
TreeFamiTF350876.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TAX0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSKTLPAPV PIHPSLQLTN YSFLQAVNGL PTVPSDHLPN LYGFSALHAV
60 70 80 90 100
HLHQWTLGYP AMHLPRSSFS KVPGTVSSLV DARFQLPAFP WFPHVIQPKP
110 120 130 140 150
EITAGGSVPA LKTKPRFDFA NLALAATQED PAKLGRGEGP GSPAGGLGAL
160 170 180 190 200
LDVTKLSPEK KPTRGRLPSK TKKEFVCKFC GRHFTKSYNL LIHERTHTDE
210 220 230 240 250
RPYTCDICHK AFRRQDHLRD HRYIHSKEKP FKCQECGKGF CQSRTLAVHK
260
TLHSQVKELK TSKIKC
Length:266
Mass (Da):29,611
Last modified:June 1, 2002 - v1
Checksum:i3D15ED2565C954E3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti214 – 2141R → G in BAG53709 (PubMed:14702039).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB082568 mRNA. Translation: BAB92079.1.
AK074591 mRNA. Translation: BAC11079.1.
AK122756 mRNA. Translation: BAG53709.1.
DQ021502 Genomic DNA. Translation: AAY26397.1.
AC018741 Genomic DNA. Translation: AAY14760.1.
CH471053 Genomic DNA. Translation: EAX00846.1.
CH471053 Genomic DNA. Translation: EAX00848.1.
BC025712 mRNA. Translation: AAH25712.1.
CCDSiCCDS1694.1.
RefSeqiNP_660303.1. NM_145260.2.
XP_006712005.1. XM_006711942.2.
UniGeneiHs.123933.

Genome annotation databases

EnsembliENST00000272223; ENSP00000272223; ENSG00000143867.
GeneIDi130497.
KEGGihsa:130497.
UCSCiuc002rdc.3. human.

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB082568 mRNA. Translation: BAB92079.1.
AK074591 mRNA. Translation: BAC11079.1.
AK122756 mRNA. Translation: BAG53709.1.
DQ021502 Genomic DNA. Translation: AAY26397.1.
AC018741 Genomic DNA. Translation: AAY14760.1.
CH471053 Genomic DNA. Translation: EAX00846.1.
CH471053 Genomic DNA. Translation: EAX00848.1.
BC025712 mRNA. Translation: AAH25712.1.
CCDSiCCDS1694.1.
RefSeqiNP_660303.1. NM_145260.2.
XP_006712005.1. XM_006711942.2.
UniGeneiHs.123933.

3D structure databases

ProteinModelPortaliQ8TAX0.
SMRiQ8TAX0. Positions 166-255.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126234. 3 interactions.
MINTiMINT-4720561.
STRINGi9606.ENSP00000272223.

PTM databases

PhosphoSiteiQ8TAX0.

Polymorphism and mutation databases

BioMutaiOSR1.
DMDMi74762600.

Proteomic databases

PaxDbiQ8TAX0.
PRIDEiQ8TAX0.

Protocols and materials databases

DNASUi130497.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000272223; ENSP00000272223; ENSG00000143867.
GeneIDi130497.
KEGGihsa:130497.
UCSCiuc002rdc.3. human.

Organism-specific databases

CTDi130497.
GeneCardsiGC02M019551.
HGNCiHGNC:8111. OSR1.
HPAiHPA015525.
MIMi608891. gene.
neXtProtiNX_Q8TAX0.
PharmGKBiPA164742217.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00760000119344.
HOGENOMiHOG000013107.
HOVERGENiHBG054398.
InParanoidiQ8TAX0.
KOiK09215.
OMAiYPAVHLP.
OrthoDBiEOG754HQ2.
PhylomeDBiQ8TAX0.
TreeFamiTF350876.

Miscellaneous databases

GeneWikiiOSR1.
GenomeRNAii130497.
NextBioi82746.
PROiQ8TAX0.
SOURCEiSearch...

Gene expression databases

BgeeiQ8TAX0.
CleanExiHS_OSR1.
GenevisibleiQ8TAX0. HS.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of OSR1 on human chromosome 2p24."
    Katoh M.
    Int. J. Mol. Med. 10:221-225(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. NIEHS SNPs program
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pancreas.

Entry informationi

Entry nameiOSR1_HUMAN
AccessioniPrimary (citable) accession number: Q8TAX0
Secondary accession number(s): B3KV97, D6W521
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: June 1, 2002
Last modified: June 24, 2015
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.